PPP2R1B (protein phosphatase 2 scaffold subunit Abeta)
- symbol:
- PPP2R1B
- locus group:
- protein-coding gene
- location:
- 11q23.1
- gene_family:
- Protein phosphatase 2 regulatory subunits
- alias symbol:
- PR65B|PP2A-Abeta
- alias name:
- PP2A-A-beta|protein phosphatase 2A…
- entrez id:
- 5519
- ensembl gene id:
- ENSG00000137713
- ucsc gene id:
- uc001plw.2
- refseq accession:
- NM_002716
- hgnc_id:
- HGNC:9303
- approved reserved:
- 1993-01-25
PPP2R1B是蛋白磷酸酶2A（PP2A）的一个调节亚基，属于PPP2R1基因家族。PP2A是一种重要的丝氨酸/苏氨酸蛋白磷酸酶，参与多种细胞过程，包括细胞周期调控、信号转导、代谢和凋亡。PPP2R1B编码PP2A的A亚基，作为支架蛋白帮助形成PP2A全酶复合物，由催化亚基（C）和调节亚基（B）组成。PPP2R1B的主要作用位点是与其他PP2A亚基结合，确保复合物的稳定性和特异性。该基因家族的共性在于它们都参与PP2A全酶的组装和功能调控，影响底物识别和酶活性。PPP2R1B突变可能导致PP2A功能异常，与多种癌症相关，如肺癌、结肠癌和乳腺癌，因为这些突变可能破坏细胞周期调控和抑癌功能。PPP2R1B的缺失或表达降低可能削弱PP2A的抑癌作用，促进肿瘤发生；而过表达可能增强PP2A活性，抑制异常细胞增殖。此外，PPP2R1B的表达变化可能影响其他信号通路，如Wnt和MAPK通路，进一步干扰细胞稳态。研究表明，PPP2R1B在染色体11q23的杂合性缺失（LOH）常见于多种肿瘤，提示其作为抑癌基因的潜在作用。PPP2R1B的功能异常还与神经退行性疾病和心血管疾病有关，突显其在多种病理过程中的重要性。
This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]
该基因编码的蛋白磷酸酶的恒定调节亚基2.蛋白质磷酸酶2是四大丝氨酸/苏氨酸磷酸酶的之一，它是在细胞生长和分裂的阴性对照牵连。它由一个共同的异核心酶，它是由一个催化亚基和一个常数调节亚基，即相关联的各种调节亚基组成。常数调节亚基一个用作脚手架分子坐标催化亚基和可变调节B亚单位的组装。该基因编码在该基因的恒定调节亚基A.突变的beta同种型已经与一些肺癌和结肠癌有关。可变剪接转录物变体已有描述。 [由RefSeq的，2010年4月提供]
基因本体信息
PPP2R1B基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
PPP2R1B基因的本体（GO）信息：
| 名称 |
|---|
| 3015 mRNA surveillance pathway [PATH:hsa03015] |
| 4350 TGF-beta signaling pathway [PATH:hsa04350] |
| 4390 Hippo signaling pathway [PATH:hsa04390] |
| 4071 Sphingolipid signaling pathway [PATH:hsa04071] |
| 4151 PI3K-Akt signaling pathway [PATH:hsa04151] |
| 4152 AMPK signaling pathway [PATH:hsa04152] |
| 4114 Oocyte meiosis [PATH:hsa04114] |
| 4530 Tight junction [PATH:hsa04530] |
| 4261 Adrenergic signaling in cardiomyocytes [PATH:hsa04261] |
| 4728 Dopaminergic synapse [PATH:hsa04728] |
| 4730 Long-term depression [PATH:hsa04730] |
| 5160 Hepatitis C [PATH:hsa05160] |
| 5142 Chagas disease (American trypanosomiasis) [PATH:hsa05142] |
| 名称 |
|---|
| Activated TLR4 signalling |
| Adaptive Immune System |
| AMER1 mutants destabilize the destruction complex |
| APC truncation mutants have impaired AXIN binding |
| AXIN missense mutants destabilize the destruction complex |
| AXIN mutants destabilize the destruction complex, activating WNT signaling |
| Beta-catenin phosphorylation cascade |
| Cell Cycle |
| Cell Cycle, Mitotic |
| Costimulation by the CD28 family |
| CTLA4 inhibitory signaling |
| Cyclin A/B1 associated events during G2/M transition |
| Cyclin D associated events in G1 |
| DARPP-32 events |
| Degradation of beta-catenin by the destruction complex |
| disassembly of the destruction complex and recruitment of AXIN to the membrane |
| Disease |
| Diseases of signal transduction |
| E2F mediated regulation of DNA replication |
| ERK/MAPK targets |
| ERKs are inactivated |
| G1 Phase |
| G1/S Transition |
| G2/M Transition |
| Glucose metabolism |
| Glycolysis |
| Hemostasis |
| Immune System |
| Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| Innate Immune System |
| Integration of energy metabolism |
| M Phase |
| MAP kinase activation in TLR cascade |
| MAPK targets/ Nuclear events mediated by MAP kinases |
| MASTL Facilitates Mitotic Progression |
| Metabolism of carbohydrates |
| misspliced GSK3beta mutants stabilize beta-catenin |
| Mitotic Anaphase |
| Mitotic G1-G1/S phases |
| Mitotic G2-G2/M phases |
| Mitotic Metaphase and Anaphase |
| Mitotic Prometaphase |
| Mitotic Prophase |
| MyD88 cascade initiated on plasma membrane |
| MyD88 dependent cascade initiated on endosome |
| MyD88-independent TLR3/TLR4 cascade |
| MyD88:Mal cascade initiated on plasma membrane |
| NGF signalling via TRKA from the plasma membrane |
| Nuclear Events (kinase and transcription factor activation) |
| Opioid Signalling |
| phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex |
| Platelet homeostasis |
| Platelet sensitization by LDL |
| PP2A-mediated dephosphorylation of key metabolic factors |
| Resolution of Sister Chromatid Cohesion |
| RHO GTPase Effectors |
| RHO GTPases Activate Formins |
| S33 mutants of beta-catenin aren't phosphorylated |
| S37 mutants of beta-catenin aren't phosphorylated |
| S45 mutants of beta-catenin aren't phosphorylated |
| Separation of Sister Chromatids |
| Signaling by GPCR |
| Signaling by Rho GTPases |
| Signaling by Wnt |
| Signaling by WNT in cancer |
| Signalling by NGF |
| T41 mutants of beta-catenin aren't phosphorylated |
| TCF dependent signaling in response to WNT |
| Toll Like Receptor 10 (TLR10) Cascade |
| Toll Like Receptor 2 (TLR2) Cascade |
| Toll Like Receptor 3 (TLR3) Cascade |
| Toll Like Receptor 4 (TLR4) Cascade |
| Toll Like Receptor 5 (TLR5) Cascade |
| Toll Like Receptor 7/8 (TLR7/8) Cascade |
| Toll Like Receptor 9 (TLR9) Cascade |
| Toll Like Receptor TLR1:TLR2 Cascade |
| Toll Like Receptor TLR6:TLR2 Cascade |
| Toll-Like Receptors Cascades |
| TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| TRAF6 Mediated Induction of proinflammatory cytokines |
| TRIF-mediated TLR3/TLR4 signaling |
| truncated APC mutants destabilize the destruction complex |
| truncations of AMER1 destabilize the destruction complex |
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Lung Neoplasms | 0.120271442 | 1 | 0 | BeFree_CTD_human |
| Carcinoma of lung | 0.12 | 0 | 1 | CLINVAR |
| Malignant neoplasm of breast | 0.003181358 | 3 | 1 | BeFree_GAD |
| Malignant neoplasm of lung | 0.002909916 | 3 | 0 | BeFree_GAD |
| Colorectal Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
| Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
| Malignant tumor of colon | 0.001085767 | 4 | 0 | BeFree |
| Ovarian Carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Carcinogenesis | 0.000814326 | 3 | 0 | BeFree |
| Malignant neoplasm of ovary | 0.000814326 | 3 | 0 | BeFree |
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