PRKCE (protein kinase C epsilon)
- symbol:
- PRKCE
- locus group:
- protein-coding gene
- location:
- 2p21
- gene_family:
- C2 domain containing protein kinases
- alias symbol:
- None
- alias name:
- None
- entrez id:
- 5581
- ensembl gene id:
- ENSG00000171132
- ucsc gene id:
- uc002rut.4
- refseq accession:
- NM_005400
- hgnc_id:
- HGNC:9401
- approved reserved:
- 1991-08-06
PRKCE（蛋白激酶C epsilon型）属于蛋白激酶C（PKC）家族，这是一个丝氨酸/苏氨酸激酶家族，参与多种细胞信号传导过程。PKC家族成员通常通过第二信使如二酰基甘油（DAG）和钙离子激活，并在细胞增殖、分化、凋亡和迁移等过程中发挥关键作用。PRKCE是PKC家族中的新型亚型（nPKC），不依赖钙离子激活，主要通过与细胞膜上的脂质结合而被激活。PRKCE在多种组织中表达，尤其在神经系统、心脏和免疫系统中具有重要作用。它通过磷酸化下游靶蛋白调控细胞功能，例如参与神经元突触可塑性、心脏保护机制以及炎症反应。PRKCE的突变或表达异常与多种疾病相关，包括癌症、心血管疾病和神经退行性疾病。例如，PRKCE在某些癌症中过表达，促进肿瘤细胞存活和转移；而在神经退行性疾病中，PRKCE的功能异常可能导致突触功能障碍和神经元死亡。降低PRKCE表达可能抑制肿瘤生长，但也可能影响心脏保护机制或神经功能。PRKCE还与其他基因或通路相互作用，如与MAPK和PI3K/AKT通路交叉调控，影响细胞存活和增殖。PKC家族的共性包括通过脂质第二信使激活、参与细胞信号传导及调控多种生理和病理过程。PRKCE的独特之处在于其对钙离子不敏感，并在特定组织中发挥关键作用。研究PRKCE有助于开发针对相关疾病的靶向治疗策略。
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. [provided by RefSeq, Jul 2008]
蛋白激酶C（PKC）是可以通过钙和第二信使甘油二酯被激活丝氨酸和苏氨酸特异性蛋白激酶家族。 PKC家族成员磷酸化多种蛋白靶和已知参与不同的细胞信号传导途径。 PKC家族成员还作为主要受体佛波醇酯，一类促癌物。蛋白激酶C家族的每个成员都有特定的表达谱，并且被认为发挥细胞不同的作用。由该基因编码的蛋白质是蛋白激酶C家族成员之一。这种激酶已经显示参与了许多不同的细胞功能，如神经元信道的激活，细胞凋亡，从局部缺血心肌，热休克反应，以及胰岛素胞吐作用。在小鼠中敲除的研究表明，该激酶为脂多糖（LPS）的重要介导的活化巨噬细胞的信号，并且还可以在控制焦虑样行为的作用。 [由RefSeq的，2008年7月提供]
基因本体信息
PRKCE基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
PRKCE基因的本体（GO）信息：
| 名称 |
|---|
| 4071 Sphingolipid signaling pathway [PATH:hsa04071] |
| 4022 cGMP - PKG signaling pathway [PATH:hsa04022] |
| 4530 Tight junction [PATH:hsa04530] |
| 4664 Fc epsilon RI signaling pathway [PATH:hsa04664] |
| 4666 Fc gamma R-mediated phagocytosis [PATH:hsa04666] |
| 4270 Vascular smooth muscle contraction [PATH:hsa04270] |
| 4750 Inflammatory mediator regulation of TRP channels [PATH:hsa04750] |
| 5206 MicroRNAs in cancer [PATH:hsa05206] |
| 4930 Type II diabetes mellitus [PATH:hsa04930] |
| 名称 |
|---|
| DAG and IP3 signaling |
| DAP12 interactions |
| DAP12 signaling |
| Downstream signal transduction |
| Downstream signaling of activated FGFR1 |
| Downstream signaling of activated FGFR2 |
| Downstream signaling of activated FGFR3 |
| Downstream signaling of activated FGFR4 |
| Effects of PIP2 hydrolysis |
| EGFR interacts with phospholipase C-gamma |
| Fcgamma receptor (FCGR) dependent phagocytosis |
| G alpha (q) signalling events |
| G alpha (z) signalling events |
| Gastrin-CREB signalling pathway via PKC and MAPK |
| GPCR downstream signaling |
| Hemostasis |
| Immune System |
| Innate Immune System |
| NGF signalling via TRKA from the plasma membrane |
| Phospholipase C-mediated cascade; FGFR2 |
| Phospholipase C-mediated cascade; FGFR3 |
| Phospholipase C-mediated cascade; FGFR4 |
| Phospholipase C-mediated cascade: FGFR1 |
| Platelet activation, signaling and aggregation |
| PLC-gamma1 signalling |
| PLCG1 events in ERBB2 signaling |
| Role of phospholipids in phagocytosis |
| Signaling by EGFR |
| Signaling by ERBB2 |
| Signaling by FGFR |
| Signaling by FGFR1 |
| Signaling by FGFR2 |
| Signaling by FGFR3 |
| Signaling by FGFR4 |
| Signaling by GPCR |
| Signaling by PDGF |
| Signalling by NGF |
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Hyperalgesia | 0.12272435 | 4 | 0 | CTD_human_LHGDN |
| Hemoglobin Adverse Event | 0.122367032 | 1 | 1 | GAD_GWASCAT |
| Hematocrit level | 0.122367032 | 1 | 1 | GAD_GWASCAT |
| Myocardial Infarction | 0.120271442 | 2 | 0 | BeFree_CTD_human |
| Coronary Stenosis | 0.12 | 1 | 0 | CTD_human |
| Diabetes Mellitus, Experimental | 0.12 | 1 | 0 | CTD_human |
| Substance-Related Disorders | 0.12 | 1 | 0 | CTD_human |
| Peripheral Neuropathy | 0.12 | 1 | 0 | CTD_human |
| Myocardial Ischemia | 0.12 | 1 | 0 | CTD_human |
| Cardiomyopathies | 0.12 | 1 | 0 | CTD_human |
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