RELA基因详情-基因数据库-基因云馆

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RELA (RELA proto-oncogene, NF-kB subunit)

symbol:: RELA
locus group:: protein-coding gene
location:: 11q13.1
gene_family:
alias symbol:: p65
alias name:: None
entrez id:: 5970
ensembl gene id:: ENSG00000173039
ucsc gene id:: uc001ofg.4
refseq accession:: NM_021975
hgnc_id:: HGNC:9955
approved reserved:: 1991-11-14

11q13.1

RELA基因编码转录因子p65，是NF-κB（核因子κB）蛋白家族的核心成员之一。NF-κB家族包含五个亚基（RELA/p65、RELB、c-REL、NFKB1/p50、NFKB2/p52），它们通过形成同源或异源二聚体调控基因表达，在免疫应答、炎症反应、细胞增殖和凋亡等生理过程中发挥关键作用。RELA/p65具有转录激活域，能直接结合DNA并招募其他转录辅因子，而其他家族成员如p50缺乏转录激活域，常需与RELA形成异源二聚体（如经典的p65-p50二聚体）才能激活靶基因。RELA的活性受IκB蛋白的抑制，当细胞受到炎症因子（如TNF-α）、病原体或应激刺激时，IκB被降解，释放RELA进入细胞核调控靶基因（如IL-6、TNF-α、COX-2等）。RELA的功能突变（如DNA结合域突变）可能导致NF-κB信号通路异常激活或抑制，与多种疾病相关：过度激活会促进慢性炎症（如类风湿性关节炎）、癌症（如淋巴瘤、乳腺癌）和自身免疫病，而功能缺失可能增加感染风险或导致免疫缺陷。RELA过表达会增强促炎因子和抗凋亡基因的转录，加速肿瘤生长和转移，同时可能抑制其他转录因子（如AP-1）的活性；低表达则可能削弱免疫防御，导致组织修复障碍。此外，RELA在发育中调控神经形成和肝细胞稳态，其条件性敲除小鼠会出现肝细胞凋亡和胚胎致死。该基因的调控异常还与阿尔茨海默病、糖尿病并发症等慢性病相关。药物开发中，靶向RELA的抑制剂（如硼替佐米）被用于治疗多发性骨髓瘤等NF-κB依赖型癌症。

None

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OMIM数据库中对RELA基因的介绍 Wikipedia数据库中对RELA基因的介绍

RELA基因的碱基序列：[NCBI]

Loading Gene Browser...

RELA基因的碱基突变：仅显示部分snp

rs7101916 rs10791822 rs10896028 rs11557248 rs11568292 rs11568293 rs11607323 rs11820062 rs55794449 rs71455773 rs71455774 rs71455775 rs72464037 rs74712780 rs75330420 rs76321190 rs77113330

RELA基因在不同组织中的表达： [UniProt]

正向引物序列

正向Tm值

反向引物序列

反向Tm值

评分

CAAGAAGCAGAACTGTTCCC

TGGTATCTGTGCTCCTCTC

CTTGTAGGAAAGGACTGCC

CAGGTTCTGGAAACTGTGG

ATCTTTGACAATCACGATCGTC

CTTCTTCATGATGCTCTTGAAGG

CACCATCAAGATCAATGGCT

CTTTCCTACAAGCTCGTGG

TGTGGAGATCATTGAGCAG

CTATAGGAACTTGATGGTGGG

AACCTGGGAATCCAGTGTG

CTGCTCTTCTATAGGAACTTGGA

GAATGGCTCGTCTGTAGTG

GCTGCTCAATGATCTCCAC

CATCTTTGACAATCGTGCC

CAGAGTTTCGGTTCACTCG

TGGAGATCATTGAGCAGCC

TCTATAGGAACTTGATGGTGGG

CGAGCTTGTAGGAAAGGAC

TTCTGGAAACTGTGGATGC

转录因子

影响基因

影响类型

参考文献链接（PubMed）

APEX1

RELA

Activation

17045925

RELA

Repression

18386814

ATF2

RELA

Activation

21350211

BCL3

RELA

Unknown

7896265

EP300

RELA

Unknown

21146504

ETV3

RELA

Repression

18025162

FHL2

RELA

Unknown

18752053

GATA3

RELA

Unknown

19686049

HDAC9

RELA

Repression

15964798

HOXA9

RELA

Repression

18068911

RELA基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

质膜
细胞质
细胞外
高尔基体
囊泡
细胞骨架
内质网
细胞核
内体
溶酶体
线粒体

RELA基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0003677

A0A087WVP0 (UniProtKB)

IEA

GO:0003700

A0A087WVP0 (UniProtKB)

IEA

GO:0005634

A0A087WVP0 (UniProtKB)

IEA

GO:0005737

A0A087WVP0 (UniProtKB)

IEA

GO:0051092

A0A087WVP0 (UniProtKB)

IEA

GO:0071159

A0A087WVP0 (UniProtKB)

IEA

GO:0003677

A0A087X0W8 (UniProtKB)

IEA

GO:0003700

A0A087X0W8 (UniProtKB)

IEA

GO:0005634

A0A087X0W8 (UniProtKB)

IEA

GO:0005737

A0A087X0W8 (UniProtKB)

IEA

GO:0051092

A0A087X0W8 (UniProtKB)

IEA

GO:0071159

A0A087X0W8 (UniProtKB)

IEA

GO:0003677

E9PI38 (UniProtKB)

IEA

GO:0003700

E9PI38 (UniProtKB)

IEA

GO:0005634

E9PI38 (UniProtKB)

IEA

GO:0005737

E9PI38 (UniProtKB)

IDA

GO:0051092

E9PI38 (UniProtKB)

IEA

GO:0071159

E9PI38 (UniProtKB)

IEA

GO:0003677

E9PJR1 (UniProtKB)

IEA

GO:0003700

E9PJR1 (UniProtKB)

IEA

GO:0005634

E9PJR1 (UniProtKB)

IEA

GO:0005737

E9PJR1 (UniProtKB)

IEA

GO:0051092

E9PJR1 (UniProtKB)

IEA

GO:0071159

E9PJR1 (UniProtKB)

IEA

GO:0003677

E9PJZ9 (UniProtKB)

IEA

GO:0003700

E9PJZ9 (UniProtKB)

IEA

GO:0005634

E9PJZ9 (UniProtKB)

IEA

GO:0005737

E9PJZ9 (UniProtKB)

IEA

GO:0051092

E9PJZ9 (UniProtKB)

IEA

GO:0071159

E9PJZ9 (UniProtKB)

IEA

GO:0003677

E9PKH5 (UniProtKB)

IEA

GO:0003700

E9PKH5 (UniProtKB)

IEA

GO:0005634

E9PKH5 (UniProtKB)

IEA

GO:0005737

E9PKH5 (UniProtKB)

IDA

GO:0051092

E9PKH5 (UniProtKB)

IEA

GO:0071159

E9PKH5 (UniProtKB)

IEA

GO:0003677

E9PKV4 (UniProtKB)

IEA

GO:0003700

E9PKV4 (UniProtKB)

IEA

GO:0005634

E9PKV4 (UniProtKB)

IEA

GO:0005737

E9PKV4 (UniProtKB)

IEA

GO:0051092

E9PKV4 (UniProtKB)

IEA

GO:0071159

E9PKV4 (UniProtKB)

IEA

GO:0003677

E9PM47 (UniProtKB)

IEA

GO:0003700

E9PM47 (UniProtKB)

IEA

GO:0005634

E9PM47 (UniProtKB)

IEA

GO:0005737

E9PM47 (UniProtKB)

IEA

GO:0051092

E9PM47 (UniProtKB)

IEA

GO:0071159

E9PM47 (UniProtKB)

IEA

GO:0003677

E9PMD5 (UniProtKB)

IEA

GO:0003700

E9PMD5 (UniProtKB)

IEA

GO:0005634

E9PMD5 (UniProtKB)

IEA

GO:0005737

E9PMD5 (UniProtKB)

IEA

GO:0051092

E9PMD5 (UniProtKB)

IEA

GO:0071159

E9PMD5 (UniProtKB)

IEA

GO:0003677

E9PN69 (UniProtKB)

IEA

GO:0003700

E9PN69 (UniProtKB)

IEA

GO:0005634

E9PN69 (UniProtKB)

IEA

GO:0005737

E9PN69 (UniProtKB)

IEA

GO:0051092

E9PN69 (UniProtKB)

IEA

GO:0071159

E9PN69 (UniProtKB)

IEA

GO:0003677

E9PNK5 (UniProtKB)

IEA

GO:0003700

E9PNK5 (UniProtKB)

IEA

GO:0005634

E9PNK5 (UniProtKB)

IEA

GO:0005737

E9PNK5 (UniProtKB)

IEA

GO:0051092

E9PNK5 (UniProtKB)

IEA

GO:0071159

E9PNK5 (UniProtKB)

IEA

GO:0003677

E9PNV4 (UniProtKB)

IEA

GO:0003700

E9PNV4 (UniProtKB)

IEA

GO:0005634

E9PNV4 (UniProtKB)

IEA

GO:0005737

E9PNV4 (UniProtKB)

IEA

GO:0051092

E9PNV4 (UniProtKB)

IEA

GO:0071159

E9PNV4 (UniProtKB)

IEA

GO:0003677

E9PQS6 (UniProtKB)

IEA

GO:0003700

E9PQS6 (UniProtKB)

IEA

GO:0005634

E9PQS6 (UniProtKB)

IEA

GO:0005737

E9PQS6 (UniProtKB)

IDA

GO:0051092

E9PQS6 (UniProtKB)

IEA

GO:0071159

E9PQS6 (UniProtKB)

IEA

GO:0003677

E9PRX2 (UniProtKB)

IEA

GO:0003700

E9PRX2 (UniProtKB)

IEA

GO:0005634

E9PRX2 (UniProtKB)

IEA

GO:0005737

E9PRX2 (UniProtKB)

IEA

GO:0051092

E9PRX2 (UniProtKB)

IEA

GO:0071159

E9PRX2 (UniProtKB)

IEA

GO:0003700

H0YCB4 (UniProtKB)

IEA

GO:0005634

H0YCB4 (UniProtKB)

IEA

GO:0005737

H0YCB4 (UniProtKB)

IEA

GO:0051092

H0YCB4 (UniProtKB)

IEA

GO:0071159

H0YCB4 (UniProtKB)

IEA

GO:0000122

Q04206 (UniProtKB)

IDA

GO:0000977

Q04206 (UniProtKB)

IDA

GO:0000977

Q04206 (UniProtKB)

IDA

GO:0000978

Q04206 (UniProtKB)

IDA

GO:0000980

Q04206 (UniProtKB)

IDA

GO:0001077

Q04206 (UniProtKB)

IDA

GO:0001078

Q04206 (UniProtKB)

IDA

GO:0001205

Q04206 (UniProtKB)

IDA

GO:0001889

Q04206 (UniProtKB)

IEA

GO:0001942

Q04206 (UniProtKB)

IEA

GO:0002223

Q04206 (UniProtKB)

TAS

GO:0003677

Q04206 (UniProtKB)

IDA

GO:0003677

Q04206 (UniProtKB)

IDA

GO:0003677

Q04206 (UniProtKB)

IMP

GO:0003677

Q04206 (UniProtKB)

IDA

GO:0003682

Q04206 (UniProtKB)

IDA

GO:0003700

Q04206 (UniProtKB)

IDA

GO:0003705

Q04206 (UniProtKB)

IDA

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005515

Q04206 (UniProtKB)

IPI

GO:0005634

Q04206 (UniProtKB)

IDA

GO:0005634

Q04206 (UniProtKB)

IDA

GO:0005634

Q04206 (UniProtKB)

IDA

GO:0005634

Q04206 (UniProtKB)

IDA

GO:0005634

Q04206 (UniProtKB)

IDA

GO:0005634

Q04206 (UniProtKB)

IDA

GO:0005634

Q04206 (UniProtKB)

IDA

GO:0005634

Q04206 (UniProtKB)

IDA

GO:0005634

Q04206 (UniProtKB)

IDA

GO:0005634

Q04206 (UniProtKB)

IDA

GO:0005654

Q04206 (UniProtKB)

TAS

GO:0005654

Q04206 (UniProtKB)

TAS

GO:0005654

Q04206 (UniProtKB)

TAS

GO:0005654

Q04206 (UniProtKB)

TAS

GO:0005654

Q04206 (UniProtKB)

TAS

GO:0005654

Q04206 (UniProtKB)

TAS

GO:0005654

Q04206 (UniProtKB)

TAS

GO:0005654

Q04206 (UniProtKB)

TAS

GO:0005654

Q04206 (UniProtKB)

TAS

GO:0005654

Q04206 (UniProtKB)

TAS

GO:0005667

Q04206 (UniProtKB)

IDA

GO:0005737

Q04206 (UniProtKB)

IDA

GO:0005737

Q04206 (UniProtKB)

IDA

GO:0005737

Q04206 (UniProtKB)

IDA

GO:0005737

Q04206 (UniProtKB)

IDA

GO:0005737

Q04206 (UniProtKB)

IDA

GO:0005737

Q04206 (UniProtKB)

IDA

GO:0005829

Q04206 (UniProtKB)

IDA

GO:0005829

Q04206 (UniProtKB)

TAS

GO:0005829

Q04206 (UniProtKB)

TAS

GO:0005829

Q04206 (UniProtKB)

TAS

GO:0005829

Q04206 (UniProtKB)

TAS

GO:0005829

Q04206 (UniProtKB)

TAS

GO:0005829

Q04206 (UniProtKB)

TAS

GO:0005829

Q04206 (UniProtKB)

TAS

GO:0005829

Q04206 (UniProtKB)

TAS

GO:0005829

Q04206 (UniProtKB)

TAS

GO:0005829

Q04206 (UniProtKB)

TAS

GO:0005829

Q04206 (UniProtKB)

TAS

GO:0005829

Q04206 (UniProtKB)

TAS

GO:0005829

Q04206 (UniProtKB)

TAS

GO:0005829

Q04206 (UniProtKB)

TAS

GO:0005829

Q04206 (UniProtKB)

TAS

GO:0005829

Q04206 (UniProtKB)

TAS

GO:0006117

Q04206 (UniProtKB)

IEA

GO:0006366

Q04206 (UniProtKB)

IEA

GO:0006366

Q04206 (UniProtKB)

IEA

GO:0006954

Q04206 (UniProtKB)

IDA

GO:0006968

Q04206 (UniProtKB)

NAS

GO:0007568

Q04206 (UniProtKB)

IEA

GO:0008134

Q04206 (UniProtKB)

IPI

GO:0008284

Q04206 (UniProtKB)

IDA

GO:0009887

Q04206 (UniProtKB)

IEA

GO:0010033

Q04206 (UniProtKB)

IDA

GO:0010224

Q04206 (UniProtKB)

IDA

GO:0014040

Q04206 (UniProtKB)

IEA

GO:0016032

Q04206 (UniProtKB)

IEA

GO:0019221

Q04206 (UniProtKB)

IDA

GO:0019901

Q04206 (UniProtKB)

IPI

GO:0019901

Q04206 (UniProtKB)

IPI

GO:0019901

Q04206 (UniProtKB)

IPI

GO:0031293

Q04206 (UniProtKB)

TAS

GO:0031490

Q04206 (UniProtKB)

IDA

GO:0031625

Q04206 (UniProtKB)

IPI

GO:0032332

Q04206 (UniProtKB)

IEA

GO:0032403

Q04206 (UniProtKB)

IEA

GO:0032481

Q04206 (UniProtKB)

TAS

GO:0032495

Q04206 (UniProtKB)

IEA

GO:0032570

Q04206 (UniProtKB)

IEA

GO:0032868

Q04206 (UniProtKB)

IEA

GO:0033256

Q04206 (UniProtKB)

IBA

GO:0033590

Q04206 (UniProtKB)

IEA

GO:0033613

Q04206 (UniProtKB)

IPI

GO:0035729

Q04206 (UniProtKB)

IEA

GO:0035994

Q04206 (UniProtKB)

IEA

GO:0038095

Q04206 (UniProtKB)

TAS

GO:0042177

Q04206 (UniProtKB)

IEA

GO:0042301

Q04206 (UniProtKB)

IDA

GO:0042493

Q04206 (UniProtKB)

IEA

GO:0042802

Q04206 (UniProtKB)

IPI

GO:0042802

Q04206 (UniProtKB)

IPI

GO:0042802

Q04206 (UniProtKB)

IDA

GO:0042803

Q04206 (UniProtKB)

IDA

GO:0042805

Q04206 (UniProtKB)

IPI

GO:0042826

Q04206 (UniProtKB)

IPI

GO:0042826

Q04206 (UniProtKB)

IPI

GO:0042826

Q04206 (UniProtKB)

IPI

GO:0043066

Q04206 (UniProtKB)

IDA

GO:0043066

Q04206 (UniProtKB)

IDA

GO:0043066

Q04206 (UniProtKB)

TAS

GO:0043123

Q04206 (UniProtKB)

IEP

GO:0043200

Q04206 (UniProtKB)

IEA

GO:0043278

Q04206 (UniProtKB)

IEA

GO:0044212

Q04206 (UniProtKB)

IDA

GO:0045084

Q04206 (UniProtKB)

IEA

GO:0045892

Q04206 (UniProtKB)

IDA

GO:0045893

Q04206 (UniProtKB)

IDA

GO:0045893

Q04206 (UniProtKB)

IDA

GO:0045944

Q04206 (UniProtKB)

IMP

GO:0045944

Q04206 (UniProtKB)

IDA

GO:0045944

Q04206 (UniProtKB)

IDA

GO:0045944

Q04206 (UniProtKB)

IDA

GO:0045944

Q04206 (UniProtKB)

IMP

GO:0045944

Q04206 (UniProtKB)

IDA

GO:0046627

Q04206 (UniProtKB)

IEA

GO:0046982

Q04206 (UniProtKB)

IDA

GO:0046982

Q04206 (UniProtKB)

IDA

GO:0047485

Q04206 (UniProtKB)

IPI

GO:0050727

Q04206 (UniProtKB)

ISS

GO:0050852

Q04206 (UniProtKB)

TAS

GO:0051059

Q04206 (UniProtKB)

IPI

GO:0051059

Q04206 (UniProtKB)

IPI

GO:0051092

Q04206 (UniProtKB)

IDA

GO:0051092

Q04206 (UniProtKB)

TAS

GO:0051591

Q04206 (UniProtKB)

IEA

GO:0051607

Q04206 (UniProtKB)

NAS

GO:0070301

Q04206 (UniProtKB)

IDA

GO:0070431

Q04206 (UniProtKB)

IDA

GO:0070491

Q04206 (UniProtKB)

IPI

GO:0070555

Q04206 (UniProtKB)

IGI

GO:0071159

Q04206 (UniProtKB)

IEA

GO:0071222

Q04206 (UniProtKB)

IEA

GO:0071222

Q04206 (UniProtKB)

IEA

GO:0071316

Q04206 (UniProtKB)

IMP

GO:0071347

Q04206 (UniProtKB)

IDA

GO:0071354

Q04206 (UniProtKB)

IMP

GO:0071356

Q04206 (UniProtKB)

IDA

GO:0071356

Q04206 (UniProtKB)

IDA

GO:0071375

Q04206 (UniProtKB)

IMP

GO:0071532

Q04206 (UniProtKB)

IEA

GO:1901223

Q04206 (UniProtKB)

IMP

GO:2000630

Q04206 (UniProtKB)

IMP

GO:2001237

Q04206 (UniProtKB)

IMP

GO:0003677

Q2TAM5 (UniProtKB)

IEA

GO:0003700

Q2TAM5 (UniProtKB)

IEA

GO:0005634

Q2TAM5 (UniProtKB)

IEA

GO:0005737

Q2TAM5 (UniProtKB)

IDA

GO:0051092

Q2TAM5 (UniProtKB)

IEA

GO:0071159

Q2TAM5 (UniProtKB)

IEA

可能调控 RELA基因的相关microRNA：

hsa-miR-124 hsa-miR-373 hsa-miR-7 hsa-miR-96 hsa-miR-103 hsa-miR-10a hsa-miR-10a* hsa-miR-125b hsa-miR-130a hsa-miR-130a*

Reactome

MINT

BioGrid

IntAct

mentha

String

序号	作用方式	资源库来源/分值	基因名称	基因名称

KEGG
Reactomepathway

名称
4014 Ras signaling pathway [PATH:hsa04014]
4010 MAPK signaling pathway [PATH:hsa04010]
4064 NF-kappa B signaling pathway [PATH:hsa04064]
4668 TNF signaling pathway [PATH:hsa04668]
4066 HIF-1 signaling pathway [PATH:hsa04066]
4071 Sphingolipid signaling pathway [PATH:hsa04071]
4024 cAMP signaling pathway [PATH:hsa04024]
4151 PI3K-Akt signaling pathway [PATH:hsa04151]
4210 Apoptosis [PATH:hsa04210]
4620 Toll-like receptor signaling pathway [PATH:hsa04620]
4621 NOD-like receptor signaling pathway [PATH:hsa04621]
4622 RIG-I-like receptor signaling pathway [PATH:hsa04622]
4623 Cytosolic DNA-sensing pathway [PATH:hsa04623]
4660 T cell receptor signaling pathway [PATH:hsa04660]
4662 B cell receptor signaling pathway [PATH:hsa04662]
4062 Chemokine signaling pathway [PATH:hsa04062]
4920 Adipocytokine signaling pathway [PATH:hsa04920]
4917 Prolactin signaling pathway [PATH:hsa04917]
4722 Neurotrophin signaling pathway [PATH:hsa04722]
4380 Osteoclast differentiation [PATH:hsa04380]
5200 Pathways in cancer [PATH:hsa05200]
5202 Transcriptional misregulation in cancers [PATH:hsa05202]
5203 Viral carcinogenesis [PATH:hsa05203]
5212 Pancreatic cancer [PATH:hsa05212]
5221 Acute myeloid leukemia [PATH:hsa05221]
5220 Chronic myeloid leukemia [PATH:hsa05220]
5215 Prostate cancer [PATH:hsa05215]
5222 Small cell lung cancer [PATH:hsa05222]
5321 Inflammatiory bowel disease (IBD) [PATH:hsa05321]
5030 Cocaine addiction [PATH:hsa05030]
4932 Non-alcoholic fatty liver disease (NAFLD) [PATH:hsa04932]
5120 Epithelial cell signaling in Helicobacter pylori infection [PATH:hsa05120]
5132 Salmonella infection [PATH:hsa05132]
5131 Shigellosis [PATH:hsa05131]
5133 Pertussis [PATH:hsa05133]
5134 Legionellosis [PATH:hsa05134]
5152 Tuberculosis [PATH:hsa05152]
5166 HTLV-I infection [PATH:hsa05166]
5162 Measles [PATH:hsa05162]
5164 Influenza A [PATH:hsa05164]
5161 Hepatitis B [PATH:hsa05161]
5160 Hepatitis C [PATH:hsa05160]
5168 Herpes simplex infection [PATH:hsa05168]
5169 Epstein-Barr virus infection [PATH:hsa05169]
5146 Amoebiasis [PATH:hsa05146]
5145 Toxoplasmosis [PATH:hsa05145]
5140 Leishmaniasis [PATH:hsa05140]
5142 Chagas disease (American trypanosomiasis) [PATH:hsa05142]

名称
Activated TLR4 signalling
Activation of NF-kappaB in B cells
Adaptive Immune System
C-type lectin receptors (CLRs)
CD209 (DC-SIGN) signaling
Cellular responses to stress
Cellular Senescence
CLEC7A (Dectin-1) signaling
CLEC7A/inflammasome pathway
Cytokine Signaling in Immune system
Cytosolic sensors of pathogen-associated DNA
Dectin-1 mediated noncanonical NF-kB signaling
Developmental Biology
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
Disease
Diseases associated with the TLR signaling cascade
Diseases of Immune System
Downstream signaling events of B Cell Receptor (BCR)
Downstream TCR signaling
Fc epsilon receptor (FCERI) signaling
FCERI mediated NF-kB activation
IkBA variant leads to EDA-ID
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
Immune System
Innate Immune System
Interleukin-1 processing
MyD88 cascade initiated on plasma membrane
MyD88 dependent cascade initiated on endosome
MyD88-independent TLR3/TLR4 cascade
MyD88:Mal cascade initiated on plasma membrane
NF-kB is activated and signals survival
p75 NTR receptor-mediated signalling
p75NTR signals via NF-kB
Regulated proteolysis of p75NTR
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
RIP-mediated NFkB activation via ZBP1
Senescence-Associated Secretory Phenotype (SASP)
Signaling by Interleukins
Signaling by the B Cell Receptor (BCR)
Signalling by NGF
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
TCR signaling
Toll Like Receptor 10 (TLR10) Cascade
Toll Like Receptor 2 (TLR2) Cascade
Toll Like Receptor 3 (TLR3) Cascade
Toll Like Receptor 4 (TLR4) Cascade
Toll Like Receptor 5 (TLR5) Cascade
Toll Like Receptor 7/8 (TLR7/8) Cascade
Toll Like Receptor 9 (TLR9) Cascade
Toll Like Receptor TLR1:TLR2 Cascade
Toll Like Receptor TLR6:TLR2 Cascade
Toll-Like Receptors Cascades
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
TRAF6 Mediated Induction of proinflammatory cytokines
TRAF6 mediated NF-kB activation
Transcriptional regulation of white adipocyte differentiation
TRIF-mediated TLR3/TLR4 signaling
ZBP1(DAI) mediated induction of type I IFNs

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
Colitis	0.200814326	5	0	BeFree_CTD_human_RGD
Kidney Failure, Chronic	0.200271442	3	0	BeFree_CTD_human_RGD
Diabetes Mellitus, Experimental	0.2	3	0	CTD_human_RGD
Reperfusion Injury	0.2	3	0	CTD_human_RGD
Hypertensive disease	0.2	2	0	CTD_human_RGD
Mammary Neoplasms	0.128715934	6	0	BeFree_CTD_human_LHGDN
Ulcerative Colitis	0.124353001	8	0	BeFree_CTD_human_LHGDN
Ependymoma	0.120814326	3	0	BeFree_ORPHANET
Diabetic Nephropathy	0.120271442	2	0	BeFree_CTD_human
Colonic Neoplasms	0.120271442	2	0	BeFree_CTD_human

联系方式

山东省济南市章丘区文博路2号齐鲁师范学院 genelibs生信实验室

山东省济南市高新区舜华路750号大学科技园北区F座4单元2楼

电话： 0531-88819269

E-mail: product@genelibs.com

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更新于2天前

RELA (RELA proto-oncogene, NF-kB subunit)

基因基本信息

基因基本信息

基因染色体位置

基因染色体位置

基因简述

基因简述

基因序列

基因序列

基因突变

基因突变

基因表达

基因表达

基因引物

基因引物

转录因子

转录因子

基因本体信息

基因相关microRNA

基因相关microRNA

基因相互作用关系

基因相互作用关系

基因通路

基因通路

基因相关疾病

基因相关疾病

基因相关服务

基因相关服务

联系方式

微信公众号