RGS4 (regulator of G protein signaling 4)
- symbol:
- RGS4
- locus group:
- protein-coding gene
- location:
- 1q23.3
- gene_family:
- Regulators of G-protein signaling
- alias symbol:
- None
- alias name:
- None
- entrez id:
- 5999
- ensembl gene id:
- ENSG00000117152
- ucsc gene id:
- uc009wuy.4
- refseq accession:
- NM_005613
- hgnc_id:
- HGNC:10000
- approved reserved:
- 1997-06-09
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
G蛋白信号传导的调节器（RGS）家族成员是充当异的G蛋白G的阿尔法亚基GTP酶激活蛋白（GAP）调节分子。 RGS蛋白能够停用在Gi的αG蛋白亚基，转到α和Gq蛋白的α亚型。他们驾驶的G蛋白进入它们的无效GDP结合的形式。 G蛋白信号4的稳压器属于这个家庭。所有RGS蛋白共享一个保守的120个氨基酸的序列被称为RGS域。 G蛋白信号4蛋白的调节剂是37％相同RGS1和97％相??同的大鼠RGS4。这种蛋白负调控上游或在异源G蛋白的水平信令和在细胞质中被定位。另外剪接转录变体也发现了这种基因。 [由RefSeq的，2008年7月提供]
基因本体信息
RGS4基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
RGS4基因的本体（GO）信息：
| 名称 |
|---|
| G alpha (i) signalling events |
| G alpha (z) signalling events |
| GPCR downstream signaling |
| Signaling by GPCR |
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Schizophrenia | 0.216710349 | 49 | 4 | BeFree_CTD_human_GAD_LHGDN |
| IGA Glomerulonephritis | 0.12 | 1 | 0 | CTD_human |
| Endometriosis | 0.12 | 1 | 0 | CTD_human |
| Bipolar Disorder | 0.008544182 | 5 | 0 | BeFree_GAD_LHGDN |
| Major Depressive Disorder | 0.002909916 | 2 | 0 | BeFree_GAD |
| Alzheimer's Disease | 0.00272435 | 1 | 0 | LHGDN |
| Alcoholic Intoxication, Chronic | 0.002638474 | 1 | 0 | BeFree_GAD |
| Neoplasm Recurrence, Local | 0.002367032 | 1 | 0 | GAD |
| Neoplasms, Second Primary | 0.002367032 | 1 | 0 | GAD |
| Schizoaffective Disorder | 0.002367032 | 1 | 0 | GAD |
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