MET (MET proto-oncogene, receptor tyrosine kinase)

基因基本信息

基因基本信息

symbol:
MET
locus group:
protein-coding gene
location:
7q31
gene_family:
Receptor Tyrosine Kinases
alias symbol:
HGFR|RCCP2|DFNB97
alias name:
hepatocyte growth factor receptor
entrez id:
4233
ensembl gene id:
ENSG00000105976
ucsc gene id:
uc003vij.4
refseq accession:
NM_000245
hgnc_id:
HGNC:7029
approved reserved:
1986-01-01

基因染色体位置

基因染色体位置

7q31
基因染色体位置图

基因简述

基因简述

MET基因编码肝细胞生长因子受体（HGFR），是一种受体酪氨酸激酶，属于RTK（受体酪氨酸激酶）基因家族。该基因在胚胎发育、组织修复和伤口愈合中起关键作用，主要通过与配体肝细胞生长因子（HGF）结合激活下游信号通路（如RAS-MAPK、PI3K-AKT），调控细胞增殖、迁移和存活。MET在肝脏、肾脏和肌肉等组织中高表达，其功能异常与多种癌症密切相关，如肝癌、胃癌和肺癌。MET突变（如外显子14跳跃突变）会导致受体持续激活，促进肿瘤生长和转移；而基因扩增则引发过表达，增强侵袭性。降低MET表达会抑制肿瘤进展，但可能影响正常组织修复。MET属于MET原癌基因家族，该家族成员均具有酪氨酸激酶活性，参与细胞信号转导和生长调控。靶向MET的药物（如克唑替尼）已用于治疗携带MET异常的癌症。

The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

原癌基因MET产品是肝细胞生长因子受体和编码酪氨酸激酶的活性。主单链前体蛋白质是翻译后切割产生的α和β亚基，它是二硫键连接以形成成熟受体。在MET基因的各种突变与乳头状肾癌有关。已发现该基因编码不同亚型的两个转录变异体。 [由RefSeq的，2008年7月提供]

OMIM数据库中对MET基因的介绍     Wikipedia数据库中对MET基因的介绍

基因序列

基因序列

MET基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

MET基因的碱基突变：           仅显示部分snp
rs1621       rs6566       rs14456       rs16945       rs28841       rs38839       rs38840       rs38841       rs38842       rs38843       rs38844       rs38845       rs38846       rs38847       rs38848       rs38849       rs38850      

基因表达

基因表达

MET基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
FOXP2
MET
Repression
21832174
HIF1A
MET
Activation
16099863
MITF
MET
Unknown
17371876
PAX3
MET
Unknown
8633043
PAX5
MET
Activation
24628993
PAX5
MET
Unknown
19139719
PAX6
MET
Activation
19651775
SMAD7
MET
Activation
15339794
SP1
MET
Activation
11910354; 21831840
SP1
MET
Repression
21831840

基因本体信息

MET基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

MET基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0017154
C9JKM5 (UniProtKB)
IEA
GO:0071526
C9JKM5 (UniProtKB)
IEA
GO:0016021
H7C130 (UniProtKB)
IEA
GO:0001886
P08581 (UniProtKB)
IDA
GO:0004713
P08581 (UniProtKB)
NAS
GO:0004713
P08581 (UniProtKB)
TAS
GO:0005008
P08581 (UniProtKB)
TAS
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005515
P08581 (UniProtKB)
IPI
GO:0005524
P08581 (UniProtKB)
IEA
GO:0005576
P08581 (UniProtKB)
IEA
GO:0005886
P08581 (UniProtKB)
TAS
GO:0005886
P08581 (UniProtKB)
TAS
GO:0005886
P08581 (UniProtKB)
TAS
GO:0005886
P08581 (UniProtKB)
TAS
GO:0005886
P08581 (UniProtKB)
TAS
GO:0005886
P08581 (UniProtKB)
TAS
GO:0005887
P08581 (UniProtKB)
TAS
GO:0007165
P08581 (UniProtKB)
TAS
GO:0007166
P08581 (UniProtKB)
NAS
GO:0008283
P08581 (UniProtKB)
TAS
GO:0009925
P08581 (UniProtKB)
IDA
GO:0009986
P08581 (UniProtKB)
IDA
GO:0010507
P08581 (UniProtKB)
NAS
GO:0016021
P08581 (UniProtKB)
NAS
GO:0018108
P08581 (UniProtKB)
IEA
GO:0018108
P08581 (UniProtKB)
IEA
GO:0019903
P08581 (UniProtKB)
IPI
GO:0019903
P08581 (UniProtKB)
IPI
GO:0045944
P08581 (UniProtKB)
IDA
GO:0048012
P08581 (UniProtKB)
IEA
GO:0048754
P08581 (UniProtKB)
IMP
GO:0050918
P08581 (UniProtKB)
IDA
GO:0071526
P08581 (UniProtKB)
IDA
GO:1901299
P08581 (UniProtKB)
IMP
GO:2001028
P08581 (UniProtKB)
IMP

基因相关microRNA

基因相关microRNA

可能调控 MET基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Liver carcinoma 0.339583541 36 0 BeFree_CTD_human_LHGDN_RGD_UNIPROT
Renal Cell Carcinoma 0.253320515 32 7 BeFree_CLINVAR_CTD_human_LHGDN
Neoplasm Metastasis 0.149616959 82 0 BeFree_CTD_human_LHGDN
Adenocarcinoma 0.147495081 29 0 BeFree_CTD_human_LHGDN
Non-Small Cell Lung Carcinoma 0.141443908 83 1 BeFree_CTD_human
Autistic Disorder 0.140726728 16 1 BeFree_CTD_human_GAD_LHGDN
Lung Neoplasms 0.137974753 13 1 BeFree_CTD_human_LHGDN
Squamous cell carcinoma 0.128977445 15 2 BeFree_CTD_human_LHGDN
Glioblastoma 0.128967513 25 0 BeFree_CTD_human_LHGDN
Osteosarcoma 0.127891677 12 0 BeFree_CTD_human_LHGDN

基因相关服务

基因相关服务

联系方式

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