PTPN11基因详情-基因数据库-基因云馆

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PTPN11 (protein tyrosine phosphatase non-receptor type 11)

symbol:: PTPN11
locus group:: protein-coding gene
location:: 12q24.13
gene_family:: SH2 domain containing|Protein tyrosine phosphatases, non-receptor type
alias symbol:: BPTP3|SH-PTP2|SHP-2|PTP2C|SHP2
alias name:: SH2 domain-containing protein tyro…
entrez id:: 5781
ensembl gene id:: ENSG00000179295
ucsc gene id:: uc001ttx.4
refseq accession:: NM_001330437
hgnc_id:: HGNC:9644
approved reserved:: 1993-03-03

12q24.13

PTPN11基因编码的蛋白称为SHP-2（Src homology region 2-containing protein tyrosine phosphatase-2），属于蛋白酪氨酸磷酸酶（PTP）家族。该基因在细胞信号传导中起关键作用，主要参与调控RAS/MAPK信号通路，影响细胞增殖、分化、迁移和存活。SHP-2由两个SH2结构域和一个催化结构域组成，通常通过与生长因子受体或其他信号分子结合而被激活，进而去磷酸化靶蛋白以调节信号传递。PTPN11突变常见于努南综合征（Noonan syndrome）和豹皮综合征（LEOPARD syndrome），这些突变通常导致SHP-2持续激活，过度刺激RAS/MAPK通路，引发发育异常、心脏缺陷和智力障碍。此外，PTPN11突变也与某些白血病（如幼年型粒单核细胞白血病）和实体瘤相关。若PTPN11过表达，可能增强细胞增殖和存活信号，促进肿瘤发生；而表达降低则可能影响正常发育和免疫功能。PTPN11属于PTP基因家族，该家族成员均含有保守的催化结构域，负责去磷酸化酪氨酸残基以调控细胞信号。PTP家族在免疫、代谢和癌症中发挥广泛作用，而SHP-2因其独特的SH2结构域和双重调节功能（既可激活也可抑制信号）在家族中尤为特殊。

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

由该基因编码的蛋白质是蛋白质酪氨酸磷酸酶（PTP）家族的一个成员。的PTPs已知是信令调节多种细胞过程，包括细胞生长，分化，有丝分裂周期，和致癌性转化的分子。这PTP包含两个串联的Src同源2结构域，其作为磷酸酪氨酸结合结构域并介导此PTP与其底物的相互作用。此PTP广泛表达在大多数组织和在这对于细胞功能，例如有丝分裂激活，代谢控制，转录调节和细胞迁移的分集重要各种细胞信号事件中起着调节作用。在这个基因的突变是Noonan综合征的原因以及急性髓细胞性白血病。已发现该基因编码不同亚型的两个转录变异体。 [由RefSeq的，2012年5月提供]

OMIM数据库中对PTPN11基因的介绍 Wikipedia数据库中对PTPN11基因的介绍

PTPN11基因的碱基序列：[NCBI]

Loading Gene Browser...

PTPN11基因的碱基突变：仅显示部分snp

rs3240 rs574656 rs574680 rs1060450 rs1419587 rs1966342 rs1966343 rs2051801 rs2107205 rs2158292 rs2301756 rs3741983 rs4767860 rs6489843 rs7132778 rs7296254 rs7310987

PTPN11基因在不同组织中的表达： [UniProt]

正向引物序列

正向Tm值

反向引物序列

反向Tm值

评分

CTTAAGTTATCTTCCCGCCG

TTACCTACTGTCTCCGAGC

GCTGTCAGGAACTGAAATACG

CTGTACCCAATGTTTCCACC

CACTGGTGATGACAAAGGG

TATTTCAGTTCCTGACAGCG

CGAGAACTAAGCAAATTAGCTG

ACCATCATTCTCAGCAAACTC

TGTTAGGAACGTCAAAGAAAGC

CGTATTCCCTTGTCCAACCT

AGAGAAAGGTGTTGACTGC

GGTACTGTGCTTCTGTCTG

TTAAGTTATCTTCCCGCCG

ATTACCTACTGTCTCCGAGC

GCTGTCAGGAACTGAAATACG

TGTACCCAATGTTTCCACCA

AGAGAAAGGTGTTGACTGC

GTACTGTGCTTCTGTCTGG

GCACTGGTGATGACAAAGG

ATTTCAGTTCCTGACAGCG

尚未收录相关数据

PTPN11基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

质膜
细胞质
细胞外
高尔基体
囊泡
细胞骨架
内质网
细胞核
内体
溶酶体
线粒体

PTPN11基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0004725

A0A0U1RRI0 (UniProtKB)

IEA

GO:0035335

A0A0U1RRI0 (UniProtKB)

IEA

GO:0000077

Q06124 (UniProtKB)

IEA

GO:0000187

Q06124 (UniProtKB)

IEA

GO:0004721

Q06124 (UniProtKB)

IDA

GO:0004725

Q06124 (UniProtKB)

IDA

GO:0004725

Q06124 (UniProtKB)

IDA

GO:0004725

Q06124 (UniProtKB)

TAS

GO:0004725

Q06124 (UniProtKB)

TAS

GO:0004725

Q06124 (UniProtKB)

TAS

GO:0004725

Q06124 (UniProtKB)

TAS

GO:0004726

Q06124 (UniProtKB)

IMP

GO:0004726

Q06124 (UniProtKB)

TAS

GO:0004726

Q06124 (UniProtKB)

TAS

GO:0004726

Q06124 (UniProtKB)

TAS

GO:0004726

Q06124 (UniProtKB)

TAS

GO:0005070

Q06124 (UniProtKB)

IPI

GO:0005158

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005515

Q06124 (UniProtKB)

IPI

GO:0005634

Q06124 (UniProtKB)

IDA

GO:0005737

Q06124 (UniProtKB)

IDA

GO:0005737

Q06124 (UniProtKB)

IDA

GO:0005739

Q06124 (UniProtKB)

IEA

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0005829

Q06124 (UniProtKB)

TAS

GO:0006641

Q06124 (UniProtKB)

IEA

GO:0007173

Q06124 (UniProtKB)

TAS

GO:0007229

Q06124 (UniProtKB)

IEA

GO:0007409

Q06124 (UniProtKB)

IEA

GO:0007420

Q06124 (UniProtKB)

IMP

GO:0007507

Q06124 (UniProtKB)

IMP

GO:0008543

Q06124 (UniProtKB)

TAS

GO:0008543

Q06124 (UniProtKB)

TAS

GO:0008543

Q06124 (UniProtKB)

TAS

GO:0008543

Q06124 (UniProtKB)

TAS

GO:0009755

Q06124 (UniProtKB)

IEA

GO:0014066

Q06124 (UniProtKB)

TAS

GO:0016303

Q06124 (UniProtKB)

TAS

GO:0019904

Q06124 (UniProtKB)

IEA

GO:0021697

Q06124 (UniProtKB)

IEA

GO:0030168

Q06124 (UniProtKB)

TAS

GO:0030220

Q06124 (UniProtKB)

IEA

GO:0030971

Q06124 (UniProtKB)

IEA

GO:0031295

Q06124 (UniProtKB)

TAS

GO:0031748

Q06124 (UniProtKB)

IEA

GO:0032528

Q06124 (UniProtKB)

IEA

GO:0033277

Q06124 (UniProtKB)

IEA

GO:0033628

Q06124 (UniProtKB)

IMP

GO:0033629

Q06124 (UniProtKB)

IEA

GO:0035264

Q06124 (UniProtKB)

IEA

GO:0035265

Q06124 (UniProtKB)

IEA

GO:0035335

Q06124 (UniProtKB)

IMP

GO:0035335

Q06124 (UniProtKB)

IDA

GO:0035855

Q06124 (UniProtKB)

IEA

GO:0036092

Q06124 (UniProtKB)

IEA

GO:0036302

Q06124 (UniProtKB)

IMP

GO:0038127

Q06124 (UniProtKB)

IDA

GO:0040014

Q06124 (UniProtKB)

IEA

GO:0042445

Q06124 (UniProtKB)

IEA

GO:0042593

Q06124 (UniProtKB)

IEA

GO:0043234

Q06124 (UniProtKB)

IEA

GO:0043254

Q06124 (UniProtKB)

IDA

GO:0043274

Q06124 (UniProtKB)

IEA

GO:0043560

Q06124 (UniProtKB)

IEA

GO:0045931

Q06124 (UniProtKB)

IEA

GO:0046676

Q06124 (UniProtKB)

IEA

GO:0046825

Q06124 (UniProtKB)

IEA

GO:0046854

Q06124 (UniProtKB)

IEA

GO:0046887

Q06124 (UniProtKB)

IEA

GO:0046934

Q06124 (UniProtKB)

TAS

GO:0048008

Q06124 (UniProtKB)

IEA

GO:0048011

Q06124 (UniProtKB)

IEA

GO:0048013

Q06124 (UniProtKB)

IDA

GO:0048015

Q06124 (UniProtKB)

TAS

GO:0048609

Q06124 (UniProtKB)

IEA

GO:0048806

Q06124 (UniProtKB)

IMP

GO:0048839

Q06124 (UniProtKB)

IMP

GO:0048873

Q06124 (UniProtKB)

IEA

GO:0050900

Q06124 (UniProtKB)

TAS

GO:0051428

Q06124 (UniProtKB)

IEA

GO:0051463

Q06124 (UniProtKB)

IEA

GO:0060020

Q06124 (UniProtKB)

IEA

GO:0060125

Q06124 (UniProtKB)

IEA

GO:0060325

Q06124 (UniProtKB)

IMP

GO:0060338

Q06124 (UniProtKB)

TAS

GO:0061582

Q06124 (UniProtKB)

IEA

GO:0070374

Q06124 (UniProtKB)

IEA

GO:2001275

Q06124 (UniProtKB)

IDA

可能调控 PTPN11基因的相关microRNA：

hsa-miR-124 hsa-miR-218 hsa-miR-130b* hsa-miR-181a hsa-miR-183 hsa-miR-193b hsa-miR-23a hsa-miR-320a hsa-miR-489

Reactome

MINT

BioGrid

IntAct

mentha

String

序号	作用方式	资源库来源/分值	基因名称	基因名称

KEGG
Reactomepathway

名称
4014 Ras signaling pathway [PATH:hsa04014]
4630 Jak-STAT signaling pathway [PATH:hsa04630]
4650 Natural killer cell mediated cytotoxicity [PATH:hsa04650]
4670 Leukocyte transendothelial migration [PATH:hsa04670]
4920 Adipocytokine signaling pathway [PATH:hsa04920]
4722 Neurotrophin signaling pathway [PATH:hsa04722]
5205 Proteoglycans in cancer [PATH:hsa05205]
5220 Chronic myeloid leukemia [PATH:hsa05220]
5211 Renal cell carcinoma [PATH:hsa05211]
5120 Epithelial cell signaling in Helicobacter pylori infection [PATH:hsa05120]
5168 Herpes simplex infection [PATH:hsa05168]

名称
Activated TLR4 signalling
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Adaptive Immune System
ARMS-mediated activation
Axon guidance
Cell surface interactions at the vascular wall
Cell-Cell communication
Constitutive Signaling by Aberrant PI3K in Cancer
Costimulation by the CD28 family
CTLA4 inhibitory signaling
Cytokine Signaling in Immune system
DAP12 interactions
DAP12 signaling
Developmental Biology
Disease
Diseases of signal transduction
Downstream signal transduction
Downstream signaling events of B Cell Receptor (BCR)
Downstream signaling of activated FGFR1
Downstream signaling of activated FGFR2
Downstream signaling of activated FGFR3
Downstream signaling of activated FGFR4
ERK activation
ERK1 activation
ERK2 activation
Fc epsilon receptor (FCERI) signaling
FCERI mediated MAPK activation
FRS-mediated FGFR1 signaling
FRS-mediated FGFR2 signaling
FRS-mediated FGFR3 signaling
Frs2-mediated activation
FRS2-mediated FGFR4 signaling
GAB1 signalosome
Gastrin-CREB signalling pathway via PKC and MAPK
GRB2 events in EGFR signaling
GRB2 events in ERBB2 signaling
Hemostasis
IGF1R signaling cascade
Immune System
Innate Immune System
Insulin receptor signalling cascade
Interferon alpha/beta signaling
Interferon gamma signaling
Interferon Signaling
Interleukin-2 signaling
Interleukin-3, 5 and GM-CSF signaling
Interleukin-6 signaling
IRS-mediated signalling
IRS-related events
IRS-related events triggered by IGF1R
MAP kinase activation in TLR cascade
MyD88 cascade initiated on plasma membrane
MyD88 dependent cascade initiated on endosome
MyD88-independent TLR3/TLR4 cascade
MyD88:Mal cascade initiated on plasma membrane
NCAM signaling for neurite out-growth
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
Netrin mediated repulsion signals
Netrin-1 signaling
NGF signalling via TRKA from the plasma membrane
Nuclear signaling by ERBB4
PD-1 signaling
PECAM1 interactions
PI-3K cascade:FGFR1
PI-3K cascade:FGFR2
PI-3K cascade:FGFR3
PI-3K cascade:FGFR4
PI3K Cascade
PI3K events in ERBB2 signaling
PI3K events in ERBB4 signaling
PI3K/AKT activation
PI3K/AKT Signaling in Cancer
PIP3 activates AKT signaling
Platelet homeostasis
Platelet sensitization by LDL
Prolactin receptor signaling
Prolonged ERK activation events
RAF/MAP kinase cascade
Regulation of IFNA signaling
Regulation of IFNG signaling
Role of LAT2/NTAL/LAB on calcium mobilization
SHC-mediated cascade:FGFR2
SHC-mediated cascade:FGFR4
SHC-mediated signalling
SHC-related events
SHC-related events triggered by IGF1R
SHC1 events in EGFR signaling
SHC1 events in ERBB2 signaling
SHC1 events in ERBB4 signaling
Signal regulatory protein (SIRP) family interactions
Signaling by EGFR
Signaling by ERBB2
Signaling by ERBB4
Signaling by FGFR
Signaling by FGFR1
Signaling by FGFR2
Signaling by FGFR3
Signaling by FGFR4
Signaling by GPCR
Signaling by Insulin receptor
Signaling by Interleukins
Signaling by Leptin
Signaling by PDGF
Signaling by SCF-KIT
Signaling by the B Cell Receptor (BCR)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Signaling by VEGF
Signalling by NGF
Signalling to ERKs
Signalling to p38 via RIT and RIN
Signalling to RAS
SOS-mediated signalling
Spry regulation of FGF signaling
Tie2 Signaling
Toll Like Receptor 10 (TLR10) Cascade
Toll Like Receptor 2 (TLR2) Cascade
Toll Like Receptor 3 (TLR3) Cascade
Toll Like Receptor 4 (TLR4) Cascade
Toll Like Receptor 5 (TLR5) Cascade
Toll Like Receptor 7/8 (TLR7/8) Cascade
Toll Like Receptor 9 (TLR9) Cascade
Toll Like Receptor TLR1:TLR2 Cascade
Toll Like Receptor TLR6:TLR2 Cascade
Toll-Like Receptors Cascades
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
TRAF6 Mediated Induction of proinflammatory cytokines
TRIF-mediated TLR3/TLR4 signaling
VEGFA-VEGFR2 Pathway
VEGFR2 mediated cell proliferation

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
Noonan Syndrome	0.694446819	171	26	BeFree_CLINVAR_CTD_human_GAD_LHGDN_MGD_ORPHANET_UNIPROT
Juvenile Myelomonocytic Leukemia	0.582212083	44	12	BeFree_CLINVAR_CTD_human_GAD_LHGDN_MGD_ORPHANET_UNIPROT
LEOPARD Syndrome	0.479558076	55	8	BeFree_CTD_human_GAD_LHGDN_MGD_ORPHANET_UNIPROT
Metachondromatosis	0.361085767	4	9	BeFree_CLINVAR_CTD_human_ORPHANET
leukemia	0.136697369	27	1	BeFree_CTD_human_GAD_LHGDN
Cardio-facio-cutaneous syndrome	0.122171535	9	0	BeFree_CTD_human
Costello syndrome (disorder)	0.121357209	6	0	BeFree_CTD_human
Neuroblastoma	0.121085767	5	1	BeFree_CTD_human
Enchondromatosis	0.120271442	2	0	BeFree_CTD_human
Astrocytoma	0.120271442	2	0	BeFree_CTD_human

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更新于2天前

PTPN11 (protein tyrosine phosphatase non-receptor type 11)

基因基本信息

基因基本信息

基因染色体位置

基因染色体位置

基因简述

基因简述

基因序列

基因序列

基因突变

基因突变

基因表达

基因表达

基因引物

基因引物

转录因子

转录因子

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基因本体信息

基因相关microRNA

基因相关microRNA

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基因相互作用关系

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基因通路

基因相关疾病

基因相关疾病

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