PAGE4 (PAGE family member 4)

symbol:
PAGE4
locus group:
protein-coding gene
location:
Xp11.23
gene_family:
alias symbol:
PAGE-4|CT16.7
alias name:
None
entrez id:
9506
ensembl gene id:
ENSG00000101951
ucsc gene id:
uc064zfy.1
refseq accession:
NM_001318877
hgnc_id:
HGNC:4108
approved reserved:
1999-04-15
Xp11.23
基因染色体位置图

This gene is a member of the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in prostate and prostate cancer. It is also expressed in other male and female reproductive tissues including testis, fallopian tube, uterus, and placenta, as well as in testicular cancer and uterine cancer. The protein encoded by this gene shares sequence similarity with other GAGE/PAGE proteins, and also belongs to a family of CT (cancer-testis) antigens. The protein may play a role in benign and malignant prostate diseases. A related pseudogene is located on chromosome 7. [provided by RefSeq, Aug 2013]

这个基因是GAGE家族的一员。的GAGE基因在多种肿瘤,并在一些胎儿和生殖组织中表达。此基因在前列腺癌和前列腺癌的强烈表达。它还在其它男性和女性生殖组织,包括睾丸,输卵管,子宫和胎盘,以及睾丸癌和子宫癌中表达。该蛋白质通过与其他GAGE / PAGE蛋白质此基因股序列相似进行编码,并且也属于一个家族的CT(癌 - 睾丸)抗原。该蛋白可能在良性和恶性前列腺疾病的作用。一个相关的假基因位于[由RefSeq的,2013年8月提供] 7号染色体

CCND1基因的碱基序列:[NCBI]
Loading Gene Browser...
PAGE4基因的碱基突变:           仅显示部分snp
rs782808398       rs782815278       rs782797037       rs782797548       rs782792270       rs782772223       rs782785759       rs782767180       rs782768091       rs782763871       rs782732396       rs782730860       rs782729291       rs782724666       rs782706628       rs782717740       rs782704850      

PAGE4基因在不同组织中的表达:    [UniProt]

基因在不同组织中的表达图
正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
AGAGGAGATGGTCAGGAGG
60
TCTTGCTGAGATTCACCGG
60
AGAGGAACCACCAACTGAC
59
ACTTTACGTTCTTCGATCGGA
60
AGAGGAACCACCAACTGAC
59
ACTTTACGTTCTTCGATCGGA
60
ATTATTGGTCCTTGCAGCC
58
ACTTTACGTTCTTCGATCGG
58
GATGTGGTTGCATTCGTGG
60
CCTGATTGTCAGTTGGTGG
59
ACCACCAACTGACAATCAG
58
CCTTCTACTTTACGTTCTTCGA
58
ATTATTGGTCCTTGCAGCC
58
CTTTACGTTCTTCGATCGGAG
59
ACCACCAACTGACAATCAG
58
CCTTCTACTTTACGTTCTTCGA
58
CCACCAACTGACAATCAGG
59
ACCTTCTACTTTACGTTCTTCG
58
CCACCAACTGACAATCAGG
59
ACCTTCTACTTTACGTTCTTCG
58
      尚未收录相关数据

PAGE4基因(以及对应的蛋白质)的细胞分布位置:

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

PAGE4基因的本体(GO)信息:

GO库代码
对应的蛋白质
来源代码
GO:0003674
O60829 (UniProtKB)
ND
GO:0005575
O60829 (UniProtKB)
ND
GO:0008150
O60829 (UniProtKB)
ND

可能调控 PAGE4基因的相关microRNA:     

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称
疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Neoplasm Invasiveness 0.12 1 0 CTD_human
Stomach Neoplasms 0.00272435 1 0 LHGDN
Colorectal Carcinoma 0.000271442 1 0 BeFree
melanoma 0.000271442 1 0 BeFree
Malignant neoplasm of prostate 0.000271442 1 0 BeFree
Germ cell tumor 0.000271442 1 0 BeFree
Prostate carcinoma 0.000271442 1 0 BeFree
Benign Prostatic Hyperplasia 0.000271442 1 0 BeFree
Secondary malignant neoplasm of liver 0.000271442 1 0 BeFree
Colorectal Cancer 0.000271442 1 0 BeFree

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