NRAS基因详情-基因数据库-基因云馆

NRAS (NRAS proto-oncogene, GTPase)

symbol:: NRAS
locus group:: protein-coding gene
location:: 1p13.2
gene_family:: RAS type family GTPases
alias symbol:: N-ras
alias name:: None
entrez id:: 4893
ensembl gene id:: ENSG00000213281
ucsc gene id:: uc009wgu.4
refseq accession:: NM_002524
hgnc_id:: HGNC:7989
approved reserved:: 2001-06-22

1p13.2

This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011]

这是一个N-ras致癌基因编码的高尔基体和质膜之间穿梭的膜蛋白。此穿梭通过棕榈酰化和depalmitoylation由ZDHHC9-GOLGA7复杂的调节。所编码的蛋白质，其具有内在的GTP酶活性，是由一个鸟嘌呤核苷酸交换因子激活和灭活由GTP酶激活蛋白。在这种基因突变与躯体直肠癌，甲状腺滤泡状癌，自身免疫性淋巴增生综合征，努南综合征，和幼年粒 - 单核细胞白血病相关。 [由RefSeq的，2011年6月提供]

OMIM数据库中对CCND1基因的介绍 Wikipedia数据库中对CCND1基因的介绍

CCND1基因的碱基序列：[NCBI]

Loading Gene Browser...

NRAS基因的碱基突变：仅显示部分snp

rs6851 rs8453 rs12254 rs1065634 rs2273267 rs4553193 rs6694035 rs9724611 rs9724612 rs9724613 rs9724614 rs9724615 rs9724616 rs9724617 rs9724618 rs61758211 rs61758212

NRAS基因在不同组织中的表达： [UniProt]

正向引物序列

正向Tm值

反向引物序列

反向Tm值

评分

ATATTAACCTCTACAGGGAGCAG

59

CACACTTGTTTCCCACTAGC

59

ATATTAACCTCTACAGGGAGCA

58

CACACTTGTTTCCCACTAGC

59

GATATTAACCTCTACAGGGAGC

58

ACACTTGTTTCCCACTAGC

58

转录因子

影响基因

影响类型

参考文献链接（PubMed）

AR

NRAS

Repression

16281084

NRAS基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

质膜
细胞质
细胞外
高尔基体
囊泡
细胞骨架
内质网
细胞核
内体
溶酶体
线粒体

NRAS基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0000139

P01111 (UniProtKB)

IEA

GO:0000165

P01111 (UniProtKB)

TAS

GO:0002223

P01111 (UniProtKB)

TAS

GO:0005525

P01111 (UniProtKB)

IEA

GO:0005794

P01111 (UniProtKB)

IDA

GO:0005886

P01111 (UniProtKB)

TAS

GO:0005886

P01111 (UniProtKB)

TAS

GO:0005886

P01111 (UniProtKB)

TAS

GO:0005886

P01111 (UniProtKB)

TAS

GO:0005886

P01111 (UniProtKB)

TAS

GO:0005886

P01111 (UniProtKB)

TAS

GO:0005886

P01111 (UniProtKB)

TAS

GO:0005886

P01111 (UniProtKB)

TAS

GO:0005886

P01111 (UniProtKB)

TAS

GO:0005886

P01111 (UniProtKB)

TAS

GO:0005886

P01111 (UniProtKB)

TAS

GO:0005886

P01111 (UniProtKB)

TAS

GO:0005886

P01111 (UniProtKB)

TAS

GO:0005886

P01111 (UniProtKB)

TAS

GO:0005886

P01111 (UniProtKB)

TAS

GO:0005886

P01111 (UniProtKB)

TAS

GO:0005886

P01111 (UniProtKB)

TAS

GO:0005886

P01111 (UniProtKB)

TAS

GO:0005886

P01111 (UniProtKB)

TAS

GO:0005886

P01111 (UniProtKB)

TAS

GO:0005886

P01111 (UniProtKB)

TAS

GO:0005886

P01111 (UniProtKB)

TAS

GO:0005886

P01111 (UniProtKB)

TAS

GO:0005886

P01111 (UniProtKB)

TAS

GO:0005886

P01111 (UniProtKB)

TAS

GO:0005886

P01111 (UniProtKB)

TAS

GO:0005886

P01111 (UniProtKB)

TAS

GO:0005886

P01111 (UniProtKB)

TAS

GO:0005886

P01111 (UniProtKB)

TAS

GO:0005886

P01111 (UniProtKB)

TAS

GO:0005886

P01111 (UniProtKB)

TAS

GO:0005886

P01111 (UniProtKB)

TAS

GO:0005886

P01111 (UniProtKB)

TAS

GO:0005886

P01111 (UniProtKB)

TAS

GO:0005886

P01111 (UniProtKB)

TAS

GO:0005886

P01111 (UniProtKB)

TAS

GO:0005886

P01111 (UniProtKB)

TAS

GO:0005886

P01111 (UniProtKB)

TAS

GO:0005886

P01111 (UniProtKB)

TAS

GO:0005886

P01111 (UniProtKB)

TAS

GO:0005886

P01111 (UniProtKB)

TAS

GO:0005886

P01111 (UniProtKB)

TAS

GO:0005886

P01111 (UniProtKB)

TAS

GO:0005886

P01111 (UniProtKB)

TAS

GO:0005886

P01111 (UniProtKB)

TAS

GO:0005886

P01111 (UniProtKB)

TAS

GO:0005886

P01111 (UniProtKB)

TAS

GO:0005886

P01111 (UniProtKB)

TAS

GO:0005886

P01111 (UniProtKB)

TAS

GO:0007173

P01111 (UniProtKB)

TAS

GO:0007265

P01111 (UniProtKB)

TAS

GO:0007411

P01111 (UniProtKB)

TAS

GO:0016020

P01111 (UniProtKB)

IDA

GO:0032403

P01111 (UniProtKB)

IDA

GO:0038095

P01111 (UniProtKB)

TAS

GO:0038128

P01111 (UniProtKB)

TAS

GO:0050900

P01111 (UniProtKB)

TAS

GO:0070062

P01111 (UniProtKB)

IDA

GO:0070062

P01111 (UniProtKB)

IDA

GO:0072600

P01111 (UniProtKB)

IMP

可能调控 NRAS基因的相关microRNA：

hsa-let-7 hsa-let-7b hsa-miR-124 hsa-miR-16 hsa-miR-340 hsa-miR-98 hsa-let-7a hsa-let-7b* hsa-let-7c hsa-let-7c*

Reactome

MINT

BioGrid

IntAct

mentha

String

序号	作用方式	资源库来源/分值	基因名称	基因名称

KEGG
Reactomepathway

名称
4014 Ras signaling pathway [PATH:hsa04014]
4015 Rap1 signaling pathway [PATH:hsa04015]
4010 MAPK signaling pathway [PATH:hsa04010]
4012 ErbB signaling pathway [PATH:hsa04012]
4370 VEGF signaling pathway [PATH:hsa04370]
4068 FoxO signaling pathway [PATH:hsa04068]
4071 Sphingolipid signaling pathway [PATH:hsa04071]
4151 PI3K-Akt signaling pathway [PATH:hsa04151]
4810 Regulation of actin cytoskeleton [PATH:hsa04810]
4530 Tight junction [PATH:hsa04530]
4540 Gap junction [PATH:hsa04540]
4550 Signaling pathways regulating pluripotency of stem cells [PATH:hsa04550]
4650 Natural killer cell mediated cytotoxicity [PATH:hsa04650]
4660 T cell receptor signaling pathway [PATH:hsa04660]
4662 B cell receptor signaling pathway [PATH:hsa04662]
4664 Fc epsilon RI signaling pathway [PATH:hsa04664]
4062 Chemokine signaling pathway [PATH:hsa04062]
4910 Insulin signaling pathway [PATH:hsa04910]
4912 GnRH signaling pathway [PATH:hsa04912]
4915 Estrogen signaling pathway [PATH:hsa04915]
4917 Prolactin signaling pathway [PATH:hsa04917]
4921 Oxytocin signaling pathway [PATH:hsa04921]
4919 Thyroid hormone signaling pathway [PATH:hsa04919]
4916 Melanogenesis [PATH:hsa04916]
4725 Cholinergic synapse [PATH:hsa04725]
4726 Serotonergic synapse [PATH:hsa04726]
4720 Long-term potentiation [PATH:hsa04720]
4730 Long-term depression [PATH:hsa04730]
4722 Neurotrophin signaling pathway [PATH:hsa04722]
4360 Axon guidance [PATH:hsa04360]
5200 Pathways in cancer [PATH:hsa05200]
5230 Central carbon metabolism in cancer [PATH:hsa05230]
5231 Choline metabolism in cancer [PATH:hsa05231]
5206 MicroRNAs in cancer [PATH:hsa05206]
5205 Proteoglycans in cancer [PATH:hsa05205]
5203 Viral carcinogenesis [PATH:hsa05203]
5214 Glioma [PATH:hsa05214]
5216 Thyroid cancer [PATH:hsa05216]
5221 Acute myeloid leukemia [PATH:hsa05221]
5220 Chronic myeloid leukemia [PATH:hsa05220]
5218 Melanoma [PATH:hsa05218]
5211 Renal cell carcinoma [PATH:hsa05211]
5219 Bladder cancer [PATH:hsa05219]
5215 Prostate cancer [PATH:hsa05215]
5213 Endometrial cancer [PATH:hsa05213]
5223 Non-small cell lung cancer [PATH:hsa05223]
5034 Alcoholism [PATH:hsa05034]
5166 HTLV-I infection [PATH:hsa05166]
5161 Hepatitis B [PATH:hsa05161]
5160 Hepatitis C [PATH:hsa05160]

名称
Activation of RAS in B cells
Adaptive Immune System
ARMS-mediated activation
Axon guidance
C-type lectin receptors (CLRs)
CD209 (DC-SIGN) signaling
Cell surface interactions at the vascular wall
Constitutive Signaling by EGFRvIII
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
Cytokine Signaling in Immune system
DAP12 interactions
DAP12 signaling
Developmental Biology
Disease
Diseases of signal transduction
Downstream signal transduction
Downstream signaling events of B Cell Receptor (BCR)
Downstream signaling of activated FGFR1
Downstream signaling of activated FGFR2
Downstream signaling of activated FGFR3
Downstream signaling of activated FGFR4
EGFR Transactivation by Gastrin
Fc epsilon receptor (FCERI) signaling
FCERI mediated MAPK activation
FRS-mediated FGFR1 signaling
FRS-mediated FGFR2 signaling
FRS-mediated FGFR3 signaling
Frs2-mediated activation
FRS2-mediated FGFR4 signaling
Gastrin-CREB signalling pathway via PKC and MAPK
GRB2 events in EGFR signaling
GRB2 events in ERBB2 signaling
Hemostasis
IGF1R signaling cascade
Immune System
Innate Immune System
Insulin receptor signalling cascade
Interleukin-2 signaling
IRS-mediated signalling
IRS-related events
IRS-related events triggered by IGF1R
MEK activation
NCAM signaling for neurite out-growth
NGF signalling via TRKA from the plasma membrane
p38MAPK events
Prolonged ERK activation events
RAF activation
RAF phosphorylates MEK
RAF/MAP kinase cascade
SHC-mediated cascade:FGFR1
SHC-mediated cascade:FGFR2
SHC-mediated cascade:FGFR3
SHC-mediated cascade:FGFR4
SHC-mediated signalling
SHC-related events
SHC-related events triggered by IGF1R
SHC1 events in EGFR signaling
SHC1 events in ERBB2 signaling
SHC1 events in ERBB4 signaling
Signaling by EGFR
Signaling by EGFR in Cancer
Signaling by EGFRvIII in Cancer
Signaling by ERBB2
Signaling by ERBB4
Signaling by FGFR
Signaling by FGFR in disease
Signaling by FGFR1
Signaling by FGFR1 in disease
Signaling by FGFR1 mutants
Signaling by FGFR2
Signaling by FGFR2 in disease
Signaling by FGFR2 mutants
Signaling by FGFR3
Signaling by FGFR3 in disease
Signaling by FGFR3 mutants
Signaling by FGFR4
Signaling by FGFR4 in disease
Signaling by FGFR4 mutants
Signaling by GPCR
Signaling by Insulin receptor
Signaling by Interleukins
Signaling by Leptin
Signaling by Ligand-Responsive EGFR Variants in Cancer
Signaling by PDGF
Signaling by SCF-KIT
Signaling by the B Cell Receptor (BCR)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Signaling by VEGF
Signalling by NGF
Signalling to ERKs
Signalling to p38 via RIT and RIN
Signalling to RAS
SOS-mediated signalling
Tie2 Signaling
VEGFA-VEGFR2 Pathway
VEGFR2 mediated cell proliferation

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
Juvenile Myelomonocytic Leukemia	0.489977336	19	3	BeFree_CLINVAR_CTD_human_GAD_LHGDN_ORPHANET_UNIPROT
GIANT PIGMENTED HAIRY NEVUS	0.360271442	3	3	BeFree_CLINVAR_ORPHANET_UNIPROT
RAS-ASSOCIATED AUTOIMMUNE LEUKOPROLIFERATIVE DISORDER	0.36	1	1	CLINVAR_ORPHANET_UNIPROT
Noonan Syndrome 6	0.36	1	5	CLINVAR_CTD_human_UNIPROT
Noonan Syndrome	0.241900093	7	0	BeFree_CTD_human_ORPHANET
NEVUS, EPIDERMAL (disorder)	0.24	3	3	CLINVAR_UNIPROT
Neurocutaneous melanosis	0.24	2	2	CLINVAR_UNIPROT
melanoma	0.235804412	215	7	BeFree_CTD_human_GAD_LHGDN
Papillary thyroid carcinoma	0.122638474	2	1	BeFree_GAD_ORPHANET
Colorectal Neoplasms	0.122367032	1	0	CTD_human_GAD

NRAS (NRAS proto-oncogene, GTPase)

基因基本信息

基因基本信息

基因染色体位置

基因染色体位置

基因简述

基因简述

基因序列

基因序列

基因突变

基因突变

基因表达

基因表达

基因引物

基因引物

转录因子

转录因子

基因本体信息

基因相关microRNA

基因相关microRNA

基因相互作用关系

基因相互作用关系

基因通路

基因通路

基因相关疾病

基因相关疾病

基因相关服务

基因相关服务

联系方式

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