PSMB2基因详情-基因数据库-基因云馆

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PSMB2 (proteasome 20S subunit beta 2)

symbol:: PSMB2
locus group:: protein-coding gene
location:: 1p34.3
gene_family:: Proteasome (prosome, macropain) subunits
alias symbol:: HC7-I
alias name:: proteasome subunit β4
entrez id:: 5690
ensembl gene id:: ENSG00000126067
ucsc gene id:: uc001bzf.4
refseq accession:: NM_002794
hgnc_id:: HGNC:9539
approved reserved:: 1995-05-03

1p34.3

PSMB2（蛋白酶体亚基β2型）是蛋白酶体20S核心颗粒的一个组成部分，属于蛋白酶体β亚基家族。蛋白酶体是一种大型蛋白质复合物，主要负责降解细胞内错误折叠或受损的蛋白质，以及调控细胞周期、信号传导和免疫反应等重要过程。PSMB2与其他β亚基（如PSMB1、PSMB5等）共同形成蛋白酶体的催化核心，负责蛋白质的切割和降解。PSMB2的突变可能影响蛋白酶体的正常功能，导致蛋白质稳态失衡，进而引发神经退行性疾病（如阿尔茨海默病、帕金森病）或癌症等疾病。如果PSMB2过表达，可能会增强蛋白质降解能力，影响细胞周期调控，甚至促进肿瘤细胞的增殖和存活；而降低表达则可能导致错误蛋白积累，触发细胞凋亡或自噬。PSMB2所在的蛋白酶体β亚基家族成员均具有类似的蛋白质水解功能，并在维持细胞内蛋白质稳态中发挥关键作用。此外，PSMB2在免疫系统中也扮演重要角色，通过参与抗原呈递过程影响MHC I类分子的生成，从而调控T细胞免疫应答。因此，PSMB2的功能异常可能与自身免疫性疾病或感染性疾病的发病机制相关。

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]

蛋白酶体是一个multicatalytic蛋白酶复杂与高度有序的环形20S核心结构。核心结构是由4个环，28个非相同亚基组成; 2环由7个α亚和2环由7个β亚基。蛋白酶在整个真核细胞中分布以高浓度和裂开的肽在一个ATP /泛素依赖的过程在非溶酶体途径。修饰的蛋白酶，免疫蛋白酶，的一个重要功能是MHC I类肽的处理。该基因编码的蛋白酶B型家族的成员，也称为T1B家族，这是一个20S核心β亚基。已发现该基因编码不同亚型多重选择性剪接转录变异体。 [由RefSeq的，2010年12月提供]

OMIM数据库中对PSMB2基因的介绍 Wikipedia数据库中对PSMB2基因的介绍

PSMB2基因的碱基序列：[NCBI]

Loading Gene Browser...

PSMB2基因的碱基突变：仅显示部分snp

rs12386 rs506288 rs506293 rs511216 rs513969 rs514651 rs516798 rs523743 rs535431 rs535434 rs545929 rs567476 rs569939 rs569942 rs571818 rs574384 rs578677

PSMB2基因在不同组织中的表达： [UniProt]

正向引物序列

正向Tm值

反向引物序列

反向Tm值

评分

AGATGAAGGACGATCATGAC

AAACTGTACAGTGTCTCCAG

CACACCGACTATCTCACGT

GCAGATTCAGGATGAAGCG

CACACCGACTATCTCACGT

GCAGATTCAGGATGAAGCG

CAGATGAAGGACGATCATGAC

ACTGTACAGTGTCTCCAGC

CACACCGACTATCTCACGT

ATTCAGGATGAAGCGTTTCTG

CACACCGACTATCTCACGT

ATTCAGGATGAAGCGTTTCTG

CACACCGACTATCTCACGT

TTCAGGATGAAGCGTTTCTG

CACACCGACTATCTCACGT

TTCAGGATGAAGCGTTTCTG

CAGATGAAGGACGATCATGAC

GTACAGTGTCTCCAGCCTC

尚未收录相关数据

PSMB2基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

质膜
细胞质
细胞外
高尔基体
囊泡
细胞骨架
内质网
细胞核
内体
溶酶体
线粒体

PSMB2基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0004298

A0A087WVV1 (UniProtKB)

IEA

GO:0005839

A0A087WVV1 (UniProtKB)

IEA

GO:0051603

A0A087WVV1 (UniProtKB)

IEA

GO:0000165

P49721 (UniProtKB)

TAS

GO:0000209

P49721 (UniProtKB)

TAS

GO:0000502

P49721 (UniProtKB)

IDA

GO:0002223

P49721 (UniProtKB)

TAS

GO:0002479

P49721 (UniProtKB)

TAS

GO:0004298

P49721 (UniProtKB)

IEA

GO:0005515

P49721 (UniProtKB)

IPI

GO:0005515

P49721 (UniProtKB)

IPI

GO:0005515

P49721 (UniProtKB)

IPI

GO:0005515

P49721 (UniProtKB)

IPI

GO:0005634

P49721 (UniProtKB)

IDA

GO:0005654

P49721 (UniProtKB)

IDA

GO:0005654

P49721 (UniProtKB)

TAS

GO:0005654

P49721 (UniProtKB)

TAS

GO:0005654

P49721 (UniProtKB)

TAS

GO:0005829

P49721 (UniProtKB)

TAS

GO:0005829

P49721 (UniProtKB)

TAS

GO:0005829

P49721 (UniProtKB)

TAS

GO:0005829

P49721 (UniProtKB)

TAS

GO:0005829

P49721 (UniProtKB)

TAS

GO:0005829

P49721 (UniProtKB)

TAS

GO:0005829

P49721 (UniProtKB)

TAS

GO:0005829

P49721 (UniProtKB)

TAS

GO:0005829

P49721 (UniProtKB)

TAS

GO:0005829

P49721 (UniProtKB)

TAS

GO:0005829

P49721 (UniProtKB)

TAS

GO:0005829

P49721 (UniProtKB)

TAS

GO:0005829

P49721 (UniProtKB)

TAS

GO:0005829

P49721 (UniProtKB)

TAS

GO:0005829

P49721 (UniProtKB)

TAS

GO:0005829

P49721 (UniProtKB)

TAS

GO:0005829

P49721 (UniProtKB)

TAS

GO:0005829

P49721 (UniProtKB)

TAS

GO:0005829

P49721 (UniProtKB)

TAS

GO:0005829

P49721 (UniProtKB)

TAS

GO:0005829

P49721 (UniProtKB)

TAS

GO:0005829

P49721 (UniProtKB)

TAS

GO:0005829

P49721 (UniProtKB)

TAS

GO:0005829

P49721 (UniProtKB)

TAS

GO:0005829

P49721 (UniProtKB)

TAS

GO:0005829

P49721 (UniProtKB)

TAS

GO:0005829

P49721 (UniProtKB)

TAS

GO:0005829

P49721 (UniProtKB)

TAS

GO:0005829

P49721 (UniProtKB)

TAS

GO:0005829

P49721 (UniProtKB)

TAS

GO:0005829

P49721 (UniProtKB)

TAS

GO:0005829

P49721 (UniProtKB)

TAS

GO:0005829

P49721 (UniProtKB)

TAS

GO:0005829

P49721 (UniProtKB)

TAS

GO:0005829

P49721 (UniProtKB)

TAS

GO:0005829

P49721 (UniProtKB)

TAS

GO:0005829

P49721 (UniProtKB)

TAS

GO:0005829

P49721 (UniProtKB)

TAS

GO:0005839

P49721 (UniProtKB)

ISS

GO:0006521

P49721 (UniProtKB)

TAS

GO:0010243

P49721 (UniProtKB)

IEA

GO:0014070

P49721 (UniProtKB)

IEA

GO:0016020

P49721 (UniProtKB)

IDA

GO:0016032

P49721 (UniProtKB)

IEA

GO:0031145

P49721 (UniProtKB)

TAS

GO:0031145

P49721 (UniProtKB)

TAS

GO:0033209

P49721 (UniProtKB)

TAS

GO:0038061

P49721 (UniProtKB)

TAS

GO:0038095

P49721 (UniProtKB)

TAS

GO:0043161

P49721 (UniProtKB)

TAS

GO:0043161

P49721 (UniProtKB)

TAS

GO:0043161

P49721 (UniProtKB)

TAS

GO:0043488

P49721 (UniProtKB)

TAS

GO:0050852

P49721 (UniProtKB)

TAS

GO:0051436

P49721 (UniProtKB)

TAS

GO:0051437

P49721 (UniProtKB)

TAS

GO:0060071

P49721 (UniProtKB)

TAS

GO:0070062

P49721 (UniProtKB)

IDA

GO:0070062

P49721 (UniProtKB)

IDA

GO:0070062

P49721 (UniProtKB)

IDA

GO:0070062

P49721 (UniProtKB)

IDA

GO:0090090

P49721 (UniProtKB)

TAS

GO:0090263

P49721 (UniProtKB)

TAS

可能调控 PSMB2基因的相关microRNA：

hsa-let-7c hsa-miR-1226 hsa-miR-744

Reactome

MINT

BioGrid

IntAct

mentha

String

序号	作用方式	资源库来源/分值	基因名称	基因名称

KEGG
Reactomepathway

名称
3050 Proteasome [PATH:hsa03050]

名称
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
Activation of NF-kappaB in B cells
Adaptive Immune System
Antigen processing-Cross presentation
Antigen processing: Ubiquitination & Proteasome degradation
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of mitotic proteins
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Apoptosis
Assembly of the pre-replicative complex
Asymmetric localization of PCP proteins
AUF1 (hnRNP D0) destabilizes mRNA
Autodegradation of Cdh1 by Cdh1:APC/C
Autodegradation of the E3 ubiquitin ligase COP1
beta-catenin independent WNT signaling
C-type lectin receptors (CLRs)
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
CDK-mediated phosphorylation and removal of Cdc6
CDT1 association with the CDC6:ORC:origin complex
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Class I MHC mediated antigen processing & presentation
CLEC7A (Dectin-1) signaling
Cross-presentation of soluble exogenous antigens (endosomes)
Cyclin A:Cdk2-associated events at S phase entry
Cyclin E associated events during G1/S transition
Dectin-1 mediated noncanonical NF-kB signaling
degradation of AXIN
Degradation of beta-catenin by the destruction complex
degradation of DVL
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
Disease
Diseases of signal transduction
DNA Replication
DNA Replication Pre-Initiation
Downstream signaling events of B Cell Receptor (BCR)
ER-Phagosome pathway
G1/S DNA Damage Checkpoints
G1/S Transition
Gene Expression
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'off' state
Hedgehog 'on' state
Hedgehog ligand biogenesis
Hh mutants abrogate ligand secretion
Hh mutants that don't undergo autocatalytic processing are degraded by ERAD
HIV Infection
Host Interactions of HIV factors
Immune System
Infectious disease
Innate Immune System
M Phase
M/G1 Transition
Metabolism of amino acids and derivatives
Mitotic Anaphase
Mitotic G1-G1/S phases
Mitotic Metaphase and Anaphase
Orc1 removal from chromatin
p53-Dependent G1 DNA Damage Response
p53-Dependent G1/S DNA damage checkpoint
p53-Independent DNA Damage Response
p53-Independent G1/S DNA damage checkpoint
PCP/CE pathway
Programmed Cell Death
Regulation of activated PAK-2p34 by proteasome mediated degradation
Regulation of APC/C activators between G1/S and early anaphase
Regulation of Apoptosis
Regulation of DNA replication
Regulation of mitotic cell cycle
Regulation of mRNA stability by proteins that bind AU-rich elements
Regulation of ornithine decarboxylase (ODC)
Removal of licensing factors from origins
S Phase
SCF-beta-TrCP mediated degradation of Emi1
SCF(Skp2)-mediated degradation of p27/p21
Separation of Sister Chromatids
Signaling by Hedgehog
Signaling by the B Cell Receptor (BCR)
Signaling by Wnt
Stabilization of p53
Switching of origins to a post-replicative state
Synthesis of DNA
TCF dependent signaling in response to WNT
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
Ubiquitin-dependent degradation of Cyclin D1
Vif-mediated degradation of APOBEC3G
Vpu mediated degradation of CD4

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
Bladder Neoplasm	0.12	1	0	CTD_human
Glomerular filtration rate finding	0.002367032	1	1	GAD
Central neuroblastoma	0.000271442	1	0	BeFree
Exanthema	0.000271442	1	0	BeFree
Neuroblastoma	0.000271442	1	0	BeFree
Spots on skin	0.000271442	1	0	BeFree

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更新于2天前

PSMB2 (proteasome 20S subunit beta 2)

基因基本信息

基因基本信息

基因染色体位置

基因染色体位置

基因简述

基因简述

基因序列

基因序列

基因突变

基因突变

基因表达

基因表达

基因引物

基因引物

转录因子

转录因子

尚未收录相关数据

基因本体信息

基因相关microRNA

基因相关microRNA

基因相互作用关系

基因相互作用关系

基因通路

基因通路

基因相关疾病

基因相关疾病

基因相关服务

基因相关服务

联系方式

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