MTOR (mechanistic target of rapamycin kinase)
- symbol:
- MTOR
- locus group:
- protein-coding gene
- location:
- 1p36.22
- gene_family:
- alias symbol:
- RAFT1|RAPT1|FLJ44809
- alias name:
- FK506 binding protein 12-rapamycin…
- entrez id:
- 2475
- ensembl gene id:
- ENSG00000198793
- ucsc gene id:
- uc001asd.4
- refseq accession:
- NM_004958
- hgnc_id:
- HGNC:3942
- approved reserved:
- 1995-07-18
MTOR（哺乳动物雷帕霉素靶蛋白）基因编码一种丝氨酸/苏氨酸蛋白激酶，属于PI3K相关激酶（PIKK）家族，在细胞生长、增殖、代谢和自噬等关键生物学过程中发挥核心调控作用。MTOR蛋白可形成两种不同的复合物：MTORC1和MTORC2。MTORC1主要响应营养、能量和生长因子信号，通过磷酸化下游靶点如S6K1和4E-BP1来促进蛋白质合成、脂质合成及抑制自噬；而MTORC2则参与细胞骨架重组和存活信号传导，通过激活AKT等分子影响胰岛素信号通路。该基因突变可能导致功能异常，与多种疾病密切相关：激活突变常见于癌症（如肾细胞癌、乳腺癌），因其持续促进细胞增殖；而失活突变则可能引发神经发育障碍或代谢性疾病。MTOR基因过表达会增强细胞增殖和存活能力，但可能导致肿瘤发生或胰岛素抵抗；表达降低则可能诱发自噬过度或细胞生长停滞。该基因属于PIKK家族，该家族成员均具有激酶活性并参与DNA损伤修复、代谢调控等保守功能。雷帕霉素等MTOR抑制剂已被开发为抗癌和免疫抑制药物，但需注意长期抑制可能引发代谢副作用。由于MTOR通路整合多种环境信号，其功能研究对理解衰老、癌症和代谢综合征等复杂生理病理过程具有重要意义。
The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008]
由该基因编码的蛋白质属于家庭磷脂激酶相关的激酶。这些激酶介导如DNA损伤和营养剥夺应力细胞反应。该蛋白质作为靶的细胞周期停滞和FKBP12雷帕霉素复合物的免疫抑制作用。该ANGPTL7基因位于该基因的内含子。 [由RefSeq的，2008年9月提供]
正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
AGATAAGCTCACTGGTCGG
59
TCGCTTGTTTGATGAGCAG
59
AGATAAGCTCACTGGTCGG
59
TCGCTTGTTTGATGAGCAG
59
CCGAAGAACCAATTATACCCG
59
GATGGGTGTCTATCTCCCAG
59
TGCCTTCACAGATACCCAG
59
GCTGTACGTTCCTTCTCCT
59
CACAAGGACAGTGTCATGG
59
TTGGTATTTGTGTCCATCAGC
59
GTATCGTAGAGGACTGGCA
58
TTTATGAGCAAGAGCCAGC
58
GTATCGTAGAGGACTGGCA
58
TTTATGAGCAAGAGCCAGC
58
ATGCTATGGAGGTTACAGGC
60
ACACTGTCCTTGTGCTCTC
60
CAACAGTTCACCCTCAGGT
60
CAAGTTTCAGGAAGCATCGG
60
GAGATAAGCTCACTGGTCG
58
CTTGTTTGATGAGCAGCTC
57
基因本体信息
MTOR基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
MTOR基因的本体（GO）信息：
GO库代码
对应的蛋白质
来源代码
GO:0004674
B1AKP8 (UniProtKB)
IEA
GO:0005524
B1AKP8 (UniProtKB)
IEA
GO:0006468
B1AKP8 (UniProtKB)
IEA
GO:0044877
B1AKP8 (UniProtKB)
IEA
GO:0004674
B1AKQ2 (UniProtKB)
IEA
GO:0006468
B1AKQ2 (UniProtKB)
IEA
GO:0000139
P42345 (UniProtKB)
IEA
GO:0001030
P42345 (UniProtKB)
IDA
GO:0001031
P42345 (UniProtKB)
IDA
GO:0001032
P42345 (UniProtKB)
IDA
GO:0001156
P42345 (UniProtKB)
IDA
GO:0001933
P42345 (UniProtKB)
IEA
GO:0001934
P42345 (UniProtKB)
IDA
GO:0001938
P42345 (UniProtKB)
IEA
GO:0003007
P42345 (UniProtKB)
IEA
GO:0003179
P42345 (UniProtKB)
IEA
GO:0004672
P42345 (UniProtKB)
IDA
GO:0004674
P42345 (UniProtKB)
IDA
GO:0004674
P42345 (UniProtKB)
EXP
GO:0004674
P42345 (UniProtKB)
TAS
GO:0004674
P42345 (UniProtKB)
TAS
GO:0004674
P42345 (UniProtKB)
TAS
GO:0004674
P42345 (UniProtKB)
TAS
GO:0004674
P42345 (UniProtKB)
TAS
GO:0005515
P42345 (UniProtKB)
IPI
GO:0005515
P42345 (UniProtKB)
IPI
GO:0005515
P42345 (UniProtKB)
IPI
GO:0005515
P42345 (UniProtKB)
IPI
GO:0005515
P42345 (UniProtKB)
IPI
GO:0005515
P42345 (UniProtKB)
IPI
GO:0005515
P42345 (UniProtKB)
IPI
GO:0005515
P42345 (UniProtKB)
IPI
GO:0005515
P42345 (UniProtKB)
IPI
GO:0005515
P42345 (UniProtKB)
IPI
GO:0005515
P42345 (UniProtKB)
IPI
GO:0005515
P42345 (UniProtKB)
IPI
GO:0005515
P42345 (UniProtKB)
IPI
GO:0005515
P42345 (UniProtKB)
IPI
GO:0005515
P42345 (UniProtKB)
IPI
GO:0005515
P42345 (UniProtKB)
IPI
GO:0005515
P42345 (UniProtKB)
IPI
GO:0005515
P42345 (UniProtKB)
IPI
GO:0005515
P42345 (UniProtKB)
IPI
GO:0005515
P42345 (UniProtKB)
IPI
GO:0005515
P42345 (UniProtKB)
IPI
GO:0005515
P42345 (UniProtKB)
IPI
GO:0005515
P42345 (UniProtKB)
IPI
GO:0005515
P42345 (UniProtKB)
IPI
GO:0005515
P42345 (UniProtKB)
IPI
GO:0005515
P42345 (UniProtKB)
IPI
GO:0005515
P42345 (UniProtKB)
IPI
GO:0005515
P42345 (UniProtKB)
IPI
GO:0005515
P42345 (UniProtKB)
IPI
GO:0005515
P42345 (UniProtKB)
IPI
GO:0005515
P42345 (UniProtKB)
IPI
GO:0005515
P42345 (UniProtKB)
IPI
GO:0005515
P42345 (UniProtKB)
IPI
GO:0005515
P42345 (UniProtKB)
IPI
GO:0005515
P42345 (UniProtKB)
IPI
GO:0005515
P42345 (UniProtKB)
IPI
GO:0005515
P42345 (UniProtKB)
IPI
GO:0005515
P42345 (UniProtKB)
IPI
GO:0005515
P42345 (UniProtKB)
IPI
GO:0005515
P42345 (UniProtKB)
IPI
GO:0005515
P42345 (UniProtKB)
IPI
GO:0005515
P42345 (UniProtKB)
IPI
GO:0005515
P42345 (UniProtKB)
IPI
GO:0005515
P42345 (UniProtKB)
IPI
GO:0005515
P42345 (UniProtKB)
IPI
GO:0005515
P42345 (UniProtKB)
IPI
GO:0005515
P42345 (UniProtKB)
IPI
GO:0005524
P42345 (UniProtKB)
IEA
GO:0005634
P42345 (UniProtKB)
IBA
GO:0005654
P42345 (UniProtKB)
TAS
GO:0005737
P42345 (UniProtKB)
IDA
GO:0005737
P42345 (UniProtKB)
IDA
GO:0005741
P42345 (UniProtKB)
IEA
GO:0005764
P42345 (UniProtKB)
IDA
GO:0005764
P42345 (UniProtKB)
IDA
GO:0005765
P42345 (UniProtKB)
IDA
GO:0005789
P42345 (UniProtKB)
IEA
GO:0005829
P42345 (UniProtKB)
TAS
GO:0005829
P42345 (UniProtKB)
TAS
GO:0005829
P42345 (UniProtKB)
TAS
GO:0005829
P42345 (UniProtKB)
TAS
GO:0005829
P42345 (UniProtKB)
TAS
GO:0005829
P42345 (UniProtKB)
TAS
GO:0005829
P42345 (UniProtKB)
TAS
GO:0005829
P42345 (UniProtKB)
TAS
GO:0005829
P42345 (UniProtKB)
TAS
GO:0005829
P42345 (UniProtKB)
TAS
GO:0005829
P42345 (UniProtKB)
TAS
GO:0005829
P42345 (UniProtKB)
TAS
GO:0005829
P42345 (UniProtKB)
TAS
GO:0005829
P42345 (UniProtKB)
TAS
GO:0005829
P42345 (UniProtKB)
TAS
GO:0005829
P42345 (UniProtKB)
TAS
GO:0005829
P42345 (UniProtKB)
TAS
GO:0005829
P42345 (UniProtKB)
TAS
GO:0005942
P42345 (UniProtKB)
NAS
GO:0005979
P42345 (UniProtKB)
IEA
GO:0006112
P42345 (UniProtKB)
IEA
GO:0006207
P42345 (UniProtKB)
IEA
GO:0006281
P42345 (UniProtKB)
IBA
GO:0006468
P42345 (UniProtKB)
IDA
GO:0006468
P42345 (UniProtKB)
IDA
GO:0006468
P42345 (UniProtKB)
IMP
GO:0006468
P42345 (UniProtKB)
IDA
GO:0006950
P42345 (UniProtKB)
IMP
GO:0007050
P42345 (UniProtKB)
TAS
GO:0007165
P42345 (UniProtKB)
NAS
GO:0007281
P42345 (UniProtKB)
IEA
GO:0007420
P42345 (UniProtKB)
IEA
GO:0007569
P42345 (UniProtKB)
IEA
GO:0007584
P42345 (UniProtKB)
NAS
GO:0007616
P42345 (UniProtKB)
IEA
GO:0008542
P42345 (UniProtKB)
IEA
GO:0009791
P42345 (UniProtKB)
IEA
GO:0010507
P42345 (UniProtKB)
ISS
GO:0010592
P42345 (UniProtKB)
IEA
GO:0010628
P42345 (UniProtKB)
IMP
GO:0010831
P42345 (UniProtKB)
IEA
GO:0012505
P42345 (UniProtKB)
IDA
GO:0014042
P42345 (UniProtKB)
IEA
GO:0014736
P42345 (UniProtKB)
IEA
GO:0016020
P42345 (UniProtKB)
IDA
GO:0016020
P42345 (UniProtKB)
IDA
GO:0016049
P42345 (UniProtKB)
TAS
GO:0016049
P42345 (UniProtKB)
IDA
GO:0016236
P42345 (UniProtKB)
TAS
GO:0016242
P42345 (UniProtKB)
IEA
GO:0016301
P42345 (UniProtKB)
TAS
GO:0016301
P42345 (UniProtKB)
IDA
GO:0016301
P42345 (UniProtKB)
TAS
GO:0016301
P42345 (UniProtKB)
TAS
GO:0016310
P42345 (UniProtKB)
IDA
GO:0018105
P42345 (UniProtKB)
IMP
GO:0018105
P42345 (UniProtKB)
IMP
GO:0018107
P42345 (UniProtKB)
IEA
GO:0019901
P42345 (UniProtKB)
IEA
GO:0019904
P42345 (UniProtKB)
IEA
GO:0021510
P42345 (UniProtKB)
IEA
GO:0030163
P42345 (UniProtKB)
TAS
GO:0030425
P42345 (UniProtKB)
IEA
GO:0030425
P42345 (UniProtKB)
IEA
GO:0030838
P42345 (UniProtKB)
IEA
GO:0031295
P42345 (UniProtKB)
TAS
GO:0031397
P42345 (UniProtKB)
IEA
GO:0031529
P42345 (UniProtKB)
IEA
GO:0031641
P42345 (UniProtKB)
IEA
GO:0031669
P42345 (UniProtKB)
ISS
GO:0031929
P42345 (UniProtKB)
IMP
GO:0031929
P42345 (UniProtKB)
IMP
GO:0031929
P42345 (UniProtKB)
IMP
GO:0031931
P42345 (UniProtKB)
IDA
GO:0031931
P42345 (UniProtKB)
IDA
GO:0031931
P42345 (UniProtKB)
IDA
GO:0031931
P42345 (UniProtKB)
IMP
GO:0031932
P42345 (UniProtKB)
IDA
GO:0031932
P42345 (UniProtKB)
IDA
GO:0031998
P42345 (UniProtKB)
IEA
GO:0032095
P42345 (UniProtKB)
IEA
GO:0032868
P42345 (UniProtKB)
IEA
GO:0032956
P42345 (UniProtKB)
IMP
GO:0035176
P42345 (UniProtKB)
IEA
GO:0035264
P42345 (UniProtKB)
IEA
GO:0040007
P42345 (UniProtKB)
NAS
GO:0042060
P42345 (UniProtKB)
IEA
GO:0042220
P42345 (UniProtKB)
IEA
GO:0043022
P42345 (UniProtKB)
IEA
GO:0043025
P42345 (UniProtKB)
IEA
GO:0043087
P42345 (UniProtKB)
IEA
GO:0043200
P42345 (UniProtKB)
IDA
GO:0043278
P42345 (UniProtKB)
IEA
GO:0043610
P42345 (UniProtKB)
IEA
GO:0045429
P42345 (UniProtKB)
IEA
GO:0045670
P42345 (UniProtKB)
ISS
GO:0045727
P42345 (UniProtKB)
IDA
GO:0045792
P42345 (UniProtKB)
IEA
GO:0045792
P42345 (UniProtKB)
IEA
GO:0045859
P42345 (UniProtKB)
IEA
GO:0045945
P42345 (UniProtKB)
IMP
GO:0046777
P42345 (UniProtKB)
IDA
GO:0046889
P42345 (UniProtKB)
IMP
GO:0048015
P42345 (UniProtKB)
TAS
GO:0048255
P42345 (UniProtKB)
IEA
GO:0048661
P42345 (UniProtKB)
IEA
GO:0048714
P42345 (UniProtKB)
IEA
GO:0048714
P42345 (UniProtKB)
IEA
GO:0050731
P42345 (UniProtKB)
IEA
GO:0050882
P42345 (UniProtKB)
IEA
GO:0051219
P42345 (UniProtKB)
IPI
GO:0051496
P42345 (UniProtKB)
IEA
GO:0051534
P42345 (UniProtKB)
IEA
GO:0051897
P42345 (UniProtKB)
IEA
GO:0055013
P42345 (UniProtKB)
IEA
GO:0060048
P42345 (UniProtKB)
IEA
GO:0060135
P42345 (UniProtKB)
IEA
GO:0060252
P42345 (UniProtKB)
IEA
GO:0060999
P42345 (UniProtKB)
IEA
GO:0061051
P42345 (UniProtKB)
IEA
GO:0071456
P42345 (UniProtKB)
ISS
GO:0090335
P42345 (UniProtKB)
IEA
GO:0090559
P42345 (UniProtKB)
IEA
GO:1900034
P42345 (UniProtKB)
TAS
GO:1901216
P42345 (UniProtKB)
IEA
GO:1901838
P42345 (UniProtKB)
IMP
GO:1904000
P42345 (UniProtKB)
IEA
GO:1904056
P42345 (UniProtKB)
IEA
GO:1904058
P42345 (UniProtKB)
IEA
GO:1904193
P42345 (UniProtKB)
IEA
GO:1904197
P42345 (UniProtKB)
IEA
GO:1904206
P42345 (UniProtKB)
IEA
GO:1904213
P42345 (UniProtKB)
IEA
GO:0016605
P42345 (UniProtKB)
ISS
| 名称 |
|---|
| 4012 ErbB signaling pathway [PATH:hsa04012] |
| 4066 HIF-1 signaling pathway [PATH:hsa04066] |
| 4151 PI3K-Akt signaling pathway [PATH:hsa04151] |
| 4152 AMPK signaling pathway [PATH:hsa04152] |
| 4150 mTOR signaling pathway [PATH:hsa04150] |
| 4910 Insulin signaling pathway [PATH:hsa04910] |
| 4920 Adipocytokine signaling pathway [PATH:hsa04920] |
| 4919 Thyroid hormone signaling pathway [PATH:hsa04919] |
| 5200 Pathways in cancer [PATH:hsa05200] |
| 5230 Central carbon metabolism in cancer [PATH:hsa05230] |
| 5231 Choline metabolism in cancer [PATH:hsa05231] |
| 5206 MicroRNAs in cancer [PATH:hsa05206] |
| 5205 Proteoglycans in cancer [PATH:hsa05205] |
| 5214 Glioma [PATH:hsa05214] |
| 5221 Acute myeloid leukemia [PATH:hsa05221] |
| 5215 Prostate cancer [PATH:hsa05215] |
| 4930 Type II diabetes mellitus [PATH:hsa04930] |
| 名称 |
|---|
| Adaptive Immune System |
| CD28 co-stimulation |
| CD28 dependent PI3K/Akt signaling |
| Cellular response to heat stress |
| Cellular responses to stress |
| Constitutive Signaling by AKT1 E17K in Cancer |
| Costimulation by the CD28 family |
| DAP12 interactions |
| DAP12 signaling |
| Disease |
| Diseases of signal transduction |
| Downstream signal transduction |
| Downstream signaling events of B Cell Receptor (BCR) |
| Downstream signaling of activated FGFR1 |
| Downstream signaling of activated FGFR2 |
| Downstream signaling of activated FGFR3 |
| Downstream signaling of activated FGFR4 |
| Energy dependent regulation of mTOR by LKB1-AMPK |
| Fc epsilon receptor (FCERI) signaling |
| GAB1 signalosome |
| Gene Expression |
| Generic Transcription Pathway |
| HSF1-dependent transactivation |
| IGF1R signaling cascade |
| Immune System |
| Innate Immune System |
| Insulin receptor signalling cascade |
| IRS-mediated signalling |
| IRS-related events |
| IRS-related events triggered by IGF1R |
| mTOR signalling |
| mTORC1-mediated signalling |
| NGF signalling via TRKA from the plasma membrane |
| PI-3K cascade:FGFR1 |
| PI-3K cascade:FGFR2 |
| PI-3K cascade:FGFR3 |
| PI-3K cascade:FGFR4 |
| PI3K Cascade |
| PI3K events in ERBB2 signaling |
| PI3K events in ERBB4 signaling |
| PI3K/AKT activation |
| PI3K/AKT Signaling in Cancer |
| PIP3 activates AKT signaling |
| PKB-mediated events |
| Regulation of AMPK activity via LKB1 |
| Regulation of Rheb GTPase activity by AMPK |
| Release of eIF4E |
| Role of LAT2/NTAL/LAB on calcium mobilization |
| S6K1-mediated signalling |
| Signaling by EGFR |
| Signaling by ERBB2 |
| Signaling by ERBB4 |
| Signaling by FGFR |
| Signaling by FGFR1 |
| Signaling by FGFR2 |
| Signaling by FGFR3 |
| Signaling by FGFR4 |
| Signaling by Insulin receptor |
| Signaling by PDGF |
| Signaling by SCF-KIT |
| Signaling by the B Cell Receptor (BCR) |
| Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) |
| Signaling by VEGF |
| Signalling by NGF |
| TP53 Regulates Metabolic Genes |
| Transcriptional Regulation by TP53 |
| VEGFA-VEGFR2 Pathway |
| VEGFR2 mediated vascular permeability |
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Schizophrenia | 0.2 | 2 | 0 | CTD_human_RGD |
| Left Ventricular Hypertrophy | 0.2 | 2 | 0 | CTD_human_RGD |
| Hypertensive disease | 0.2 | 2 | 0 | CTD_human_RGD |
| Liver carcinoma | 0.130606096 | 22 | 0 | BeFree_CTD_human_LHGDN |
| Renal Cell Carcinoma | 0.129781839 | 27 | 0 | BeFree_CTD_human_LHGDN |
| ovarian neoplasm | 0.1254487 | 3 | 0 | CTD_human_LHGDN |
| Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | 0.124895885 | 8 | 0 | BeFree_CTD_human_LHGDN |
| Adenocarcinoma | 0.123538676 | 5 | 0 | BeFree_CTD_human_LHGDN |
| Mesothelioma | 0.122995792 | 2 | 0 | BeFree_CTD_human_LHGDN |
| Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | 0.120814326 | 4 | 0 | BeFree_CTD_human |
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