PTGFR (prostaglandin F receptor)
- symbol:
- PTGFR
- locus group:
- protein-coding gene
- location:
- 1p31.1
- gene_family:
- Prostaglandin (prostanoid) receptors
- alias symbol:
- FP
- alias name:
- FP prostanoid receptor
- entrez id:
- 5737
- ensembl gene id:
- ENSG00000122420
- ucsc gene id:
- uc057hvr.1
- refseq accession:
- NM_000959
- hgnc_id:
- HGNC:9600
- approved reserved:
- 1994-07-29
The protein encoded by this gene is member of the G-protein coupled receptor family. This protein is a receptor for prostaglandin F2-alpha (PGF2-alpha), which is known to be a potent luteolytic agent, and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus. Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor may initiate parturition in ovarian luteal cells and thus induce luteolysis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
由该基因编码的蛋白质是G蛋白偶联受体家族的成员。这种蛋白是前列腺素F2-α（PGF2-α），这是已知的一种有效的溶黄剂的受体，并且也可以参与调节在子宫眼压和平滑肌收缩。在小鼠中敲除的研究表明，PGF2-α与该受体的相互作用可能在卵巢黄体细胞开始分娩从而诱发luteolysis。已发现该基因编码不同亚型的两个转录变异体。 [由RefSeq的，2008年7月提供]
基因本体信息
PTGFR基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
PTGFR基因的本体（GO）信息：
| 名称 |
|---|
| 4020 Calcium signaling pathway [PATH:hsa04020] |
| 4080 Neuroactive ligand-receptor interaction [PATH:hsa04080] |
| 名称 |
|---|
| Class A/1 (Rhodopsin-like receptors) |
| Eicosanoid ligand-binding receptors |
| G alpha (q) signalling events |
| Gastrin-CREB signalling pathway via PKC and MAPK |
| GPCR downstream signaling |
| GPCR ligand binding |
| Prostanoid ligand receptors |
| Signaling by GPCR |
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Airway Obstruction | 0.12 | 1 | 0 | CTD_human |
| Endometriosis | 0.12 | 1 | 0 | CTD_human |
| Premature Birth | 0.007101096 | 3 | 0 | GAD |
| Glaucoma | 0.005362824 | 2 | 0 | BeFree_GAD_LHGDN |
| Inflammation | 0.004734064 | 2 | 0 | GAD |
| Adenocarcinoma | 0.00272435 | 1 | 0 | LHGDN |
| Connective Tissue Diseases | 0.002367032 | 1 | 0 | GAD |
| Infection | 0.002367032 | 1 | 0 | GAD |
| Fetal Diseases | 0.002367032 | 1 | 0 | GAD |
| Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
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