MAPK13 (mitogen-activated protein kinase 13)
- symbol:
- MAPK13
- locus group:
- protein-coding gene
- location:
- 6p21.31
- gene_family:
- Mitogen-activated protein kinases
- alias symbol:
- SAPK4|p38delta
- alias name:
- None
- entrez id:
- 5603
- ensembl gene id:
- ENSG00000156711
- ucsc gene id:
- uc003ols.5
- refseq accession:
- NM_002754
- hgnc_id:
- HGNC:6875
- approved reserved:
- 1998-04-28
MAPK13（丝裂原活化蛋白激酶13）属于MAPK（丝裂原活化蛋白激酶）家族，是p38亚家族的一员。MAPK家族成员在细胞信号转导中起核心作用，参与调控细胞增殖、分化、凋亡、应激反应和炎症等过程。MAPK13作为p38亚家族的成员，与其他p38激酶（如p38α、p38β、p38γ）具有高度相似的激酶结构域，但表现出独特的表达模式和功能特性。MAPK13主要在肺、肾、睾丸等组织中表达，其激活依赖于上游激酶MKK3和MKK6的磷酸化。MAPK13的生物学功能涉及炎症反应调控，它能磷酸化下游靶蛋白如转录因子ATF2和MAPKAPK2，从而影响细胞因子（如TNF-α和IL-1β）的产生。此外，MAPK13在氧化应激反应和细胞凋亡中也发挥作用。突变或异常表达可能影响其功能，例如某些突变可能导致激酶活性丧失，从而削弱炎症反应或应激应答能力。研究表明，MAPK13与多种疾病相关，包括慢性炎症性疾病（如类风湿性关节炎和哮喘）以及某些癌症（如肺癌和前列腺癌）。MAPK13过表达可能加剧炎症反应，促进肿瘤细胞的存活和迁移，而降低表达则可能减轻炎症但削弱某些应激保护机制。在基因家族层面，MAPK家族成员共享保守的三级激酶级联激活机制（MAPKKK→MAPKK→MAPK），但不同亚家族（如ERK、JNK、p38）具有各自特异的底物和功能。p38亚家族主要响应应激刺激和炎症信号，而MAPK13在其中的独特作用仍在深入研究。
This gene encodes a member of the mitogen-activated protein (MAP) kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The encoded protein is a p38 MAP kinase and is activated by proinflammatory cytokines and cellular stress. Substrates of the encoded protein include the transcription factor ATF2 and the microtubule dynamics regulator stathmin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]
该基因编码的促分裂原活化蛋白（MAP）激酶家族的一个成员。 MAP激酶充当集成点多种生化信号，??并参与各种细胞过程如增殖，分化，转录调控和发育的。所编码的蛋白质是一个p38MAP激酶，由炎性细胞因子和细胞应激活化。所编码的蛋白质的底物包括转录因子ATF2和微管动力学调节stathmin的。可变剪接转录物变体已经观察到这种基因。 [由RefSeq的，2012年7月提供]
基因本体信息
MAPK13基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
MAPK13基因的本体（GO）信息：
| 名称 |
|---|
| 4015 Rap1 signaling pathway [PATH:hsa04015] |
| 4010 MAPK signaling pathway [PATH:hsa04010] |
| 4370 VEGF signaling pathway [PATH:hsa04370] |
| 4668 TNF signaling pathway [PATH:hsa04668] |
| 4068 FoxO signaling pathway [PATH:hsa04068] |
| 4071 Sphingolipid signaling pathway [PATH:hsa04071] |
| 4550 Signaling pathways regulating pluripotency of stem cells [PATH:hsa04550] |
| 4611 Platelet activation [PATH:hsa04611] |
| 4620 Toll-like receptor signaling pathway [PATH:hsa04620] |
| 4621 NOD-like receptor signaling pathway [PATH:hsa04621] |
| 4622 RIG-I-like receptor signaling pathway [PATH:hsa04622] |
| 4660 T cell receptor signaling pathway [PATH:hsa04660] |
| 4664 Fc epsilon RI signaling pathway [PATH:hsa04664] |
| 4670 Leukocyte transendothelial migration [PATH:hsa04670] |
| 4912 GnRH signaling pathway [PATH:hsa04912] |
| 4914 Progesterone-mediated oocyte maturation [PATH:hsa04914] |
| 4917 Prolactin signaling pathway [PATH:hsa04917] |
| 4261 Adrenergic signaling in cardiomyocytes [PATH:hsa04261] |
| 4728 Dopaminergic synapse [PATH:hsa04728] |
| 4723 Retrograde endocannabinoid signaling [PATH:hsa04723] |
| 4722 Neurotrophin signaling pathway [PATH:hsa04722] |
| 4750 Inflammatory mediator regulation of TRP channels [PATH:hsa04750] |
| 4380 Osteoclast differentiation [PATH:hsa04380] |
| 5205 Proteoglycans in cancer [PATH:hsa05205] |
| 5014 Amyotrophic lateral sclerosis (ALS) [PATH:hsa05014] |
| 5120 Epithelial cell signaling in Helicobacter pylori infection [PATH:hsa05120] |
| 5132 Salmonella infection [PATH:hsa05132] |
| 5131 Shigellosis [PATH:hsa05131] |
| 5133 Pertussis [PATH:hsa05133] |
| 5152 Tuberculosis [PATH:hsa05152] |
| 5164 Influenza A [PATH:hsa05164] |
| 5160 Hepatitis C [PATH:hsa05160] |
| 5169 Epstein-Barr virus infection [PATH:hsa05169] |
| 5145 Toxoplasmosis [PATH:hsa05145] |
| 5140 Leishmaniasis [PATH:hsa05140] |
| 5142 Chagas disease (American trypanosomiasis) [PATH:hsa05142] |
| 名称 |
|---|
| Cell-Cell communication |
| DSCAM interactions |
| Immune System |
| Innate Immune System |
| NGF signalling via TRKA from the plasma membrane |
| NOD1/2 Signaling Pathway |
| Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
| p38MAPK events |
| Signal Transduction |
| Signaling by VEGF |
| Signalling by NGF |
| Signalling to ERKs |
| Signalling to RAS |
| VEGFA-VEGFR2 Pathway |
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Cholestasis | 0.12 | 1 | 0 | CTD_human |
| Rheumatoid Arthritis | 0.002909916 | 3 | 0 | BeFree_GAD |
| Neuronal Ceroid-Lipofuscinoses | 0.00272435 | 1 | 0 | LHGDN |
| HIV Infections | 0.002367032 | 1 | 0 | GAD |
| Malignant Pleural Mesothelioma | 0.000542884 | 2 | 0 | BeFree |
| Neoplasm Metastasis | 0.000271442 | 1 | 0 | BeFree |
| Peritoneal Mesothelioma | 0.000271442 | 1 | 0 | BeFree |
| Glioma | 0.000271442 | 1 | 0 | BeFree |
| Cholangiocarcinoma | 0.000271442 | 1 | 0 | BeFree |
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