PTK2 (protein tyrosine kinase 2)

基因基本信息

基因基本信息

symbol:
PTK2
locus group:
protein-coding gene
location:
8q24.3
gene_family:
Protein phosphatase 1 regulatory subunits
alias symbol:
FAK|FADK|FAK1|PPP1R71
alias name:
protein phosphatase 1, regulatory …
entrez id:
5747
ensembl gene id:
ENSG00000169398
ucsc gene id:
uc003yvu.4
refseq accession:
NM_005607
hgnc_id:
HGNC:9611
approved reserved:
1992-10-02

基因染色体位置

基因染色体位置

8q24.3
基因染色体位置图

基因简述

基因简述

PTK2（Protein Tyrosine Kinase 2），也称为FAK（Focal Adhesion Kinase），是一种非受体型酪氨酸激酶，在细胞黏附、迁移、增殖和存活等生物学过程中发挥关键作用。它主要定位于细胞膜上的黏着斑（focal adhesion），通过与整合素和其他信号分子相互作用，调控细胞与细胞外基质的连接。PTK2的生物学功能包括激活下游信号通路如RAS-MAPK和PI3K-AKT，从而影响细胞运动、生长和抗凋亡能力。突变或异常表达会导致PTK2功能失调，与多种癌症（如乳腺癌、结肠癌）的侵袭和转移密切相关，还可能影响心血管疾病和纤维化疾病的发展。PTK2过表达通常促进肿瘤细胞的迁移和侵袭，而降低表达则可能抑制这些恶性行为，但过度抑制可能影响正常组织的修复功能。PTK2属于FAK亚家族，该家族成员（如PTK2B）均具有高度保守的激酶结构域，参与细胞骨架重组和机械信号转导。这一家族的共性是通过磷酸化底物蛋白传递外界机械或化学刺激，协调细胞对外部环境的响应。

This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only three of them have been determined. [provided by RefSeq, Dec 2010]

这个基因编码被发现集中在细胞外基质成分的存在下生长的细胞之间形成的粘着斑细胞质蛋白酪氨酸激酶。所编码的蛋白质是蛋白酪氨酸激酶的FAK亚科的成员，但缺乏显著的序列相似性，从其他亚家族激酶。该基因的活化可能是在细胞生长和响应于某些神经肽或与胞外基质的细胞之间的相互作用引起的细胞内信号转导途径的一个重要的早期步骤。几个转录变体编码不同同种型已发现这种基因，但只有其中的三个全长性质已经确定。 [由RefSeq的，2010年12月提供]

OMIM数据库中对CCND1基因的介绍     Wikipedia数据库中对CCND1基因的介绍

基因序列

基因序列

CCND1基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

PTK2基因的碱基突变：           仅显示部分snp
rs12682125       rs34275384       rs72681719       rs72681720       rs73369957       rs114377846       rs114637211       rs115308549       rs138894966       rs140605278       rs142018540       rs145056493       rs145655755       rs146830661       rs149074929       rs150261137       rs181530048      

基因表达

基因表达

PTK2基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
AGAACTTGGACGATGTATTGGA
60
CTGACGCATTGTTATGGACTC
60
GGGCTAAAGAATATGACAGATACC
59
GAGTCTTAGTACTCGAATTTGGTG
59
TAGCTCCTCGCTGAAACTG
60
TGACACAGCAAGACTCTGAG
60
GTCAGAGGAGGTTCACTGG
59
CAATTCATATTTCCACTCCTCTGG
60
TTCTCCTGGTGCAATGGAG
60
CAATTCATATCCTGACATCAGTAGC
60
ATCATTACCAGGTTTCTGGCT
60
AAAGAGATGCCTGACCTGG
59
GGAATAGATGAAGCCAGGGA
59
CTCCAAATTGGCCTTCTCC
59
ACTGTATTGCAGAACTGGG
58
GTCTTAGTACTCGAATTTGGTG
57
TTCTTCAAGAAGCCTGCCT
59
TGCAGGACACTGAGTATGG
59
TTTGGAAGATTGCGGAAGC
59
AATTTGGAAGGTGTTCCTTCTG
59

转录因子

转录因子

      尚未收录相关数据

基因本体信息

PTK2基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

PTK2基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0004713
B4DWJ1 (UniProtKB)
ISS
GO:0004713
B4DWJ1 (UniProtKB)
ISS
GO:0004871
B4DWJ1 (UniProtKB)
IEA
GO:0005925
B4DWJ1 (UniProtKB)
IEA
GO:0007165
B4DWJ1 (UniProtKB)
IEA
GO:0007172
B4DWJ1 (UniProtKB)
IEA
GO:0018108
B4DWJ1 (UniProtKB)
IEA
GO:0005856
E5RG86 (UniProtKB)
IEA
GO:0005856
E5RGA6 (UniProtKB)
IEA
GO:0004713
E5RHD8 (UniProtKB)
IEA
GO:0004871
E5RHD8 (UniProtKB)
IEA
GO:0005925
E5RHD8 (UniProtKB)
IEA
GO:0007165
E5RHD8 (UniProtKB)
IEA
GO:0007172
E5RHD8 (UniProtKB)
IEA
GO:0018108
E5RHD8 (UniProtKB)
IEA
GO:0004713
E5RI03 (UniProtKB)
IEA
GO:0004871
E5RI03 (UniProtKB)
IEA
GO:0005925
E5RI03 (UniProtKB)
IEA
GO:0007165
E5RI03 (UniProtKB)
IEA
GO:0007172
E5RI03 (UniProtKB)
IEA
GO:0018108
E5RI03 (UniProtKB)
IEA
GO:0004672
E5RI29 (UniProtKB)
IEA
GO:0005524
E5RI29 (UniProtKB)
IEA
GO:0006468
E5RI29 (UniProtKB)
IEA
GO:0004713
E5RJI4 (UniProtKB)
IEA
GO:0005524
E5RJI4 (UniProtKB)
IEA
GO:0018108
E5RJI4 (UniProtKB)
IEA
GO:0004713
E7ESA6 (UniProtKB)
IEA
GO:0004871
E7ESA6 (UniProtKB)
IEA
GO:0005524
E7ESA6 (UniProtKB)
IEA
GO:0005737
E7ESA6 (UniProtKB)
IDA
GO:0005856
E7ESA6 (UniProtKB)
IEA
GO:0005925
E7ESA6 (UniProtKB)
IDA
GO:0007165
E7ESA6 (UniProtKB)
IEA
GO:0007172
E7ESA6 (UniProtKB)
IEA
GO:0018108
E7ESA6 (UniProtKB)
IEA
GO:0004713
E9PEI4 (UniProtKB)
IEA
GO:0004871
E9PEI4 (UniProtKB)
IEA
GO:0005524
E9PEI4 (UniProtKB)
IEA
GO:0005925
E9PEI4 (UniProtKB)
IEA
GO:0007165
E9PEI4 (UniProtKB)
IEA
GO:0007172
E9PEI4 (UniProtKB)
IEA
GO:0018108
E9PEI4 (UniProtKB)
IEA
GO:0004713
H0YB16 (UniProtKB)
IEA
GO:0004871
H0YB16 (UniProtKB)
IEA
GO:0005524
H0YB16 (UniProtKB)
IEA
GO:0005925
H0YB16 (UniProtKB)
IEA
GO:0007165
H0YB16 (UniProtKB)
IEA
GO:0007172
H0YB16 (UniProtKB)
IEA
GO:0018108
H0YB16 (UniProtKB)
IEA
GO:0004672
H0YB99 (UniProtKB)
IEA
GO:0005524
H0YB99 (UniProtKB)
IEA
GO:0005856
H0YB99 (UniProtKB)
IEA
GO:0006468
H0YB99 (UniProtKB)
IEA
GO:0004713
H0YBP1 (UniProtKB)
IEA
GO:0004871
H0YBP1 (UniProtKB)
IEA
GO:0005524
H0YBP1 (UniProtKB)
IEA
GO:0005856
H0YBP1 (UniProtKB)
IEA
GO:0005925
H0YBP1 (UniProtKB)
IEA
GO:0007165
H0YBP1 (UniProtKB)
IEA
GO:0007172
H0YBP1 (UniProtKB)
IEA
GO:0018108
H0YBP1 (UniProtKB)
IEA
GO:0004713
H0YBZ1 (UniProtKB)
IEA
GO:0004871
H0YBZ1 (UniProtKB)
IEA
GO:0005524
H0YBZ1 (UniProtKB)
IEA
GO:0005925
H0YBZ1 (UniProtKB)
IEA
GO:0007165
H0YBZ1 (UniProtKB)
IEA
GO:0007172
H0YBZ1 (UniProtKB)
IEA
GO:0018108
H0YBZ1 (UniProtKB)
IEA
GO:0000165
Q05397 (UniProtKB)
TAS
GO:0000226
Q05397 (UniProtKB)
IEA
GO:0001525
Q05397 (UniProtKB)
TAS
GO:0001570
Q05397 (UniProtKB)
IEA
GO:0001725
Q05397 (UniProtKB)
IDA
GO:0001764
Q05397 (UniProtKB)
IEA
GO:0001890
Q05397 (UniProtKB)
TAS
GO:0001932
Q05397 (UniProtKB)
IGI
GO:0001934
Q05397 (UniProtKB)
IMP
GO:0003007
Q05397 (UniProtKB)
TAS
GO:0003779
Q05397 (UniProtKB)
IDA
GO:0004672
Q05397 (UniProtKB)
TAS
GO:0004713
Q05397 (UniProtKB)
ISS
GO:0004713
Q05397 (UniProtKB)
ISS
GO:0004713
Q05397 (UniProtKB)
EXP
GO:0004713
Q05397 (UniProtKB)
EXP
GO:0004713
Q05397 (UniProtKB)
EXP
GO:0004715
Q05397 (UniProtKB)
IDA
GO:0004715
Q05397 (UniProtKB)
IDA
GO:0004871
Q05397 (UniProtKB)
IEA
GO:0005088
Q05397 (UniProtKB)
TAS
GO:0005102
Q05397 (UniProtKB)
IBA
GO:0005515
Q05397 (UniProtKB)
IPI
GO:0005515
Q05397 (UniProtKB)
IPI
GO:0005515
Q05397 (UniProtKB)
IPI
GO:0005515
Q05397 (UniProtKB)
IPI
GO:0005515
Q05397 (UniProtKB)
IPI
GO:0005515
Q05397 (UniProtKB)
IPI
GO:0005515
Q05397 (UniProtKB)
IPI
GO:0005515
Q05397 (UniProtKB)
IPI
GO:0005515
Q05397 (UniProtKB)
IPI
GO:0005515
Q05397 (UniProtKB)
IPI
GO:0005515
Q05397 (UniProtKB)
IPI
GO:0005515
Q05397 (UniProtKB)
IPI
GO:0005515
Q05397 (UniProtKB)
IPI
GO:0005515
Q05397 (UniProtKB)
IPI
GO:0005515
Q05397 (UniProtKB)
IPI
GO:0005515
Q05397 (UniProtKB)
IPI
GO:0005515
Q05397 (UniProtKB)
IPI
GO:0005515
Q05397 (UniProtKB)
IPI
GO:0005515
Q05397 (UniProtKB)
IPI
GO:0005515
Q05397 (UniProtKB)
IPI
GO:0005515
Q05397 (UniProtKB)
IPI
GO:0005515
Q05397 (UniProtKB)
IPI
GO:0005515
Q05397 (UniProtKB)
IPI
GO:0005515
Q05397 (UniProtKB)
IPI
GO:0005515
Q05397 (UniProtKB)
IPI
GO:0005515
Q05397 (UniProtKB)
IPI
GO:0005515
Q05397 (UniProtKB)
IPI
GO:0005515
Q05397 (UniProtKB)
IPI
GO:0005515
Q05397 (UniProtKB)
IPI
GO:0005515
Q05397 (UniProtKB)
IPI
GO:0005515
Q05397 (UniProtKB)
IPI
GO:0005515
Q05397 (UniProtKB)
IPI
GO:0005515
Q05397 (UniProtKB)
IPI
GO:0005515
Q05397 (UniProtKB)
IPI
GO:0005515
Q05397 (UniProtKB)
IPI
GO:0005515
Q05397 (UniProtKB)
IPI
GO:0005515
Q05397 (UniProtKB)
IPI
GO:0005515
Q05397 (UniProtKB)
IPI
GO:0005515
Q05397 (UniProtKB)
IPI
GO:0005515
Q05397 (UniProtKB)
IPI
GO:0005515
Q05397 (UniProtKB)
IPI
GO:0005515
Q05397 (UniProtKB)
IPI
GO:0005515
Q05397 (UniProtKB)
IPI
GO:0005515
Q05397 (UniProtKB)
IPI
GO:0005515
Q05397 (UniProtKB)
IPI
GO:0005515
Q05397 (UniProtKB)
IPI
GO:0005515
Q05397 (UniProtKB)
IPI
GO:0005515
Q05397 (UniProtKB)
IPI
GO:0005515
Q05397 (UniProtKB)
IPI
GO:0005515
Q05397 (UniProtKB)
IPI
GO:0005515
Q05397 (UniProtKB)
IPI
GO:0005515
Q05397 (UniProtKB)
IPI
GO:0005524
Q05397 (UniProtKB)
IEA
GO:0005634
Q05397 (UniProtKB)
IDA
GO:0005737
Q05397 (UniProtKB)
IDA
GO:0005737
Q05397 (UniProtKB)
IDA
GO:0005815
Q05397 (UniProtKB)
IEA
GO:0005829
Q05397 (UniProtKB)
IDA
GO:0005829
Q05397 (UniProtKB)
TAS
GO:0005829
Q05397 (UniProtKB)
TAS
GO:0005829
Q05397 (UniProtKB)
TAS
GO:0005829
Q05397 (UniProtKB)
TAS
GO:0005829
Q05397 (UniProtKB)
TAS
GO:0005829
Q05397 (UniProtKB)
TAS
GO:0005829
Q05397 (UniProtKB)
TAS
GO:0005829
Q05397 (UniProtKB)
TAS
GO:0005829
Q05397 (UniProtKB)
TAS
GO:0005829
Q05397 (UniProtKB)
TAS
GO:0005829
Q05397 (UniProtKB)
TAS
GO:0005829
Q05397 (UniProtKB)
TAS
GO:0005829
Q05397 (UniProtKB)
TAS
GO:0005829
Q05397 (UniProtKB)
TAS
GO:0005829
Q05397 (UniProtKB)
TAS
GO:0005829
Q05397 (UniProtKB)
TAS
GO:0005829
Q05397 (UniProtKB)
TAS
GO:0005829
Q05397 (UniProtKB)
TAS
GO:0005829
Q05397 (UniProtKB)
TAS
GO:0005829
Q05397 (UniProtKB)
TAS
GO:0005829
Q05397 (UniProtKB)
TAS
GO:0005829
Q05397 (UniProtKB)
TAS
GO:0005829
Q05397 (UniProtKB)
TAS
GO:0005829
Q05397 (UniProtKB)
TAS
GO:0005829
Q05397 (UniProtKB)
TAS
GO:0005829
Q05397 (UniProtKB)
TAS
GO:0005829
Q05397 (UniProtKB)
TAS
GO:0005829
Q05397 (UniProtKB)
TAS
GO:0005829
Q05397 (UniProtKB)
TAS
GO:0005829
Q05397 (UniProtKB)
TAS
GO:0005829
Q05397 (UniProtKB)
TAS
GO:0005829
Q05397 (UniProtKB)
TAS
GO:0005829
Q05397 (UniProtKB)
TAS
GO:0005829
Q05397 (UniProtKB)
TAS
GO:0005829
Q05397 (UniProtKB)
TAS
GO:0005829
Q05397 (UniProtKB)
TAS
GO:0005829
Q05397 (UniProtKB)
TAS
GO:0005829
Q05397 (UniProtKB)
TAS
GO:0005856
Q05397 (UniProtKB)
TAS
GO:0005886
Q05397 (UniProtKB)
IDA
GO:0005925
Q05397 (UniProtKB)
IDA
GO:0005925
Q05397 (UniProtKB)
IDA
GO:0005925
Q05397 (UniProtKB)
IDA
GO:0005938
Q05397 (UniProtKB)
IEA
GO:0006921
Q05397 (UniProtKB)
TAS
GO:0007172
Q05397 (UniProtKB)
IEA
GO:0007173
Q05397 (UniProtKB)
IBA
GO:0007179
Q05397 (UniProtKB)
IDA
GO:0007229
Q05397 (UniProtKB)
IMP
GO:0007229
Q05397 (UniProtKB)
TAS
GO:0007229
Q05397 (UniProtKB)
IDA
GO:0007411
Q05397 (UniProtKB)
TAS
GO:0007411
Q05397 (UniProtKB)
TAS
GO:0008284
Q05397 (UniProtKB)
ISS
GO:0008360
Q05397 (UniProtKB)
IMP
GO:0008360
Q05397 (UniProtKB)
IMP
GO:0008432
Q05397 (UniProtKB)
IDA
GO:0009790
Q05397 (UniProtKB)
TAS
GO:0010594
Q05397 (UniProtKB)
TAS
GO:0010632
Q05397 (UniProtKB)
IGI
GO:0014068
Q05397 (UniProtKB)
IMP
GO:0016324
Q05397 (UniProtKB)
IEA
GO:0018108
Q05397 (UniProtKB)
IEA
GO:0018108
Q05397 (UniProtKB)
IDA
GO:0018108
Q05397 (UniProtKB)
IDA
GO:0019901
Q05397 (UniProtKB)
IPI
GO:0021955
Q05397 (UniProtKB)
IEA
GO:0022408
Q05397 (UniProtKB)
IDA
GO:0030010
Q05397 (UniProtKB)
TAS
GO:0030027
Q05397 (UniProtKB)
IEA
GO:0030198
Q05397 (UniProtKB)
IEA
GO:0030335
Q05397 (UniProtKB)
IDA
GO:0030335
Q05397 (UniProtKB)
IDA
GO:0031234
Q05397 (UniProtKB)
IBA
GO:0033628
Q05397 (UniProtKB)
IDA
GO:0038007
Q05397 (UniProtKB)
TAS
GO:0038083
Q05397 (UniProtKB)
IBA
GO:0038096
Q05397 (UniProtKB)
TAS
GO:0040023
Q05397 (UniProtKB)
IEA
GO:0042127
Q05397 (UniProtKB)
IMP
GO:0042169
Q05397 (UniProtKB)
IPI
GO:0043066
Q05397 (UniProtKB)
IMP
GO:0043087
Q05397 (UniProtKB)
TAS
GO:0043542
Q05397 (UniProtKB)
IEA
GO:0043547
Q05397 (UniProtKB)
IEA
GO:0043552
Q05397 (UniProtKB)
TAS
GO:0045087
Q05397 (UniProtKB)
IBA
GO:0045667
Q05397 (UniProtKB)
IMP
GO:0045860
Q05397 (UniProtKB)
IMP
GO:0046621
Q05397 (UniProtKB)
IEA
GO:0046777
Q05397 (UniProtKB)
IDA
GO:0046777
Q05397 (UniProtKB)
IDA
GO:0048010
Q05397 (UniProtKB)
TAS
GO:0048013
Q05397 (UniProtKB)
IDA
GO:0048013
Q05397 (UniProtKB)
TAS
GO:0048870
Q05397 (UniProtKB)
TAS
GO:0050771
Q05397 (UniProtKB)
IEA
GO:0051493
Q05397 (UniProtKB)
TAS
GO:0051893
Q05397 (UniProtKB)
TAS
GO:0051893
Q05397 (UniProtKB)
TAS
GO:0051893
Q05397 (UniProtKB)
IGI
GO:0051897
Q05397 (UniProtKB)
IMP
GO:0051964
Q05397 (UniProtKB)
IEA
GO:0060396
Q05397 (UniProtKB)
IDA
GO:1900024
Q05397 (UniProtKB)
IGI
GO:2000060
Q05397 (UniProtKB)
ISS
GO:2000811
Q05397 (UniProtKB)
IMP

基因相关microRNA

基因相关microRNA

可能调控 PTK2基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Liver carcinoma 0.211897292 9 0 BeFree_CTD_human_GAD_LHGDN_RGD
Squamous cell carcinoma 0.126534468 7 0 BeFree_CTD_human_LHGDN
Glioblastoma 0.125991584 5 0 BeFree_CTD_human_LHGDN
Neoplasm Invasiveness 0.12 1 0 CTD_human
Rheumatoid Arthritis 0.12 1 0 CTD_human
Neoplasm Metastasis 0.08842463 22 0 BeFree_LHGDN_RGD
Ischemia 0.080271442 2 0 BeFree_RGD
Hypertensive disease 0.08 2 0 RGD
Nephritis 0.08 1 0 RGD
Left Ventricular Hypertrophy 0.08 1 0 RGD

基因相关服务

基因相关服务

联系方式

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