PCNA (proliferating cell nuclear antigen)

基因基本信息

基因基本信息

symbol:
PCNA
locus group:
protein-coding gene
location:
20p12.3
gene_family:
alias symbol:
None
alias name:
None
entrez id:
5111
ensembl gene id:
ENSG00000132646
ucsc gene id:
uc002wlq.4
refseq accession:
NM_002592
hgnc_id:
HGNC:8729
approved reserved:
1990-01-15

基因染色体位置

基因染色体位置

20p12.3
基因染色体位置图

基因简述

基因简述

PCNA（增殖细胞核抗原）是一种在DNA复制和修复过程中起关键作用的蛋白质，属于滑动夹蛋白家族。它的主要功能是作为DNA聚合酶的辅助蛋白，通过与DNA聚合酶δ和ε结合形成复合物，显著提高DNA合成的持续性和准确性。PCNA在细胞周期的S期表达量最高，是细胞增殖的重要标志物。PCNA以三聚体形式环绕DNA，形成一个滑动夹结构，确保DNA聚合酶在复制过程中不会从模板上脱落。此外，PCNA还参与多种DNA修复途径，包括核苷酸切除修复、碱基切除修复和错配修复等。PCNA的突变通常会导致DNA复制和修复功能障碍，可能引发基因组不稳定，增加癌症风险。PCNA的过表达常见于多种肿瘤细胞中，与肿瘤的恶性程度和预后不良相关，因为它促进了肿瘤细胞的快速增殖。相反，PCNA表达降低会导致细胞增殖受阻，可能引起发育缺陷或加速衰老。PCNA属于PCNA基因家族，该家族成员在结构上具有保守的滑动夹结构域，能够与其他蛋白质相互作用，参与DNA代谢过程。PCNA还与多种蛋白质如p21、FEN1和MSH6等相互作用，调控细胞周期和DNA修复。PCNA的表达和活性受到多种因素的调控，包括转录水平、翻译后修饰和蛋白质降解等。PCNA在癌症、神经退行性疾病和衰老等疾病中具有重要作用，是潜在的诊断标志物和治疗靶点。

The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008]

由该基因编码的蛋白质在细胞核中被发现，为DNA聚合酶δ的辅助因子。所编码的蛋白质作为同三聚体，并有助于提高在DNA复制期间前导链合成的合成能力。响应于DNA损伤，这种蛋白是泛素化，并参与在RAD6依赖性DNA修复途径。已发现了该基因编码的蛋白质相同的两个转录变异体。这个基因的假基因已在4号染色体和X染色体上的说明。 [由RefSeq的，2008年7月提供]

OMIM数据库中对PCNA基因的介绍     Wikipedia数据库中对PCNA基因的介绍

基因序列

基因序列

PCNA基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

PCNA基因的碱基突变：           仅显示部分snp
rs4239760       rs6053124       rs8117209       rs8122586       rs8125170       rs11466986       rs13038869       rs13043456       rs34361216       rs35360937       rs41282114       rs41282116       rs57651330       rs58921284       rs71332873       rs73602874       rs74684880      

基因表达

基因表达

PCNA基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
CAAGTGGAGAACTTGGAAATGG
60
CTATGGTAACAGCTTCCTCCT
59
CAAGTGGAGAACTTGGAAATGG
60
CTATGGTAACAGCTTCCTCCT
59
GTGGAGAACTTGGAAATGGA
58
TCTCTATGGTAACAGCTTCCT
58
GTGGAGAACTTGGAAATGGA
58
TCTCTATGGTAACAGCTTCCT
58
AGTGGAGAACTTGGAAATGG
58
CTCTATGGTAACAGCTTCCTC
58
AGTGGAGAACTTGGAAATGG
58
CTCTATGGTAACAGCTTCCTC
58

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
AHR
PCNA
Activation
12417031
ATM
PCNA
Unknown
22362778
CDX1
PCNA
Activation
11743638
E2F1
PCNA
Activation
14618416
EP300
PCNA
Repression
10618724
EZH2
PCNA
Activation
21629038
HDAC1
PCNA
Repression
9650586
HDAC1
PCNA
Unknown
18691180
HMGN1
PCNA
Unknown
22393258
HOXA1
PCNA
Unknown
17213808

基因本体信息

PCNA基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

PCNA基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0000082
P12004 (UniProtKB)
TAS
GO:0000083
P12004 (UniProtKB)
TAS
GO:0000701
P12004 (UniProtKB)
IDA
GO:0000722
P12004 (UniProtKB)
TAS
GO:0000722
P12004 (UniProtKB)
TAS
GO:0000722
P12004 (UniProtKB)
TAS
GO:0000722
P12004 (UniProtKB)
TAS
GO:0000722
P12004 (UniProtKB)
TAS
GO:0000722
P12004 (UniProtKB)
TAS
GO:0000722
P12004 (UniProtKB)
TAS
GO:0000722
P12004 (UniProtKB)
TAS
GO:0000722
P12004 (UniProtKB)
TAS
GO:0000722
P12004 (UniProtKB)
TAS
GO:0000723
P12004 (UniProtKB)
TAS
GO:0000784
P12004 (UniProtKB)
IDA
GO:0003682
P12004 (UniProtKB)
IDA
GO:0003684
P12004 (UniProtKB)
IDA
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005515
P12004 (UniProtKB)
IPI
GO:0005634
P12004 (UniProtKB)
IDA
GO:0005634
P12004 (UniProtKB)
IDA
GO:0005654
P12004 (UniProtKB)
IDA
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005654
P12004 (UniProtKB)
TAS
GO:0005663
P12004 (UniProtKB)
TAS
GO:0005737
P12004 (UniProtKB)
IDA
GO:0005813
P12004 (UniProtKB)
IDA
GO:0006271
P12004 (UniProtKB)
TAS
GO:0006272
P12004 (UniProtKB)
IBA
GO:0006283
P12004 (UniProtKB)
TAS
GO:0006296
P12004 (UniProtKB)
TAS
GO:0006297
P12004 (UniProtKB)
TAS
GO:0006298
P12004 (UniProtKB)
IDA
GO:0006298
P12004 (UniProtKB)
TAS
GO:0006977
P12004 (UniProtKB)
TAS
GO:0007507
P12004 (UniProtKB)
IEA
GO:0008283
P12004 (UniProtKB)
TAS
GO:0016925
P12004 (UniProtKB)
TAS
GO:0019899
P12004 (UniProtKB)
IPI
GO:0019985
P12004 (UniProtKB)
IDA
GO:0019985
P12004 (UniProtKB)
TAS
GO:0030331
P12004 (UniProtKB)
IEA
GO:0030337
P12004 (UniProtKB)
IBA
GO:0030855
P12004 (UniProtKB)
IEP
GO:0030894
P12004 (UniProtKB)
TAS
GO:0030971
P12004 (UniProtKB)
IPI
GO:0031297
P12004 (UniProtKB)
ISS
GO:0032077
P12004 (UniProtKB)
IDA
GO:0032139
P12004 (UniProtKB)
IDA
GO:0032405
P12004 (UniProtKB)
IDA
GO:0033683
P12004 (UniProtKB)
TAS
GO:0033993
P12004 (UniProtKB)
IEA
GO:0034644
P12004 (UniProtKB)
IDA
GO:0035035
P12004 (UniProtKB)
IPI
GO:0035035
P12004 (UniProtKB)
IPI
GO:0042276
P12004 (UniProtKB)
TAS
GO:0042276
P12004 (UniProtKB)
TAS
GO:0042276
P12004 (UniProtKB)
TAS
GO:0042769
P12004 (UniProtKB)
TAS
GO:0042802
P12004 (UniProtKB)
IPI
GO:0042802
P12004 (UniProtKB)
IPI
GO:0043596
P12004 (UniProtKB)
IDA
GO:0043626
P12004 (UniProtKB)
IDA
GO:0045739
P12004 (UniProtKB)
IMP
GO:0045740
P12004 (UniProtKB)
IMP
GO:0046686
P12004 (UniProtKB)
IEA
GO:0070062
P12004 (UniProtKB)
IDA
GO:0070182
P12004 (UniProtKB)
IPI
GO:0070182
P12004 (UniProtKB)
IPI
GO:0070557
P12004 (UniProtKB)
IDA
GO:0070987
P12004 (UniProtKB)
TAS
GO:1902990
P12004 (UniProtKB)
ISS

基因相关microRNA

基因相关microRNA

可能调控 PCNA基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
ATAXIA-TELANGIECTASIA-LIKE DISORDER 2 0.24 1 0 ORPHANET_UNIPROT
Adenocarcinoma 0.128967513 25 0 BeFree_CTD_human_LHGDN
Lung Neoplasms 0.123538676 5 0 BeFree_CTD_human_LHGDN
Brain Neoplasms 0.123452799 6 0 BeFree_CTD_human_GAD
Hepatoblastoma 0.120814326 4 0 BeFree_CTD_human
Ischemia 0.120542884 3 0 BeFree_CTD_human
Psoriasis 0.120271442 2 0 BeFree_CTD_human
IGA Glomerulonephritis 0.120271442 2 0 BeFree_CTD_human
Focal glomerulosclerosis 0.12 1 0 CTD_human
Neoplasms, Experimental 0.12 1 0 CTD_human

基因相关服务

基因相关服务

联系方式

山东省济南市章丘区文博路2号 齐鲁师范学院 genelibs生信实验室

山东省济南市高新区舜华路750号大学科技园北区F座4单元2楼

电话： 0531-88819269

E-mail: product@genelibs.com

微信公众号

关注微信订阅号，实时查看信息，关注医学生物学动态。

版权所有 © 2025.Genelibs 济南弘晖生物技术有限公司 鲁ICP备13024435号-2