PRKCQ (protein kinase C theta)
- symbol:
- PRKCQ
- locus group:
- protein-coding gene
- location:
- 10p15.1
- gene_family:
- C2 domain containing protein kinases
- alias symbol:
- None
- alias name:
- None
- entrez id:
- 5588
- ensembl gene id:
- ENSG00000065675
- ucsc gene id:
- uc001ijj.3
- refseq accession:
- NM_006257
- hgnc_id:
- HGNC:9410
- approved reserved:
- 1992-12-14
PRKCQ（蛋白激酶Cθ）属于蛋白激酶C（PKC）家族，是一种钙非依赖性、磷脂酰丝氨酸依赖性激酶，主要在T细胞和骨骼肌中高表达。它在免疫系统中发挥关键作用，尤其是T细胞激活和信号转导过程中。PRKCQ通过参与T细胞受体（TCR）信号通路，调控NF-κB和AP-1等转录因子的激活，从而影响细胞增殖、存活和细胞因子的产生。此外，PRKCQ在胰岛素信号通路中也发挥作用，影响葡萄糖代谢和胰岛素敏感性。PRKCQ的突变或异常表达可能导致免疫功能障碍，如自身免疫性疾病（如类风湿性关节炎和多发性硬化症）或代谢紊乱（如2型糖尿病）。研究表明，PRKCQ缺失的小鼠表现出T细胞功能缺陷，而过度激活的PRKCQ可能促进炎症和自身免疫反应。PRKCQ属于PKC基因家族，该家族成员多为丝氨酸/苏氨酸激酶，参与细胞增殖、分化、凋亡和信号转导等过程。PKC家族成员通常通过第二信使（如二酰基甘油或钙离子）激活，并在多种生理和病理过程中发挥调控作用。PRKCQ的过表达可能增强T细胞反应，导致过度炎症或自身免疫疾病，而表达降低则可能削弱免疫应答，增加感染风险。此外，PRKCQ在肿瘤微环境中的作用也受到关注，可能影响肿瘤免疫逃逸。因此，PRKCQ是免疫调节和代谢疾病研究的重要靶点。
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors. [provided by RefSeq, Jul 2008]
蛋白激酶C（PKC）是可以通过钙和第二信使甘油二酯被激活丝氨酸和苏氨酸特异性蛋白激酶家族。 PKC家族成员磷酸化多种蛋白靶和已知参与不同的细胞信号传导途径。 PKC家族成员还作为主要受体佛波醇酯，一类促癌物。在PKC家族的每个成员都有一个特定的表达谱，被认为发挥了显着作用。由该基因编码的蛋白质是蛋白激酶C家族成员之一。它是钙独立的，磷脂依赖性蛋白激酶。这种激酶为T细胞活化重要的。它是所必需的转录活化因子NF-κB和AP-1，并且可以在T细胞受体（TCR）信号复合链接到转录因子的激活。 [由RefSeq的，2008年7月提供]
基因本体信息
PRKCQ基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
PRKCQ基因的本体（GO）信息：
| 名称 |
|---|
| 4064 NF-kappa B signaling pathway [PATH:hsa04064] |
| 4530 Tight junction [PATH:hsa04530] |
| 4660 T cell receptor signaling pathway [PATH:hsa04660] |
| 4920 Adipocytokine signaling pathway [PATH:hsa04920] |
| 4270 Vascular smooth muscle contraction [PATH:hsa04270] |
| 4750 Inflammatory mediator regulation of TRP channels [PATH:hsa04750] |
| 5162 Measles [PATH:hsa05162] |
| 名称 |
|---|
| Adaptive Immune System |
| Apoptosis |
| Apoptotic cleavage of cellular proteins |
| Apoptotic execution phase |
| Axon guidance |
| Developmental Biology |
| Downstream TCR signaling |
| Effects of PIP2 hydrolysis |
| Fc epsilon receptor (FCERI) signaling |
| FCERI mediated NF-kB activation |
| G alpha (q) signalling events |
| G alpha (z) signalling events |
| Gastrin-CREB signalling pathway via PKC and MAPK |
| GPCR downstream signaling |
| Hemostasis |
| Immune System |
| Inactivation, recovery and regulation of the phototransduction cascade |
| Innate Immune System |
| Netrin-1 signaling |
| Platelet activation, signaling and aggregation |
| Programmed Cell Death |
| Signaling by GPCR |
| TCR signaling |
| The phototransduction cascade |
| Visual phototransduction |
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Diabetes Mellitus, Insulin-Dependent | 0.247101096 | 3 | 2 | CTD_human_GAD_GWASCAT |
| Rheumatoid Arthritis | 0.139750581 | 13 | 1 | BeFree_CTD_human_GAD |
| Lymphoma, T-Cell, Cutaneous | 0.12 | 1 | 0 | CTD_human |
| Sepsis | 0.08 | 1 | 0 | RGD |
| Insulin Resistance | 0.08 | 2 | 0 | RGD |
| Hyperammonemia | 0.08 | 1 | 0 | RGD |
| Hyperinsulinism | 0.08 | 1 | 0 | RGD |
| Prostatic Neoplasms | 0.08 | 1 | 0 | RGD |
| Gastrointestinal Stromal Tumors | 0.00680591 | 6 | 0 | BeFree_LHGDN |
| Cerebrovascular accident | 0.004734064 | 1 | 1 | GAD |
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