S100A11 (S100 calcium binding protein A11)
- symbol:
- S100A11
- locus group:
- protein-coding gene
- location:
- 1q21.3
- gene_family:
- S100 calcium binding proteins|EF-hand domain containing
- alias symbol:
- S100C
- alias name:
- calgizzarin
- entrez id:
- 6282
- ensembl gene id:
- ENSG00000163191
- ucsc gene id:
- uc001ezn.3
- refseq accession:
- NM_005620
- hgnc_id:
- HGNC:10488
- approved reserved:
- 1997-10-30
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. [provided by RefSeq, Jul 2008]
由该基因编码的蛋白质是S100家族含有2 EF手钙结合基序的蛋白质的成员。 S100蛋白是局部在广泛的细胞的细胞质和/或细胞核，并参与了许多细胞过程的调控，如细胞周期进程和分化。 S100基因包括至少13名成员分别位于作为染色体1q21集群。这种蛋白可以以运动，侵袭和微管蛋白聚合起作用。染色体重排和该基因的改变的表达有牵连肿瘤转移。 [由RefSeq的，2008年7月提供]
基因本体信息
S100A11基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
S100A11基因的本体（GO）信息：
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Degenerative polyarthritis | 0.003267234 | 2 | 0 | BeFree_LHGDN |
| Neoplasm Metastasis | 0.003267234 | 3 | 0 | BeFree_LHGDN |
| Liver carcinoma | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Fibroid Tumor | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Dermatitis, Atopic | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Lung Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
| Bladder Neoplasm | 0.00272435 | 1 | 0 | LHGDN |
| Colorectal Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
| Stomach Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
| Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
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