This gene is a member of the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in prostate and prostate cancer. It is also expressed in other male and female reproductive tissues including testis, fallopian tube, uterus, and placenta, as well as in testicular cancer and uterine cancer. The protein encoded by this gene shares sequence similarity with other GAGE/PAGE proteins, and also belongs to a family of CT (cancer-testis) antigens. The protein may play a role in benign and malignant prostate diseases. A related pseudogene is located on chromosome 7. [provided by RefSeq, Aug 2013]
这个基因是GAGE家族的一员。的GAGE基因在多种肿瘤,并在一些胎儿和生殖组织中表达。此基因在前列腺癌和前列腺癌的强烈表达。它还在其它男性和女性生殖组织,包括睾丸,输卵管,子宫和胎盘,以及睾丸癌和子宫癌中表达。该蛋白质通过与其他GAGE / PAGE蛋白质此基因股序列相似进行编码,并且也属于一个家族的CT(癌 - 睾丸)抗原。该蛋白可能在良性和恶性前列腺疾病的作用。一个相关的假基因位于[由RefSeq的,2013年8月提供] 7号染色体
PAGE4基因(以及对应的蛋白质)的细胞分布位置:
PAGE4基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Neoplasm Invasiveness | 0.12 | 1 | 0 | CTD_human |
Stomach Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Colorectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
melanoma | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of prostate | 0.000271442 | 1 | 0 | BeFree |
Germ cell tumor | 0.000271442 | 1 | 0 | BeFree |
Prostate carcinoma | 0.000271442 | 1 | 0 | BeFree |
Benign Prostatic Hyperplasia | 0.000271442 | 1 | 0 | BeFree |
Secondary malignant neoplasm of liver | 0.000271442 | 1 | 0 | BeFree |
Colorectal Cancer | 0.000271442 | 1 | 0 | BeFree |
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