SDCBP (syndecan binding protein)
- symbol:
- SDCBP
- locus group:
- protein-coding gene
- location:
- 8q12.1
- gene_family:
- alias symbol:
- SYCL|MDA-9
- alias name:
- syntenin|syntenin-1
- entrez id:
- 6386
- ensembl gene id:
- ENSG00000137575
- ucsc gene id:
- uc003xtn.3
- refseq accession:
- NM_005625
- hgnc_id:
- HGNC:10662
- approved reserved:
- 1998-02-11
SDCBP（Syndecan Binding Protein，也称为syntenin-1）是一种多功能支架蛋白，主要通过与跨膜蛋白syndecan家族（一类细胞表面硫酸乙酰肝素蛋白聚糖）结合参与细胞黏附、信号传导和膜运输等过程。其生物学功能包括调控细胞迁移（如伤口愈合和肿瘤转移）、神经突触形成、外泌体（细胞分泌的微小囊泡）的生物发生以及Wnt/β-catenin等信号通路的激活。SDCBP通过PDZ结构域（一种蛋白质相互作用模块）与多种靶蛋白（如syndecan、IL-5受体α、神经生长因子受体TrkA）结合，形成信号复合物。突变可能导致其结合能力丧失，例如PDZ结构域突变会破坏与syndecan的相互作用，影响细胞-基质黏附，促进肿瘤侵袭性。SDCBP过表达与多种癌症（乳腺癌、黑色素瘤、肺癌）的转移相关，因其能增强整合素（细胞黏附分子）激活和基质降解酶分泌；而敲低表达会抑制肿瘤细胞迁移并减少外泌体释放，但可能损害神经突触可塑性（神经元连接强度的调节能力）。该基因属于syntenin基因家族，成员包括SDCBP和SDCBP2，共性为含有两个保守的PDZ结构域，介导蛋白质-蛋白质相互作用，参与细胞极性建立和膜受体聚集。在疾病中，SDCBP异常表达还与阿尔茨海默病（影响突触功能）和病毒感染（如HIV通过外泌体传播）相关。其表达水平变化可能通过调控VEGF（血管生长因子）或EGFR（表皮生长因子受体）通路间接影响血管生成和细胞增殖。
The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
由该基因编码的蛋白质被初步确定为聚糖介导的信号链接至细胞骨架的分子。该syntenin蛋白含有串联重复结合各种跨膜蛋白的胞质，C端结构域PDZ结构域。这种蛋白也可能影响细胞骨架 - 膜组织，细胞粘附，蛋白质运输，和转录因子的活化。该蛋白质主要定位于膜相关粘着结和粘着斑但在内质网和核中也有发现。在多个转录剪接变异体导致编码不同亚型。 [由RefSeq的，2008年7月提供]
正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
GAGAAGATTACCATGACCATTCG
59
CCTTATGCATGGTAATCGTCC
59
TGAAAGATAGCTCTGCAGC
58
CAATTTGAGAGTCCTTCAATCC
58
TTGTAATGGTGAAGAATCCTGC
59
AAATTGCTGGATTGGCAGG
59
CCCAGACTGTATCCAGAGC
59
AAGGTCTTGCTACCAACCC
60
TGAAAGATAGCTCTGCAGC
58
CAATTTGAGAGTCCTTCAATCC
58
TTGTAATGGTGAAGAATCCTGC
59
AAATTGCTGGATTGGCAGG
59
CATGACCATTCGTGACAGG
58
ACATGTCCAGTGCTATCCT
58
CTCGAAGACTTGAAGGTAGAC
57
GGGATAGAGATTTCCATCGTG
58
CACGATGGAAATCTCTATCCC
58
AAGGTCTTGCTACCAACTG
57
GAAGACTTGAAGGCTCAAACTG
60
AGGGATAGGAGCAGAAGCT
60
基因本体信息
SDCBP基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
SDCBP基因的本体（GO）信息：
GO库代码
对应的蛋白质
来源代码
GO:0005622
B4DHN5 (UniProtKB)
IEA
GO:0007268
B4DHN5 (UniProtKB)
IEA
GO:0016021
B4DHN5 (UniProtKB)
IEA
GO:0030036
B4DHN5 (UniProtKB)
IEA
GO:0035556
B4DHN5 (UniProtKB)
IEA
GO:0005622
E9PBU7 (UniProtKB)
IEA
GO:0007268
E9PBU7 (UniProtKB)
IEA
GO:0016021
E9PBU7 (UniProtKB)
IEA
GO:0030036
E9PBU7 (UniProtKB)
IEA
GO:0035556
E9PBU7 (UniProtKB)
IEA
GO:0005622
G5EA09 (UniProtKB)
IEA
GO:0007268
G5EA09 (UniProtKB)
IEA
GO:0016021
G5EA09 (UniProtKB)
IEA
GO:0030036
G5EA09 (UniProtKB)
IEA
GO:0035556
G5EA09 (UniProtKB)
IEA
GO:0001948
O00560 (UniProtKB)
IEA
GO:0002091
O00560 (UniProtKB)
IMP
GO:0005109
O00560 (UniProtKB)
IPI
GO:0005109
O00560 (UniProtKB)
IPI
GO:0005109
O00560 (UniProtKB)
IPI
GO:0005137
O00560 (UniProtKB)
ISS
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005515
O00560 (UniProtKB)
IPI
GO:0005615
O00560 (UniProtKB)
IDA
GO:0005634
O00560 (UniProtKB)
NAS
GO:0005737
O00560 (UniProtKB)
IDA
GO:0005789
O00560 (UniProtKB)
IEA
GO:0005829
O00560 (UniProtKB)
TAS
GO:0005829
O00560 (UniProtKB)
TAS
GO:0005856
O00560 (UniProtKB)
NAS
GO:0005886
O00560 (UniProtKB)
IDA
GO:0005886
O00560 (UniProtKB)
IDA
GO:0005895
O00560 (UniProtKB)
ISS
GO:0005912
O00560 (UniProtKB)
NAS
GO:0005925
O00560 (UniProtKB)
IEA
GO:0006612
O00560 (UniProtKB)
NAS
GO:0006930
O00560 (UniProtKB)
NAS
GO:0007265
O00560 (UniProtKB)
IEA
GO:0007268
O00560 (UniProtKB)
NAS
GO:0007346
O00560 (UniProtKB)
IMP
GO:0008022
O00560 (UniProtKB)
IEA
GO:0008093
O00560 (UniProtKB)
NAS
GO:0008284
O00560 (UniProtKB)
IMP
GO:0010718
O00560 (UniProtKB)
IMP
GO:0010862
O00560 (UniProtKB)
IMP
GO:0016020
O00560 (UniProtKB)
NAS
GO:0019838
O00560 (UniProtKB)
IEA
GO:0030036
O00560 (UniProtKB)
NAS
GO:0030307
O00560 (UniProtKB)
IMP
GO:0030335
O00560 (UniProtKB)
IMP
GO:0030335
O00560 (UniProtKB)
IMP
GO:0030511
O00560 (UniProtKB)
IMP
GO:0032435
O00560 (UniProtKB)
IMP
GO:0035556
O00560 (UniProtKB)
NAS
GO:0042043
O00560 (UniProtKB)
IEA
GO:0042327
O00560 (UniProtKB)
IDA
GO:0042470
O00560 (UniProtKB)
IEA
GO:0042802
O00560 (UniProtKB)
IPI
GO:0042803
O00560 (UniProtKB)
IEA
GO:0045121
O00560 (UniProtKB)
IDA
GO:0045545
O00560 (UniProtKB)
IPI
GO:0045545
O00560 (UniProtKB)
IPI
GO:0045545
O00560 (UniProtKB)
NAS
GO:0046330
O00560 (UniProtKB)
IC
GO:0046875
O00560 (UniProtKB)
IEA
GO:0046982
O00560 (UniProtKB)
IPI
GO:0047485
O00560 (UniProtKB)
IPI
GO:0048013
O00560 (UniProtKB)
TAS
GO:0050839
O00560 (UniProtKB)
IEA
GO:0070062
O00560 (UniProtKB)
IDA
GO:0070062
O00560 (UniProtKB)
IDA
GO:0070062
O00560 (UniProtKB)
IDA
GO:0070062
O00560 (UniProtKB)
IDA
GO:0070062
O00560 (UniProtKB)
IDA
GO:0070062
O00560 (UniProtKB)
IDA
GO:0070062
O00560 (UniProtKB)
IDA
GO:0072562
O00560 (UniProtKB)
IDA
GO:1903543
O00560 (UniProtKB)
IMP
GO:1903553
O00560 (UniProtKB)
IMP
GO:1903561
O00560 (UniProtKB)
IDA
| 名称 |
|---|
| Axon guidance |
| Developmental Biology |
| EPH-Ephrin signaling |
| Ephrin signaling |
| L1CAM interactions |
| Neurofascin interactions |
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Degenerative polyarthritis | 0.12 | 1 | 0 | CTD_human |
| Neoplasm Metastasis | 0.008163119 | 12 | 0 | BeFree_LHGDN |
| melanoma | 0.005710211 | 12 | 0 | BeFree_LHGDN |
| Metastatic melanoma | 0.000814326 | 3 | 0 | BeFree |
| Tumor Progression | 0.000814326 | 3 | 0 | BeFree |
| Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Stomach Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Secondary malignant neoplasm of lymph node | 0.000271442 | 1 | 0 | BeFree |
| Uveal melanoma | 0.000271442 | 1 | 0 | BeFree |
| Severe Combined Immunodeficiency | 0.000271442 | 1 | 0 | BeFree |
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