SOD2 (superoxide dismutase 2)

基因基本信息

基因基本信息

symbol:
SOD2
locus group:
protein-coding gene
location:
6q25.3
gene_family:
alias symbol:
GClnc1|MnSOD|IPOB|GC1
alias name:
gastric cancer–associated lncRNA 1…
entrez id:
6648
ensembl gene id:
ENSG00000112096
ucsc gene id:
uc003qsf.6
refseq accession:
NM_000636
hgnc_id:
HGNC:11180
approved reserved:
1986-01-01

基因染色体位置

基因染色体位置

6q25.3
基因染色体位置图

基因简述

基因简述

This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

此基因是铁/锰超氧化物歧化酶家族的一个成员。它编码形成同源四聚体并结合每亚基1锰离子线粒体蛋白。该蛋白质结合的氧化磷酸化的超氧化物副产物，并将其转换成过氧化氢和二原子氧。在这种基因突变与特发性心肌病（IDC），早衰，散发性运动神经元疾病，和癌症相关联。备用转录剪接变体，编码不同同种型，已经表征。 [由RefSeq的，2008年7月提供]

OMIM数据库中对CCND1基因的介绍     Wikipedia数据库中对CCND1基因的介绍

基因序列

基因序列

CCND1基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

SOD2基因的碱基突变：           仅显示部分snp
rs4880       rs7855       rs8031       rs10370       rs11854       rs1064563       rs1141718       rs1570318       rs1800665       rs1800666       rs1804451       rs2070994       rs2495277       rs2495280       rs2495281       rs2758330       rs2758331      

基因表达

基因表达

SOD2基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
CACTAGCAGCATGTTGAGC
59
GTTGATGTGAGGTTCCAGG
58
CTGGAACCTCACATCAACG
59
CTGTAACATCTCCCTTGGC
58
CTGGAACCTCACATCAACG
59
CTGTAACATCTCCCTTGGC
58
CTAGGACTTGGAGACTCCC
58
TAACATCTCCTGAAGTCAAGTG
58
ATTCATCTTGCTTCTCCTGC
58
ATTCCAGTCCTGAGCTCAG
59
TTGTAGAAGGAGTGCCTCG
59
GCAACTCCCAACAGTAAGG
59
TTGGTTTCAATAAGGAACGGG
59
GGAATAAGGCCTGTTGTTCC
59
TTGGTTTCAATAAGGAACGGG
59
GGAATAAGGCCTGTTGTTCC
59
GTGGTGGTCATATCAATCATAGC
60
GTGGAATAAGGCCTTTGGG
59
GAACAACCTGAACGTCACC
59
CTGTAACATCTCCCTTGGC
58

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
DDB2
SOD2
Repression
18431487
FOXO4
SOD2
Activation
21536589
JUN
SOD2
Unknown
15330761
NFE2L2
SOD2
Activation
22493435
NFKB1
SOD2
Activation
11880364; 14515147; 19507253
NFKB1
SOD2
Unknown
15330761; 18779124
PPARA
SOD2
Unknown
19958503
REL
SOD2
Activation
11880364
RELA
SOD2
Activation
11880364; 14515147; 19507253
RELA
SOD2
Unknown
15330761; 18779124

基因本体信息

SOD2基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

SOD2基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0004784
A0A0C4DFU1 (UniProtKB)
IEA
GO:0019430
A0A0C4DFU1 (UniProtKB)
IEA
GO:0046872
A0A0C4DFU1 (UniProtKB)
IEA
GO:0055114
A0A0C4DFU1 (UniProtKB)
IEA
GO:0001306
A0A0C4DFU2 (UniProtKB)
IEA
GO:0001666
A0A0C4DFU2 (UniProtKB)
IEA
GO:0001836
A0A0C4DFU2 (UniProtKB)
IEA
GO:0001889
A0A0C4DFU2 (UniProtKB)
IEA
GO:0003032
A0A0C4DFU2 (UniProtKB)
IEA
GO:0003069
A0A0C4DFU2 (UniProtKB)
IEA
GO:0003677
A0A0C4DFU2 (UniProtKB)
IEA
GO:0004784
A0A0C4DFU2 (UniProtKB)
IEA
GO:0005743
A0A0C4DFU2 (UniProtKB)
IEA
GO:0006357
A0A0C4DFU2 (UniProtKB)
IEA
GO:0006749
A0A0C4DFU2 (UniProtKB)
IEA
GO:0007507
A0A0C4DFU2 (UniProtKB)
IEA
GO:0007626
A0A0C4DFU2 (UniProtKB)
IEA
GO:0008630
A0A0C4DFU2 (UniProtKB)
IEA
GO:0008631
A0A0C4DFU2 (UniProtKB)
IEA
GO:0009409
A0A0C4DFU2 (UniProtKB)
IEA
GO:0009791
A0A0C4DFU2 (UniProtKB)
IEA
GO:0010042
A0A0C4DFU2 (UniProtKB)
IEA
GO:0010043
A0A0C4DFU2 (UniProtKB)
IEA
GO:0010269
A0A0C4DFU2 (UniProtKB)
IEA
GO:0010332
A0A0C4DFU2 (UniProtKB)
IEA
GO:0014823
A0A0C4DFU2 (UniProtKB)
IEA
GO:0014823
A0A0C4DFU2 (UniProtKB)
IEA
GO:0019430
A0A0C4DFU2 (UniProtKB)
IEA
GO:0019430
A0A0C4DFU2 (UniProtKB)
IEA
GO:0019825
A0A0C4DFU2 (UniProtKB)
IEA
GO:0019899
A0A0C4DFU2 (UniProtKB)
IEA
GO:0022904
A0A0C4DFU2 (UniProtKB)
IEA
GO:0030097
A0A0C4DFU2 (UniProtKB)
IEA
GO:0030145
A0A0C4DFU2 (UniProtKB)
IEA
GO:0032496
A0A0C4DFU2 (UniProtKB)
IEA
GO:0033591
A0A0C4DFU2 (UniProtKB)
IEA
GO:0034021
A0A0C4DFU2 (UniProtKB)
IEA
GO:0035900
A0A0C4DFU2 (UniProtKB)
IEA
GO:0035902
A0A0C4DFU2 (UniProtKB)
IEA
GO:0042493
A0A0C4DFU2 (UniProtKB)
IEA
GO:0042542
A0A0C4DFU2 (UniProtKB)
IEA
GO:0042542
A0A0C4DFU2 (UniProtKB)
IEA
GO:0042554
A0A0C4DFU2 (UniProtKB)
IEA
GO:0042645
A0A0C4DFU2 (UniProtKB)
IEA
GO:0042802
A0A0C4DFU2 (UniProtKB)
IEA
GO:0043066
A0A0C4DFU2 (UniProtKB)
IEA
GO:0043209
A0A0C4DFU2 (UniProtKB)
IEA
GO:0045429
A0A0C4DFU2 (UniProtKB)
IEA
GO:0045599
A0A0C4DFU2 (UniProtKB)
IEA
GO:0046686
A0A0C4DFU2 (UniProtKB)
IEA
GO:0048147
A0A0C4DFU2 (UniProtKB)
IEA
GO:0048666
A0A0C4DFU2 (UniProtKB)
IEA
GO:0048678
A0A0C4DFU2 (UniProtKB)
IEA
GO:0048773
A0A0C4DFU2 (UniProtKB)
IEA
GO:0050665
A0A0C4DFU2 (UniProtKB)
IEA
GO:0050790
A0A0C4DFU2 (UniProtKB)
IEA
GO:0051260
A0A0C4DFU2 (UniProtKB)
IEA
GO:0051602
A0A0C4DFU2 (UniProtKB)
IEA
GO:0051881
A0A0C4DFU2 (UniProtKB)
IEA
GO:0055072
A0A0C4DFU2 (UniProtKB)
IEA
GO:0055093
A0A0C4DFU2 (UniProtKB)
IEA
GO:0071000
A0A0C4DFU2 (UniProtKB)
IEA
GO:0071361
A0A0C4DFU2 (UniProtKB)
IEA
GO:0004784
A0A0C4DG56 (UniProtKB)
IEA
GO:0019430
A0A0C4DG56 (UniProtKB)
IEA
GO:0046872
A0A0C4DG56 (UniProtKB)
IEA
GO:0055114
A0A0C4DG56 (UniProtKB)
IEA
GO:0004784
F5GXZ9 (UniProtKB)
IEA
GO:0019430
F5GXZ9 (UniProtKB)
IEA
GO:0046872
F5GXZ9 (UniProtKB)
IEA
GO:0055114
F5GXZ9 (UniProtKB)
IEA
GO:0004784
F5GYZ5 (UniProtKB)
IEA
GO:0019430
F5GYZ5 (UniProtKB)
IEA
GO:0046872
F5GYZ5 (UniProtKB)
IEA
GO:0055114
F5GYZ5 (UniProtKB)
IEA
GO:0004784
F5H3C5 (UniProtKB)
IEA
GO:0019430
F5H3C5 (UniProtKB)
IEA
GO:0046872
F5H3C5 (UniProtKB)
IEA
GO:0055114
F5H3C5 (UniProtKB)
IEA
GO:0004784
F5H4R2 (UniProtKB)
IEA
GO:0019430
F5H4R2 (UniProtKB)
IEA
GO:0046872
F5H4R2 (UniProtKB)
IEA
GO:0055114
F5H4R2 (UniProtKB)
IEA
GO:0004784
G5E9P6 (UniProtKB)
IEA
GO:0019430
G5E9P6 (UniProtKB)
IEA
GO:0046872
G5E9P6 (UniProtKB)
IEA
GO:0055114
G5E9P6 (UniProtKB)
IEA
GO:0004784
G8JLJ2 (UniProtKB)
IEA
GO:0019430
G8JLJ2 (UniProtKB)
IEA
GO:0046872
G8JLJ2 (UniProtKB)
IEA
GO:0055114
G8JLJ2 (UniProtKB)
IEA
GO:0000302
P04179 (UniProtKB)
TAS
GO:0000303
P04179 (UniProtKB)
IMP
GO:0001315
P04179 (UniProtKB)
IMP
GO:0001836
P04179 (UniProtKB)
ISS
GO:0003069
P04179 (UniProtKB)
ISS
GO:0004784
P04179 (UniProtKB)
IDA
GO:0004784
P04179 (UniProtKB)
IDA
GO:0004784
P04179 (UniProtKB)
IDA
GO:0004784
P04179 (UniProtKB)
TAS
GO:0005739
P04179 (UniProtKB)
IDA
GO:0005759
P04179 (UniProtKB)
TAS
GO:0005759
P04179 (UniProtKB)
TAS
GO:0006357
P04179 (UniProtKB)
IMP
GO:0006801
P04179 (UniProtKB)
IDA
GO:0006801
P04179 (UniProtKB)
IDA
GO:0008217
P04179 (UniProtKB)
ISS
GO:0008285
P04179 (UniProtKB)
IMP
GO:0019430
P04179 (UniProtKB)
IMP
GO:0030145
P04179 (UniProtKB)
TAS
GO:0030145
P04179 (UniProtKB)
IDA
GO:0032364
P04179 (UniProtKB)
IMP
GO:0042802
P04179 (UniProtKB)
IPI
GO:0042802
P04179 (UniProtKB)
IPI
GO:0043524
P04179 (UniProtKB)
IGI
GO:0051289
P04179 (UniProtKB)
IPI
GO:0055114
P04179 (UniProtKB)
IEA
GO:0070062
P04179 (UniProtKB)
IDA
GO:0070062
P04179 (UniProtKB)
IDA
GO:1902176
P04179 (UniProtKB)
IMP

基因相关microRNA

基因相关microRNA

可能调控 SOD2基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
MICROVASCULAR COMPLICATIONS OF DIABETES, SUSCEPTIBILITY TO, 6 (finding) 0.24 0 1 CLINVAR_CTD_human
Esophageal Neoplasms 0.210096888 7 0 BeFree_CTD_human_GAD_LHGDN_RGD
Hypertensive disease 0.210011012 10 0 BeFree_CTD_human_GAD_RGD
Myocardial Infarction 0.204734064 5 0 CTD_human_GAD_RGD
Aortic Aneurysm, Abdominal 0.2 1 0 CTD_human_RGD
Diabetes Mellitus, Experimental 0.2 3 0 CTD_human_RGD
Reperfusion Injury 0.2 7 0 CTD_human_RGD
Mammary Neoplasms 0.149524658 16 0 BeFree_CTD_human_GAD_LHGDN
Diabetes Mellitus, Non-Insulin-Dependent 0.143474823 18 4 BeFree_CTD_human_GAD
Prostatic Neoplasms 0.141351607 12 1 BeFree_CTD_human_GAD_LHGDN

基因相关服务

基因相关服务

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