RPA1基因详情-基因数据库-基因云馆

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RPA1 (replication protein A1)

symbol:: RPA1
locus group:: protein-coding gene
location:: 17p13.3
gene_family:
alias symbol:: REPA1|RPA70|HSSB|RF-A|RP-A
alias name:: None
entrez id:: 6117
ensembl gene id:: ENSG00000132383
ucsc gene id:: uc002fto.3
refseq accession:: NM_002945
hgnc_id:: HGNC:10289
approved reserved:: 1993-12-14

17p13.3

RPA1（Replication Protein A1）是复制蛋白A（RPA）复合体的核心亚基，属于RPA基因家族。RPA是由RPA1、RPA2和RPA3组成的异源三聚体，在DNA代谢过程中发挥关键作用，包括DNA复制、修复和重组。RPA1是其中最大的亚基，直接结合单链DNA（ssDNA），通过其寡核苷酸/寡糖结合结构域（OB-fold）稳定ssDNA并招募其他修复因子。RPA复合体作为"守护者"防止ssDNA降解或形成二级结构，并为DNA聚合酶提供平台。RPA1还参与细胞周期检查点调控，通过ATR激酶通路传递DNA损伤信号。该基因突变会导致基因组不稳定性，与多种癌症（如乳腺癌、卵巢癌）和早衰综合征相关。RPA1过表达常见于恶性肿瘤，可能促进肿瘤细胞增殖和耐药性；而表达降低则导致DNA损伤修复缺陷，增加细胞对辐射或化疗的敏感性。RPA基因家族成员均含有OB-fold结构域，具有保守的ssDNA结合能力，但各亚基在结合亲和力和功能调控上存在差异。RPA1的N端结构域还参与蛋白质相互作用，这是区别于其他家族成员的特征。研究表明，RPA1磷酸化状态（如Ser33位点）可调节其与DNA及其他修复因子的结合动态，影响同源重组修复效率。在端粒维持中，RPA1与端粒酶协同作用，其异常表达可能导致端粒功能障碍。某些病毒（如HPV）会劫持RPA1以完成自身基因组复制，这成为抗病毒治疗的潜在靶点。针对RPA1的小分子抑制剂正在开发中，旨在增强肿瘤细胞对DNA损伤剂的敏感性。

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OMIM数据库中对RPA1基因的介绍 Wikipedia数据库中对RPA1基因的介绍

RPA1基因的碱基序列：[NCBI]

Loading Gene Browser...

RPA1基因的碱基突变：仅显示部分snp

rs9082 rs10100 rs12727 rs17734 rs1051315 rs1051318 rs1055761 rs1131636 rs2230930 rs2230931 rs2270411 rs2270412 rs2277694 rs2287320 rs2287321 rs3214399 rs3729643

RPA1基因在不同组织中的表达： [UniProt]

正向引物序列

正向Tm值

反向引物序列

反向Tm值

评分

TTGTTTCCAGGAGTCTGCT

CAAATGCCTGTTCATTCTTGTC

TGCCCTATAATGAAGAAGCTG

AGGGCAAACAATCCTTTCC

TCCAAGTCATCAACATCCGT

TGTTCAATCCATCACTCATGAG

CTGAAGGCTATCAATTCTAAGCAG

CAGTAGAACCCATTCCCGA

TCCAAGTCATCAACATCCGT

TGTTCAATCCATCACTCATGAG

GAGGGAGTAACACCAACTG

CTAAAGTAGTCCGGCTTGTC

TTGTTTCCAGGAGTCTGCT

CAAATGCCTGTTCATTCTTGTC

CTATCAATTCTAAGCAGGACTCG

TTCCCGAGCTTCCATTCTG

GCGACAAGGTAAATATTGCAG

GTCCAAGGATAGCTTCAGC

ACAATTGTCCAGCAACTGTG

AAGATAACTACTCTCCTTCCGTC

尚未收录相关数据

RPA1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

质膜
细胞质
细胞外
高尔基体
囊泡
细胞骨架
内质网
细胞核
内体
溶酶体
线粒体

RPA1基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0003677

I3L2M5 (UniProtKB)

IEA

GO:0005634

I3L2M5 (UniProtKB)

IEA

GO:0006260

I3L2M5 (UniProtKB)

IEA

GO:0003677

I3L524 (UniProtKB)

IEA

GO:0005634

I3L524 (UniProtKB)

IEA

GO:0006260

I3L524 (UniProtKB)

IEA

GO:0000082

P27694 (UniProtKB)

TAS

GO:0000722

P27694 (UniProtKB)

TAS

GO:0000722

P27694 (UniProtKB)

TAS

GO:0000722

P27694 (UniProtKB)

TAS

GO:0000723

P27694 (UniProtKB)

IMP

GO:0000724

P27694 (UniProtKB)

IMP

GO:0000784

P27694 (UniProtKB)

IDA

GO:0003684

P27694 (UniProtKB)

IDA

GO:0003697

P27694 (UniProtKB)

IDA

GO:0003697

P27694 (UniProtKB)

IDA

GO:0005515

P27694 (UniProtKB)

IPI

GO:0005515

P27694 (UniProtKB)

IPI

GO:0005515

P27694 (UniProtKB)

IPI

GO:0005515

P27694 (UniProtKB)

IPI

GO:0005515

P27694 (UniProtKB)

IPI

GO:0005515

P27694 (UniProtKB)

IPI

GO:0005515

P27694 (UniProtKB)

IPI

GO:0005515

P27694 (UniProtKB)

IPI

GO:0005515

P27694 (UniProtKB)

IPI

GO:0005515

P27694 (UniProtKB)

IPI

GO:0005515

P27694 (UniProtKB)

IPI

GO:0005515

P27694 (UniProtKB)

IPI

GO:0005515

P27694 (UniProtKB)

IPI

GO:0005515

P27694 (UniProtKB)

IPI

GO:0005515

P27694 (UniProtKB)

IPI

GO:0005515

P27694 (UniProtKB)

IPI

GO:0005515

P27694 (UniProtKB)

IPI

GO:0005515

P27694 (UniProtKB)

IPI

GO:0005515

P27694 (UniProtKB)

IPI

GO:0005515

P27694 (UniProtKB)

IPI

GO:0005515

P27694 (UniProtKB)

IPI

GO:0005515

P27694 (UniProtKB)

IPI

GO:0005515

P27694 (UniProtKB)

IPI

GO:0005515

P27694 (UniProtKB)

IPI

GO:0005515

P27694 (UniProtKB)

IPI

GO:0005515

P27694 (UniProtKB)

IPI

GO:0005515

P27694 (UniProtKB)

IPI

GO:0005515

P27694 (UniProtKB)

IPI

GO:0005515

P27694 (UniProtKB)

IPI

GO:0005634

P27694 (UniProtKB)

IDA

GO:0005654

P27694 (UniProtKB)

IDA

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005654

P27694 (UniProtKB)

TAS

GO:0005662

P27694 (UniProtKB)

IDA

GO:0005662

P27694 (UniProtKB)

IPI

GO:0006260

P27694 (UniProtKB)

IMP

GO:0006260

P27694 (UniProtKB)

TAS

GO:0006260

P27694 (UniProtKB)

TAS

GO:0006260

P27694 (UniProtKB)

TAS

GO:0006260

P27694 (UniProtKB)

TAS

GO:0006260

P27694 (UniProtKB)

TAS

GO:0006260

P27694 (UniProtKB)

TAS

GO:0006261

P27694 (UniProtKB)

TAS

GO:0006281

P27694 (UniProtKB)

IMP

GO:0006283

P27694 (UniProtKB)

TAS

GO:0006284

P27694 (UniProtKB)

IDA

GO:0006289

P27694 (UniProtKB)

IMP

GO:0006293

P27694 (UniProtKB)

TAS

GO:0006294

P27694 (UniProtKB)

TAS

GO:0006295

P27694 (UniProtKB)

TAS

GO:0006296

P27694 (UniProtKB)

TAS

GO:0006297

P27694 (UniProtKB)

TAS

GO:0006298

P27694 (UniProtKB)

IMP

GO:0006298

P27694 (UniProtKB)

TAS

GO:0006298

P27694 (UniProtKB)

TAS

GO:0006310

P27694 (UniProtKB)

TAS

GO:0016605

P27694 (UniProtKB)

IDA

GO:0016925

P27694 (UniProtKB)

TAS

GO:0019985

P27694 (UniProtKB)

TAS

GO:0033683

P27694 (UniProtKB)

TAS

GO:0036297

P27694 (UniProtKB)

TAS

GO:0042276

P27694 (UniProtKB)

TAS

GO:0042276

P27694 (UniProtKB)

TAS

GO:0042276

P27694 (UniProtKB)

TAS

GO:0042769

P27694 (UniProtKB)

TAS

GO:0046872

P27694 (UniProtKB)

IEA

GO:0070987

P27694 (UniProtKB)

TAS

GO:1900034

P27694 (UniProtKB)

TAS

GO:1901796

P27694 (UniProtKB)

TAS

GO:0016605

P27694 (UniProtKB)

IDA

可能调控 RPA1基因的相关microRNA：

hsa-let-7e hsa-miR-1301 hsa-miR-31 hsa-miR-339-5p hsa-miR-615-3p

Reactome

MINT

BioGrid

IntAct

mentha

String

序号	作用方式	资源库来源/分值	基因名称	基因名称

KEGG
Reactomepathway

名称
3030 DNA replication [PATH:hsa03030]
3420 Nucleotide excision repair [PATH:hsa03420]
3430 Mismatch repair [PATH:hsa03430]
3440 Homologous recombination [PATH:hsa03440]
3460 Fanconi anemia pathway [PATH:hsa03460]

名称
Activation of ATR in response to replication stress
Activation of the pre-replicative complex
Assembly of the RAD51-ssDNA nucleoprotein complex
Base Excision Repair
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Cellular response to heat stress
Cellular responses to stress
Chromosome Maintenance
DNA Damage Bypass
DNA Repair
DNA Replication
DNA Replication Pre-Initiation
DNA strand elongation
Double-Strand Break Repair
Dual incision reaction in GG-NER
Extension of Telomeres
Formation of incision complex in GG-NER
G1/S Transition
G2/M Checkpoints
Gap-filling DNA repair synthesis and ligation in GG-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Global Genomic NER (GG-NER)
Homologous DNA pairing and strand exchange
Homologous Recombination Repair
Homologous recombination repair of replication-independent double-strand breaks
HSF1 activation
Lagging Strand Synthesis
M/G1 Transition
Meiosis
Meiotic recombination
Metabolism of proteins
Mismatch Repair
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mitotic G1-G1/S phases
Nucleotide Excision Repair
PCNA-Dependent Long Patch Base Excision Repair
Post-translational protein modification
Presynaptic phase of homologous DNA pairing and strand exchange
Processing of DNA double-strand break ends
Processive synthesis on the C-strand of the telomere
Processive synthesis on the lagging strand
Recognition of DNA damage by PCNA-containing replication complex
Regulation of HSF1-mediated heat shock response
Removal of the Flap Intermediate
Removal of the Flap Intermediate from the C-strand
Repair synthesis for gap-filling by DNA polymerase in TC-NER
Repair synthesis of patch ~27-30 bases long by DNA polymerase
Resolution of Abasic Sites (AP sites)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway
S Phase
SUMO E3 ligases SUMOylate target proteins
SUMOylation
SUMOylation of DNA damage response and repair proteins
Synthesis of DNA
Telomere C-strand (Lagging Strand) Synthesis
Telomere Maintenance
Termination of translesion DNA synthesis
Transcription-coupled NER (TC-NER)
Translesion Synthesis by POLH
Translesion synthesis by POLI
Translesion synthesis by POLK
Translesion synthesis by REV1
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
Chloracne	0.12	1	0	CTD_human
Mammary Neoplasms	0.00272435	1	0	LHGDN
Coronary heart disease	0.002638474	1	1	BeFree_GAD
Head and Neck Neoplasms	0.002367032	1	0	GAD
Multiple Sclerosis	0.002367032	1	0	GAD
Neoplasms, Second Primary	0.002367032	1	0	GAD
Malignant neoplasm of urinary bladder	0.002367032	1	0	GAD
Neoplasm Recurrence, Local	0.002367032	1	0	GAD
Schizophrenia	0.002367032	1	0	GAD
Leukemia, Myeloid, Chronic-Phase	0.002367032	1	0	GAD

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更新于2天前

RPA1 (replication protein A1)

基因基本信息

基因基本信息

基因染色体位置

基因染色体位置

基因简述

基因简述

基因序列

基因序列

基因突变

基因突变

基因表达

基因表达

基因引物

基因引物

转录因子

转录因子

尚未收录相关数据

基因本体信息

基因相关microRNA

基因相关microRNA

基因相互作用关系

基因相互作用关系

基因通路

基因通路

基因相关疾病

基因相关疾病

基因相关服务

基因相关服务

联系方式

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