RAC1 (Rac family small GTPase 1)

symbol:
RAC1
locus group:
protein-coding gene
location:
7p22.1
gene_family:
Rho family GTPases|Endogenous ligands
alias symbol:
TC-25|p21-Rac1|Rac-1
alias name:
None
entrez id:
5879
ensembl gene id:
ENSG00000136238
ucsc gene id:
uc003spx.4
refseq accession:
NM_018890
hgnc_id:
HGNC:9801
approved reserved:
1993-11-05
7p22.1
基因染色体位置图

RAC1(Ras-related C3 botulinum toxin substrate 1)属于Rho家族的小GTP酶基因家族,该家族成员在细胞信号传导中起关键作用,主要调控细胞骨架重组、细胞迁移、增殖和存活等过程。RAC1通过切换GDP结合(失活)和GTP结合(激活)状态来调控下游效应蛋白,影响肌动蛋白动力学、膜皱褶形成和细胞极性。其表达产物是一种分子开关蛋白,广泛分布于多种组织,尤其在神经系统和免疫系统中发挥重要作用。RAC1的突变可能导致功能异常,如持续激活突变(如P29S)与黑色素瘤、乳腺癌等癌症相关,而功能丧失突变可能影响神经发育或免疫细胞功能。过表达RAC1会增强细胞迁移和侵袭能力,促进肿瘤转移,还可能通过激活PAK1和NF-κB等通路加剧炎症反应;降低表达则可能导致细胞运动缺陷、突触形成障碍或免疫细胞功能受损。在神经系统中,RAC1调节树突棘形态发生,其表达异常与阿尔茨海默病和精神分裂症有关。Rho家族基因的共性包括:均含GTP酶结构域,受GEF(鸟苷酸交换因子)、GAP(GTP酶激活蛋白)和GDI(鸟苷酸解离抑制因子)调控,并通过调控细胞骨架参与细胞形态和运动。此外,RAC1与CDC42和RHOA等家族成员存在功能交叉,共同协调复杂细胞行为。

None

RAC1基因的碱基序列:[NCBI]
Loading Gene Browser...
RAC1基因的碱基突变:           仅显示部分snp
rs5828       rs5835       rs5836       rs9374       rs12977       rs14627       rs16063       rs702482       rs702483       rs702484       rs768409       rs836468       rs836469       rs836470       rs836471       rs836472       rs836473      

RAC1基因在不同组织中的表达:    [UniProt]

基因在不同组织中的表达图
正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
TGGGCTTATGGGATACAGC
59
ACGTTTCTCCAACTGTTTGC
60
CGTGCAAAGTGGTATCCTG
59
CCCTAAGATCAAGTTTAGTTCCC
59
GCTAAGGAGATTGGTGCTG
58
ATCGCTTCGTCAAACACTG
59
TCTGGGCTTATGGGATACAG
59
AAGAACACATCTGTTTGCGG
60
GGAGACGGAAACAAGAATCTC
59
TTGTGTAACTGATCAGTAGGCA
60
TCTGGGCTTATGGGATACAG
59
AAGAACACATCTGTTTGCGG
60
GCTAAGGAGATTGGTGCTG
58
ATCGCTTCGTCAAACACTG
58
GGCTAAGGAGATTGGTGCT
59
CGCTTCGTCAAACACTGTC
59
GGAGACGGAAACAAGAATCTC
59
TTGTGTAACTGATCAGTAGGC
58
GGGCTTATGGGATACAGCT
59
TACGTTTCTCCAACTGTTTGC
60
转录因子
影响基因
影响类型
参考文献链接(PubMed)
PTTG1
RAC1
Activation

RAC1基因(以及对应的蛋白质)的细胞分布位置:

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

RAC1基因的本体(GO)信息:

GO库代码
对应的蛋白质
来源代码
GO:0000139
P63000 (UniProtKB)
IEA
GO:0001891
P63000 (UniProtKB)
IEA
GO:0001934
P63000 (UniProtKB)
IMP
GO:0002093
P63000 (UniProtKB)
IEA
GO:0002551
P63000 (UniProtKB)
IEA
GO:0003382
P63000 (UniProtKB)
IEA
GO:0003924
P63000 (UniProtKB)
TAS
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005515
P63000 (UniProtKB)
IPI
GO:0005525
P63000 (UniProtKB)
IDA
GO:0005525
P63000 (UniProtKB)
IDA
GO:0005525
P63000 (UniProtKB)
IMP
GO:0005525
P63000 (UniProtKB)
IDA
GO:0005525
P63000 (UniProtKB)
IDA
GO:0005634
P63000 (UniProtKB)
IEA
GO:0005737
P63000 (UniProtKB)
IDA
GO:0005789
P63000 (UniProtKB)
TAS
GO:0005789
P63000 (UniProtKB)
TAS
GO:0005802
P63000 (UniProtKB)
IDA
GO:0005829
P63000 (UniProtKB)
ISS
GO:0005829
P63000 (UniProtKB)
TAS
GO:0005829
P63000 (UniProtKB)
TAS
GO:0005829
P63000 (UniProtKB)
TAS
GO:0005829
P63000 (UniProtKB)
TAS
GO:0005829
P63000 (UniProtKB)
TAS
GO:0005829
P63000 (UniProtKB)
TAS
GO:0005829
P63000 (UniProtKB)
TAS
GO:0005829
P63000 (UniProtKB)
TAS
GO:0005829
P63000 (UniProtKB)
TAS
GO:0005829
P63000 (UniProtKB)
TAS
GO:0005829
P63000 (UniProtKB)
TAS
GO:0005829
P63000 (UniProtKB)
TAS
GO:0005829
P63000 (UniProtKB)
TAS
GO:0005829
P63000 (UniProtKB)
TAS
GO:0005829
P63000 (UniProtKB)
TAS
GO:0005829
P63000 (UniProtKB)
TAS
GO:0005829
P63000 (UniProtKB)
TAS
GO:0005829
P63000 (UniProtKB)
TAS
GO:0005829
P63000 (UniProtKB)
TAS
GO:0005829
P63000 (UniProtKB)
TAS
GO:0005829
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005886
P63000 (UniProtKB)
TAS
GO:0005925
P63000 (UniProtKB)
IDA
GO:0006928
P63000 (UniProtKB)
TAS
GO:0006954
P63000 (UniProtKB)
TAS
GO:0006972
P63000 (UniProtKB)
IEA
GO:0007155
P63000 (UniProtKB)
TAS
GO:0007160
P63000 (UniProtKB)
NAS
GO:0007186
P63000 (UniProtKB)
IEA
GO:0007264
P63000 (UniProtKB)
IEA
GO:0007411
P63000 (UniProtKB)
IEA
GO:0007596
P63000 (UniProtKB)
TAS
GO:0008283
P63000 (UniProtKB)
IEA
GO:0008361
P63000 (UniProtKB)
IGI
GO:0008361
P63000 (UniProtKB)
IMP
GO:0009611
P63000 (UniProtKB)
TAS
GO:0009653
P63000 (UniProtKB)
TAS
GO:0010310
P63000 (UniProtKB)
TAS
GO:0010592
P63000 (UniProtKB)
IDA
GO:0010592
P63000 (UniProtKB)
IMP
GO:0010762
P63000 (UniProtKB)
IEA
GO:0010811
P63000 (UniProtKB)
IGI
GO:0010811
P63000 (UniProtKB)
IGI
GO:0014041
P63000 (UniProtKB)
IEA
GO:0016020
P63000 (UniProtKB)
ISS
GO:0017137
P63000 (UniProtKB)
IEA
GO:0019897
P63000 (UniProtKB)
IEA
GO:0019899
P63000 (UniProtKB)
IPI
GO:0019901
P63000 (UniProtKB)
IEA
GO:0021799
P63000 (UniProtKB)
IEA
GO:0021831
P63000 (UniProtKB)
IEA
GO:0021894
P63000 (UniProtKB)
IEA
GO:0030027
P63000 (UniProtKB)
IDA
GO:0030032
P63000 (UniProtKB)
IMP
GO:0030036
P63000 (UniProtKB)
IGI
GO:0030041
P63000 (UniProtKB)
TAS
GO:0030168
P63000 (UniProtKB)
TAS
GO:0030334
P63000 (UniProtKB)
IMP
GO:0030334
P63000 (UniProtKB)
IMP
GO:0030742
P63000 (UniProtKB)
IEA
GO:0030838
P63000 (UniProtKB)
IEA
GO:0031295
P63000 (UniProtKB)
TAS
GO:0031529
P63000 (UniProtKB)
IDA
GO:0031529
P63000 (UniProtKB)
TAS
GO:0031901
P63000 (UniProtKB)
IEA
GO:0031996
P63000 (UniProtKB)
IPI
GO:0032587
P63000 (UniProtKB)
IEA
GO:0032707
P63000 (UniProtKB)
IDA
GO:0034446
P63000 (UniProtKB)
IMP
GO:0035025
P63000 (UniProtKB)
TAS
GO:0035556
P63000 (UniProtKB)
TAS
GO:0036464
P63000 (UniProtKB)
IDA
GO:0038095
P63000 (UniProtKB)
TAS
GO:0038096
P63000 (UniProtKB)
TAS
GO:0042470
P63000 (UniProtKB)
IEA
GO:0042826
P63000 (UniProtKB)
IEA
GO:0043065
P63000 (UniProtKB)
TAS
GO:0043552
P63000 (UniProtKB)
IEA
GO:0043652
P63000 (UniProtKB)
IEA
GO:0045216
P63000 (UniProtKB)
IEA
GO:0045453
P63000 (UniProtKB)
IEA
GO:0045740
P63000 (UniProtKB)
IEA
GO:0048010
P63000 (UniProtKB)
TAS
GO:0048013
P63000 (UniProtKB)
TAS
GO:0048261
P63000 (UniProtKB)
TAS
GO:0048532
P63000 (UniProtKB)
IEA
GO:0048813
P63000 (UniProtKB)
IEA
GO:0048870
P63000 (UniProtKB)
IDA
GO:0048873
P63000 (UniProtKB)
IEA
GO:0050690
P63000 (UniProtKB)
TAS
GO:0051022
P63000 (UniProtKB)
ISS
GO:0051056
P63000 (UniProtKB)
TAS
GO:0051496
P63000 (UniProtKB)
IDA
GO:0051668
P63000 (UniProtKB)
IMP
GO:0051894
P63000 (UniProtKB)
IDA
GO:0051932
P63000 (UniProtKB)
IEA
GO:0060071
P63000 (UniProtKB)
NAS
GO:0060071
P63000 (UniProtKB)
TAS
GO:0060263
P63000 (UniProtKB)
IDA
GO:0070062
P63000 (UniProtKB)
IDA
GO:0070062
P63000 (UniProtKB)
IDA
GO:0070062
P63000 (UniProtKB)
IDA
GO:0071260
P63000 (UniProtKB)
IEA
GO:0071526
P63000 (UniProtKB)
ISS
GO:0071542
P63000 (UniProtKB)
IEA
GO:0072659
P63000 (UniProtKB)
IEA
GO:0090023
P63000 (UniProtKB)
IMP
GO:0090103
P63000 (UniProtKB)
IEA
GO:0097178
P63000 (UniProtKB)
IEA
GO:1900026
P63000 (UniProtKB)
IDA
GO:0005884
P63000 (UniProtKB)
IDA

可能调控 RAC1基因的相关microRNA:     

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称
疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Heart failure 0.2 2 0 CTD_human_RGD
Neoplasm Metastasis 0.132224816 36 0 BeFree_CTD_human_LHGDN
melanoma 0.125981653 13 0 BeFree_CTD_human_LHGDN
Liver carcinoma 0.12408156 6 0 BeFree_CTD_human_LHGDN
Cardiomyopathy, Dilated 0.12 1 0 CTD_human
Liver diseases 0.12 1 0 CTD_human
Neoplastic Cell Transformation 0.12 1 0 CTD_human
Diabetes Mellitus 0.12 1 0 CTD_human
Left Ventricular Hypertrophy 0.08 1 0 RGD
Mammary Neoplasms 0.014436077 8 0 BeFree_LHGDN

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