MAVS (mitochondrial antiviral signaling protein)

基因基本信息

基因基本信息

symbol:
MAVS
locus group:
protein-coding gene
location:
20p13
gene_family:
alias symbol:
VISA|KIAA1271|IPS-1|Cardif
alias name:
virus-induced signaling adaptor|IF…
entrez id:
57506
ensembl gene id:
ENSG00000088888
ucsc gene id:
uc002wjw.5
refseq accession:
NM_020746
hgnc_id:
HGNC:29233
approved reserved:
2009-04-01

基因染色体位置

基因染色体位置

20p13
基因染色体位置图

基因简述

基因简述

MAVS（线粒体抗病毒信号蛋白，Mitochondrial Antiviral Signaling Protein）是一种在先天免疫系统中起关键作用的基因，主要参与识别病毒RNA并激活抗病毒免疫反应。MAVS位于线粒体外膜，是RIG-I样受体（RLRs）信号通路的核心接头蛋白。当RIG-I或MDA5检测到病毒RNA时，会与MAVS相互作用，触发MAVS形成多聚体，进而激活下游的NF-κB和IRF3信号通路，诱导I型干扰素（如IFN-α/β）和促炎细胞因子的产生，从而启动抗病毒免疫应答。MAVS的功能特点包括其线粒体定位对信号传导至关重要，因为线粒体的膜结构为MAVS多聚化提供了平台。MAVS属于线粒体抗病毒信号蛋白家族，该家族成员通常参与连接病毒识别与免疫应答的激活。MAVS的突变可能导致其功能丧失，使机体对RNA病毒的易感性增加，例如丙型肝炎病毒（HCV）或登革热病毒。某些突变与自身免疫性疾病或慢性炎症相关，因为MAVS信号过度激活可能引发不受控制的炎症反应。MAVS过表达会增强抗病毒反应，可能导致过度炎症或自身免疫疾病；而降低表达或缺失则削弱免疫应答，增加病毒感染风险。此外，MAVS还与其他免疫相关基因（如TRAF6、TBK1）相互作用，协调免疫信号的传递。研究表明，MAVS在癌症免疫中也发挥作用，其异常表达可能影响肿瘤微环境。总之，MAVS是先天免疫的关键调节因子，其功能平衡对维持有效的抗病毒防御和避免免疫病理损伤至关重要。

This gene encodes an intermediary protein necessary in the virus-triggered beta interferon signaling pathways. It is required for activation of transcription factors which regulate expression of beta interferon and contributes to antiviral immunity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

该基因编码必要的病毒引发的β干扰素信号传导途径的中介蛋白。它需要的从而调节β干扰素的表达，并有助于抗病毒免疫的转录因子的活化。已发现该基因编码不同亚型的多个抄本变形。 [由RefSeq的，2011年9月提供]

OMIM数据库中对MAVS基因的介绍     Wikipedia数据库中对MAVS基因的介绍

基因序列

基因序列

MAVS基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

MAVS基因的碱基突变：           仅显示部分snp
rs2464       rs14161       rs15851       rs709021       rs709022       rs867335       rs914294       rs1060127       rs1060128       rs1132922       rs1137153       rs1137154       rs1137168       rs1137174       rs2274826       rs2326369       rs3746660      

基因表达

基因表达

MAVS基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
CAGCAGAAATGAGGAGACC
58
CCTATTCTCAGAGCTGCTG
57
AAGAGACCAGGATCGACTG
59
CGCTGAAGGGTATTGAAGAG
59
GCAGCAGAAATGAGGAGAC
59
CTATTCTCAGAGCTGCTGTC
58
AAGAGACCAGGATCGACTG
59
CTGAAGGGTATTGAAGAGATGC
59
CAGCAGAAATGAGGAGACC
58
CTATTCTCAGAGCTGCTGTC
58
AAGAGACCAGGATCGACTG
59
TGAAGGGTATTGAAGAGATGC
58

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
IRF3
MAVS
Activation
18207245

基因本体信息

MAVS基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

MAVS基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0001934
Q7Z434 (UniProtKB)
IDA
GO:0002218
Q7Z434 (UniProtKB)
IMP
GO:0002230
Q7Z434 (UniProtKB)
IDA
GO:0002230
Q7Z434 (UniProtKB)
IMP
GO:0004871
Q7Z434 (UniProtKB)
IMP
GO:0004871
Q7Z434 (UniProtKB)
IMP
GO:0005515
Q7Z434 (UniProtKB)
IPI
GO:0005515
Q7Z434 (UniProtKB)
IPI
GO:0005515
Q7Z434 (UniProtKB)
IPI
GO:0005515
Q7Z434 (UniProtKB)
IPI
GO:0005515
Q7Z434 (UniProtKB)
IPI
GO:0005515
Q7Z434 (UniProtKB)
IPI
GO:0005515
Q7Z434 (UniProtKB)
IPI
GO:0005515
Q7Z434 (UniProtKB)
IPI
GO:0005515
Q7Z434 (UniProtKB)
IPI
GO:0005515
Q7Z434 (UniProtKB)
IPI
GO:0005515
Q7Z434 (UniProtKB)
IPI
GO:0005515
Q7Z434 (UniProtKB)
IPI
GO:0005515
Q7Z434 (UniProtKB)
IPI
GO:0005515
Q7Z434 (UniProtKB)
IPI
GO:0005515
Q7Z434 (UniProtKB)
IPI
GO:0005515
Q7Z434 (UniProtKB)
IPI
GO:0005515
Q7Z434 (UniProtKB)
IPI
GO:0005515
Q7Z434 (UniProtKB)
IPI
GO:0005515
Q7Z434 (UniProtKB)
IPI
GO:0005515
Q7Z434 (UniProtKB)
IPI
GO:0005515
Q7Z434 (UniProtKB)
IPI
GO:0005515
Q7Z434 (UniProtKB)
IPI
GO:0005515
Q7Z434 (UniProtKB)
IPI
GO:0005515
Q7Z434 (UniProtKB)
IPI
GO:0005515
Q7Z434 (UniProtKB)
IPI
GO:0005515
Q7Z434 (UniProtKB)
IPI
GO:0005515
Q7Z434 (UniProtKB)
IPI
GO:0005515
Q7Z434 (UniProtKB)
IPI
GO:0005515
Q7Z434 (UniProtKB)
IPI
GO:0005515
Q7Z434 (UniProtKB)
IPI
GO:0005515
Q7Z434 (UniProtKB)
IPI
GO:0005515
Q7Z434 (UniProtKB)
IPI
GO:0005515
Q7Z434 (UniProtKB)
IPI
GO:0005515
Q7Z434 (UniProtKB)
IPI
GO:0005515
Q7Z434 (UniProtKB)
IPI
GO:0005515
Q7Z434 (UniProtKB)
IPI
GO:0005515
Q7Z434 (UniProtKB)
IPI
GO:0005515
Q7Z434 (UniProtKB)
IPI
GO:0005515
Q7Z434 (UniProtKB)
IPI
GO:0005515
Q7Z434 (UniProtKB)
IPI
GO:0005515
Q7Z434 (UniProtKB)
IPI
GO:0005515
Q7Z434 (UniProtKB)
IPI
GO:0005515
Q7Z434 (UniProtKB)
IPI
GO:0005515
Q7Z434 (UniProtKB)
IPI
GO:0005515
Q7Z434 (UniProtKB)
IPI
GO:0005515
Q7Z434 (UniProtKB)
IPI
GO:0005515
Q7Z434 (UniProtKB)
IPI
GO:0005515
Q7Z434 (UniProtKB)
IPI
GO:0005515
Q7Z434 (UniProtKB)
IPI
GO:0005515
Q7Z434 (UniProtKB)
IPI
GO:0005515
Q7Z434 (UniProtKB)
IPI
GO:0005515
Q7Z434 (UniProtKB)
IPI
GO:0005739
Q7Z434 (UniProtKB)
IDA
GO:0005741
Q7Z434 (UniProtKB)
IDA
GO:0005741
Q7Z434 (UniProtKB)
TAS
GO:0005741
Q7Z434 (UniProtKB)
TAS
GO:0005741
Q7Z434 (UniProtKB)
TAS
GO:0005741
Q7Z434 (UniProtKB)
TAS
GO:0005741
Q7Z434 (UniProtKB)
TAS
GO:0005741
Q7Z434 (UniProtKB)
TAS
GO:0005741
Q7Z434 (UniProtKB)
TAS
GO:0005741
Q7Z434 (UniProtKB)
TAS
GO:0005741
Q7Z434 (UniProtKB)
TAS
GO:0005741
Q7Z434 (UniProtKB)
TAS
GO:0005741
Q7Z434 (UniProtKB)
TAS
GO:0005741
Q7Z434 (UniProtKB)
TAS
GO:0005741
Q7Z434 (UniProtKB)
TAS
GO:0005741
Q7Z434 (UniProtKB)
TAS
GO:0005741
Q7Z434 (UniProtKB)
TAS
GO:0005741
Q7Z434 (UniProtKB)
TAS
GO:0005741
Q7Z434 (UniProtKB)
TAS
GO:0005741
Q7Z434 (UniProtKB)
TAS
GO:0005741
Q7Z434 (UniProtKB)
TAS
GO:0005741
Q7Z434 (UniProtKB)
TAS
GO:0005741
Q7Z434 (UniProtKB)
TAS
GO:0005778
Q7Z434 (UniProtKB)
IDA
GO:0007165
Q7Z434 (UniProtKB)
IMP
GO:0016021
Q7Z434 (UniProtKB)
IEA
GO:0016032
Q7Z434 (UniProtKB)
IEA
GO:0019901
Q7Z434 (UniProtKB)
IPI
GO:0031966
Q7Z434 (UniProtKB)
IDA
GO:0032480
Q7Z434 (UniProtKB)
TAS
GO:0032727
Q7Z434 (UniProtKB)
IDA
GO:0032727
Q7Z434 (UniProtKB)
IMP
GO:0032728
Q7Z434 (UniProtKB)
IDA
GO:0032728
Q7Z434 (UniProtKB)
IMP
GO:0032728
Q7Z434 (UniProtKB)
IMP
GO:0032757
Q7Z434 (UniProtKB)
IDA
GO:0032760
Q7Z434 (UniProtKB)
IDA
GO:0033160
Q7Z434 (UniProtKB)
IDA
GO:0039529
Q7Z434 (UniProtKB)
IEA
GO:0042742
Q7Z434 (UniProtKB)
IMP
GO:0042993
Q7Z434 (UniProtKB)
IDA
GO:0043123
Q7Z434 (UniProtKB)
IMP
GO:0045071
Q7Z434 (UniProtKB)
IDA
GO:0045087
Q7Z434 (UniProtKB)
IMP
GO:0045087
Q7Z434 (UniProtKB)
IMP
GO:0045087
Q7Z434 (UniProtKB)
TAS
GO:0045944
Q7Z434 (UniProtKB)
IDA
GO:0045944
Q7Z434 (UniProtKB)
IDA
GO:0050700
Q7Z434 (UniProtKB)
IPI
GO:0050700
Q7Z434 (UniProtKB)
IPI
GO:0051091
Q7Z434 (UniProtKB)
IDA
GO:0051607
Q7Z434 (UniProtKB)
IDA
GO:0051607
Q7Z434 (UniProtKB)
IDA
GO:0060340
Q7Z434 (UniProtKB)
IDA
GO:0060340
Q7Z434 (UniProtKB)
IDA
GO:0071360
Q7Z434 (UniProtKB)
IMP
GO:0071651
Q7Z434 (UniProtKB)
IDA
GO:0071660
Q7Z434 (UniProtKB)
IDA
GO:1900063
Q7Z434 (UniProtKB)
IMP

基因相关microRNA

基因相关microRNA

可能调控 MAVS基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Infection 0.008173051 3 0 LHGDN
Hepatitis C 0.004624443 8 0 BeFree_LHGDN
Asthma 0.002367032 1 1 GAD
Thrombocytopenia 0.002367032 1 0 GAD
Neutropenia 0.002367032 1 0 GAD
Hepatitis C, Chronic 0.002367032 1 0 GAD
MRSA - Methicillin resistant Staphylococcus aureus infection 0.002171535 8 0 BeFree
Virus Diseases 0.001900093 7 0 BeFree
Vancomycin intermediate staphylococcus aureus infection 0.000814326 3 0 BeFree
Infection due to vancomycin resistant Staphylococcus aureus 0.000814326 3 0 BeFree

基因相关服务

基因相关服务

联系方式

山东省济南市章丘区文博路2号 齐鲁师范学院 genelibs生信实验室

山东省济南市高新区舜华路750号大学科技园北区F座4单元2楼

电话： 0531-88819269

E-mail: product@genelibs.com

微信公众号

关注微信订阅号，实时查看信息，关注医学生物学动态。

版权所有 © 2025.Genelibs 济南弘晖生物技术有限公司 鲁ICP备13024435号-2