This gene was originally cloned from human myeloblasts and found to be selectively expressed in inflammed colonic epithelium. This gene encodes a member of the olfactomedin family. The encoded protein is an antiapoptotic factor that promotes tumor growth and is an extracellular matrix glycoprotein that facilitates cell adhesion. [provided by RefSeq, Mar 2011]
这个基因最初是从人的原粒细胞克隆,并发现,在发炎的结肠上皮被选择性地表达。该基因编码的olfactomedin家族的一个成员。所编码的蛋白质是促进肿瘤的生长,是一种细胞外基质糖蛋白,促进细胞粘附的抗凋亡因子。 [由RefSeq的,2011年3月提供]
OLFM4基因(以及对应的蛋白质)的细胞分布位置:
OLFM4基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Amyotrophic Lateral Sclerosis | 0.122367032 | 2 | 2 | GAD_GWASCAT |
Endometriosis | 0.120271442 | 1 | 0 | BeFree_CTD_human |
Stomach Carcinoma | 0.002714419 | 10 | 0 | BeFree |
Obesity | 0.002638474 | 2 | 1 | BeFree_GAD |
Malignant neoplasm of stomach | 0.002442977 | 9 | 0 | BeFree |
Insulin Resistance | 0.002367032 | 1 | 1 | GAD |
Heart Diseases | 0.002367032 | 1 | 1 | GAD |
Cerebrovascular accident | 0.002367032 | 1 | 1 | GAD |
Neoplasm Metastasis | 0.001357209 | 5 | 0 | BeFree |
Carcinogenesis | 0.001085767 | 4 | 0 | BeFree |
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