SOS2基因详情-基因数据库-基因云馆

SOS2 (SOS Ras/Rho guanine nucleotide exchange factor 2)

symbol:: SOS2
locus group:: protein-coding gene
location:: 14q21.3
gene_family:: Pleckstrin homology domain containing|Rho guanine nucleotide exchange factors
alias symbol:: None
alias name:: None
entrez id:: 6655
ensembl gene id:: ENSG00000100485
ucsc gene id:: uc001wxs.5
refseq accession:: NM_006939
hgnc_id:: HGNC:11188
approved reserved:: 1993-10-27

14q21.3

SOS2（Son of Sevenless homolog 2）是SOS基因家族的重要成员，该家族还包括SOS1，它们编码鸟苷酸交换因子（GEFs），主要功能是激活RAS蛋白（一类调控细胞生长的关键分子开关）。SOS2通过促进RAS从非活性的GDP结合状态转变为活性的GTP结合状态，从而激活下游的MAPK信号通路（控制细胞增殖、分化的关键通路）。其表达产物主要作用于细胞膜附近，与生长因子受体（如EGFR）结合后传递信号。突变可能导致SOS2功能异常，例如过度激活RAS-MAPK通路，与努南综合征（Noonan syndrome，一种发育障碍疾病）和某些癌症（如肺癌、结肠癌）相关。若SOS2过表达，会持续激活RAS信号，导致细胞不受控增殖；而表达降低则可能影响组织发育或修复。SOS基因家族的共性是通过保守的CDC25结构域（负责催化RAS激活的区域）和PH结构域（帮助定位到细胞膜）发挥作用。目前“Son of Sevenless”的中文译名“七号之子”存在争议，部分文献直接使用英文原名。

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OMIM数据库中对SOS2基因的介绍 Wikipedia数据库中对SOS2基因的介绍

SOS2基因的碱基序列：[NCBI]

Loading Gene Browser...

SOS2基因的碱基突变：仅显示部分snp

rs735210 rs764350 rs1075537 rs1543425 rs1543426 rs1569898 rs1803661 rs1884405 rs1950510 rs1950511 rs1950512 rs1950513 rs1955921 rs1955922 rs1955923 rs1955924 rs2009577

SOS2基因在不同组织中的表达： [UniProt]

正向引物序列

正向Tm值

反向引物序列

反向Tm值

评分

TACTGCTCTCATGAATCTCCA

58

CAAACAGGATCTCCAGGTC

57

GCCTTACGAGTTCTTCAGC

58

GCTTTACACTTCTTCCGCA

58

TCAAGATGTAGAGGAGCGAG

58

TATAGCAGATTGTGCATCAGC

58

TACTGCTCTCATGAATCTCCA

58

AAACAGGATCTCCAGGTCG

59

TACGAGTTCTTCAGCGAGG

59

CCATGCTTTACACTTCTTCCG

59

TCAAGATGTAGAGGAGCGAG

58

ATAGCAGATTGTGCATCAGC

58

TTACGAGTTCTTCAGCGAG

57

CATGCTTTACACTTCTTCCG

57

ACTGCTCTCATGAATCTCCA

58

AAACAGGATCTCCAGGTCG

59

TTCAAGATGTAGAGGAGCGA

58

TAGCAGATTGTGCATCAGC

58

尚未收录相关数据

SOS2基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

质膜
细胞质
细胞外
高尔基体
囊泡
细胞骨架
内质网
细胞核
内体
溶酶体
线粒体

SOS2基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0005089

A0A087X277 (UniProtKB)

IEA

GO:0035023

A0A087X277 (UniProtKB)

IEA

GO:0043547

A0A087X277 (UniProtKB)

IEA

GO:0003677

Q07890 (UniProtKB)

IEA

GO:0005085

Q07890 (UniProtKB)

TAS

GO:0005089

Q07890 (UniProtKB)

TAS

GO:0005089

Q07890 (UniProtKB)

TAS

GO:0005515

Q07890 (UniProtKB)

IPI

GO:0005515

Q07890 (UniProtKB)

IPI

GO:0005515

Q07890 (UniProtKB)

IPI

GO:0005515

Q07890 (UniProtKB)

IPI

GO:0005515

Q07890 (UniProtKB)

IPI

GO:0005515

Q07890 (UniProtKB)

IPI

GO:0005515

Q07890 (UniProtKB)

IPI

GO:0005515

Q07890 (UniProtKB)

IPI

GO:0005515

Q07890 (UniProtKB)

IPI

GO:0005515

Q07890 (UniProtKB)

IPI

GO:0005515

Q07890 (UniProtKB)

IPI

GO:0005515

Q07890 (UniProtKB)

IPI

GO:0005515

Q07890 (UniProtKB)

IPI

GO:0005829

Q07890 (UniProtKB)

TAS

GO:0005829

Q07890 (UniProtKB)

TAS

GO:0005829

Q07890 (UniProtKB)

TAS

GO:0007264

Q07890 (UniProtKB)

IEA

GO:0035023

Q07890 (UniProtKB)

IEA

GO:0043065

Q07890 (UniProtKB)

TAS

GO:0043547

Q07890 (UniProtKB)

IEA

GO:0043547

Q07890 (UniProtKB)

IEA

GO:0046982

Q07890 (UniProtKB)

IEA

GO:0051056

Q07890 (UniProtKB)

TAS

GO:0051057

Q07890 (UniProtKB)

IEA

可能调控 SOS2基因的相关microRNA：

hsa-miR-124 hsa-miR-335 hsa-miR-1

Reactome

MINT

BioGrid

IntAct

mentha

String

序号	作用方式	资源库来源/分值	基因名称	基因名称

KEGG
Reactomepathway

名称
4014 Ras signaling pathway [PATH:hsa04014]
4010 MAPK signaling pathway [PATH:hsa04010]
4012 ErbB signaling pathway [PATH:hsa04012]
4630 Jak-STAT signaling pathway [PATH:hsa04630]
4068 FoxO signaling pathway [PATH:hsa04068]
4151 PI3K-Akt signaling pathway [PATH:hsa04151]
4810 Regulation of actin cytoskeleton [PATH:hsa04810]
4510 Focal adhesion [PATH:hsa04510]
4540 Gap junction [PATH:hsa04540]
4650 Natural killer cell mediated cytotoxicity [PATH:hsa04650]
4660 T cell receptor signaling pathway [PATH:hsa04660]
4662 B cell receptor signaling pathway [PATH:hsa04662]
4664 Fc epsilon RI signaling pathway [PATH:hsa04664]
4062 Chemokine signaling pathway [PATH:hsa04062]
4910 Insulin signaling pathway [PATH:hsa04910]
4912 GnRH signaling pathway [PATH:hsa04912]
4915 Estrogen signaling pathway [PATH:hsa04915]
4917 Prolactin signaling pathway [PATH:hsa04917]
4722 Neurotrophin signaling pathway [PATH:hsa04722]
4320 Dorso-ventral axis formation [PATH:hsa04320]
5200 Pathways in cancer [PATH:hsa05200]
5231 Choline metabolism in cancer [PATH:hsa05231]
5206 MicroRNAs in cancer [PATH:hsa05206]
5205 Proteoglycans in cancer [PATH:hsa05205]
5214 Glioma [PATH:hsa05214]
5221 Acute myeloid leukemia [PATH:hsa05221]
5220 Chronic myeloid leukemia [PATH:hsa05220]
5211 Renal cell carcinoma [PATH:hsa05211]
5215 Prostate cancer [PATH:hsa05215]
5213 Endometrial cancer [PATH:hsa05213]
5223 Non-small cell lung cancer [PATH:hsa05223]
5034 Alcoholism [PATH:hsa05034]
5160 Hepatitis C [PATH:hsa05160]

名称
Activation of Rac
Axon guidance
Cell death signalling via NRAGE, NRIF and NADE
Developmental Biology
G alpha (12/13) signalling events
GPCR downstream signaling
NRAGE signals death through JNK
p75 NTR receptor-mediated signalling
Rho GTPase cycle
Signaling by GPCR
Signaling by Rho GTPases
Signaling by Robo receptor
Signalling by NGF

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
Noonan Syndrome	0.120271442	1	0	BeFree_ORPHANET
Alzheimer's Disease	0.005091382	1	0	GAD_LHGDN
Malignant neoplasm of prostate	0.001357209	5	0	BeFree
Prostate carcinoma	0.001085767	4	0	BeFree
Neoplasm Metastasis	0.001085767	4	0	BeFree
Breast Carcinoma	0.000814326	3	0	BeFree
Non-Small Cell Lung Carcinoma	0.000814326	3	0	BeFree
X-linked retinitis pigmentosa	0.000814326	3	0	BeFree
Malignant neoplasm of breast	0.000814326	3	0	BeFree
Aarskog syndrome	0.000814326	3	0	BeFree

SOS2 (SOS Ras/Rho guanine nucleotide exchange factor 2)

基因基本信息

基因基本信息

基因染色体位置

基因染色体位置

基因简述

基因简述

基因序列

基因序列

基因突变

基因突变

基因表达

基因表达

基因引物

基因引物

转录因子

转录因子

尚未收录相关数据

基因本体信息

基因相关microRNA

基因相关microRNA

基因相互作用关系

基因相互作用关系

基因通路

基因通路

基因相关疾病

基因相关疾病

基因相关服务

基因相关服务

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