SIGLEC8 (sialic acid binding Ig like lectin 8)
- symbol:
- SIGLEC8
- locus group:
- protein-coding gene
- location:
- 19q13.33-q13.41
- gene_family:
- V-set domain containing|Immunoglobulin-like domain containing|Sialic acid binding Ig-like lectins
- alias symbol:
- SIGLEC-8|SAF2|SIGLEC8L|MGC59785
- alias name:
- None
- entrez id:
- 27181
- ensembl gene id:
- ENSG00000105366
- ucsc gene id:
- uc002pwt.3
- refseq accession:
- NM_014442
- hgnc_id:
- HGNC:10877
- approved reserved:
- 2000-01-26
Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an association with SLAM-associated protein (SAP; MIM 300490) (summarized by Foussias et al., 2000 [PubMed 11095983]).[supplied by OMIM, May 2010]
唾液酸结合免疫球蛋白（Ig）样凝集素，或SIGLECs（例如，CD33（MIM 159590）），是1型跨膜蛋白各自具有独特的表达模式，主要是在造血细胞的一个家族。 SIGLEC8是SIGLECs的CD33状亚组，其定位于19q13.3-q13.4和有2个保守的胞质基于酪氨酸的基序中的一员：一个基于免疫受体酪氨酸的抑制性基序，或ITIM（见MIM 604964），和一个基序同源的一个信令淋巴细胞激活分子识别（SLAM; MIM 603492），其介导与SLAM相关蛋白的关联（SAP; MIM 300490）（由Foussias总结等，2000 [搜索PubMed 11095983]）[供给。通过OMIM，2010年5月]
基因本体信息
SIGLEC8基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
SIGLEC8基因的本体（GO）信息：
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Asthma | 0.003181358 | 3 | 0 | BeFree_GAD |
| Alzheimer Disease, Late Onset | 0.000271442 | 1 | 0 | BeFree |
| Hematologic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Chronic Obstructive Airway Disease | 0.000271442 | 1 | 0 | BeFree |
| Chronic sinusitis | 0.000271442 | 1 | 0 | BeFree |
| Eosinophilic esophagitis | 0.000271442 | 1 | 0 | BeFree |
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