NCR3 (natural cytotoxicity triggering receptor 3)
- symbol:
- NCR3
- locus group:
- protein-coding gene
- location:
- 6p21.33
- gene_family:
- CD molecules|V-set domain containing
- alias symbol:
- 1C7|NKp30|CD337
- alias name:
- None
- entrez id:
- 259197
- ensembl gene id:
- ENSG00000204475
- ucsc gene id:
- uc003nuv.3
- refseq accession:
- NM_001145466
- hgnc_id:
- HGNC:19077
- approved reserved:
- 2002-08-05
The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]
由该基因编码的蛋白质是一种天然细胞毒性受体（NCR），该可有助于NK细胞中的肿瘤细胞的裂解。所编码的蛋白质用CD3-ζ电（CD247），T细胞受体相互作用。在该基因的5‘非翻译区的单核苷酸多态性已被轻度疟疾suceptibility相关联。三个转录变异体的编码不同亚型也发现了这种基因。[由RefSeq的，2010年5月提供]
基因本体信息
NCR3基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
NCR3基因的本体（GO）信息：
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Malaria | 0.125634266 | 3 | 0 | BeFree_CTD_human_GAD_LHGDN |
| MALARIA, MILD, SUSCEPTIBILITY TO | 0.12 | 0 | 1 | CLINVAR |
| Lupus Erythematosus, Systemic | 0.007101096 | 2 | 1 | GAD |
| Spontaneous abortion | 0.005091382 | 2 | 0 | GAD_LHGDN |
| Multiple Myeloma | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Diabetes Mellitus, Insulin-Dependent | 0.002367032 | 1 | 0 | GAD |
| Proliferative vitreoretinopathy | 0.002367032 | 1 | 0 | GAD |
| Retinal Detachment | 0.002367032 | 1 | 0 | GAD |
| Obesity | 0.002367032 | 1 | 0 | GAD |
| Behcet Syndrome | 0.002367032 | 1 | 1 | GAD |
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