S100A8 (S100 calcium binding protein A8)

基因基本信息

基因基本信息

symbol:
S100A8
locus group:
protein-coding gene
location:
1q21.3
gene_family:
S100 calcium binding proteins|EF-hand domain containing
alias symbol:
P8|MRP8|MRP-8|60B8AG|CGLA|S100-A8
alias name:
Migration inhibitory factor-relate…
entrez id:
6279
ensembl gene id:
ENSG00000143546
ucsc gene id:
uc001fbs.3
refseq accession:
NM_002964
hgnc_id:
HGNC:10498
approved reserved:
1989-05-19

基因染色体位置

基因染色体位置

1q21.3
基因染色体位置图

基因简述

基因简述

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis. [provided by RefSeq, Jul 2008]

由该基因编码的蛋白质是S100家族含有2 EF手钙结合基序的蛋白质的成员。 S100蛋白是局部在广泛的细胞的细胞质和/或细胞核，并参与了许多细胞过程的调控，如细胞周期进程和分化。 S100基因包括至少13名成员分别位于作为染色体1q21集群。这种蛋白可以以酪蛋白激酶的抑制和细胞因子的作用。这种蛋白质的改变的表达与疾病囊性纤维化相关联。 [由RefSeq的，2008年7月提供]

OMIM数据库中对CCND1基因的介绍     Wikipedia数据库中对CCND1基因的介绍

基因序列

基因序列

CCND1基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

S100A8基因的碱基突变：           仅显示部分snp
rs3006412       rs3006413       rs3006414       rs3006415       rs3006416       rs3006417       rs3014812       rs3014813       rs3014814       rs3014815       rs3014816       rs3014817       rs3014818       rs3014819       rs3125229       rs3795392       rs4845348      

基因表达

基因表达

S100A8基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
CTTTCAGAAGACCTGGTGG
58
TGGTAGACGTCGATGATAGAG
59
AGTGTCCTCAGTATATCAGGA
57
CATCAGTGTTGATATCCAACTC
57
ATTGCTAGAGACCGAGTGTC
59
TTTGAACCAGACGTCTGCA
60
ATTGCTAGAGACCGAGTGTC
59
TTTGAACCAGACGTCTGCA
60
TTGCTAGAGACCGAGTGTC
59
CTTTGAACCAGACGTCTGC
59
TTTCCATGCCGTCTACAGG
60
TTCCTGATATACTGAGGACACTC
59
TTGCTAGAGACCGAGTGTC
59
CTTTGAACCAGACGTCTGC
59
TTTCAGAAGACCTGGTGGG
59
TGGTAGACGTCGATGATAGAG
59
CGAGTGTCCTCAGTATATCAGG
60
GATATCCAACTCTTTGAACCAGAC
60
TCTTTCAGAAGACCTGGTGG
59
CGTCGATGATAGAGTTCAAGG
58

转录因子

转录因子

      尚未收录相关数据

基因本体信息

S100A8基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

S100A8基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0001816
P05109 (UniProtKB)
TAS
GO:0002523
P05109 (UniProtKB)
IDA
GO:0002526
P05109 (UniProtKB)
IEA
GO:0002544
P05109 (UniProtKB)
IEA
GO:0002793
P05109 (UniProtKB)
IEA
GO:0005509
P05109 (UniProtKB)
TAS
GO:0005515
P05109 (UniProtKB)
IPI
GO:0005515
P05109 (UniProtKB)
IPI
GO:0005515
P05109 (UniProtKB)
IPI
GO:0005515
P05109 (UniProtKB)
IPI
GO:0005576
P05109 (UniProtKB)
TAS
GO:0005615
P05109 (UniProtKB)
IDA
GO:0005615
P05109 (UniProtKB)
IDA
GO:0005634
P05109 (UniProtKB)
IDA
GO:0005829
P05109 (UniProtKB)
TAS
GO:0005856
P05109 (UniProtKB)
TAS
GO:0005886
P05109 (UniProtKB)
TAS
GO:0006914
P05109 (UniProtKB)
IDA
GO:0006919
P05109 (UniProtKB)
IDA
GO:0006954
P05109 (UniProtKB)
TAS
GO:0008017
P05109 (UniProtKB)
TAS
GO:0008270
P05109 (UniProtKB)
TAS
GO:0010043
P05109 (UniProtKB)
IEA
GO:0014002
P05109 (UniProtKB)
IEA
GO:0018119
P05109 (UniProtKB)
IMP
GO:0030307
P05109 (UniProtKB)
TAS
GO:0030593
P05109 (UniProtKB)
IDA
GO:0032119
P05109 (UniProtKB)
TAS
GO:0032496
P05109 (UniProtKB)
IEA
GO:0032602
P05109 (UniProtKB)
TAS
GO:0035662
P05109 (UniProtKB)
TAS
GO:0042060
P05109 (UniProtKB)
IEA
GO:0042742
P05109 (UniProtKB)
TAS
GO:0045087
P05109 (UniProtKB)
IEA
GO:0045471
P05109 (UniProtKB)
IEA
GO:0050544
P05109 (UniProtKB)
TAS
GO:0050729
P05109 (UniProtKB)
IDA
GO:0050786
P05109 (UniProtKB)
TAS
GO:0050832
P05109 (UniProtKB)
TAS
GO:0051092
P05109 (UniProtKB)
TAS
GO:0051493
P05109 (UniProtKB)
TAS
GO:0070062
P05109 (UniProtKB)
IDA
GO:0070062
P05109 (UniProtKB)
IDA
GO:0070062
P05109 (UniProtKB)
IDA
GO:0070062
P05109 (UniProtKB)
IDA
GO:0070488
P05109 (UniProtKB)
IDA
GO:2001244
P05109 (UniProtKB)
IDA

基因相关microRNA

基因相关microRNA

可能调控 S100A8基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Dermatitis, Atopic 0.123181358 5 0 BeFree_CTD_human_GAD
Leukemia, Myelocytic, Acute 0.120814326 4 0 BeFree_CTD_human
Animal Mammary Neoplasms 0.12 1 0 CTD_human
Contact Dermatitis 0.12 1 0 CTD_human
Keloid 0.12 1 0 CTD_human
Arthritis, Experimental 0.080271442 2 0 BeFree_RGD
Inflammation 0.08 1 0 RGD
Bladder Neoplasm 0.08 1 0 RGD
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site 0.026872745 99 0 BeFree
Stomach Carcinoma 0.009500466 35 0 BeFree

基因相关服务

基因相关服务

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