NCK1 (NCK adaptor protein 1)

基因基本信息

基因基本信息

symbol:
NCK1
locus group:
protein-coding gene
location:
3q22.3
gene_family:
SH2 domain containing
alias symbol:
NCKalpha
alias name:
None
entrez id:
4690
ensembl gene id:
ENSG00000158092
ucsc gene id:
uc062odz.1
refseq accession:
NM_006153
hgnc_id:
HGNC:7664
approved reserved:
1998-11-04

基因染色体位置

基因染色体位置

3q22.3
基因染色体位置图

基因简述

基因简述

NCK1（也称为NCK adaptor protein 1）是一种重要的衔接蛋白，属于NCK基因家族，该家族还包括NCK2。NCK家族成员的主要共性是作为信号转导中的关键衔接分子，通过其SH2和SH3结构域与其他蛋白质相互作用，参与调控细胞骨架重组、细胞迁移、增殖和分化等过程。NCK1广泛表达于多种组织中，尤其在发育和免疫系统中发挥重要作用。它通过结合磷酸化的酪氨酸残基（如生长因子受体或激酶）招募下游效应蛋白，激活RAS-MAPK、PAK和WASp等信号通路，从而影响肌动蛋白动力学和细胞运动。NCK1的突变或表达异常可能导致功能紊乱，例如错义突变可能破坏其与配体的结合能力，影响信号传导。研究发现NCK1与多种疾病相关，包括癌症（如乳腺癌、肺癌）、免疫缺陷和神经系统疾病。在癌症中，NCK1过表达可能促进肿瘤细胞侵袭和转移，而敲低NCK1可抑制这些表型。此外，NCK1还参与血管生成和炎症反应，其表达水平变化可能影响VEGF和趋化因子信号。在发育中，NCK1缺失会导致小鼠胚胎血管形成缺陷和神经嵴细胞迁移异常。NCK1与NCK2功能部分冗余，但组织分布和特定通路偏好存在差异。例如，NCK1在血小板中更丰富，而NCK2在神经元中作用更突出。总体而言，NCK1是细胞信号网络的核心调节者，其表达失衡可能通过干扰细胞骨架和生长信号导致病理状态，成为潜在的治疗靶点。

The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jun 2010]

由该基因编码的蛋白质是信令和含有Src同源2和3（SH2和SH3结构）域变换蛋白之一。它位于细胞质，是参与转导的受体酪氨酸激酶信号到下游信号接收者，如RAS的衔接蛋白。已发现编码不同亚型选择性剪接转录变异体。 [由RefSeq的，2010年6月提供]

OMIM数据库中对NCK1基因的介绍     Wikipedia数据库中对NCK1基因的介绍

基因序列

基因序列

NCK1基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

NCK1基因的碱基突变：           仅显示部分snp
rs938525       rs3076203       rs5852852       rs6439672       rs6777873       rs9836807       rs56050231       rs56308712       rs62410398       rs71630059       rs77618629       rs111457267       rs111530852       rs112330514       rs112373633       rs113175028       rs115751655      

基因表达

基因表达

NCK1基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
TCTCTATGACCTCAACATGCC
60
CCTAATGTAATCACACTTTGTCCC
60
TGACTTCAAGAATGAAGCCG
59
TACCACCACTTCTTCTGCC
59
GCCTTCTAACTATGTGGAAAGG
59
TTCCAATGCCTAAGGTATCCT
59
ATTATGGCAAAGTCACCAGG
58
CCTAAGCAGTATCGAAGATTCAC
59
CAAGGGCTAGGTAAGTTTGAG
59
ATGACCTTCACTGGTCTTCTG
60
GCCTTCTAACTATGTGGAAAGG
59
TTCCAATGCCTAAGGTATCCT
59
ATTATGGCAAAGTCACCAGG
58
ACTGAGAAATCATTTGGCGA
58
CAAGGGCTAGGTAAGTTTGAG
59
ATGACCTTCACTGGTCTTCTG
60
GGGAAGAGACAGTCTCACTG
59
TACCACCACTTCTTCTGCC
59
TCTATGACCTCAACATGCCC
60
CCTAATGTAATCACACTTTGTCCC
60

转录因子

转录因子

      尚未收录相关数据

基因本体信息

NCK1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

NCK1基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0005737
C9J869 (UniProtKB)
IDA
GO:0005886
C9J869 (UniProtKB)
IDA
GO:0005737
C9JVV5 (UniProtKB)
IDA
GO:0005886
C9JVV5 (UniProtKB)
IDA
GO:0000164
P16333 (UniProtKB)
IDA
GO:0004860
P16333 (UniProtKB)
IDA
GO:0005070
P16333 (UniProtKB)
NAS
GO:0005086
P16333 (UniProtKB)
IBA
GO:0005102
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005515
P16333 (UniProtKB)
IPI
GO:0005634
P16333 (UniProtKB)
IEA
GO:0005737
P16333 (UniProtKB)
IDA
GO:0005737
P16333 (UniProtKB)
NAS
GO:0005783
P16333 (UniProtKB)
IDA
GO:0005802
P16333 (UniProtKB)
IBA
GO:0005829
P16333 (UniProtKB)
TAS
GO:0005829
P16333 (UniProtKB)
TAS
GO:0005829
P16333 (UniProtKB)
TAS
GO:0005829
P16333 (UniProtKB)
TAS
GO:0005829
P16333 (UniProtKB)
TAS
GO:0005829
P16333 (UniProtKB)
TAS
GO:0005829
P16333 (UniProtKB)
TAS
GO:0005829
P16333 (UniProtKB)
TAS
GO:0005829
P16333 (UniProtKB)
TAS
GO:0005829
P16333 (UniProtKB)
TAS
GO:0005829
P16333 (UniProtKB)
TAS
GO:0005829
P16333 (UniProtKB)
TAS
GO:0005829
P16333 (UniProtKB)
TAS
GO:0005829
P16333 (UniProtKB)
TAS
GO:0005829
P16333 (UniProtKB)
TAS
GO:0005829
P16333 (UniProtKB)
TAS
GO:0005829
P16333 (UniProtKB)
TAS
GO:0005829
P16333 (UniProtKB)
TAS
GO:0005829
P16333 (UniProtKB)
TAS
GO:0005829
P16333 (UniProtKB)
TAS
GO:0005829
P16333 (UniProtKB)
TAS
GO:0005829
P16333 (UniProtKB)
TAS
GO:0005829
P16333 (UniProtKB)
TAS
GO:0005829
P16333 (UniProtKB)
TAS
GO:0005829
P16333 (UniProtKB)
TAS
GO:0005829
P16333 (UniProtKB)
TAS
GO:0005829
P16333 (UniProtKB)
TAS
GO:0005829
P16333 (UniProtKB)
TAS
GO:0005840
P16333 (UniProtKB)
IDA
GO:0005886
P16333 (UniProtKB)
IDA
GO:0005886
P16333 (UniProtKB)
TAS
GO:0005886
P16333 (UniProtKB)
TAS
GO:0005911
P16333 (UniProtKB)
IEA
GO:0006469
P16333 (UniProtKB)
IEA
GO:0006930
P16333 (UniProtKB)
IEA
GO:0007015
P16333 (UniProtKB)
IEA
GO:0007172
P16333 (UniProtKB)
NAS
GO:0008093
P16333 (UniProtKB)
NAS
GO:0012506
P16333 (UniProtKB)
IEA
GO:0016192
P16333 (UniProtKB)
IBA
GO:0019904
P16333 (UniProtKB)
IEA
GO:0030032
P16333 (UniProtKB)
IEA
GO:0030159
P16333 (UniProtKB)
NAS
GO:0030674
P16333 (UniProtKB)
IC
GO:0030838
P16333 (UniProtKB)
IMP
GO:0030971
P16333 (UniProtKB)
IPI
GO:0033137
P16333 (UniProtKB)
IDA
GO:0033137
P16333 (UniProtKB)
IDA
GO:0036493
P16333 (UniProtKB)
IDA
GO:0038096
P16333 (UniProtKB)
TAS
GO:0042102
P16333 (UniProtKB)
IMP
GO:0042110
P16333 (UniProtKB)
IMP
GO:0043547
P16333 (UniProtKB)
IEA
GO:0045944
P16333 (UniProtKB)
IDA
GO:0048010
P16333 (UniProtKB)
TAS
GO:0050852
P16333 (UniProtKB)
TAS
GO:0051707
P16333 (UniProtKB)
IEA
GO:0060548
P16333 (UniProtKB)
IDA
GO:0070262
P16333 (UniProtKB)
IDA
GO:0071074
P16333 (UniProtKB)
IPI
GO:0071074
P16333 (UniProtKB)
IPI
GO:1902237
P16333 (UniProtKB)
IDA
GO:1903676
P16333 (UniProtKB)
IDA
GO:1903679
P16333 (UniProtKB)
IDA
GO:1903898
P16333 (UniProtKB)
IDA
GO:1903912
P16333 (UniProtKB)
IDA
GO:1903912
P16333 (UniProtKB)
IDA
GO:1990441
P16333 (UniProtKB)
IDA

基因相关microRNA

基因相关microRNA

可能调控 NCK1基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Albuminuria 0.12 1 0 CTD_human
Proteinuria 0.12 1 0 CTD_human
Nephrotic Syndrome 0.12 1 0 CTD_human
Wiskott-Aldrich Syndrome 0.00272435 1 0 LHGDN
Liver carcinoma 0.000814326 3 0 BeFree
Diabetic Nephropathy 0.000271442 1 0 BeFree
Kidney Diseases 0.000271442 1 0 BeFree
Metastatic melanoma 0.000271442 1 0 BeFree
Obesity 0.000271442 1 0 BeFree
Hyperglycemia 0.000271442 1 0 BeFree

基因相关服务

基因相关服务

联系方式

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