PSMA8基因详情-基因数据库-基因云馆

PSMA8 (proteasome 20S subunit alpha 8)

symbol:: PSMA8
locus group:: protein-coding gene
location:: 18q11.2
gene_family:: Proteasome (prosome, macropain) subunits
alias symbol:: MGC26605|PSMA7L
alias name:: None
entrez id:: 143471
ensembl gene id:: ENSG00000154611
ucsc gene id:: uc002kvq.4
refseq accession:: NM_144662
hgnc_id:: HGNC:22985
approved reserved:: 2005-01-14

18q11.2

PSMA8（Proteasome Subunit Alpha 8）是蛋白酶体α亚基家族的一员，属于蛋白酶体20S核心复合物的组成部分。蛋白酶体是一种大型蛋白复合物，主要负责细胞内蛋白质的降解，尤其是通过泛素-蛋白酶体途径清除错误折叠或受损的蛋白质，从而维持细胞稳态。PSMA8主要在睾丸中高表达，可能参与精子发生过程中的蛋白质质量控制。与其他蛋白酶体α亚基（如PSMA1-PSMA7）类似，PSMA8具有保守的N端苏氨酸蛋白酶活性位点，能够与其他亚基组装形成20S核心颗粒，介导蛋白质的切割和降解。PSMA8的突变可能影响蛋白酶体的组装或功能，导致蛋白质稳态失衡，进而可能影响生殖功能或增加疾病风险。研究表明，PSMA8的异常表达可能与男性不育相关，因为其在精子发生中起关键作用。若PSMA8过表达，可能增强蛋白质降解效率，但过度激活可能导致正常蛋白的异常降解；而表达降低则可能削弱蛋白酶体功能，导致错误蛋白积累，引发细胞应激或凋亡。PSMA8所属的蛋白酶体α亚基家族成员均参与20S核心复合物的形成，具有类似的蛋白水解功能，但组织分布和调控可能存在差异。该基因的深入研究有助于理解男性生殖健康及蛋白质代谢相关疾病的机制。

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OMIM数据库中对PSMA8基因的介绍 Wikipedia数据库中对PSMA8基因的介绍

PSMA8基因的碱基序列：[NCBI]

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PSMA8基因的碱基突变：仅显示部分snp

rs11198 rs752362 rs895630 rs1072615 rs1072905 rs1447103 rs1790520 rs1790521 rs1790522 rs1993768 rs1993769 rs2069310 rs2121561 rs2339049 rs3794196 rs4800242 rs4800243

PSMA8基因在不同组织中的表达： [UniProt]

正向引物序列

正向Tm值

反向引物序列

反向Tm值

评分

ATGCTTGGAAGGCAAATGC

59

CACTTGCTATGGCATCTTCTG

59

ATGCTTGGAAGGCAAATGC

59

CTTGCTATGGCATCTTCTGTG

59

ATTACACAGAAGATGCCATAGC

58

CAGACTGGACAACTTCTAGC

58

尚未收录相关数据

PSMA8基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

质膜
细胞质
细胞外
高尔基体
囊泡
细胞骨架
内质网
细胞核
内体
溶酶体
线粒体

PSMA8基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0004298

A0A087WYS6 (UniProtKB)

IEA

GO:0005839

A0A087WYS6 (UniProtKB)

IEA

GO:0051603

A0A087WYS6 (UniProtKB)

IEA

GO:0004175

F5GY34 (UniProtKB)

IEA

GO:0005634

F5GY34 (UniProtKB)

IEA

GO:0006511

F5GY34 (UniProtKB)

IEA

GO:0019773

F5GY34 (UniProtKB)

IEA

GO:0000165

Q8TAA3 (UniProtKB)

TAS

GO:0000209

Q8TAA3 (UniProtKB)

TAS

GO:0002223

Q8TAA3 (UniProtKB)

TAS

GO:0002479

Q8TAA3 (UniProtKB)

TAS

GO:0004298

Q8TAA3 (UniProtKB)

IEA

GO:0005634

Q8TAA3 (UniProtKB)

IDA

GO:0005829

Q8TAA3 (UniProtKB)

TAS

GO:0005829

Q8TAA3 (UniProtKB)

TAS

GO:0005829

Q8TAA3 (UniProtKB)

TAS

GO:0005829

Q8TAA3 (UniProtKB)

TAS

GO:0005829

Q8TAA3 (UniProtKB)

TAS

GO:0005829

Q8TAA3 (UniProtKB)

TAS

GO:0005829

Q8TAA3 (UniProtKB)

TAS

GO:0005829

Q8TAA3 (UniProtKB)

TAS

GO:0005829

Q8TAA3 (UniProtKB)

TAS

GO:0005829

Q8TAA3 (UniProtKB)

TAS

GO:0005829

Q8TAA3 (UniProtKB)

TAS

GO:0005829

Q8TAA3 (UniProtKB)

TAS

GO:0005829

Q8TAA3 (UniProtKB)

TAS

GO:0005829

Q8TAA3 (UniProtKB)

TAS

GO:0005829

Q8TAA3 (UniProtKB)

TAS

GO:0005829

Q8TAA3 (UniProtKB)

TAS

GO:0005829

Q8TAA3 (UniProtKB)

TAS

GO:0005829

Q8TAA3 (UniProtKB)

TAS

GO:0005829

Q8TAA3 (UniProtKB)

TAS

GO:0005829

Q8TAA3 (UniProtKB)

TAS

GO:0005829

Q8TAA3 (UniProtKB)

TAS

GO:0005829

Q8TAA3 (UniProtKB)

TAS

GO:0005829

Q8TAA3 (UniProtKB)

TAS

GO:0005829

Q8TAA3 (UniProtKB)

TAS

GO:0005829

Q8TAA3 (UniProtKB)

TAS

GO:0005829

Q8TAA3 (UniProtKB)

TAS

GO:0005829

Q8TAA3 (UniProtKB)

TAS

GO:0005829

Q8TAA3 (UniProtKB)

TAS

GO:0005829

Q8TAA3 (UniProtKB)

TAS

GO:0005829

Q8TAA3 (UniProtKB)

TAS

GO:0005829

Q8TAA3 (UniProtKB)

TAS

GO:0005829

Q8TAA3 (UniProtKB)

TAS

GO:0005829

Q8TAA3 (UniProtKB)

TAS

GO:0005829

Q8TAA3 (UniProtKB)

TAS

GO:0005829

Q8TAA3 (UniProtKB)

TAS

GO:0005829

Q8TAA3 (UniProtKB)

TAS

GO:0005829

Q8TAA3 (UniProtKB)

TAS

GO:0005829

Q8TAA3 (UniProtKB)

TAS

GO:0006521

Q8TAA3 (UniProtKB)

TAS

GO:0019773

Q8TAA3 (UniProtKB)

IEA

GO:0031145

Q8TAA3 (UniProtKB)

TAS

GO:0031145

Q8TAA3 (UniProtKB)

TAS

GO:0033209

Q8TAA3 (UniProtKB)

TAS

GO:0038061

Q8TAA3 (UniProtKB)

TAS

GO:0038095

Q8TAA3 (UniProtKB)

TAS

GO:0043161

Q8TAA3 (UniProtKB)

TAS

GO:0043161

Q8TAA3 (UniProtKB)

TAS

GO:0043161

Q8TAA3 (UniProtKB)

TAS

GO:0043488

Q8TAA3 (UniProtKB)

TAS

GO:0050852

Q8TAA3 (UniProtKB)

TAS

GO:0051437

Q8TAA3 (UniProtKB)

TAS

GO:0060071

Q8TAA3 (UniProtKB)

TAS

GO:0070062

Q8TAA3 (UniProtKB)

IDA

GO:0090090

Q8TAA3 (UniProtKB)

TAS

GO:0090263

Q8TAA3 (UniProtKB)

TAS

GO:1990111

Q8TAA3 (UniProtKB)

ISS

可能调控 PSMA8基因的相关microRNA：

Reactome

BioGrid

mentha

String

序号	作用方式	资源库来源/分值	基因名称	基因名称

KEGG
Reactomepathway

名称
3050 Proteasome [PATH:hsa03050]

名称
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
Activation of NF-kappaB in B cells
Adaptive Immune System
Antigen processing-Cross presentation
Antigen processing: Ubiquitination & Proteasome degradation
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of mitotic proteins
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Apoptosis
Assembly of the pre-replicative complex
Asymmetric localization of PCP proteins
AUF1 (hnRNP D0) destabilizes mRNA
Autodegradation of the E3 ubiquitin ligase COP1
beta-catenin independent WNT signaling
C-type lectin receptors (CLRs)
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
CDK-mediated phosphorylation and removal of Cdc6
CDT1 association with the CDC6:ORC:origin complex
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Class I MHC mediated antigen processing & presentation
CLEC7A (Dectin-1) signaling
Cross-presentation of soluble exogenous antigens (endosomes)
Dectin-1 mediated noncanonical NF-kB signaling
degradation of AXIN
Degradation of beta-catenin by the destruction complex
degradation of DVL
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
Disease
Diseases of signal transduction
DNA Replication
DNA Replication Pre-Initiation
Downstream signaling events of B Cell Receptor (BCR)
ER-Phagosome pathway
G1/S DNA Damage Checkpoints
Gene Expression
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'off' state
Hedgehog 'on' state
Hedgehog ligand biogenesis
Hh mutants abrogate ligand secretion
Hh mutants that don't undergo autocatalytic processing are degraded by ERAD
HIV Infection
Host Interactions of HIV factors
Immune System
Infectious disease
Innate Immune System
M Phase
M/G1 Transition
Metabolism of amino acids and derivatives
Mitotic Anaphase
Mitotic Metaphase and Anaphase
Orc1 removal from chromatin
p53-Dependent G1 DNA Damage Response
p53-Dependent G1/S DNA damage checkpoint
p53-Independent DNA Damage Response
p53-Independent G1/S DNA damage checkpoint
PCP/CE pathway
Programmed Cell Death
Regulation of activated PAK-2p34 by proteasome mediated degradation
Regulation of APC/C activators between G1/S and early anaphase
Regulation of Apoptosis
Regulation of DNA replication
Regulation of mitotic cell cycle
Regulation of mRNA stability by proteins that bind AU-rich elements
Regulation of ornithine decarboxylase (ODC)
Removal of licensing factors from origins
S Phase
SCF-beta-TrCP mediated degradation of Emi1
Separation of Sister Chromatids
Signaling by Hedgehog
Signaling by the B Cell Receptor (BCR)
Signaling by Wnt
Stabilization of p53
Switching of origins to a post-replicative state
Synthesis of DNA
TCF dependent signaling in response to WNT
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
Ubiquitin-dependent degradation of Cyclin D1
Vif-mediated degradation of APOBEC3G
Vpu mediated degradation of CD4

疾病名称

关系值

NofPmids

NofSnps

来源

PSMA8 (proteasome 20S subunit alpha 8)

基因基本信息

基因基本信息

基因染色体位置

基因染色体位置

基因简述

基因简述

基因序列

基因序列

基因突变

基因突变

基因表达

基因表达

基因引物

基因引物

转录因子

转录因子

尚未收录相关数据

基因本体信息

基因相关microRNA

基因相关microRNA

基因相互作用关系

基因相互作用关系

基因通路

基因通路

基因相关疾病

基因相关疾病

基因相关服务

基因相关服务

联系方式

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