SFRP1 (secreted frizzled related protein 1)

基因基本信息

基因基本信息

symbol:
SFRP1
locus group:
protein-coding gene
location:
8p11.21
gene_family:
Secreted frizzled-related proteins
alias symbol:
SARP2|FRP|FRP-1
alias name:
None
entrez id:
6422
ensembl gene id:
ENSG00000104332
ucsc gene id:
uc003xnt.4
refseq accession:
NM_003012
hgnc_id:
HGNC:10776
approved reserved:
1998-07-15

基因染色体位置

基因染色体位置

8p11.21
基因染色体位置图

基因简述

基因简述

SFRP1（Secreted Frizzled-Related Protein 1）属于分泌型卷曲相关蛋白（SFRP）基因家族，该家族共有5个成员（SFRP1-5），其共同特点是能够模拟或抑制Wnt信号通路的受体——卷曲蛋白（Frizzled）的功能。SFRP家族蛋白通过结合Wnt配体或直接与卷曲蛋白相互作用，调控Wnt信号通路的活性，这一通路在胚胎发育、细胞增殖和分化中起关键作用。SFRP1编码一种分泌型糖蛋白，其结构包含一个与卷曲蛋白相似的富含半胱氨酸的结构域（CRD），能竞争性结合Wnt蛋白，从而负调控经典Wnt/β-catenin通路。该基因在多种组织中表达，尤其在心脏、胎盘和骨骼肌中活性较高。SFRP1的功能异常与多种疾病相关。其启动子区域的高甲基化（一种表观遗传沉默机制）导致的表达降低常见于结直肠癌、乳腺癌和肺癌，这可能通过解除对Wnt通路的抑制而促进肿瘤发生。相反，在骨关节炎中，SFRP1的过表达会过度抑制Wnt信号，导致软骨细胞功能异常。突变研究显示，SFRP1基因缺失的小鼠会出现心脏发育缺陷和骨骼畸形，印证了其在形态发生中的重要性。在阿尔茨海默病中，SFRP1能与β-淀粉样蛋白相互作用，可能加剧神经毒性。当SFRP1过表达时，会过度抑制Wnt信号，影响胚胎发育和成体组织稳态；而表达不足则可能导致Wnt信号过度激活，促进肿瘤生长和转移。该基因还与代谢疾病相关，在肥胖人群中其脂肪组织表达水平显著降低。由于SFRP1在Wnt通路中的调控作用，它被认为是多种疾病的潜在治疗靶点，特别是在癌症和退行性疾病领域。

This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009]

这个基因编码包含富含半胱氨酸的结构域同源的卷曲蛋白的推定的Wnt结合位点的SFRP家族的一个成员。这个家庭的行为Wnt信号的可溶性调节剂的成员; SFRP基因的后生沉默导致其与癌症相关的的Wnt-途径的失调的活化。此基因也可能是参与确定视网膜感光细胞的极性。 [由RefSeq的，2009年09月提供]

OMIM数据库中对SFRP1基因的介绍     Wikipedia数据库中对SFRP1基因的介绍

基因序列

基因序列

SFRP1基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

SFRP1基因的碱基突变：           仅显示部分snp
rs4736801       rs5891135       rs6991734       rs6992406       rs10691164       rs11779707       rs11781990       rs13272265       rs13272971       rs36088020       rs59325121       rs60021850       rs62636760       rs74686581       rs79091838       rs80341790       rs112417512      

基因表达

基因表达

SFRP1基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
ACGAGTTGAAATCTGAGGC
58
CATCCTCAGTGCAAACTCG
59
CGAGTTGAAATCTGAGGCC
59
CATCCTCAGTGCAAACTCG
59
GAGTTGAAATCTGAGGCCA
58
TCATCCTCAGTGCAAACTC
58

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
DNMT1
SFRP1
Unknown
23770846; 24374650
DNMT3A
SFRP1
Unknown
24374650
EZH2
SFRP1
Unknown
21515604
GLI1
SFRP1
Activation
19930158
HDAC1
SFRP1
Unknown
23770846
MYC
SFRP1
Repression
20697356

基因本体信息

SFRP1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

SFRP1基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0005576
Q6ZSL4 (UniProtKB)
IEA
GO:0001649
Q8N474 (UniProtKB)
IEP
GO:0001657
Q8N474 (UniProtKB)
IEA
GO:0001954
Q8N474 (UniProtKB)
ISS
GO:0002244
Q8N474 (UniProtKB)
IDA
GO:0004197
Q8N474 (UniProtKB)
IMP
GO:0004930
Q8N474 (UniProtKB)
IBA
GO:0005109
Q8N474 (UniProtKB)
IPI
GO:0005109
Q8N474 (UniProtKB)
IPI
GO:0005109
Q8N474 (UniProtKB)
IPI
GO:0005109
Q8N474 (UniProtKB)
IPI
GO:0005109
Q8N474 (UniProtKB)
IPI
GO:0005515
Q8N474 (UniProtKB)
IPI
GO:0005576
Q8N474 (UniProtKB)
TAS
GO:0005578
Q8N474 (UniProtKB)
IDA
GO:0005615
Q8N474 (UniProtKB)
IDA
GO:0005615
Q8N474 (UniProtKB)
IDA
GO:0005615
Q8N474 (UniProtKB)
IDA
GO:0005615
Q8N474 (UniProtKB)
IDA
GO:0005622
Q8N474 (UniProtKB)
IDA
GO:0005829
Q8N474 (UniProtKB)
IDA
GO:0005886
Q8N474 (UniProtKB)
ISS
GO:0006508
Q8N474 (UniProtKB)
IEA
GO:0007186
Q8N474 (UniProtKB)
IEA
GO:0008144
Q8N474 (UniProtKB)
IDA
GO:0008144
Q8N474 (UniProtKB)
IDA
GO:0008201
Q8N474 (UniProtKB)
IDA
GO:0008201
Q8N474 (UniProtKB)
IDA
GO:0008201
Q8N474 (UniProtKB)
IDA
GO:0008284
Q8N474 (UniProtKB)
IDA
GO:0008285
Q8N474 (UniProtKB)
IDA
GO:0008285
Q8N474 (UniProtKB)
IDA
GO:0008285
Q8N474 (UniProtKB)
IDA
GO:0008285
Q8N474 (UniProtKB)
IDA
GO:0008285
Q8N474 (UniProtKB)
IDA
GO:0008584
Q8N474 (UniProtKB)
IEA
GO:0008585
Q8N474 (UniProtKB)
IEA
GO:0009267
Q8N474 (UniProtKB)
IEP
GO:0009267
Q8N474 (UniProtKB)
IEP
GO:0009950
Q8N474 (UniProtKB)
IDA
GO:0009986
Q8N474 (UniProtKB)
IDA
GO:0010564
Q8N474 (UniProtKB)
IMP
GO:0010629
Q8N474 (UniProtKB)
IDA
GO:0010719
Q8N474 (UniProtKB)
IDA
GO:0014034
Q8N474 (UniProtKB)
IEA
GO:0014070
Q8N474 (UniProtKB)
IDA
GO:0016021
Q8N474 (UniProtKB)
IBA
GO:0017147
Q8N474 (UniProtKB)
IPI
GO:0017147
Q8N474 (UniProtKB)
IPI
GO:0017147
Q8N474 (UniProtKB)
IDA
GO:0017147
Q8N474 (UniProtKB)
IPI
GO:0017147
Q8N474 (UniProtKB)
IPI
GO:0017147
Q8N474 (UniProtKB)
IPI
GO:0017147
Q8N474 (UniProtKB)
IPI
GO:0017147
Q8N474 (UniProtKB)
NAS
GO:0022601
Q8N474 (UniProtKB)
IEP
GO:0030177
Q8N474 (UniProtKB)
IDA
GO:0030178
Q8N474 (UniProtKB)
IDA
GO:0030178
Q8N474 (UniProtKB)
IDA
GO:0030178
Q8N474 (UniProtKB)
IMP
GO:0030178
Q8N474 (UniProtKB)
IDA
GO:0030178
Q8N474 (UniProtKB)
NAS
GO:0030178
Q8N474 (UniProtKB)
IDA
GO:0030279
Q8N474 (UniProtKB)
IDA
GO:0030279
Q8N474 (UniProtKB)
IMP
GO:0030307
Q8N474 (UniProtKB)
IDA
GO:0030307
Q8N474 (UniProtKB)
IDA
GO:0030308
Q8N474 (UniProtKB)
IDA
GO:0030308
Q8N474 (UniProtKB)
IDA
GO:0030336
Q8N474 (UniProtKB)
IDA
GO:0030514
Q8N474 (UniProtKB)
IEA
GO:0031012
Q8N474 (UniProtKB)
IDA
GO:0033689
Q8N474 (UniProtKB)
IMP
GO:0035019
Q8N474 (UniProtKB)
IEA
GO:0042493
Q8N474 (UniProtKB)
IDA
GO:0042493
Q8N474 (UniProtKB)
IDA
GO:0042802
Q8N474 (UniProtKB)
IPI
GO:0042813
Q8N474 (UniProtKB)
IBA
GO:0043065
Q8N474 (UniProtKB)
IDA
GO:0043065
Q8N474 (UniProtKB)
IMP
GO:0043065
Q8N474 (UniProtKB)
IMP
GO:0043065
Q8N474 (UniProtKB)
IMP
GO:0043065
Q8N474 (UniProtKB)
IDA
GO:0043065
Q8N474 (UniProtKB)
IMP
GO:0043066
Q8N474 (UniProtKB)
IMP
GO:0043066
Q8N474 (UniProtKB)
IMP
GO:0043066
Q8N474 (UniProtKB)
IMP
GO:0043066
Q8N474 (UniProtKB)
IMP
GO:0043066
Q8N474 (UniProtKB)
IMP
GO:0043508
Q8N474 (UniProtKB)
IEA
GO:0043547
Q8N474 (UniProtKB)
ISS
GO:0044344
Q8N474 (UniProtKB)
IDA
GO:0044345
Q8N474 (UniProtKB)
IEA
GO:0045578
Q8N474 (UniProtKB)
IMP
GO:0045600
Q8N474 (UniProtKB)
IDA
GO:0045600
Q8N474 (UniProtKB)
IDA
GO:0045668
Q8N474 (UniProtKB)
IEA
GO:0045671
Q8N474 (UniProtKB)
IEA
GO:0045671
Q8N474 (UniProtKB)
IEA
GO:0045765
Q8N474 (UniProtKB)
ISS
GO:0045880
Q8N474 (UniProtKB)
IMP
GO:0045892
Q8N474 (UniProtKB)
IDA
GO:0045892
Q8N474 (UniProtKB)
IMP
GO:0045892
Q8N474 (UniProtKB)
IDA
GO:0045892
Q8N474 (UniProtKB)
IDA
GO:0045892
Q8N474 (UniProtKB)
IDA
GO:0045893
Q8N474 (UniProtKB)
IDA
GO:0045893
Q8N474 (UniProtKB)
IDA
GO:0045893
Q8N474 (UniProtKB)
IDA
GO:0045893
Q8N474 (UniProtKB)
IMP
GO:0046676
Q8N474 (UniProtKB)
IDA
GO:0046851
Q8N474 (UniProtKB)
IMP
GO:0048147
Q8N474 (UniProtKB)
IDA
GO:0048546
Q8N474 (UniProtKB)
IEA
GO:0050679
Q8N474 (UniProtKB)
IMP
GO:0050680
Q8N474 (UniProtKB)
IDA
GO:0050732
Q8N474 (UniProtKB)
IDA
GO:0051496
Q8N474 (UniProtKB)
ISS
GO:0051894
Q8N474 (UniProtKB)
ISS
GO:0060070
Q8N474 (UniProtKB)
IDA
GO:0060218
Q8N474 (UniProtKB)
IDA
GO:0060346
Q8N474 (UniProtKB)
IEA
GO:0060527
Q8N474 (UniProtKB)
IEA
GO:0060687
Q8N474 (UniProtKB)
IEA
GO:0060766
Q8N474 (UniProtKB)
IDA
GO:0070062
Q8N474 (UniProtKB)
IDA
GO:0070062
Q8N474 (UniProtKB)
IDA
GO:0071305
Q8N474 (UniProtKB)
IEP
GO:0071347
Q8N474 (UniProtKB)
IEP
GO:0071356
Q8N474 (UniProtKB)
IDA
GO:0071363
Q8N474 (UniProtKB)
IDA
GO:0071380
Q8N474 (UniProtKB)
IEP
GO:0071391
Q8N474 (UniProtKB)
IDA
GO:0071392
Q8N474 (UniProtKB)
IEP
GO:0071456
Q8N474 (UniProtKB)
IEP
GO:0071481
Q8N474 (UniProtKB)
IEA
GO:0071504
Q8N474 (UniProtKB)
IDA
GO:0071542
Q8N474 (UniProtKB)
IEA
GO:0071560
Q8N474 (UniProtKB)
IEP
GO:0071773
Q8N474 (UniProtKB)
IEP
GO:0090090
Q8N474 (UniProtKB)
IDA
GO:0090090
Q8N474 (UniProtKB)
IDA
GO:0090090
Q8N474 (UniProtKB)
IDA
GO:0090090
Q8N474 (UniProtKB)
IMP
GO:0090090
Q8N474 (UniProtKB)
IMP
GO:0090090
Q8N474 (UniProtKB)
IDA
GO:0090090
Q8N474 (UniProtKB)
IGI
GO:0090090
Q8N474 (UniProtKB)
IDA
GO:0090090
Q8N474 (UniProtKB)
IDA
GO:0090090
Q8N474 (UniProtKB)
IDA
GO:0090090
Q8N474 (UniProtKB)
IDA
GO:0090090
Q8N474 (UniProtKB)
IGI
GO:0090090
Q8N474 (UniProtKB)
IDA
GO:0090090
Q8N474 (UniProtKB)
IMP
GO:0090179
Q8N474 (UniProtKB)
IEA
GO:0090244
Q8N474 (UniProtKB)
IEA
GO:0090246
Q8N474 (UniProtKB)
IEA
GO:0090263
Q8N474 (UniProtKB)
IDA
GO:0090263
Q8N474 (UniProtKB)
IGI
GO:1902043
Q8N474 (UniProtKB)
IDA
GO:1904338
Q8N474 (UniProtKB)
IEA
GO:1904693
Q8N474 (UniProtKB)
IEA
GO:2000041
Q8N474 (UniProtKB)
IEA
GO:2000052
Q8N474 (UniProtKB)
IDA
GO:2000054
Q8N474 (UniProtKB)
IDA
GO:2000080
Q8N474 (UniProtKB)
IDA
GO:2000270
Q8N474 (UniProtKB)
IDA
GO:2000271
Q8N474 (UniProtKB)
IDA
GO:0031012
Q8N474 (UniProtKB)
IDA

基因相关microRNA

基因相关microRNA

可能调控 SFRP1基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Mammary Neoplasms 0.132526052 8 0 BeFree_CTD_human_LHGDN
Colorectal Neoplasms 0.125991584 6 0 BeFree_CTD_human_LHGDN
Fibroid Tumor 0.120542884 2 0 BeFree_CTD_human
Inflammatory Bowel Diseases 0.12 1 0 CTD_human
Renal Cell Carcinoma 0.012797494 7 0 BeFree_LHGDN
Bladder Neoplasm 0.006263026 3 0 BeFree_LHGDN
Liver neoplasms 0.005991584 4 0 BeFree_LHGDN
Breast Carcinoma 0.005971721 22 0 BeFree
Malignant neoplasm of breast 0.005971721 22 0 BeFree
Pancreatic Neoplasm 0.005720142 3 0 BeFree_LHGDN

基因相关服务

基因相关服务

联系方式

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