PSCA (prostate stem cell antigen)
- symbol:
- PSCA
- locus group:
- protein-coding gene
- location:
- 8q24.3
- gene_family:
- alias symbol:
- lncPSCA
- alias name:
- None
- entrez id:
- 8000
- ensembl gene id:
- ENSG00000167653
- ucsc gene id:
- uc003ywu.4
- refseq accession:
- NM_005672
- hgnc_id:
- HGNC:9500
- approved reserved:
- 1999-08-25
This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene includes a polymorphism that results in an upstream start codon in some individuals; this polymorphism is thought to be associated with a risk for certain gastric and bladder cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
该基因编码一个糖基锚定的细胞膜糖蛋白。除了在前列腺它也是在膀胱，胎盘，结肠癌，肾癌和胃癌表达被高度表达。该基因是上调大比例的前列腺癌，并在膀胱和胰腺的癌症也检测到。这种基因包括多态性，其导致在一些个人的上游起始密码子;这种多态性被认为是与某些胃和膀胱癌的危险有关。选择性剪接结果在多个抄本变形。 [由RefSeq的，2010年2月提供]
基因本体信息
PSCA基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
PSCA基因的本体（GO）信息：
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Duodenal Ulcer | 0.243452799 | 4 | 1 | BeFree_CTD_human_GAD_GWASCAT |
| Stomach Neoplasms | 0.134830952 | 7 | 0 | BeFree_CTD_human_GAD_LHGDN |
| Malignant neoplasm of urinary bladder | 0.128805692 | 16 | 6 | BeFree_GAD_GWASCAT |
| Prostatic Neoplasms | 0.128444493 | 5 | 0 | BeFree_CTD_human_LHGDN |
| Bladder Neoplasm | 0.125276948 | 5 | 1 | BeFree_CTD_human_GAD |
| Linitis Plastica | 0.12 | 1 | 0 | CTD_human |
| Malignant neoplasm of stomach | 0.009771907 | 36 | 8 | BeFree |
| Stomach Carcinoma | 0.009771907 | 36 | 8 | BeFree |
| Malignant neoplasm of prostate | 0.009771907 | 36 | 0 | BeFree |
| Prostate carcinoma | 0.009229024 | 34 | 0 | BeFree |
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