RPA2基因详情-基因数据库-基因云馆

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RPA2 (replication protein A2)

symbol:: RPA2
locus group:: protein-coding gene
location:: 1p35.3
gene_family:
alias symbol:: None
alias name:: None
entrez id:: 6118
ensembl gene id:: ENSG00000117748
ucsc gene id:: uc001bpe.3
refseq accession:: NM_002946
hgnc_id:: HGNC:10290
approved reserved:: 1993-12-14

1p35.3

RPA2（Replication Protein A2）是复制蛋白A（RPA）复合物的一个亚基，属于RPA基因家族。RPA是由RPA1、RPA2和RPA3三个亚基组成的异源三聚体蛋白复合物，在DNA代谢过程中发挥核心作用，包括DNA复制、修复和重组。RPA复合物通过与单链DNA（ssDNA）高亲和力结合，保护其免受核酸酶降解或形成二级结构，并为其他DNA处理蛋白提供平台。RPA2是该复合物的中间亚基，具有多个磷酸化位点，可调节其功能。RPA2在细胞周期检查点调控中起关键作用，特别是在DNA损伤应答（DDR）中，其磷酸化状态可影响下游信号通路的激活。RPA2突变可能导致基因组不稳定，增加癌症风险，如乳腺癌和卵巢癌。RPA2表达异常（过表达或低表达）会破坏DNA复制和修复的平衡，过表达可能促进肿瘤细胞增殖和耐药性，而低表达则导致DNA损伤积累和细胞凋亡。RPA基因家族的共性在于它们均参与DNA代谢，具有保守的ssDNA结合域（OB-fold），并在维持基因组稳定性中起协同作用。RPA2的功能障碍与多种疾病相关，包括癌症、神经退行性疾病和早衰综合征。

None

无

OMIM数据库中对RPA2基因的介绍 Wikipedia数据库中对RPA2基因的介绍

RPA2基因的碱基序列：[NCBI]

Loading Gene Browser...

RPA2基因的碱基突变：仅显示部分snp

rs7356 rs1000431 rs1000432 rs1884469 rs2064708 rs2064709 rs2064710 rs2078328 rs2295367 rs2474470 rs2749110 rs2749118 rs2749119 rs2749120 rs2815705 rs2815707 rs3766396

RPA2基因在不同组织中的表达： [UniProt]

正向引物序列

正向Tm值

反向引物序列

反向Tm值

评分

ACTATATCTCAGCTGCTTTCTG

CAATAGTGACCTGTGAAATCTC

GTAGCATCCGTGGATTCGA

AGCAGCTGAGATATAGTACAGG

ACTATATCTCAGCTGCTTTCTG

CAATAGTGACCTGTGAAATCTC

ACTATATCTCAGCTGCTTTCTG

CAATAGTGACCTGTGAAATCTC

TGTGGAACAGTGGATTCGA

GCTGAGATATAGTACAGGGCA

CTTGTCCAAGACCTGAAGG

ACAGCTTGCTTGATTGAGG

AAGAAATCAAGAGCCCGAG

CACTTCATCAACCAAAGTGG

AAGAAATCAAGAGCCCGAG

CACTTCATCAACCAAAGTGG

TTGTCCAAGACCTGAAGGG

CACAGCTTGCTTGATTGAGG

AAGAAATCAAGAGCCCGAG

CACTTCATCAACCAAAGTGG

转录因子

影响基因

影响类型

参考文献链接（PubMed）

E2F1

RPA2

Unknown

11313881

RPA2基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

质膜
细胞质
细胞外
高尔基体
囊泡
细胞骨架
内质网
细胞核
内体
溶酶体
线粒体

RPA2基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0000082

P15927 (UniProtKB)

TAS

GO:0000722

P15927 (UniProtKB)

TAS

GO:0000722

P15927 (UniProtKB)

TAS

GO:0000722

P15927 (UniProtKB)

TAS

GO:0000723

P15927 (UniProtKB)

IMP

GO:0000724

P15927 (UniProtKB)

IMP

GO:0000784

P15927 (UniProtKB)

IDA

GO:0000785

P15927 (UniProtKB)

IDA

GO:0003684

P15927 (UniProtKB)

IDA

GO:0003697

P15927 (UniProtKB)

ISS

GO:0003697

P15927 (UniProtKB)

IDA

GO:0003697

P15927 (UniProtKB)

GO:0005515

P15927 (UniProtKB)

IPI

GO:0005515

P15927 (UniProtKB)

IPI

GO:0005515

P15927 (UniProtKB)

IPI

GO:0005515

P15927 (UniProtKB)

IPI

GO:0005515

P15927 (UniProtKB)

IPI

GO:0005515

P15927 (UniProtKB)

IPI

GO:0005515

P15927 (UniProtKB)

IPI

GO:0005515

P15927 (UniProtKB)

IPI

GO:0005515

P15927 (UniProtKB)

IPI

GO:0005515

P15927 (UniProtKB)

IPI

GO:0005515

P15927 (UniProtKB)

IPI

GO:0005515

P15927 (UniProtKB)

IPI

GO:0005515

P15927 (UniProtKB)

IPI

GO:0005515

P15927 (UniProtKB)

IPI

GO:0005515

P15927 (UniProtKB)

IPI

GO:0005515

P15927 (UniProtKB)

IPI

GO:0005515

P15927 (UniProtKB)

IPI

GO:0005515

P15927 (UniProtKB)

IPI

GO:0005515

P15927 (UniProtKB)

IPI

GO:0005515

P15927 (UniProtKB)

IPI

GO:0005515

P15927 (UniProtKB)

IPI

GO:0005515

P15927 (UniProtKB)

IPI

GO:0005515

P15927 (UniProtKB)

IPI

GO:0005515

P15927 (UniProtKB)

IPI

GO:0005515

P15927 (UniProtKB)

IPI

GO:0005515

P15927 (UniProtKB)

IPI

GO:0005515

P15927 (UniProtKB)

IPI

GO:0005515

P15927 (UniProtKB)

IPI

GO:0005515

P15927 (UniProtKB)

IPI

GO:0005515

P15927 (UniProtKB)

IPI

GO:0005634

P15927 (UniProtKB)

IDA

GO:0005654

P15927 (UniProtKB)

IDA

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005654

P15927 (UniProtKB)

TAS

GO:0005662

P15927 (UniProtKB)

IDA

GO:0005662

P15927 (UniProtKB)

IPI

GO:0005662

P15927 (UniProtKB)

IDA

GO:0006260

P15927 (UniProtKB)

IDA

GO:0006260

P15927 (UniProtKB)

IMP

GO:0006260

P15927 (UniProtKB)

TAS

GO:0006260

P15927 (UniProtKB)

TAS

GO:0006260

P15927 (UniProtKB)

TAS

GO:0006260

P15927 (UniProtKB)

TAS

GO:0006260

P15927 (UniProtKB)

TAS

GO:0006260

P15927 (UniProtKB)

TAS

GO:0006283

P15927 (UniProtKB)

TAS

GO:0006284

P15927 (UniProtKB)

IDA

GO:0006289

P15927 (UniProtKB)

IMP

GO:0006293

P15927 (UniProtKB)

TAS

GO:0006294

P15927 (UniProtKB)

TAS

GO:0006295

P15927 (UniProtKB)

TAS

GO:0006296

P15927 (UniProtKB)

TAS

GO:0006297

P15927 (UniProtKB)

TAS

GO:0006298

P15927 (UniProtKB)

IMP

GO:0006298

P15927 (UniProtKB)

TAS

GO:0006298

P15927 (UniProtKB)

TAS

GO:0010569

P15927 (UniProtKB)

IMP

GO:0016605

P15927 (UniProtKB)

IDA

GO:0019899

P15927 (UniProtKB)

IPI

GO:0019899

P15927 (UniProtKB)

IPI

GO:0019903

P15927 (UniProtKB)

IPI

GO:0019985

P15927 (UniProtKB)

TAS

GO:0031571

P15927 (UniProtKB)

IMP

GO:0031625

P15927 (UniProtKB)

IPI

GO:0033683

P15927 (UniProtKB)

TAS

GO:0036297

P15927 (UniProtKB)

TAS

GO:0042276

P15927 (UniProtKB)

TAS

GO:0042276

P15927 (UniProtKB)

TAS

GO:0042276

P15927 (UniProtKB)

TAS

GO:0042769

P15927 (UniProtKB)

TAS

GO:0047485

P15927 (UniProtKB)

IEA

GO:0070987

P15927 (UniProtKB)

TAS

GO:1900034

P15927 (UniProtKB)

TAS

GO:1901796

P15927 (UniProtKB)

TAS

GO:2000001

P15927 (UniProtKB)

IMP

GO:0000781

P15927 (UniProtKB)

IDA

GO:0016605

P15927 (UniProtKB)

IDA

GO:0035861

P15927 (UniProtKB)

IDA

GO:0005654

Q5TEJ0 (UniProtKB)

IDA

GO:0005654

Q5TEJ7 (UniProtKB)

IDA

可能调控 RPA2基因的相关microRNA：

hsa-miR-130b hsa-miR-19b hsa-miR-93 hsa-miR-1226 hsa-miR-20a hsa-miR-92a

Reactome

MINT

BioGrid

IntAct

mentha

String

序号	作用方式	资源库来源/分值	基因名称	基因名称

KEGG
Reactomepathway

名称
3030 DNA replication [PATH:hsa03030]
3420 Nucleotide excision repair [PATH:hsa03420]
3430 Mismatch repair [PATH:hsa03430]
3440 Homologous recombination [PATH:hsa03440]
3460 Fanconi anemia pathway [PATH:hsa03460]

名称
Activation of ATR in response to replication stress
Activation of the pre-replicative complex
Assembly of the RAD51-ssDNA nucleoprotein complex
Base Excision Repair
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Cellular response to heat stress
Cellular responses to stress
Chromosome Maintenance
DNA Damage Bypass
DNA Repair
DNA Replication
DNA Replication Pre-Initiation
DNA strand elongation
Double-Strand Break Repair
Dual incision reaction in GG-NER
Extension of Telomeres
Formation of incision complex in GG-NER
G1/S Transition
G2/M Checkpoints
Gap-filling DNA repair synthesis and ligation in GG-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Global Genomic NER (GG-NER)
Homologous DNA pairing and strand exchange
Homologous Recombination Repair
Homologous recombination repair of replication-independent double-strand breaks
HSF1 activation
Lagging Strand Synthesis
M/G1 Transition
Meiosis
Meiotic recombination
Mismatch Repair
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mitotic G1-G1/S phases
Nucleotide Excision Repair
PCNA-Dependent Long Patch Base Excision Repair
Presynaptic phase of homologous DNA pairing and strand exchange
Processing of DNA double-strand break ends
Processive synthesis on the C-strand of the telomere
Processive synthesis on the lagging strand
Recognition of DNA damage by PCNA-containing replication complex
Regulation of HSF1-mediated heat shock response
Removal of the Flap Intermediate
Removal of the Flap Intermediate from the C-strand
Repair synthesis for gap-filling by DNA polymerase in TC-NER
Repair synthesis of patch ~27-30 bases long by DNA polymerase
Resolution of Abasic Sites (AP sites)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway
S Phase
Synthesis of DNA
Telomere C-strand (Lagging Strand) Synthesis
Telomere Maintenance
Termination of translesion DNA synthesis
Transcription-coupled NER (TC-NER)
Translesion Synthesis by POLH
Translesion synthesis by POLI
Translesion synthesis by POLK
Translesion synthesis by REV1
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
Multiple Endocrine Neoplasia	0.00272435	1	0	LHGDN
Malignant neoplasm of breast	0.002638474	2	0	BeFree_GAD
Malignant neoplasm of urinary bladder	0.002367032	1	0	GAD
Alcoholic Intoxication, Chronic	0.002367032	1	0	GAD
Multiple Sclerosis	0.002367032	1	0	GAD
Mammary Ductal Carcinoma	0.000271442	1	0	BeFree
Breast Carcinoma	0.000271442	1	0	BeFree
Carcinogenesis	0.000271442	1	0	BeFree
Malignant neoplasm of female breast	0.000271442	1	0	BeFree
Ductal Breast Carcinoma	0.000271442	1	0	BeFree

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更新于2天前

RPA2 (replication protein A2)

基因基本信息

基因基本信息

基因染色体位置

基因染色体位置

基因简述

基因简述

基因序列

基因序列

基因突变

基因突变

基因表达

基因表达

基因引物

基因引物

转录因子

转录因子

基因本体信息

基因相关microRNA

基因相关microRNA

基因相互作用关系

基因相互作用关系

基因通路

基因通路

基因相关疾病

基因相关疾病

基因相关服务

基因相关服务

联系方式

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