SNCA (synuclein alpha)

基因基本信息

基因基本信息

symbol:
SNCA
locus group:
protein-coding gene
location:
4q22.1
gene_family:
Parkinson disease associated genes
alias symbol:
NACP|PD1
alias name:
non A4 component of amyloid precur…
entrez id:
6622
ensembl gene id:
ENSG00000145335
ucsc gene id:
uc003hsr.4
refseq accession:
NM_000345
hgnc_id:
HGNC:11138
approved reserved:
1995-01-24

基因染色体位置

基因染色体位置

4q22.1
基因染色体位置图

基因简述

基因简述

SNCA基因（α-突触核蛋白基因，原英文alpha-synuclein gene）位于人类第4号染色体上，编码α-突触核蛋白（α-synuclein），这是一种在中枢神经系统突触前末端高度表达的蛋白质。α-突触核蛋白的主要功能包括参与突触可塑性（神经元之间连接强度的调节）、神经递质释放的调控以及维持突触囊泡的稳定性。该蛋白还能与细胞膜结合，可能在脂质代谢和运输中发挥作用。SNCA属于突触核蛋白家族（synuclein family），该家族还包括β-突触核蛋白（β-synuclein）和γ-突触核蛋白（γ-synuclein），这些成员在结构上相似，但功能上存在差异，主要参与神经系统的正常功能。SNCA基因的突变或异常表达与多种神经系统疾病密切相关，尤其是帕金森病（Parkinson's disease, PD）。某些突变（如A53T、A30P和E46K）会导致α-突触核蛋白的错误折叠和聚集，形成路易小体（Lewy bodies），这是帕金森病的病理标志之一。此外，SNCA基因的拷贝数变异（如重复或三倍体）会导致该基因的过表达，进而增加α-突触核蛋白的积累，加剧蛋白聚集和神经毒性，最终引发神经元死亡和多巴胺能神经元的退化。SNCA表达水平的变化对机体有显著影响：过表达会加速α-突触核蛋白的聚集，促进神经退行性病变，并可能干扰其他突触蛋白的功能，如突触小泡循环和神经递质释放；而降低表达（如通过基因沉默）可能减轻蛋白聚集和神经毒性，但完全缺失可能影响突触功能和神经传递效率。除了帕金森病，SNCA的异常还与路易体痴呆（dementia with Lewy bodies, DLB）和多系统萎缩（multiple system atrophy, MSA）等神经退行性疾病相关。研究SNCA基因及其蛋白产物对于理解这些疾病的发病机制和开发靶向治疗策略具有重要意义。

None

无

OMIM数据库中对SNCA基因的介绍     Wikipedia数据库中对SNCA基因的介绍

基因序列

基因序列

SNCA基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

SNCA基因的碱基突变：           仅显示部分snp
rs3857054       rs3857055       rs3857056       rs6814683       rs6820267       rs11303281       rs17180628       rs17795208       rs61378184       rs62306304       rs62306305       rs62306306       rs71594890       rs71609576       rs77406136       rs78504001       rs78735560      

基因表达

基因表达

SNCA基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
GGTGTTCTCTATGTAGGCTC
57
TTGCTCTTTGGTCTTCTCAG
58
GGTGTTCTCTATGTAGGCTC
57
TTGCTCTTTGGTCTTCTCAG
58
GTGTTCTCTATGTAGTGGCTG
58
ACTGTCTTCTGGGCTACTG
59
GAAGGAATTCTGGAAGATATGCC
59
GTAGTCTTGATACCCTTCCTCAG
60
CAGAAGACAGTGGAGGGAG
59
GTCTTGATACCCTTCCTTGC
58
GAAGGAATTCTGGAAGATATGCC
59
GTAGTCTTGATACCCTTCCTCAG
60
GAAGGAATTCTGGAAGATATGCC
59
GTAGTCTTGATACCCTTCCTCAG
60
GAAGGAATTCTGGAAGATATGCC
59
GTAGTCTTGATACCCTTCCTCAG
60
GAAGGAATTCTGGAAGATATGCC
59
GTAGTCTTGATACCCTTCCTCAG
60
GAAGGAATTCTGGAAGATATGCC
59
GTAGTCTTGATACCCTTCCTCAG
60

转录因子

转录因子

      尚未收录相关数据

基因本体信息

SNCA基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

SNCA基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0005737
D6RA31 (UniProtKB)
IEA
GO:0014059
D6RA31 (UniProtKB)
IEA
GO:0005737
E7EPV7 (UniProtKB)
IEA
GO:0014059
E7EPV7 (UniProtKB)
IEA
GO:0005737
H6UYS7 (UniProtKB)
IEA
GO:0014059
H6UYS7 (UniProtKB)
IEA
GO:0000122
P37840 (UniProtKB)
TAS
GO:0000287
P37840 (UniProtKB)
IDA
GO:0001774
P37840 (UniProtKB)
TAS
GO:0001921
P37840 (UniProtKB)
IDA
GO:0001933
P37840 (UniProtKB)
IEA
GO:0001956
P37840 (UniProtKB)
IEA
GO:0005507
P37840 (UniProtKB)
IDA
GO:0005507
P37840 (UniProtKB)
IDA
GO:0005509
P37840 (UniProtKB)
IDA
GO:0005509
P37840 (UniProtKB)
IDA
GO:0005515
P37840 (UniProtKB)
IPI
GO:0005515
P37840 (UniProtKB)
IPI
GO:0005515
P37840 (UniProtKB)
IPI
GO:0005515
P37840 (UniProtKB)
IPI
GO:0005515
P37840 (UniProtKB)
IPI
GO:0005515
P37840 (UniProtKB)
IPI
GO:0005515
P37840 (UniProtKB)
IPI
GO:0005515
P37840 (UniProtKB)
IPI
GO:0005515
P37840 (UniProtKB)
IPI
GO:0005515
P37840 (UniProtKB)
IPI
GO:0005515
P37840 (UniProtKB)
IPI
GO:0005515
P37840 (UniProtKB)
IPI
GO:0005515
P37840 (UniProtKB)
IPI
GO:0005515
P37840 (UniProtKB)
IPI
GO:0005515
P37840 (UniProtKB)
IPI
GO:0005515
P37840 (UniProtKB)
IPI
GO:0005515
P37840 (UniProtKB)
IPI
GO:0005515
P37840 (UniProtKB)
IPI
GO:0005515
P37840 (UniProtKB)
IPI
GO:0005515
P37840 (UniProtKB)
IPI
GO:0005515
P37840 (UniProtKB)
IPI
GO:0005515
P37840 (UniProtKB)
IPI
GO:0005515
P37840 (UniProtKB)
IPI
GO:0005515
P37840 (UniProtKB)
IPI
GO:0005515
P37840 (UniProtKB)
IPI
GO:0005543
P37840 (UniProtKB)
IDA
GO:0005576
P37840 (UniProtKB)
IDA
GO:0005576
P37840 (UniProtKB)
TAS
GO:0005576
P37840 (UniProtKB)
TAS
GO:0005615
P37840 (UniProtKB)
IDA
GO:0005634
P37840 (UniProtKB)
IDA
GO:0005634
P37840 (UniProtKB)
IDA
GO:0005634
P37840 (UniProtKB)
IDA
GO:0005634
P37840 (UniProtKB)
IDA
GO:0005640
P37840 (UniProtKB)
IEA
GO:0005737
P37840 (UniProtKB)
IDA
GO:0005737
P37840 (UniProtKB)
IDA
GO:0005737
P37840 (UniProtKB)
IDA
GO:0005737
P37840 (UniProtKB)
IDA
GO:0005737
P37840 (UniProtKB)
IDA
GO:0005737
P37840 (UniProtKB)
IDA
GO:0005737
P37840 (UniProtKB)
IDA
GO:0005737
P37840 (UniProtKB)
IDA
GO:0005739
P37840 (UniProtKB)
TAS
GO:0005764
P37840 (UniProtKB)
TAS
GO:0005791
P37840 (UniProtKB)
IEA
GO:0005794
P37840 (UniProtKB)
IEA
GO:0005829
P37840 (UniProtKB)
IDA
GO:0005829
P37840 (UniProtKB)
IDA
GO:0005829
P37840 (UniProtKB)
TAS
GO:0005829
P37840 (UniProtKB)
TAS
GO:0005829
P37840 (UniProtKB)
TAS
GO:0005829
P37840 (UniProtKB)
TAS
GO:0005829
P37840 (UniProtKB)
TAS
GO:0005829
P37840 (UniProtKB)
TAS
GO:0005829
P37840 (UniProtKB)
TAS
GO:0005840
P37840 (UniProtKB)
IEA
GO:0005886
P37840 (UniProtKB)
IDA
GO:0005886
P37840 (UniProtKB)
IDA
GO:0005886
P37840 (UniProtKB)
IDA
GO:0005938
P37840 (UniProtKB)
IDA
GO:0006631
P37840 (UniProtKB)
IEA
GO:0006638
P37840 (UniProtKB)
IEA
GO:0006644
P37840 (UniProtKB)
IEA
GO:0006919
P37840 (UniProtKB)
IDA
GO:0007006
P37840 (UniProtKB)
IEA
GO:0007568
P37840 (UniProtKB)
IEA
GO:0008017
P37840 (UniProtKB)
IEA
GO:0008021
P37840 (UniProtKB)
IEA
GO:0008198
P37840 (UniProtKB)
IDA
GO:0008270
P37840 (UniProtKB)
IDA
GO:0008344
P37840 (UniProtKB)
IEA
GO:0010040
P37840 (UniProtKB)
IDA
GO:0010517
P37840 (UniProtKB)
IDA
GO:0010642
P37840 (UniProtKB)
IDA
GO:0014048
P37840 (UniProtKB)
IEA
GO:0014059
P37840 (UniProtKB)
TAS
GO:0015629
P37840 (UniProtKB)
IDA
GO:0016020
P37840 (UniProtKB)
IDA
GO:0016234
P37840 (UniProtKB)
IDA
GO:0016234
P37840 (UniProtKB)
IDA
GO:0016491
P37840 (UniProtKB)
IDA
GO:0019894
P37840 (UniProtKB)
IPI
GO:0019904
P37840 (UniProtKB)
IEA
GO:0030054
P37840 (UniProtKB)
IEA
GO:0030424
P37840 (UniProtKB)
IDA
GO:0030426
P37840 (UniProtKB)
IDA
GO:0031115
P37840 (UniProtKB)
IDA
GO:0031623
P37840 (UniProtKB)
IDA
GO:0031648
P37840 (UniProtKB)
IDA
GO:0032026
P37840 (UniProtKB)
IDA
GO:0032410
P37840 (UniProtKB)
IDA
GO:0032496
P37840 (UniProtKB)
IDA
GO:0032769
P37840 (UniProtKB)
IDA
GO:0033138
P37840 (UniProtKB)
ISS
GO:0034341
P37840 (UniProtKB)
IDA
GO:0034599
P37840 (UniProtKB)
IC
GO:0035067
P37840 (UniProtKB)
IDA
GO:0040012
P37840 (UniProtKB)
IEA
GO:0042393
P37840 (UniProtKB)
IDA
GO:0042416
P37840 (UniProtKB)
TAS
GO:0042493
P37840 (UniProtKB)
IEA
GO:0042775
P37840 (UniProtKB)
IEA
GO:0042802
P37840 (UniProtKB)
IPI
GO:0042802
P37840 (UniProtKB)
IPI
GO:0042802
P37840 (UniProtKB)
IPI
GO:0042802
P37840 (UniProtKB)
IPI
GO:0042802
P37840 (UniProtKB)
IPI
GO:0042802
P37840 (UniProtKB)
IPI
GO:0042802
P37840 (UniProtKB)
IPI
GO:0042802
P37840 (UniProtKB)
IPI
GO:0042802
P37840 (UniProtKB)
IPI
GO:0042802
P37840 (UniProtKB)
IPI
GO:0042802
P37840 (UniProtKB)
IPI
GO:0042802
P37840 (UniProtKB)
IDA
GO:0042802
P37840 (UniProtKB)
IPI
GO:0042802
P37840 (UniProtKB)
IDA
GO:0042802
P37840 (UniProtKB)
IPI
GO:0042802
P37840 (UniProtKB)
IPI
GO:0043014
P37840 (UniProtKB)
IPI
GO:0043027
P37840 (UniProtKB)
IDA
GO:0043030
P37840 (UniProtKB)
IEA
GO:0043065
P37840 (UniProtKB)
TAS
GO:0043066
P37840 (UniProtKB)
IMP
GO:0043154
P37840 (UniProtKB)
IMP
GO:0043195
P37840 (UniProtKB)
IEA
GO:0043205
P37840 (UniProtKB)
IDA
GO:0043205
P37840 (UniProtKB)
IDA
GO:0043205
P37840 (UniProtKB)
IDA
GO:0043206
P37840 (UniProtKB)
TAS
GO:0043274
P37840 (UniProtKB)
IEA
GO:0043524
P37840 (UniProtKB)
IEA
GO:0043524
P37840 (UniProtKB)
IEA
GO:0044212
P37840 (UniProtKB)
TAS
GO:0044267
P37840 (UniProtKB)
TAS
GO:0044344
P37840 (UniProtKB)
IEA
GO:0045502
P37840 (UniProtKB)
IPI
GO:0045807
P37840 (UniProtKB)
IDA
GO:0045920
P37840 (UniProtKB)
IMP
GO:0045963
P37840 (UniProtKB)
IEA
GO:0047485
P37840 (UniProtKB)
IEA
GO:0048148
P37840 (UniProtKB)
IEA
GO:0048156
P37840 (UniProtKB)
IDA
GO:0048156
P37840 (UniProtKB)
IDA
GO:0048169
P37840 (UniProtKB)
IEA
GO:0048471
P37840 (UniProtKB)
IDA
GO:0048487
P37840 (UniProtKB)
IEA
GO:0048488
P37840 (UniProtKB)
ISS
GO:0050808
P37840 (UniProtKB)
IEA
GO:0050812
P37840 (UniProtKB)
IEA
GO:0051219
P37840 (UniProtKB)
IDA
GO:0051281
P37840 (UniProtKB)
IDA
GO:0051583
P37840 (UniProtKB)
TAS
GO:0051585
P37840 (UniProtKB)
IDA
GO:0051612
P37840 (UniProtKB)
IDA
GO:0051622
P37840 (UniProtKB)
IDA
GO:0055114
P37840 (UniProtKB)
IDA
GO:0060079
P37840 (UniProtKB)
IEA
GO:0060291
P37840 (UniProtKB)
IEA
GO:0060732
P37840 (UniProtKB)
IDA
GO:0070495
P37840 (UniProtKB)
IDA
GO:0070555
P37840 (UniProtKB)
IDA
GO:0071280
P37840 (UniProtKB)
IDA
GO:0071872
P37840 (UniProtKB)
TAS
GO:0071902
P37840 (UniProtKB)
IDA
GO:0098794
P37840 (UniProtKB)
IEA
GO:1901215
P37840 (UniProtKB)
IDA
GO:1902957
P37840 (UniProtKB)
TAS
GO:1903284
P37840 (UniProtKB)
IDA
GO:1903285
P37840 (UniProtKB)
IDA
GO:1903421
P37840 (UniProtKB)
TAS
GO:1903426
P37840 (UniProtKB)
TAS
GO:1904715
P37840 (UniProtKB)
IMP
GO:0005504
P37840 (UniProtKB)
IDA
GO:0055074
P37840 (UniProtKB)
IDA
GO:0060961
P37840 (UniProtKB)
IDA
GO:0005747
P37840 (UniProtKB)
TAS
GO:0031092
P37840 (UniProtKB)
IDA

基因相关microRNA

基因相关microRNA

可能调控 SNCA基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Parkinson Disease 0.493572094 169 4 BeFree_CTD_human_GAD_GWASCAT_LHGDN_RGD
PARKINSON DISEASE 1, AUTOSOMAL DOMINANT (disorder) 0.44 4 4 CLINVAR_CTD_human_MGD_UNIPROT
Lewy Body Disease 0.385780554 24 3 BeFree_CLINVAR_CTD_human_GAD_LHGDN_UNIPROT
PARKINSON DISEASE 4, AUTOSOMAL DOMINANT LEWY BODY (disorder) 0.32 0 0 CLINVAR_CTD_human_MGD
Neurodegenerative Disorders 0.141970436 22 2 BeFree_CTD_human_GAD_LHGDN
Parkinsonian Disorders 0.137673516 38 3 BeFree_CTD_human_LHGDN
Alcoholic Intoxication, Chronic 0.123810118 5 0 BeFree_CTD_human_LHGDN
Nerve Degeneration 0.122367032 3 0 CTD_human_GAD
Hepatolenticular Degeneration 0.12 1 0 CTD_human
Gaucher Disease 0.12 1 0 CTD_human

基因相关服务

基因相关服务

联系方式

山东省济南市章丘区文博路2号 齐鲁师范学院 genelibs生信实验室

山东省济南市高新区舜华路750号大学科技园北区F座4单元2楼

电话： 0531-88819269

E-mail: product@genelibs.com

微信公众号

关注微信订阅号，实时查看信息，关注医学生物学动态。

版权所有 © 2025.Genelibs 济南弘晖生物技术有限公司 鲁ICP备13024435号-2