PIK3CG基因详情-基因数据库-基因云馆

PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma)

symbol:: PIK3CG
locus group:: protein-coding gene
location:: 7q22.3
gene_family:: Phosphatidylinositol 3-kinase subunits
alias symbol:: None
alias name:: None
entrez id:: 5294
ensembl gene id:: ENSG00000105851
ucsc gene id:: uc003vdu.5
refseq accession:: NM_001282426
hgnc_id:: HGNC:8978
approved reserved:: 1994-07-15

7q22.3

PIK3CG（磷脂酰肌醇-4,5-二磷酸3-激酶催化亚基γ）属于PI3K（磷脂酰肌醇3-激酶）基因家族，该家族主要参与细胞信号传导，调控细胞增殖、存活、代谢和迁移等过程。PI3K家族分为I、II、III三类，PIK3CG属于I类PI3K的IB亚型，与免疫细胞功能密切相关。PIK3CG编码的蛋白是一种催化亚基，能够磷酸化磷脂酰肌醇-4,5-二磷酸（PIP2）生成磷脂酰肌醇-3,4,5-三磷酸（PIP3），从而激活下游信号通路如AKT和mTOR，影响细胞生长和免疫反应。PIK3CG主要在白细胞中表达，尤其在T细胞、B细胞、中性粒细胞和巨噬细胞中发挥关键作用，参与炎症反应和免疫调节。突变或异常表达可能导致免疫功能紊乱，如PIK3CG功能获得性突变可能引发过度炎症或自身免疫疾病，而功能缺失性突变则可能导致免疫缺陷或感染易感性增加。研究表明，PIK3CG与类风湿性关节炎、系统性红斑狼疮等自身免疫疾病以及某些癌症的发生发展相关。当PIK3CG过表达时，可能增强免疫细胞的活化和炎症反应，甚至促进肿瘤细胞的生存和转移；而降低表达则可能抑制免疫细胞功能，导致免疫应答减弱或抗肿瘤能力下降。PIK3CG抑制剂已被研究用于治疗炎症性疾病和癌症，但需注意平衡其免疫调节作用以避免副作用。PI3K基因家族的共性在于它们均参与调控细胞内的脂质信号分子，影响多种生理和病理过程，尤其在代谢和免疫中起核心作用。

This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]

这个基因编码属于蛋白质的PI3 / PI4激酶家族的蛋白。的基因产物是磷酸的肌醇环的3-羟基磷酸肌醇的酶。它是细胞外的信号，包括由E-钙粘蛋白介导的细胞 - 细胞粘附，这在维护上皮的结构和功能完整性的起着重要的作用引起的重要调节剂。除了其在促进粘着结组件的作用，该蛋白质被认为发挥细胞毒性的中NK细胞的调节了关键作用。该基因位于先前在骨髓性白血病染色体鉴定7的共同缺失段。已发现了该基因编码相同的蛋白质几个抄本变形。 [由RefSeq的，2013年9月提供]

OMIM数据库中对PIK3CG基因的介绍 Wikipedia数据库中对PIK3CG基因的介绍

PIK3CG基因的碱基序列：[NCBI]

Loading Gene Browser...

PIK3CG基因的碱基突变：仅显示部分snp

rs718207 rs849367 rs849368 rs849369 rs849370 rs849371 rs849372 rs849388 rs849389 rs849390 rs849392 rs849397 rs849398 rs849399 rs849400 rs849401 rs849402

PIK3CG基因在不同组织中的表达： [UniProt]

正向引物序列

正向Tm值

反向引物序列

反向Tm值

评分

GTTGCATTTCAACTGGTGAC

58

CCTCAGATGGCAATCTGTG

58

GTCAGTTCCCAAGTTATTTCAC

58

TATGGAACTCTAAAGCTTTCGG

58

GTCAGTTCCCAAGTTATTTCAC

58

ATGGAACTCTAAAGCTTTCGG

59

GGTTGCATTTCAACTGGTG

58

CTCAGATGGCAATCTGTGC

59

GTTGCATTTCAACTGGTGAC

58

CTCAGATGGCAATCTGTGC

59

GTCAGTTCCCAAGTTATTTCAC

58

TGGAACTCTAAAGCTTTCGG

58

尚未收录相关数据

PIK3CG基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

质膜
细胞质
细胞外
高尔基体
囊泡
细胞骨架
内质网
细胞核
内体
溶酶体
线粒体

PIK3CG基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0005622

E9PDN7 (UniProtKB)

IEA

GO:0016301

E9PDN7 (UniProtKB)

IEA

GO:0046854

E9PDN7 (UniProtKB)

IEA

GO:0048015

E9PDN7 (UniProtKB)

IEA

GO:0001525

P48736 (UniProtKB)

IEA

GO:0001816

P48736 (UniProtKB)

TAS

GO:0002250

P48736 (UniProtKB)

TAS

GO:0002407

P48736 (UniProtKB)

TAS

GO:0002675

P48736 (UniProtKB)

IEA

GO:0002679

P48736 (UniProtKB)

TAS

GO:0004672

P48736 (UniProtKB)

TAS

GO:0004674

P48736 (UniProtKB)

IEA

GO:0005515

P48736 (UniProtKB)

IPI

GO:0005515

P48736 (UniProtKB)

IPI

GO:0005515

P48736 (UniProtKB)

IPI

GO:0005524

P48736 (UniProtKB)

IEA

GO:0005737

P48736 (UniProtKB)

IDA

GO:0005829

P48736 (UniProtKB)

TAS

GO:0005829

P48736 (UniProtKB)

TAS

GO:0005829

P48736 (UniProtKB)

TAS

GO:0005829

P48736 (UniProtKB)

TAS

GO:0005829

P48736 (UniProtKB)

TAS

GO:0005829

P48736 (UniProtKB)

TAS

GO:0005886

P48736 (UniProtKB)

IBA

GO:0005944

P48736 (UniProtKB)

IDA

GO:0006468

P48736 (UniProtKB)

IEA

GO:0006661

P48736 (UniProtKB)

TAS

GO:0006897

P48736 (UniProtKB)

IEA

GO:0006954

P48736 (UniProtKB)

TAS

GO:0007186

P48736 (UniProtKB)

IDA

GO:0007204

P48736 (UniProtKB)

IEA

GO:0010818

P48736 (UniProtKB)

TAS

GO:0010897

P48736 (UniProtKB)

IEA

GO:0014065

P48736 (UniProtKB)

IDA

GO:0014065

P48736 (UniProtKB)

TAS

GO:0016020

P48736 (UniProtKB)

IDA

GO:0016020

P48736 (UniProtKB)

IDA

GO:0016303

P48736 (UniProtKB)

IEA

GO:0030168

P48736 (UniProtKB)

TAS

GO:0030593

P48736 (UniProtKB)

TAS

GO:0032252

P48736 (UniProtKB)

IEA

GO:0033628

P48736 (UniProtKB)

TAS

GO:0035004

P48736 (UniProtKB)

TAS

GO:0035005

P48736 (UniProtKB)

IBA

GO:0035747

P48736 (UniProtKB)

TAS

GO:0036092

P48736 (UniProtKB)

IEA

GO:0042098

P48736 (UniProtKB)

TAS

GO:0042110

P48736 (UniProtKB)

TAS

GO:0042629

P48736 (UniProtKB)

IEA

GO:0043303

P48736 (UniProtKB)

TAS

GO:0043406

P48736 (UniProtKB)

IDA

GO:0045087

P48736 (UniProtKB)

TAS

GO:0046854

P48736 (UniProtKB)

IEA

GO:0046875

P48736 (UniProtKB)

IPI

GO:0046934

P48736 (UniProtKB)

IBA

GO:0046934

P48736 (UniProtKB)

TAS

GO:0051897

P48736 (UniProtKB)

IDA

GO:0055118

P48736 (UniProtKB)

TAS

GO:0070527

P48736 (UniProtKB)

TAS

GO:0071320

P48736 (UniProtKB)

IEA

GO:0072672

P48736 (UniProtKB)

TAS

GO:0097284

P48736 (UniProtKB)

IEA

GO:1903169

P48736 (UniProtKB)

IEA

GO:2000270

P48736 (UniProtKB)

IEA

可能调控 PIK3CG基因的相关microRNA：

hsa-miR-148b hsa-miR-26b

Reactome

MINT

BioGrid

IntAct

mentha

String

序号	作用方式	资源库来源/分值	基因名称	基因名称

KEGG
Reactomepathway

名称
562 Inositol phosphate metabolism [PATH:hsa00562]
4014 Ras signaling pathway [PATH:hsa04014]
4015 Rap1 signaling pathway [PATH:hsa04015]
4012 ErbB signaling pathway [PATH:hsa04012]
4370 VEGF signaling pathway [PATH:hsa04370]
4630 Jak-STAT signaling pathway [PATH:hsa04630]
4668 TNF signaling pathway [PATH:hsa04668]
4066 HIF-1 signaling pathway [PATH:hsa04066]
4068 FoxO signaling pathway [PATH:hsa04068]
4070 Phosphatidylinositol signaling system [PATH:hsa04070]
4071 Sphingolipid signaling pathway [PATH:hsa04071]
4024 cAMP signaling pathway [PATH:hsa04024]
4022 cGMP - PKG signaling pathway [PATH:hsa04022]
4151 PI3K-Akt signaling pathway [PATH:hsa04151]
4152 AMPK signaling pathway [PATH:hsa04152]
4150 mTOR signaling pathway [PATH:hsa04150]
4810 Regulation of actin cytoskeleton [PATH:hsa04810]
4210 Apoptosis [PATH:hsa04210]
4510 Focal adhesion [PATH:hsa04510]
4550 Signaling pathways regulating pluripotency of stem cells [PATH:hsa04550]
4611 Platelet activation [PATH:hsa04611]
4620 Toll-like receptor signaling pathway [PATH:hsa04620]
4650 Natural killer cell mediated cytotoxicity [PATH:hsa04650]
4660 T cell receptor signaling pathway [PATH:hsa04660]
4662 B cell receptor signaling pathway [PATH:hsa04662]
4664 Fc epsilon RI signaling pathway [PATH:hsa04664]
4666 Fc gamma R-mediated phagocytosis [PATH:hsa04666]
4670 Leukocyte transendothelial migration [PATH:hsa04670]
4062 Chemokine signaling pathway [PATH:hsa04062]
4910 Insulin signaling pathway [PATH:hsa04910]
4915 Estrogen signaling pathway [PATH:hsa04915]
4914 Progesterone-mediated oocyte maturation [PATH:hsa04914]
4917 Prolactin signaling pathway [PATH:hsa04917]
4921 Oxytocin signaling pathway [PATH:hsa04921]
4919 Thyroid hormone signaling pathway [PATH:hsa04919]
4261 Adrenergic signaling in cardiomyocytes [PATH:hsa04261]
4973 Carbohydrate digestion and absorption [PATH:hsa04973]
4960 Aldosterone-regulated sodium reabsorption [PATH:hsa04960]
4725 Cholinergic synapse [PATH:hsa04725]
4722 Neurotrophin signaling pathway [PATH:hsa04722]
4750 Inflammatory mediator regulation of TRP channels [PATH:hsa04750]
4380 Osteoclast differentiation [PATH:hsa04380]
5200 Pathways in cancer [PATH:hsa05200]
5230 Central carbon metabolism in cancer [PATH:hsa05230]
5231 Choline metabolism in cancer [PATH:hsa05231]
5205 Proteoglycans in cancer [PATH:hsa05205]
5203 Viral carcinogenesis [PATH:hsa05203]
5210 Colorectal cancer [PATH:hsa05210]
5212 Pancreatic cancer [PATH:hsa05212]
5214 Glioma [PATH:hsa05214]
5221 Acute myeloid leukemia [PATH:hsa05221]
5220 Chronic myeloid leukemia [PATH:hsa05220]
5218 Melanoma [PATH:hsa05218]
5211 Renal cell carcinoma [PATH:hsa05211]
5215 Prostate cancer [PATH:hsa05215]
5213 Endometrial cancer [PATH:hsa05213]
5222 Small cell lung cancer [PATH:hsa05222]
5223 Non-small cell lung cancer [PATH:hsa05223]
4930 Type II diabetes mellitus [PATH:hsa04930]
4932 Non-alcoholic fatty liver disease (NAFLD) [PATH:hsa04932]
5100 Bacterial invasion of epithelial cells [PATH:hsa05100]
5166 HTLV-I infection [PATH:hsa05166]
5162 Measles [PATH:hsa05162]
5164 Influenza A [PATH:hsa05164]
5161 Hepatitis B [PATH:hsa05161]
5160 Hepatitis C [PATH:hsa05160]
5169 Epstein-Barr virus infection [PATH:hsa05169]
5146 Amoebiasis [PATH:hsa05146]
5145 Toxoplasmosis [PATH:hsa05145]
5142 Chagas disease (American trypanosomiasis) [PATH:hsa05142]

名称
G beta:gamma signalling through PI3Kgamma
G-protein beta:gamma signalling
GPCR downstream signaling
GPVI-mediated activation cascade
Hemostasis
Metabolism of lipids and lipoproteins
Phospholipid metabolism
PI Metabolism
Platelet activation, signaling and aggregation
Signaling by GPCR
Synthesis of PIPs at the plasma membrane

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
Fibrosis	0.2	2	0	CTD_human_RGD
Diffuse Large B-Cell Lymphoma	0.122714419	10	0	BeFree_CTD_human
Medulloblastoma	0.122171535	8	0	BeFree_CTD_human
Heart failure	0.121357209	6	0	BeFree_CTD_human
Autistic Disorder	0.120271442	2	0	BeFree_CTD_human
Peripheral Neuropathy	0.12	1	0	CTD_human
Cardiomegaly	0.12	1	0	CTD_human
Inflammation	0.08	1	0	RGD
Malignant neoplasm of breast	0.047426383	167	0	BeFree_GAD
Breast Carcinoma	0.043973583	162	0	BeFree

PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma)

基因基本信息

基因基本信息

基因染色体位置

基因染色体位置

基因简述

基因简述

基因序列

基因序列

基因突变

基因突变

基因表达

基因表达

基因引物

基因引物

转录因子

转录因子

尚未收录相关数据

基因本体信息

基因相关microRNA

基因相关microRNA

基因相互作用关系

基因相互作用关系

基因通路

基因通路

基因相关疾病

基因相关疾病

基因相关服务

基因相关服务

联系方式

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