PCBP2（多聚胞嘧啶结合蛋白2）属于PCBP基因家族，也称为hnRNP E家族，该家族成员主要参与RNA代谢，包括mRNA稳定性调控、剪接和翻译控制。PCBP2作为一种RNA结合蛋白，通过识别并结合富含胞嘧啶的序列（如poly(C)区域）发挥作用，广泛参与细胞内的转录后调控。其表达产物在维持mRNA稳定性、调控铁代谢（通过与铁响应元件IRE结合影响铁蛋白和转铁蛋白受体的表达）以及病毒RNA复制（如与脊髓灰质炎病毒RNA相互作用）中起关键作用。PCBP2的突变可能导致RNA结合能力下降，影响靶mRNA的稳定性或翻译效率，例如与神经退行性疾病或癌症发展相关。在家族共性方面，PCBP家族成员（PCBP1-4）均含有KH结构域，介导RNA/DNA结合，并参与细胞增殖、分化及应激响应。当PCBP2过表达时，可能增强对靶mRNA的稳定作用，促进某些促癌基因（如c-myc）的表达，与肝癌等肿瘤发生相关；而表达降低则可能导致铁代谢紊乱或病毒复制异常。此外，PCBP2与阿尔茨海默病相关蛋白APP的mRNA存在相互作用，其表达异常可能影响APP加工过程。该基因还通过调控选择性剪接参与红细胞分化，其缺失可导致α-地中海贫血表型。

The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. Thsi gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

由该基因编码的蛋白质似乎是多功能的。随着PCBP-1和hnRNPK，它是主要的蜂窝聚（RC）结合蛋白之一。所编码的蛋白质包含可能参与RNA结合3 K - 同源（KH）域。连同PCBP-1，这种蛋白还用作通过与IRES的茎 - 环四序列特异性相互作用脊髓灰质炎病毒RNA的转译共激活剂，通过结合到其5‘端三叶草结构促进脊髓灰质炎病毒RNA的复制。它也被牵连的15-脂肪氧化酶的mRNA的翻译控制，人乳头瘤病毒16型的L2的mRNA，和A型肝炎病毒的RNA。所编码的蛋白质也建议在形成其中用α-珠蛋白mRNA的稳定性相关的特定序列-α-珠蛋白MRNP复杂的过程中发挥作用。此multiexon结构的mRNA被认为是re??trotransposed生成PCBP-1，无内含子基因具有类似于PCBP2的功能。此基因和PCBP-1具有这被认为旁系同源基??因（PCBP3和PCBP4）到已经出现作为整个基因复制事件的结果。 Thsi基因也有两个加工假（PCBP2P1和PCBP2P2）。已发现该基因编码不同亚型的多个抄本变形。 [由RefSeq的，2008年7月提供]

PCBP2基因在不同组织中的表达：    [UniProt]

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