RPL36A (ribosomal protein L36a)
- symbol:
- RPL36A
- locus group:
- protein-coding gene
- location:
- Xq22.1
- gene_family:
- L ribosomal proteins
- alias symbol:
- L36A
- alias name:
- None
- entrez id:
- 6173
- ensembl gene id:
- ENSG00000241343
- ucsc gene id:
- uc065agx.1
- refseq accession:
- NM_021029
- hgnc_id:
- HGNC:10359
- approved reserved:
- 1993-01-19
RPL36A（核糖体蛋白L36a）是核糖体蛋白家族的一员，属于核糖体大亚基（60S）的组成部分，参与蛋白质合成的翻译过程。核糖体蛋白家族（Ribosomal Protein Family）的共性是为核糖体的结构和功能提供支持，确保mRNA（信使RNA）被准确翻译为蛋白质。RPL36A在细胞质中表达，主要作用位点是核糖体，帮助稳定核糖体的结构并促进肽键形成。该基因的突变可能影响核糖体组装或功能，导致翻译效率下降，进而影响细胞生长和增殖。研究发现，RPL36A的异常表达可能与某些癌症（如肝癌、结直肠癌）相关，其过表达可能促进肿瘤细胞增殖，而低表达可能导致核糖体功能缺陷，引发核糖体病（Ribosomopathy），如Diamond-Blackfan贫血（一种骨髓衰竭性疾病）。此外，RPL36A的表达水平变化可能影响其他核糖体蛋白的稳定性或功能，从而干扰整体蛋白质合成。核糖体蛋白家族成员通常高度保守，在多种生物中具有相似功能，但某些成员（如RPL36A）可能在特定组织或疾病中发挥独特作用。目前关于RPL36A的具体调控机制和病理作用仍在研究中，但其作为核糖体的关键组分，对细胞稳态至关重要。
Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which shares sequence similarity with yeast ribosomal protein L44, belongs to the L44E (L36AE) family of ribosomal proteins. Although this gene has been referred to as ribosomal protein L44 (RPL44), its official name is ribosomal protein L36a (RPL36A). This gene and the human gene officially named ribosomal protein L36a-like (RPL36AL) encode nearly identical proteins; however, they are distinct genes. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Naturally occurring read-through transcription occurs between this locus and the heterogeneous nuclear ribonucleoprotein H2 (H') gene. [provided by RefSeq, Jan 2011]
细胞质核糖体，催化蛋白质合成的细胞器，由一个小40S亚基和60S大亚基。一起这些亚基组成的4 RNA种类和大约80结构不同的蛋白质。该基因编码一种核糖体蛋白，它是60S亚基的一个组成部分。这股用酵母核糖体蛋白L44序列相似性，蛋白质，属于L44E（L36AE）家族核糖体蛋白的。虽然这个基因被称为核糖体蛋白L44（RPL44），它的正式名称是核糖体蛋白L36a（RPL36A）。这种基因与人类基因正式命名为核糖体蛋白L36a样（RPL36AL）编码几乎相同的蛋白质;然而，它们是不同的基因。作为典型编码核糖体蛋白的基因，有该基因通过基因组分散的多个经处理的假基因。该位点和所述异质核核糖H 2（H‘）基因之间发生天然存在的通读转录。 [由RefSeq的，2011年1月提供]
基因本体信息
RPL36A基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
RPL36A基因的本体（GO）信息：
| 名称 |
|---|
| 3010 Ribosome [PATH:hsa03010] |
| 名称 |
|---|
| 3' -UTR-mediated translational regulation |
| Cap-dependent Translation Initiation |
| Disease |
| Eukaryotic Translation Elongation |
| Eukaryotic Translation Initiation |
| Eukaryotic Translation Termination |
| Formation of a pool of free 40S subunits |
| Gene Expression |
| GTP hydrolysis and joining of the 60S ribosomal subunit |
| Infectious disease |
| Influenza Infection |
| Influenza Life Cycle |
| Influenza Viral RNA Transcription and Replication |
| L13a-mediated translational silencing of Ceruloplasmin expression |
| Metabolism of proteins |
| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) |
| Nonsense-Mediated Decay (NMD) |
| Peptide chain elongation |
| SRP-dependent cotranslational protein targeting to membrane |
| Translation |
| Viral mRNA Translation |
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Liver carcinoma | 0.003267234 | 2 | 0 | BeFree_LHGDN |
| Malignant neoplasm of lung | 0.001085767 | 4 | 0 | BeFree |
| Non-Small Cell Lung Carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Carcinoma of lung | 0.000814326 | 3 | 0 | BeFree |
| Papillary thyroid carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Carcinogenesis | 0.000542884 | 2 | 0 | BeFree |
| Breast Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of pancreas | 0.000271442 | 1 | 0 | BeFree |
| Diabetes Mellitus | 0.000271442 | 1 | 0 | BeFree |
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