SLC11A1 (solute carrier family 11 member 1)

基因基本信息

基因基本信息

symbol:
SLC11A1
locus group:
protein-coding gene
location:
2q35
gene_family:
Solute carriers
alias symbol:
None
alias name:
None
entrez id:
6556
ensembl gene id:
ENSG00000018280
ucsc gene id:
uc002vhv.3
refseq accession:
NM_000578
hgnc_id:
HGNC:10907
approved reserved:
1994-07-21

基因染色体位置

基因染色体位置

2q35
基因染色体位置图

基因简述

基因简述

This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn disease. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]

该基??因为溶质载体家族11（质子偶联的二价金属离子转运）家族的成员，编码多遍膜蛋白。该蛋白质作为二价过渡金属（铁和锰）转运参与铁代谢和宿主抗某些病原体。在这种基因突变与易感性传染病如结核病和麻风病，和炎性疾病，如类风湿关节炎和克罗恩病有关。编码不同蛋白同种型的可变剪接变体已被描述，但只有一个的全长性质已确定。 [由RefSeq的，2008年7月提供]

OMIM数据库中对CCND1基因的介绍     Wikipedia数据库中对CCND1基因的介绍

基因序列

基因序列

CCND1基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

SLC11A1基因的碱基突变：           仅显示部分snp
rs2279014       rs73073084       rs73073088       rs73073090       rs73073091       rs73990437       rs79089524       rs112449293       rs143779484       rs147599569       rs149058752       rs184795769       rs185320528       rs189131894       rs193149658       rs376303740       rs376908443      

基因表达

基因表达

SLC11A1基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
TCTCTACTACCCTAAGTCGGAG
60
TAGAGGTTGCAGTGAGCTG
59
CCTCTTTGTCATGGCTGTC
59
TTGGCACAGATGTTGAACG
59
TACCTGAGTGAGAAGATCCC
58
CCAGAGAAGTTTGAATCCCG
59
CTCTACTACCCTAAGGTGCC
59
GATGACTTCCTGCATGTCG
59
ATGAGCATTGCTTTCCTGG
59
CCCAGAGAAGTTTGAATCCC
58
GGTTGAGGGACTACAGAGG
59
TTGGTGAGGAGTAGACAGG
58
CGGTTGAGGGACTACAGAG
59
TGGTGAGGAGTAGACAGGA
59
TTTGTCATGGCTGTCTTTGG
59
TTGGCACAGATGTTGAACG
59
ACCTGAGTGAGAAGATCCC
58
CCCAGAGAAGTTTGAATCCC
58
GAGCATTGCTTTCCTGGAC
59
CACCCAGAGAAGTTTGAATCC
59

转录因子

转录因子

      尚未收录相关数据

基因本体信息

SLC11A1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

SLC11A1基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0000060
P49279 (UniProtKB)
IEA
GO:0001818
P49279 (UniProtKB)
ISS
GO:0001819
P49279 (UniProtKB)
ISS
GO:0002309
P49279 (UniProtKB)
ISS
GO:0002369
P49279 (UniProtKB)
ISS
GO:0002606
P49279 (UniProtKB)
ISS
GO:0002827
P49279 (UniProtKB)
ISS
GO:0005384
P49279 (UniProtKB)
ISS
GO:0005764
P49279 (UniProtKB)
ISS
GO:0005770
P49279 (UniProtKB)
ISS
GO:0005886
P49279 (UniProtKB)
IMP
GO:0005887
P49279 (UniProtKB)
NAS
GO:0006826
P49279 (UniProtKB)
IMP
GO:0006828
P49279 (UniProtKB)
ISS
GO:0006876
P49279 (UniProtKB)
IGI
GO:0006879
P49279 (UniProtKB)
IMP
GO:0006909
P49279 (UniProtKB)
ISS
GO:0006954
P49279 (UniProtKB)
ISS
GO:0007035
P49279 (UniProtKB)
ISS
GO:0009279
P49279 (UniProtKB)
IEA
GO:0009617
P49279 (UniProtKB)
IDA
GO:0010628
P49279 (UniProtKB)
ISS
GO:0015707
P49279 (UniProtKB)
ISS
GO:0030670
P49279 (UniProtKB)
IDA
GO:0031902
P49279 (UniProtKB)
TAS
GO:0032147
P49279 (UniProtKB)
ISS
GO:0032496
P49279 (UniProtKB)
ISS
GO:0032623
P49279 (UniProtKB)
ISS
GO:0032632
P49279 (UniProtKB)
ISS
GO:0032729
P49279 (UniProtKB)
ISS
GO:0034341
P49279 (UniProtKB)
ISS
GO:0042060
P49279 (UniProtKB)
ISS
GO:0042116
P49279 (UniProtKB)
ISS
GO:0042742
P49279 (UniProtKB)
ISS
GO:0042803
P49279 (UniProtKB)
IDA
GO:0042832
P49279 (UniProtKB)
ISS
GO:0043091
P49279 (UniProtKB)
ISS
GO:0045342
P49279 (UniProtKB)
ISS
GO:0045454
P49279 (UniProtKB)
TAS
GO:0045730
P49279 (UniProtKB)
ISS
GO:0045944
P49279 (UniProtKB)
ISS
GO:0046915
P49279 (UniProtKB)
IGI
GO:0048002
P49279 (UniProtKB)
ISS
GO:0048255
P49279 (UniProtKB)
ISS
GO:0050766
P49279 (UniProtKB)
ISS
GO:0050829
P49279 (UniProtKB)
ISS
GO:0051139
P49279 (UniProtKB)
IGI
GO:0051139
P49279 (UniProtKB)
TAS
GO:0055072
P49279 (UniProtKB)
ISS
GO:0060586
P49279 (UniProtKB)
ISS
GO:0070574
P49279 (UniProtKB)
IGI
GO:0070821
P49279 (UniProtKB)
IDA
GO:0070839
P49279 (UniProtKB)
ISS
GO:0071421
P49279 (UniProtKB)
IEA
GO:0003674
Q9HBK0 (UniProtKB)
ND
GO:0005215
Q9HBK0 (UniProtKB)
IEA
GO:0005575
Q9HBK0 (UniProtKB)
ND
GO:0006810
Q9HBK0 (UniProtKB)
IEA
GO:0006955
Q9HBK0 (UniProtKB)
NAS
GO:0016020
Q9HBK0 (UniProtKB)
IEA

基因相关microRNA

基因相关microRNA

可能调控 SLC11A1基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Tuberculosis 0.336899795 72 1 BeFree_CTD_human_GAD_LHGDN_ORPHANET
Crohn Disease 0.144460901 11 0 BeFree_CTD_human_GAD_LHGDN
Rheumatoid Arthritis 0.143265513 15 0 BeFree_CTD_human_GAD_LHGDN
Leprosy 0.136721114 20 1 BeFree_CTD_human_GAD
Sarcoidosis 0.133635564 6 0 BeFree_CTD_human_GAD_LHGDN
Diabetes Mellitus, Insulin-Dependent 0.133192369 7 0 BeFree_CTD_human_GAD
Multiple Sclerosis 0.130911214 6 0 BeFree_CTD_human_GAD_LHGDN
Inflammatory Bowel Diseases 0.128815624 6 0 BeFree_CTD_human_GAD_LHGDN
Ulcerative Colitis 0.127915422 5 0 BeFree_CTD_human_GAD
Leishmaniasis, Visceral 0.127262917 9 2 BeFree_CTD_human_GAD_LHGDN

基因相关服务

基因相关服务

联系方式

山东省济南市 高新区 崇华路359号 三庆世纪财富中心C1115室

电话： 0531-88819269

E-mail: product@genelibs.com

微信公众号

关注微信订阅号，实时查看信息，关注医学生物学动态。

版权所有 © 2025.Genelibs 济南弘晖生物技术有限公司 鲁ICP备13024435号-2