PARP1 (poly(ADP-ribose) polymerase 1)

基因基本信息

基因基本信息

symbol:
PARP1
locus group:
protein-coding gene
location:
1q42.12
gene_family:
Zinc fingers, PARP-type|Poly (ADP-ribose) polymerases|Zinc fingers - ungrouped
alias symbol:
PARP|ARTD1|Poly-PARP|PARS
alias name:
None
entrez id:
142
ensembl gene id:
ENSG00000143799
ucsc gene id:
uc001hqd.5
refseq accession:
NM_001618
hgnc_id:
HGNC:270
approved reserved:
1986-01-01

基因染色体位置

基因染色体位置

1q42.12
基因染色体位置图

基因简述

基因简述

PARP1（聚腺苷二磷酸核糖聚合酶1）是一种关键的DNA修复酶，属于PARP基因家族（包括PARP1、PARP2、PARP3等），该家族成员均参与DNA损伤修复和细胞应激反应。PARP1的主要功能是通过催化ADP核糖基化修饰靶蛋白（如组蛋白和DNA修复蛋白），促进单链断裂（SSB）的修复，维持基因组稳定性。此外，它还参与转录调控、炎症反应和细胞凋亡等过程。PARP1在细胞核中高度活跃，尤其在DNA损伤位点富集。PARP1突变可能导致其功能丧失，引发DNA修复缺陷，增加基因组不稳定性，与多种癌症（如乳腺癌、卵巢癌）和神经退行性疾病相关。PARP抑制剂（如奥拉帕尼）已用于治疗携带BRCA突变的癌症，通过“合成致死”效应选择性杀死癌细胞。PARP1过表达可能增强DNA修复能力，导致肿瘤细胞对放化疗产生耐药性；而低表达或抑制PARP1会加剧DNA损伤积累，引发细胞凋亡或衰老。PARP家族成员的共性是依赖NAD+催化ADP核糖基化反应，参与DNA损伤应答和染色质重塑。PARP1还与炎症性疾病（如败血症）和缺血再灌注损伤有关，因其过度激活会消耗NAD+，导致细胞能量衰竭。研究还发现PARP1通过调控NF-κB等信号通路影响免疫反应。

This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008]

本基因编码的染色质相关酶，聚（ADP-核糖基）转移酶，其由聚修改各种核蛋白质（ADP-核糖基）化。改性是依赖于DNA和参与多种重要的细胞过程，如分化，增殖和肿瘤转化和也参与细胞的DNA损伤的恢复的分子事件的调节的调节。此外，这种酶可以是在范可尼贫血突变的位点，并可能参与I型糖尿病的病理生理学。 [由RefSeq的，2008年7月提供]

OMIM数据库中对CCND1基因的介绍     Wikipedia数据库中对CCND1基因的介绍

基因序列

基因序列

CCND1基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

PARP1基因的碱基突变：           仅显示部分snp
rs8679       rs167591       rs172743       rs178437       rs178439       rs184366       rs184367       rs188825       rs192893       rs317208       rs317209       rs317210       rs317211       rs317212       rs374643       rs379806       rs380715      

基因表达

基因表达

PARP1基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
CAGTGTCAAAGGTTTGGGC
60
CACCAGATGAAATCCCGGT
60
AGTCAAGAGTGAAGGAAAGAG
57
CTTCTTCGCCACTTCATCC
59
GGAGGGTCTGATGATAGCA
58
CTCTGTCAACCACCTTAATGTC
59
GGTGTGAATGACACCTCTC
58
GCAGATACTTCAGATTTACCTGAG
59
TGGTGTGAATGACACCTCTC
60
CAGATACTTCAGATTTACCTGAGC
59
GAGTCAAGAGTGAAGGAAAGAG
59
TTCTTCGCCACTTCATCCA
59
GGAGGGTCTGATGATAGCA
58
TCTGTCAACCACCTTAATGTC
58
CAGTGTCAAAGGTTTGGGC
60
ACCAGATGAAATCCCGGTC
60
GCCTCTTGCAAGAAATGCA
59
CATCAAACATGGGCGACTG
60
AGTCAAGAGTGAAGGAAAGAG
57
TTCTTCGCCACTTCATCCA
59

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
EP300
PARP1
Unknown
17065349
ETS1
PARP1
Activation
11973649; 24448423
ETS1
PARP1
Repression
10435618
PARP1
BCL2
Repression
20564216
PARP1
BRCA2
Repression
18990703
PARP1
CDH1
Activation
21577210
PARP1
CDH1
Unknown
18773488
PARP1
CDKN1A
Unknown
20711239
PARP1
CXCL1
Unknown
11112786
PARP1
DNAAF4
Unknown
18445785

基因本体信息

PARP1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

PARP1基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0000122
P09874 (UniProtKB)
TAS
GO:0000715
P09874 (UniProtKB)
TAS
GO:0000717
P09874 (UniProtKB)
TAS
GO:0000724
P09874 (UniProtKB)
TAS
GO:0000784
P09874 (UniProtKB)
IDA
GO:0003677
P09874 (UniProtKB)
IEA
GO:0003910
P09874 (UniProtKB)
IBA
GO:0003950
P09874 (UniProtKB)
IDA
GO:0003950
P09874 (UniProtKB)
IDA
GO:0003950
P09874 (UniProtKB)
IDA
GO:0003950
P09874 (UniProtKB)
IDA
GO:0003950
P09874 (UniProtKB)
TAS
GO:0005515
P09874 (UniProtKB)
IPI
GO:0005515
P09874 (UniProtKB)
IPI
GO:0005515
P09874 (UniProtKB)
IPI
GO:0005515
P09874 (UniProtKB)
IPI
GO:0005515
P09874 (UniProtKB)
IPI
GO:0005515
P09874 (UniProtKB)
IPI
GO:0005515
P09874 (UniProtKB)
IPI
GO:0005515
P09874 (UniProtKB)
IPI
GO:0005515
P09874 (UniProtKB)
IPI
GO:0005515
P09874 (UniProtKB)
IPI
GO:0005515
P09874 (UniProtKB)
IPI
GO:0005515
P09874 (UniProtKB)
IPI
GO:0005515
P09874 (UniProtKB)
IPI
GO:0005515
P09874 (UniProtKB)
IPI
GO:0005515
P09874 (UniProtKB)
IPI
GO:0005515
P09874 (UniProtKB)
IPI
GO:0005515
P09874 (UniProtKB)
IPI
GO:0005515
P09874 (UniProtKB)
IPI
GO:0005515
P09874 (UniProtKB)
IPI
GO:0005515
P09874 (UniProtKB)
IPI
GO:0005515
P09874 (UniProtKB)
IPI
GO:0005515
P09874 (UniProtKB)
IPI
GO:0005515
P09874 (UniProtKB)
IPI
GO:0005515
P09874 (UniProtKB)
IPI
GO:0005515
P09874 (UniProtKB)
IPI
GO:0005515
P09874 (UniProtKB)
IPI
GO:0005515
P09874 (UniProtKB)
IPI
GO:0005515
P09874 (UniProtKB)
IPI
GO:0005515
P09874 (UniProtKB)
IPI
GO:0005515
P09874 (UniProtKB)
IPI
GO:0005515
P09874 (UniProtKB)
IPI
GO:0005515
P09874 (UniProtKB)
IPI
GO:0005515
P09874 (UniProtKB)
IPI
GO:0005634
P09874 (UniProtKB)
IDA
GO:0005634
P09874 (UniProtKB)
IDA
GO:0005635
P09874 (UniProtKB)
IDA
GO:0005654
P09874 (UniProtKB)
TAS
GO:0005654
P09874 (UniProtKB)
TAS
GO:0005654
P09874 (UniProtKB)
TAS
GO:0005654
P09874 (UniProtKB)
TAS
GO:0005654
P09874 (UniProtKB)
TAS
GO:0005654
P09874 (UniProtKB)
TAS
GO:0005654
P09874 (UniProtKB)
TAS
GO:0005654
P09874 (UniProtKB)
TAS
GO:0005654
P09874 (UniProtKB)
TAS
GO:0005654
P09874 (UniProtKB)
TAS
GO:0005654
P09874 (UniProtKB)
TAS
GO:0005654
P09874 (UniProtKB)
TAS
GO:0005654
P09874 (UniProtKB)
TAS
GO:0005654
P09874 (UniProtKB)
TAS
GO:0005654
P09874 (UniProtKB)
TAS
GO:0005654
P09874 (UniProtKB)
TAS
GO:0005654
P09874 (UniProtKB)
TAS
GO:0005654
P09874 (UniProtKB)
TAS
GO:0005654
P09874 (UniProtKB)
TAS
GO:0005654
P09874 (UniProtKB)
TAS
GO:0005654
P09874 (UniProtKB)
TAS
GO:0005654
P09874 (UniProtKB)
TAS
GO:0005654
P09874 (UniProtKB)
TAS
GO:0005654
P09874 (UniProtKB)
TAS
GO:0005654
P09874 (UniProtKB)
TAS
GO:0005667
P09874 (UniProtKB)
IDA
GO:0005730
P09874 (UniProtKB)
IDA
GO:0005730
P09874 (UniProtKB)
IDA
GO:0005739
P09874 (UniProtKB)
IDA
GO:0006273
P09874 (UniProtKB)
IBA
GO:0006281
P09874 (UniProtKB)
TAS
GO:0006293
P09874 (UniProtKB)
TAS
GO:0006294
P09874 (UniProtKB)
TAS
GO:0006294
P09874 (UniProtKB)
TAS
GO:0006294
P09874 (UniProtKB)
TAS
GO:0006295
P09874 (UniProtKB)
TAS
GO:0006296
P09874 (UniProtKB)
TAS
GO:0006302
P09874 (UniProtKB)
IMP
GO:0006366
P09874 (UniProtKB)
TAS
GO:0006471
P09874 (UniProtKB)
IDA
GO:0006974
P09874 (UniProtKB)
IMP
GO:0007005
P09874 (UniProtKB)
IMP
GO:0007179
P09874 (UniProtKB)
IEA
GO:0008134
P09874 (UniProtKB)
IPI
GO:0008270
P09874 (UniProtKB)
IEA
GO:0010613
P09874 (UniProtKB)
ISS
GO:0016020
P09874 (UniProtKB)
IDA
GO:0016540
P09874 (UniProtKB)
IEA
GO:0016925
P09874 (UniProtKB)
TAS
GO:0019899
P09874 (UniProtKB)
IPI
GO:0019901
P09874 (UniProtKB)
IPI
GO:0023019
P09874 (UniProtKB)
IEA
GO:0030225
P09874 (UniProtKB)
TAS
GO:0032042
P09874 (UniProtKB)
IMP
GO:0032869
P09874 (UniProtKB)
IDA
GO:0033683
P09874 (UniProtKB)
TAS
GO:0034599
P09874 (UniProtKB)
IMP
GO:0036211
P09874 (UniProtKB)
IMP
GO:0042769
P09874 (UniProtKB)
IEA
GO:0042802
P09874 (UniProtKB)
IPI
GO:0042802
P09874 (UniProtKB)
IPI
GO:0042826
P09874 (UniProtKB)
IEA
GO:0043234
P09874 (UniProtKB)
IDA
GO:0043504
P09874 (UniProtKB)
IMP
GO:0044822
P09874 (UniProtKB)
IDA
GO:0044822
P09874 (UniProtKB)
IDA
GO:0045944
P09874 (UniProtKB)
IEA
GO:0047485
P09874 (UniProtKB)
IPI
GO:0051103
P09874 (UniProtKB)
IBA
GO:0051287
P09874 (UniProtKB)
IEA
GO:0060391
P09874 (UniProtKB)
IEA
GO:0070212
P09874 (UniProtKB)
IDA
GO:0070212
P09874 (UniProtKB)
IDA
GO:0070412
P09874 (UniProtKB)
IEA
GO:0070911
P09874 (UniProtKB)
TAS
GO:1903827
P09874 (UniProtKB)
IMP
GO:1904357
P09874 (UniProtKB)
ISS
GO:2000679
P09874 (UniProtKB)
IEA
GO:0003677
Q5VX84 (UniProtKB)
IEA
GO:0008270
Q5VX84 (UniProtKB)
IEA
GO:0003677
Q5VX85 (UniProtKB)
IEA
GO:0008270
Q5VX85 (UniProtKB)
IEA

基因相关microRNA

基因相关microRNA

可能调控 PARP1基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Mammary Neoplasms 0.127348794 10 0 BeFree_CTD_human_LHGDN
Inflammation 0.1254487 3 0 CTD_human_LHGDN
melanoma 0.125352893 12 2 BeFree_GAD_GWASCAT
Asthma 0.123724241 6 1 BeFree_CTD_human_GAD
Multiple Myeloma 0.122171535 8 0 BeFree_CTD_human
Prostatic Neoplasms 0.120814326 4 0 BeFree_CTD_human
Atherosclerosis 0.120271442 2 0 BeFree_CTD_human
Obesity 0.120271442 2 0 BeFree_CTD_human
Dermatitis 0.120271442 2 0 BeFree_CTD_human
Brain Ischemia 0.120271442 2 0 BeFree_CTD_human

基因相关服务

基因相关服务

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