PHLPP1(PH domain Leucine-rich repeat Protein Phosphatase 1)是一种重要的蛋白磷酸酶,属于PHLPP蛋白家族成员。该基因编码的蛋白主要功能是通过去磷酸化作用调控多种信号通路的关键蛋白,尤其是Akt(蛋白激酶B)和PKC(蛋白激酶C),从而影响细胞存活、增殖和代谢等过程。PHLPP1通过抑制Akt的活性,促进细胞凋亡并抑制肿瘤发生,因此在癌症中常被视为抑癌基因。此外,PHLPP1还参与调节胰岛素信号通路,其功能异常可能与糖尿病等代谢性疾病相关。PHLPP1的突变或表达异常可能导致信号通路失调,例如突变可能削弱其磷酸酶活性,导致Akt过度激活,进而促进细胞异常增殖和肿瘤发展。研究表明,PHLPP1在多种癌症(如乳腺癌、前列腺癌和结肠癌)中表达降低,而其过表达可抑制肿瘤生长。相反,PHLPP1的过度抑制可能增强Akt信号,促进细胞存活和耐药性。PHLPP家族包括PHLPP1和PHLPP2两个成员,它们具有相似的结构域(如PH结构域和亮氨酸重复序列)和功能,均通过去磷酸化Akt和PKC调控细胞信号。PHLPP1的生物学作用复杂,在不同组织中可能具有特异性,例如在神经系统中可能影响突触可塑性和学习记忆功能。总体而言,PHLPP1是一个关键的信号调节分子,其表达水平的变化对疾病发生发展具有重要影响,尤其在癌症和代谢性疾病中具有潜在的治疗靶点价值。
This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling. [provided by RefSeq, Dec 2011]
该基因编码的丝氨酸/苏氨酸磷酸酶家族的一个成员。所编码的蛋白质通过去磷酸化和失活的丝氨酸/苏氨酸激酶Akt和功能在多种类型的癌症的肿瘤抑制促进凋亡。该基因的表达的增加也可通过与Akt的介导的胰岛素信号干扰起到肥胖和2型糖尿病的作用。 [由RefSeq的,2011年12月提供]
PHLPP1基因(以及对应的蛋白质)的细胞分布位置:
PHLPP1基因的本体(GO)信息:
名称 |
---|
4151 PI3K-Akt signaling pathway [PATH:hsa04151] |
名称 |
---|
Adaptive Immune System |
DAP12 interactions |
DAP12 signaling |
Downstream signal transduction |
Downstream signaling events of B Cell Receptor (BCR) |
Downstream signaling of activated FGFR1 |
Downstream signaling of activated FGFR2 |
Downstream signaling of activated FGFR3 |
Downstream signaling of activated FGFR4 |
Fc epsilon receptor (FCERI) signaling |
GAB1 signalosome |
Immune System |
Innate Immune System |
Negative regulation of the PI3K/AKT network |
NGF signalling via TRKA from the plasma membrane |
PI-3K cascade:FGFR1 |
PI-3K cascade:FGFR2 |
PI-3K cascade:FGFR3 |
PI-3K cascade:FGFR4 |
PI3K events in ERBB2 signaling |
PI3K events in ERBB4 signaling |
PI3K/AKT activation |
PIP3 activates AKT signaling |
Role of LAT2/NTAL/LAB on calcium mobilization |
Signaling by EGFR |
Signaling by ERBB2 |
Signaling by ERBB4 |
Signaling by FGFR |
Signaling by FGFR1 |
Signaling by FGFR2 |
Signaling by FGFR3 |
Signaling by FGFR4 |
Signaling by PDGF |
Signaling by SCF-KIT |
Signaling by the B Cell Receptor (BCR) |
Signalling by NGF |
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Neoplastic Cell Transformation | 0.12 | 1 | 0 | CTD_human |
Colonic Neoplasms | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Diabetic Nephropathy | 0.002638474 | 2 | 5 | BeFree_GAD |
Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
Narcolepsy | 0.002367032 | 1 | 0 | GAD |
Colorectal Cancer | 0.000814326 | 3 | 1 | BeFree |
Prostate carcinoma | 0.000814326 | 3 | 0 | BeFree |
Malignant tumor of colon | 0.000814326 | 3 | 0 | BeFree |
Colon Carcinoma | 0.000814326 | 3 | 0 | BeFree |
Liver carcinoma | 0.000542884 | 2 | 0 | BeFree |
山东省济南市章丘区文博路2号 齐鲁师范学院 genelibs生信实验室
山东省济南市高新区舜华路750号大学科技园北区F座4单元2楼
电话: 0531-88819269
E-mail: product@genelibs.com
关注微信订阅号,实时查看信息,关注医学生物学动态。