PRKCA基因详情-基因数据库-基因云馆

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PRKCA (protein kinase C alpha)

symbol:: PRKCA
locus group:: protein-coding gene
location:: 17q24.2
gene_family:: C2 domain containing protein kinases
alias symbol:: PKCα
alias name:: None
entrez id:: 5578
ensembl gene id:: ENSG00000154229
ucsc gene id:: uc002jfp.2
refseq accession:: NM_002737
hgnc_id:: HGNC:9393
approved reserved:: 1991-08-02

17q24.2

PRKCA（蛋白激酶Cα）属于蛋白激酶C（PKC）家族，这是一个丝氨酸/苏氨酸激酶家族，参与多种细胞信号传导途径。PKC家族成员通常通过第二信使（如二酰基甘油和钙离子）激活，并在细胞增殖、分化、凋亡和迁移等过程中发挥关键作用。PRKCA是PKC家族中经典的亚型之一，广泛表达于多种组织中，尤其在脑、心脏和肌肉中含量较高。它的主要功能包括调控细胞膜受体信号、离子通道活性以及基因表达。PRKCA通过磷酸化靶蛋白发挥作用，影响细胞骨架重组、炎症反应和代谢调控等过程。突变或异常表达可能导致PRKCA功能失调，与多种疾病相关，如癌症、心血管疾病和神经系统疾病。在癌症中，PRKCA的过表达可能促进肿瘤细胞增殖、侵袭和转移，例如在乳腺癌和结肠癌中已观察到其高表达与不良预后相关。相反，PRKCA表达降低可能影响突触可塑性和学习记忆功能，与阿尔茨海默病等神经退行性疾病有关。此外，PRKCA还参与胰岛素信号通路，其异常表达可能影响糖代谢，与糖尿病发展相关。PKC家族的共性包括依赖脂质第二信使激活、通过磷酸化底物调控细胞功能，并在应激反应和细胞存活中起重要作用。PRKCA作为该家族的重要成员，其活性受多种因子调控，包括生长因子和激素。研究PRKCA的功能和调控机制不仅有助于理解其在生理和病理过程中的作用，还可能为相关疾病的治疗提供新靶点。

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq, Jul 2008]

蛋白激酶C（PKC）是可以通过钙和第二信使甘油二酯被激活丝氨酸和苏氨酸特异性蛋白激酶家族。 PKC家族成员磷酸化多种蛋白靶和已知参与不同的细胞信号传导途径。 PKC家族成员还作为主要受体佛波醇酯，一类促癌物。蛋白激酶C家族的每个成员都有特定的表达谱，并且被认为发挥细胞不同的作用。由该基因编码的蛋白质是蛋白激酶C家族成员之一。这种激酶已经报道在许多不同的细胞过程，例如细胞粘附，细胞转化，细胞周期关卡和细胞体积控制来发挥作用。在小鼠中敲除的研究表明，该激酶可能是心脏收缩和Ca（2+）在肌细胞的处理的基本调节。 [由RefSeq的，2008年7月提供]

OMIM数据库中对PRKCA基因的介绍 Wikipedia数据库中对PRKCA基因的介绍

PRKCA基因的碱基序列：[NCBI]

Loading Gene Browser...

PRKCA基因的碱基突变：仅显示部分snp

rs4144639 rs4144640 rs6504458 rs6504459 rs7211902 rs7218270 rs8072956 rs8073185 rs8073633 rs8074268 rs9889353 rs9901261 rs9902281 rs9916272 rs9916520 rs34133255 rs56007627

PRKCA基因在不同组织中的表达： [UniProt]

正向引物序列

正向Tm值

反向引物序列

反向Tm值

评分

GTGAGTACTACAACGTACCCA

ATCATCTCCACTCGAATTTCTG

ATATGAGGGCTGTAAATTTGGG

TCTATATGCAGATTAGTAGGCCC

AATGACTTCATGGGATCCCT

GTTAAGCAACTTGTACCATCCA

TTGTGGTCCACAAGAGGTG

GGGAGAAGAGATCAGTGTCG

GAAGGACCACAAATTCATCG

AAGCCTTGTTTCCCAAACC

GTCTATCATGGAGCACAACG

TTTGGTCATCAGTCCTTTGC

GAGGGCTGTAAATTTGGGC

CAGCTCTATATGCAGATTAGTAGG

AAGGACCACAAATTCATCGC

AAGCCTTGTTTCCCAAACC

TCTATCATGGAGCACAACGT

TTTGGTCATCAGTCCTTTGC

TTTGTGGTCCACAAGAGGT

GGAGAAGAGATCAGTGTCGG

转录因子

影响基因

影响类型

参考文献链接（PubMed）

RARA

PRKCA

Activation

11525643

TFAP2A

PRKCA

Activation

12269829

PRKCA基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

质膜
细胞质
细胞外
高尔基体
囊泡
细胞骨架
内质网
细胞核
内体
溶酶体
线粒体

PRKCA基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0005622

J3KN97 (UniProtKB)

IEA

GO:0035556

J3KN97 (UniProtKB)

IEA

GO:0046872

J3KN97 (UniProtKB)

IEA

GO:0005622

J3KRN5 (UniProtKB)

IEA

GO:0035556

J3KRN5 (UniProtKB)

IEA

GO:0046872

J3KRN5 (UniProtKB)

IEA

GO:0001525

P17252 (UniProtKB)

IEA

GO:0001938

P17252 (UniProtKB)

IMP

GO:0002159

P17252 (UniProtKB)

IMP

GO:0004672

P17252 (UniProtKB)

IDA

GO:0004674

P17252 (UniProtKB)

EXP

GO:0004674

P17252 (UniProtKB)

EXP

GO:0004674

P17252 (UniProtKB)

EXP

GO:0004674

P17252 (UniProtKB)

EXP

GO:0004674

P17252 (UniProtKB)

TAS

GO:0004674

P17252 (UniProtKB)

TAS

GO:0004697

P17252 (UniProtKB)

ISS

GO:0004697

P17252 (UniProtKB)

TAS

GO:0004697

P17252 (UniProtKB)

TAS

GO:0004698

P17252 (UniProtKB)

TAS

GO:0004698

P17252 (UniProtKB)

TAS

GO:0004698

P17252 (UniProtKB)

TAS

GO:0004698

P17252 (UniProtKB)

TAS

GO:0005515

P17252 (UniProtKB)

IPI

GO:0005515

P17252 (UniProtKB)

IPI

GO:0005515

P17252 (UniProtKB)

IPI

GO:0005515

P17252 (UniProtKB)

IPI

GO:0005515

P17252 (UniProtKB)

IPI

GO:0005515

P17252 (UniProtKB)

IPI

GO:0005515

P17252 (UniProtKB)

IPI

GO:0005524

P17252 (UniProtKB)

IEA

GO:0005654

P17252 (UniProtKB)

TAS

GO:0005654

P17252 (UniProtKB)

TAS

GO:0005654

P17252 (UniProtKB)

TAS

GO:0005737

P17252 (UniProtKB)

IDA

GO:0005737

P17252 (UniProtKB)

IDA

GO:0005737

P17252 (UniProtKB)

IDA

GO:0005739

P17252 (UniProtKB)

IDA

GO:0005783

P17252 (UniProtKB)

IDA

GO:0005829

P17252 (UniProtKB)

IDA

GO:0005829

P17252 (UniProtKB)

TAS

GO:0005829

P17252 (UniProtKB)

TAS

GO:0005829

P17252 (UniProtKB)

TAS

GO:0005829

P17252 (UniProtKB)

TAS

GO:0005829

P17252 (UniProtKB)

TAS

GO:0005829

P17252 (UniProtKB)

TAS

GO:0005829

P17252 (UniProtKB)

TAS

GO:0005829

P17252 (UniProtKB)

TAS

GO:0005886

P17252 (UniProtKB)

IDA

GO:0005886

P17252 (UniProtKB)

IDA

GO:0005886

P17252 (UniProtKB)

IDA

GO:0005886

P17252 (UniProtKB)

TAS

GO:0005886

P17252 (UniProtKB)

TAS

GO:0005886

P17252 (UniProtKB)

TAS

GO:0005886

P17252 (UniProtKB)

TAS

GO:0005886

P17252 (UniProtKB)

TAS

GO:0005886

P17252 (UniProtKB)

TAS

GO:0005886

P17252 (UniProtKB)

TAS

GO:0005886

P17252 (UniProtKB)

TAS

GO:0005886

P17252 (UniProtKB)

TAS

GO:0006468

P17252 (UniProtKB)

IDA

GO:0007077

P17252 (UniProtKB)

TAS

GO:0007155

P17252 (UniProtKB)

IEA

GO:0007190

P17252 (UniProtKB)

ISS

GO:0007194

P17252 (UniProtKB)

ISS

GO:0008270

P17252 (UniProtKB)

IEA

GO:0010595

P17252 (UniProtKB)

IMP

GO:0010613

P17252 (UniProtKB)

ISS

GO:0018105

P17252 (UniProtKB)

IBA

GO:0019899

P17252 (UniProtKB)

IDA

GO:0030168

P17252 (UniProtKB)

TAS

GO:0030335

P17252 (UniProtKB)

IMP

GO:0031666

P17252 (UniProtKB)

IMP

GO:0031966

P17252 (UniProtKB)

IEA

GO:0034351

P17252 (UniProtKB)

IMP

GO:0035403

P17252 (UniProtKB)

IDA

GO:0035408

P17252 (UniProtKB)

IDA

GO:0035556

P17252 (UniProtKB)

IBA

GO:0043488

P17252 (UniProtKB)

TAS

GO:0043536

P17252 (UniProtKB)

IDA

GO:0045651

P17252 (UniProtKB)

ISS

GO:0045766

P17252 (UniProtKB)

IMP

GO:0045785

P17252 (UniProtKB)

IMP

GO:0045931

P17252 (UniProtKB)

IMP

GO:0048471

P17252 (UniProtKB)

ISS

GO:0050796

P17252 (UniProtKB)

TAS

GO:0070062

P17252 (UniProtKB)

IDA

GO:0070374

P17252 (UniProtKB)

ISS

GO:0070555

P17252 (UniProtKB)

IMP

GO:0090330

P17252 (UniProtKB)

IDA

GO:0097190

P17252 (UniProtKB)

TAS

GO:2000707

P17252 (UniProtKB)

ISS

可能调控 PRKCA基因的相关microRNA：

hsa-miR-375 hsa-miR-101 hsa-miR-15a hsa-miR-15a* hsa-miR-29c hsa-miR-29c* hsa-miR-17* hsa-miR-193b hsa-miR-505 hsa-miR-92a

Reactome

MINT

BioGrid

IntAct

mentha

String

序号	作用方式	资源库来源/分值	基因名称	基因名称

KEGG
Reactomepathway

名称
4014 Ras signaling pathway [PATH:hsa04014]
4015 Rap1 signaling pathway [PATH:hsa04015]
4010 MAPK signaling pathway [PATH:hsa04010]
4012 ErbB signaling pathway [PATH:hsa04012]
4310 Wnt signaling pathway [PATH:hsa04310]
4370 VEGF signaling pathway [PATH:hsa04370]
4066 HIF-1 signaling pathway [PATH:hsa04066]
4020 Calcium signaling pathway [PATH:hsa04020]
4070 Phosphatidylinositol signaling system [PATH:hsa04070]
4071 Sphingolipid signaling pathway [PATH:hsa04071]
4151 PI3K-Akt signaling pathway [PATH:hsa04151]
4150 mTOR signaling pathway [PATH:hsa04150]
4510 Focal adhesion [PATH:hsa04510]
4530 Tight junction [PATH:hsa04530]
4540 Gap junction [PATH:hsa04540]
4650 Natural killer cell mediated cytotoxicity [PATH:hsa04650]
4664 Fc epsilon RI signaling pathway [PATH:hsa04664]
4666 Fc gamma R-mediated phagocytosis [PATH:hsa04666]
4670 Leukocyte transendothelial migration [PATH:hsa04670]
4911 Insulin secretion [PATH:hsa04911]
4912 GnRH signaling pathway [PATH:hsa04912]
4921 Oxytocin signaling pathway [PATH:hsa04921]
4918 Thyroid hormone synthesis [PATH:hsa04918]
4919 Thyroid hormone signaling pathway [PATH:hsa04919]
4916 Melanogenesis [PATH:hsa04916]
4261 Adrenergic signaling in cardiomyocytes [PATH:hsa04261]
4270 Vascular smooth muscle contraction [PATH:hsa04270]
4970 Salivary secretion [PATH:hsa04970]
4971 Gastric acid secretion [PATH:hsa04971]
4972 Pancreatic secretion [PATH:hsa04972]
4960 Aldosterone-regulated sodium reabsorption [PATH:hsa04960]
4961 Endocrine and other factor-regulated calcium reabsorption [PATH:hsa04961]
4724 Glutamatergic synapse [PATH:hsa04724]
4727 GABAergic synapse [PATH:hsa04727]
4725 Cholinergic synapse [PATH:hsa04725]
4728 Dopaminergic synapse [PATH:hsa04728]
4726 Serotonergic synapse [PATH:hsa04726]
4720 Long-term potentiation [PATH:hsa04720]
4730 Long-term depression [PATH:hsa04730]
4723 Retrograde endocannabinoid signaling [PATH:hsa04723]
4750 Inflammatory mediator regulation of TRP channels [PATH:hsa04750]
4713 Circadian entrainment [PATH:hsa04713]
5200 Pathways in cancer [PATH:hsa05200]
5231 Choline metabolism in cancer [PATH:hsa05231]
5206 MicroRNAs in cancer [PATH:hsa05206]
5205 Proteoglycans in cancer [PATH:hsa05205]
5214 Glioma [PATH:hsa05214]
5223 Non-small cell lung cancer [PATH:hsa05223]
5031 Amphetamine addiction [PATH:hsa05031]
5032 Morphine addiction [PATH:hsa05032]
5110 Vibrio cholerae infection [PATH:hsa05110]
5130 Pathogenic Escherichia coli infection [PATH:hsa05130]
5164 Influenza A [PATH:hsa05164]
5161 Hepatitis B [PATH:hsa05161]
5146 Amoebiasis [PATH:hsa05146]
5143 African trypanosomiasis [PATH:hsa05143]

名称
Acetylcholine regulates insulin secretion
beta-catenin independent WNT signaling
Ca-dependent events
Ca2+ pathway
Calmodulin induced events
CaM pathway
Cell Cycle
Cell Cycle, Mitotic
DAG and IP3 signaling
DAP12 interactions
DAP12 signaling
Depolymerisation of the Nuclear Lamina
Disinhibition of SNARE formation
Downstream signal transduction
Downstream signaling of activated FGFR1
Downstream signaling of activated FGFR2
Downstream signaling of activated FGFR3
Downstream signaling of activated FGFR4
EGFR interacts with phospholipase C-gamma
EGFR Transactivation by Gastrin
Extracellular matrix organization
G alpha (z) signalling events
G-protein mediated events
Gastrin-CREB signalling pathway via PKC and MAPK
Gene Expression
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity
GPCR downstream signaling
Hemostasis
HuR stabilizes mRNA
Immune System
Inactivation, recovery and regulation of the phototransduction cascade
Innate Immune System
Integration of energy metabolism
M Phase
Mitotic Prophase
Neuronal System
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
NGF signalling via TRKA from the plasma membrane
Non-integrin membrane-ECM interactions
Nuclear Envelope Breakdown
Opioid Signalling
PCP/CE pathway
Phospholipase C-mediated cascade; FGFR2
Phospholipase C-mediated cascade; FGFR3
Phospholipase C-mediated cascade; FGFR4
Phospholipase C-mediated cascade: FGFR1
Platelet activation, signaling and aggregation
PLC beta mediated events
PLC-gamma1 signalling
PLCG1 events in ERBB2 signaling
Regulation of insulin secretion
Regulation of KIT signaling
Regulation of mRNA stability by proteins that bind AU-rich elements
Response to elevated platelet cytosolic Ca2+
Signaling by EGFR
Signaling by ERBB2
Signaling by FGFR
Signaling by FGFR1
Signaling by FGFR2
Signaling by FGFR3
Signaling by FGFR4
Signaling by GPCR
Signaling by PDGF
Signaling by SCF-KIT
Signaling by VEGF
Signaling by Wnt
Signalling by NGF
Syndecan interactions
The phototransduction cascade
Trafficking of AMPA receptors
Trafficking of GluR2-containing AMPA receptors
Transmission across Chemical Synapses
VEGFA-VEGFR2 Pathway
VEGFR2 mediated cell proliferation
Visual phototransduction
WNT5A-dependent internalization of FZD4

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
Cardiomegaly	0.2	2	0	CTD_human_RGD
Diabetes Mellitus, Experimental	0.12	1	0	CTD_human
Nephrogenic Diabetes Insipidus	0.12	1	0	CTD_human
Intestinal Neoplasms	0.12	1	0	CTD_human
Polyuria	0.12	1	0	CTD_human
Ischemia	0.080542884	3	0	BeFree_RGD
Heart failure	0.080271442	2	0	BeFree_RGD
Reperfusion Injury	0.08	1	0	RGD
Hypertensive disease	0.08	1	0	RGD
Left Ventricular Hypertrophy	0.08	1	0	RGD

联系方式

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PRKCA (protein kinase C alpha)

基因基本信息

基因基本信息

基因染色体位置

基因染色体位置

基因简述

基因简述

基因序列

基因序列

基因突变

基因突变

基因表达

基因表达

基因引物

基因引物

转录因子

转录因子

基因本体信息

基因相关microRNA

基因相关microRNA

基因相互作用关系

基因相互作用关系

基因通路

基因通路

基因相关疾病

基因相关疾病

基因相关服务

基因相关服务

联系方式

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