MAPK1 (mitogen-activated protein kinase 1)
- symbol:
- MAPK1
- locus group:
- protein-coding gene
- location:
- 22q11.22
- gene_family:
- Mitogen-activated protein kinases
- alias symbol:
- ERK|ERK2|p41mapk|MAPK2
- alias name:
- None
- entrez id:
- 5594
- ensembl gene id:
- ENSG00000100030
- ucsc gene id:
- uc002zvn.4
- refseq accession:
- NM_002745
- hgnc_id:
- HGNC:6871
- approved reserved:
- 1993-11-05
MAPK1（丝裂原活化蛋白激酶1）是MAPK家族的重要成员，属于ERK（细胞外信号调节激酶）亚家族，也被称为ERK2。该基因编码的蛋白是一种丝氨酸/苏氨酸激酶，在细胞增殖、分化、存活和凋亡等关键生物学过程中发挥核心作用。MAPK1通常被上游的RAS-RAF-MEK信号通路激活，通过磷酸化下游靶蛋白（如转录因子、细胞骨架蛋白等）传递信号。该基因的突变或异常表达与多种疾病密切相关，尤其是癌症。例如，MAPK1的功能获得性突变可能导致信号通路持续激活，促进肿瘤发生；而功能缺失性突变则可能影响细胞正常生长和分化。MAPK1过表达常见于多种恶性肿瘤（如乳腺癌、肺癌和结直肠癌），与肿瘤侵袭性和不良预后相关；相反，其表达降低可能导致发育缺陷或免疫功能障碍。MAPK家族（包括ERK、JNK和p38等亚家族）的共性在于它们都能被不同的细胞外刺激激活，通过三级激酶级联反应转导信号，参与应激反应、炎症和细胞周期调控等过程。该基因还与阿尔茨海默病、自身免疫性疾病和心血管疾病存在关联，其抑制剂已被开发为抗癌药物（如MEK抑制剂）。研究还发现MAPK1能与其他信号通路（如PI3K-AKT）交叉作用，形成复杂的调控网络。
None
无
正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
CTATTTGCTTTCTCTTCCACAC
58
CAATAAGTCCAGAGCTTTGGA
58
AAATGCTTTCTAACAGGCCC
59
TCCAATAAGTCCAGAGCCA
58
AATTTGTCAGGACAAGGGC
58
AAGTGGATAAGCCAAGACG
58
CTATTTGCTTTCTCTTCCACAC
58
CAATAAGTCCAGAGCTTTGGA
58
AATTCCAAGGGCTACACCA
59
GATGGGCCTGTTAGAAAGC
59
ATGCTTTCTAACAGGCCCA
59
GTCCAATAAGTCCAGAGCCA
60
CTATTTGCTTTCTCTTCCACAC
58
AATAAGTCCAGAGCTTTGGAG
58
AAATTTGTCAGGACAAGGGC
59
AGTGGATAAGCCAAGACGG
60
TTCAGCTAACGTTCTGCAC
59
AAGTCACAGATCTTGAGATCAC
58
CTATTTGCTTTCTCTTCCACAC
58
AATAAGTCCAGAGCTTTGGAG
58
基因本体信息
MAPK1基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
MAPK1基因的本体（GO）信息：
GO库代码
对应的蛋白质
来源代码
GO:0000165
P28482 (UniProtKB)
TAS
GO:0000187
P28482 (UniProtKB)
TAS
GO:0000189
P28482 (UniProtKB)
IEA
GO:0001784
P28482 (UniProtKB)
IEA
GO:0003677
P28482 (UniProtKB)
IEA
GO:0004674
P28482 (UniProtKB)
IDA
GO:0004674
P28482 (UniProtKB)
IDA
GO:0004674
P28482 (UniProtKB)
TAS
GO:0004674
P28482 (UniProtKB)
TAS
GO:0004674
P28482 (UniProtKB)
TAS
GO:0004674
P28482 (UniProtKB)
TAS
GO:0004674
P28482 (UniProtKB)
TAS
GO:0004674
P28482 (UniProtKB)
TAS
GO:0004674
P28482 (UniProtKB)
TAS
GO:0004674
P28482 (UniProtKB)
TAS
GO:0004674
P28482 (UniProtKB)
TAS
GO:0004674
P28482 (UniProtKB)
TAS
GO:0004674
P28482 (UniProtKB)
TAS
GO:0004707
P28482 (UniProtKB)
TAS
GO:0004707
P28482 (UniProtKB)
TAS
GO:0004707
P28482 (UniProtKB)
TAS
GO:0004707
P28482 (UniProtKB)
TAS
GO:0005515
P28482 (UniProtKB)
IPI
GO:0005515
P28482 (UniProtKB)
IPI
GO:0005515
P28482 (UniProtKB)
IPI
GO:0005515
P28482 (UniProtKB)
IPI
GO:0005515
P28482 (UniProtKB)
IPI
GO:0005515
P28482 (UniProtKB)
IPI
GO:0005515
P28482 (UniProtKB)
IPI
GO:0005515
P28482 (UniProtKB)
IPI
GO:0005515
P28482 (UniProtKB)
IPI
GO:0005515
P28482 (UniProtKB)
IPI
GO:0005515
P28482 (UniProtKB)
IPI
GO:0005515
P28482 (UniProtKB)
IPI
GO:0005515
P28482 (UniProtKB)
IPI
GO:0005515
P28482 (UniProtKB)
IPI
GO:0005515
P28482 (UniProtKB)
IPI
GO:0005515
P28482 (UniProtKB)
IPI
GO:0005515
P28482 (UniProtKB)
IPI
GO:0005515
P28482 (UniProtKB)
IPI
GO:0005515
P28482 (UniProtKB)
IPI
GO:0005515
P28482 (UniProtKB)
IPI
GO:0005515
P28482 (UniProtKB)
IPI
GO:0005515
P28482 (UniProtKB)
IPI
GO:0005515
P28482 (UniProtKB)
IPI
GO:0005515
P28482 (UniProtKB)
IPI
GO:0005515
P28482 (UniProtKB)
IPI
GO:0005515
P28482 (UniProtKB)
IPI
GO:0005515
P28482 (UniProtKB)
IPI
GO:0005515
P28482 (UniProtKB)
IPI
GO:0005515
P28482 (UniProtKB)
IPI
GO:0005515
P28482 (UniProtKB)
IPI
GO:0005515
P28482 (UniProtKB)
IPI
GO:0005515
P28482 (UniProtKB)
IPI
GO:0005515
P28482 (UniProtKB)
IPI
GO:0005515
P28482 (UniProtKB)
IPI
GO:0005515
P28482 (UniProtKB)
IPI
GO:0005524
P28482 (UniProtKB)
IEA
GO:0005634
P28482 (UniProtKB)
IDA
GO:0005634
P28482 (UniProtKB)
IDA
GO:0005634
P28482 (UniProtKB)
TAS
GO:0005654
P28482 (UniProtKB)
IDA
GO:0005654
P28482 (UniProtKB)
TAS
GO:0005654
P28482 (UniProtKB)
TAS
GO:0005654
P28482 (UniProtKB)
TAS
GO:0005654
P28482 (UniProtKB)
TAS
GO:0005654
P28482 (UniProtKB)
TAS
GO:0005654
P28482 (UniProtKB)
TAS
GO:0005654
P28482 (UniProtKB)
TAS
GO:0005654
P28482 (UniProtKB)
TAS
GO:0005654
P28482 (UniProtKB)
TAS
GO:0005737
P28482 (UniProtKB)
ISS
GO:0005737
P28482 (UniProtKB)
IDA
GO:0005737
P28482 (UniProtKB)
IDA
GO:0005739
P28482 (UniProtKB)
TAS
GO:0005769
P28482 (UniProtKB)
TAS
GO:0005770
P28482 (UniProtKB)
TAS
GO:0005794
P28482 (UniProtKB)
TAS
GO:0005815
P28482 (UniProtKB)
IEA
GO:0005829
P28482 (UniProtKB)
TAS
GO:0005829
P28482 (UniProtKB)
TAS
GO:0005829
P28482 (UniProtKB)
TAS
GO:0005829
P28482 (UniProtKB)
TAS
GO:0005829
P28482 (UniProtKB)
TAS
GO:0005829
P28482 (UniProtKB)
TAS
GO:0005829
P28482 (UniProtKB)
TAS
GO:0005829
P28482 (UniProtKB)
TAS
GO:0005829
P28482 (UniProtKB)
TAS
GO:0005829
P28482 (UniProtKB)
TAS
GO:0005829
P28482 (UniProtKB)
TAS
GO:0005829
P28482 (UniProtKB)
TAS
GO:0005829
P28482 (UniProtKB)
TAS
GO:0005829
P28482 (UniProtKB)
TAS
GO:0005829
P28482 (UniProtKB)
TAS
GO:0005829
P28482 (UniProtKB)
TAS
GO:0005829
P28482 (UniProtKB)
TAS
GO:0005829
P28482 (UniProtKB)
TAS
GO:0005829
P28482 (UniProtKB)
TAS
GO:0005829
P28482 (UniProtKB)
TAS
GO:0005829
P28482 (UniProtKB)
TAS
GO:0005829
P28482 (UniProtKB)
TAS
GO:0005829
P28482 (UniProtKB)
TAS
GO:0005829
P28482 (UniProtKB)
TAS
GO:0005829
P28482 (UniProtKB)
TAS
GO:0005829
P28482 (UniProtKB)
TAS
GO:0005829
P28482 (UniProtKB)
TAS
GO:0005829
P28482 (UniProtKB)
TAS
GO:0005829
P28482 (UniProtKB)
TAS
GO:0005829
P28482 (UniProtKB)
TAS
GO:0005829
P28482 (UniProtKB)
TAS
GO:0005829
P28482 (UniProtKB)
TAS
GO:0005829
P28482 (UniProtKB)
TAS
GO:0005829
P28482 (UniProtKB)
TAS
GO:0005829
P28482 (UniProtKB)
TAS
GO:0005829
P28482 (UniProtKB)
TAS
GO:0005829
P28482 (UniProtKB)
TAS
GO:0005856
P28482 (UniProtKB)
TAS
GO:0005901
P28482 (UniProtKB)
TAS
GO:0005925
P28482 (UniProtKB)
TAS
GO:0006351
P28482 (UniProtKB)
IEA
GO:0006468
P28482 (UniProtKB)
IDA
GO:0006915
P28482 (UniProtKB)
IEA
GO:0006935
P28482 (UniProtKB)
TAS
GO:0006950
P28482 (UniProtKB)
TAS
GO:0006974
P28482 (UniProtKB)
IEA
GO:0007049
P28482 (UniProtKB)
IEA
GO:0007165
P28482 (UniProtKB)
TAS
GO:0007268
P28482 (UniProtKB)
TAS
GO:0007411
P28482 (UniProtKB)
TAS
GO:0008134
P28482 (UniProtKB)
IEA
GO:0008284
P28482 (UniProtKB)
IEA
GO:0008353
P28482 (UniProtKB)
ISS
GO:0008543
P28482 (UniProtKB)
TAS
GO:0008543
P28482 (UniProtKB)
TAS
GO:0008543
P28482 (UniProtKB)
TAS
GO:0008543
P28482 (UniProtKB)
TAS
GO:0009636
P28482 (UniProtKB)
IEA
GO:0010800
P28482 (UniProtKB)
IDA
GO:0014066
P28482 (UniProtKB)
TAS
GO:0015630
P28482 (UniProtKB)
IDA
GO:0016032
P28482 (UniProtKB)
IEA
GO:0016301
P28482 (UniProtKB)
TAS
GO:0016301
P28482 (UniProtKB)
TAS
GO:0016301
P28482 (UniProtKB)
TAS
GO:0018105
P28482 (UniProtKB)
IDA
GO:0018107
P28482 (UniProtKB)
ISS
GO:0019233
P28482 (UniProtKB)
IEA
GO:0019858
P28482 (UniProtKB)
IEA
GO:0019902
P28482 (UniProtKB)
IPI
GO:0030168
P28482 (UniProtKB)
TAS
GO:0030335
P28482 (UniProtKB)
IEA
GO:0030424
P28482 (UniProtKB)
IEA
GO:0030878
P28482 (UniProtKB)
IEA
GO:0031143
P28482 (UniProtKB)
IEA
GO:0031435
P28482 (UniProtKB)
IEA
GO:0031647
P28482 (UniProtKB)
ISS
GO:0031663
P28482 (UniProtKB)
IEA
GO:0032212
P28482 (UniProtKB)
IMP
GO:0032839
P28482 (UniProtKB)
IEA
GO:0032872
P28482 (UniProtKB)
TAS
GO:0033598
P28482 (UniProtKB)
IEA
GO:0038095
P28482 (UniProtKB)
TAS
GO:0038096
P28482 (UniProtKB)
TAS
GO:0038127
P28482 (UniProtKB)
IDA
GO:0042473
P28482 (UniProtKB)
IEA
GO:0042802
P28482 (UniProtKB)
IPI
GO:0043204
P28482 (UniProtKB)
IEA
GO:0043234
P28482 (UniProtKB)
IEA
GO:0043330
P28482 (UniProtKB)
IEA
GO:0043627
P28482 (UniProtKB)
IEA
GO:0045596
P28482 (UniProtKB)
IEA
GO:0045727
P28482 (UniProtKB)
IEA
GO:0045893
P28482 (UniProtKB)
IEA
GO:0048538
P28482 (UniProtKB)
IEA
GO:0050852
P28482 (UniProtKB)
IEA
GO:0050853
P28482 (UniProtKB)
IEA
GO:0051090
P28482 (UniProtKB)
TAS
GO:0051493
P28482 (UniProtKB)
TAS
GO:0051973
P28482 (UniProtKB)
IMP
GO:0060020
P28482 (UniProtKB)
IEA
GO:0060291
P28482 (UniProtKB)
IEA
GO:0060324
P28482 (UniProtKB)
IEA
GO:0060397
P28482 (UniProtKB)
TAS
GO:0060425
P28482 (UniProtKB)
IEA
GO:0060440
P28482 (UniProtKB)
IEA
GO:0060716
P28482 (UniProtKB)
IEA
GO:0061308
P28482 (UniProtKB)
IEA
GO:0070062
P28482 (UniProtKB)
IDA
GO:0070371
P28482 (UniProtKB)
IDA
GO:0070371
P28482 (UniProtKB)
TAS
GO:0070849
P28482 (UniProtKB)
IDA
GO:0072584
P28482 (UniProtKB)
TAS
GO:0072686
P28482 (UniProtKB)
ISS
GO:0090170
P28482 (UniProtKB)
TAS
GO:0097011
P28482 (UniProtKB)
IEA
GO:1900034
P28482 (UniProtKB)
TAS
GO:1904355
P28482 (UniProtKB)
IMP
GO:2000641
P28482 (UniProtKB)
TAS
| 名称 |
|---|
| 4014 Ras signaling pathway [PATH:hsa04014] |
| 4015 Rap1 signaling pathway [PATH:hsa04015] |
| 4010 MAPK signaling pathway [PATH:hsa04010] |
| 4012 ErbB signaling pathway [PATH:hsa04012] |
| 4350 TGF-beta signaling pathway [PATH:hsa04350] |
| 4370 VEGF signaling pathway [PATH:hsa04370] |
| 4668 TNF signaling pathway [PATH:hsa04668] |
| 4066 HIF-1 signaling pathway [PATH:hsa04066] |
| 4068 FoxO signaling pathway [PATH:hsa04068] |
| 4071 Sphingolipid signaling pathway [PATH:hsa04071] |
| 4024 cAMP signaling pathway [PATH:hsa04024] |
| 4022 cGMP - PKG signaling pathway [PATH:hsa04022] |
| 4151 PI3K-Akt signaling pathway [PATH:hsa04151] |
| 4150 mTOR signaling pathway [PATH:hsa04150] |
| 4810 Regulation of actin cytoskeleton [PATH:hsa04810] |
| 4114 Oocyte meiosis [PATH:hsa04114] |
| 4510 Focal adhesion [PATH:hsa04510] |
| 4520 Adherens junction [PATH:hsa04520] |
| 4540 Gap junction [PATH:hsa04540] |
| 4550 Signaling pathways regulating pluripotency of stem cells [PATH:hsa04550] |
| 4611 Platelet activation [PATH:hsa04611] |
| 4620 Toll-like receptor signaling pathway [PATH:hsa04620] |
| 4621 NOD-like receptor signaling pathway [PATH:hsa04621] |
| 4650 Natural killer cell mediated cytotoxicity [PATH:hsa04650] |
| 4660 T cell receptor signaling pathway [PATH:hsa04660] |
| 4662 B cell receptor signaling pathway [PATH:hsa04662] |
| 4664 Fc epsilon RI signaling pathway [PATH:hsa04664] |
| 4666 Fc gamma R-mediated phagocytosis [PATH:hsa04666] |
| 4062 Chemokine signaling pathway [PATH:hsa04062] |
| 4910 Insulin signaling pathway [PATH:hsa04910] |
| 4912 GnRH signaling pathway [PATH:hsa04912] |
| 4915 Estrogen signaling pathway [PATH:hsa04915] |
| 4914 Progesterone-mediated oocyte maturation [PATH:hsa04914] |
| 4917 Prolactin signaling pathway [PATH:hsa04917] |
| 4921 Oxytocin signaling pathway [PATH:hsa04921] |
| 4919 Thyroid hormone signaling pathway [PATH:hsa04919] |
| 4916 Melanogenesis [PATH:hsa04916] |
| 4261 Adrenergic signaling in cardiomyocytes [PATH:hsa04261] |
| 4270 Vascular smooth muscle contraction [PATH:hsa04270] |
| 4960 Aldosterone-regulated sodium reabsorption [PATH:hsa04960] |
| 4724 Glutamatergic synapse [PATH:hsa04724] |
| 4725 Cholinergic synapse [PATH:hsa04725] |
| 4726 Serotonergic synapse [PATH:hsa04726] |
| 4720 Long-term potentiation [PATH:hsa04720] |
| 4730 Long-term depression [PATH:hsa04730] |
| 4723 Retrograde endocannabinoid signaling [PATH:hsa04723] |
| 4722 Neurotrophin signaling pathway [PATH:hsa04722] |
| 4320 Dorso-ventral axis formation [PATH:hsa04320] |
| 4360 Axon guidance [PATH:hsa04360] |
| 4380 Osteoclast differentiation [PATH:hsa04380] |
| 4713 Circadian entrainment [PATH:hsa04713] |
| 5200 Pathways in cancer [PATH:hsa05200] |
| 5230 Central carbon metabolism in cancer [PATH:hsa05230] |
| 5231 Choline metabolism in cancer [PATH:hsa05231] |
| 5206 MicroRNAs in cancer [PATH:hsa05206] |
| 5205 Proteoglycans in cancer [PATH:hsa05205] |
| 5203 Viral carcinogenesis [PATH:hsa05203] |
| 5210 Colorectal cancer [PATH:hsa05210] |
| 5212 Pancreatic cancer [PATH:hsa05212] |
| 5214 Glioma [PATH:hsa05214] |
| 5216 Thyroid cancer [PATH:hsa05216] |
| 5221 Acute myeloid leukemia [PATH:hsa05221] |
| 5220 Chronic myeloid leukemia [PATH:hsa05220] |
| 5218 Melanoma [PATH:hsa05218] |
| 5211 Renal cell carcinoma [PATH:hsa05211] |
| 5219 Bladder cancer [PATH:hsa05219] |
| 5215 Prostate cancer [PATH:hsa05215] |
| 5213 Endometrial cancer [PATH:hsa05213] |
| 5223 Non-small cell lung cancer [PATH:hsa05223] |
| 5010 Alzheimer's disease [PATH:hsa05010] |
| 5020 Prion diseases [PATH:hsa05020] |
| 5034 Alcoholism [PATH:hsa05034] |
| 4930 Type II diabetes mellitus [PATH:hsa04930] |
| 5132 Salmonella infection [PATH:hsa05132] |
| 5131 Shigellosis [PATH:hsa05131] |
| 5133 Pertussis [PATH:hsa05133] |
| 5152 Tuberculosis [PATH:hsa05152] |
| 5164 Influenza A [PATH:hsa05164] |
| 5161 Hepatitis B [PATH:hsa05161] |
| 5160 Hepatitis C [PATH:hsa05160] |
| 5145 Toxoplasmosis [PATH:hsa05145] |
| 5140 Leishmaniasis [PATH:hsa05140] |
| 5142 Chagas disease (American trypanosomiasis) [PATH:hsa05142] |
| 名称 |
|---|
| Activated TLR4 signalling |
| Activation of NMDA receptor upon glutamate binding and postsynaptic events |
| Activation of the AP-1 family of transcription factors |
| Advanced glycosylation endproduct receptor signaling |
| ARMS-mediated activation |
| Axon guidance |
| Ca-dependent events |
| Cell Cycle |
| Cell Cycle, Mitotic |
| Cellular response to heat stress |
| Cellular responses to stress |
| Cellular Senescence |
| CREB phosphorylation through the activation of Ras |
| Cytokine Signaling in Immune system |
| DAP12 interactions |
| DAP12 signaling |
| Developmental Biology |
| Downstream signal transduction |
| Downstream signaling of activated FGFR1 |
| Downstream signaling of activated FGFR2 |
| Downstream signaling of activated FGFR3 |
| Downstream signaling of activated FGFR4 |
| ERK activation |
| ERK/MAPK targets |
| ERK2 activation |
| ERKs are inactivated |
| Fc epsilon receptor (FCERI) signaling |
| FCERI mediated MAPK activation |
| Fcgamma receptor (FCGR) dependent phagocytosis |
| FRS-mediated FGFR1 signaling |
| FRS-mediated FGFR2 signaling |
| FRS-mediated FGFR3 signaling |
| Frs2-mediated activation |
| FRS2-mediated FGFR4 signaling |
| G-protein mediated events |
| Gastrin-CREB signalling pathway via PKC and MAPK |
| Golgi Cisternae Pericentriolar Stack Reorganization |
| GRB2 events in EGFR signaling |
| GRB2 events in ERBB2 signaling |
| Growth hormone receptor signaling |
| Hemostasis |
| IGF1R signaling cascade |
| Immune System |
| Innate Immune System |
| Insulin receptor signalling cascade |
| Interleukin-2 signaling |
| IRS-mediated signalling |
| IRS-related events |
| IRS-related events triggered by IGF1R |
| L1CAM interactions |
| M Phase |
| MAP kinase activation in TLR cascade |
| MAPK targets/ Nuclear events mediated by MAP kinases |
| Mitotic Prophase |
| MyD88 cascade initiated on plasma membrane |
| MyD88 dependent cascade initiated on endosome |
| MyD88-independent TLR3/TLR4 cascade |
| MyD88:Mal cascade initiated on plasma membrane |
| NCAM signaling for neurite out-growth |
| Negative regulation of FGFR1 signaling |
| Negative regulation of FGFR2 signaling |
| Negative regulation of FGFR3 signaling |
| Negative regulation of FGFR4 signaling |
| Neuronal System |
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell |
| NGF signalling via TRKA from the plasma membrane |
| Nuclear Events (kinase and transcription factor activation) |
| Oncogene Induced Senescence |
| Opioid Signalling |
| Oxidative Stress Induced Senescence |
| phospho-PLA2 pathway |
| Platelet activation, signaling and aggregation |
| PLC beta mediated events |
| Post NMDA receptor activation events |
| Prolonged ERK activation events |
| RAF/MAP kinase cascade |
| Recycling pathway of L1 |
| Regulation of actin dynamics for phagocytic cup formation |
| Regulation of HSF1-mediated heat shock response |
| RHO GTPase Effectors |
| RHO GTPases Activate WASPs and WAVEs |
| RSK activation |
| Senescence-Associated Secretory Phenotype (SASP) |
| SHC-mediated signalling |
| SHC-related events |
| SHC-related events triggered by IGF1R |
| SHC1 events in EGFR signaling |
| SHC1 events in ERBB2 signaling |
| SHC1 events in ERBB4 signaling |
| Signal attenuation |
| Signal Transduction |
| Signal transduction by L1 |
| Signaling by EGFR |
| Signaling by ERBB2 |
| Signaling by ERBB4 |
| Signaling by FGFR |
| Signaling by FGFR1 |
| Signaling by FGFR2 |
| Signaling by FGFR3 |
| Signaling by FGFR4 |
| Signaling by GPCR |
| Signaling by Insulin receptor |
| Signaling by Interleukins |
| Signaling by Leptin |
| Signaling by PDGF |
| Signaling by Rho GTPases |
| Signaling by SCF-KIT |
| Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) |
| Signaling by VEGF |
| Signalling by NGF |
| Signalling to ERKs |
| Signalling to p38 via RIT and RIN |
| Signalling to RAS |
| SOS-mediated signalling |
| Spry regulation of FGF signaling |
| Thrombin signalling through proteinase activated receptors (PARs) |
| Toll Like Receptor 10 (TLR10) Cascade |
| Toll Like Receptor 2 (TLR2) Cascade |
| Toll Like Receptor 3 (TLR3) Cascade |
| Toll Like Receptor 4 (TLR4) Cascade |
| Toll Like Receptor 5 (TLR5) Cascade |
| Toll Like Receptor 7/8 (TLR7/8) Cascade |
| Toll Like Receptor 9 (TLR9) Cascade |
| Toll Like Receptor TLR1:TLR2 Cascade |
| Toll Like Receptor TLR6:TLR2 Cascade |
| Toll-Like Receptors Cascades |
| TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| TRAF6 Mediated Induction of proinflammatory cytokines |
| Transmission across Chemical Synapses |
| TRIF-mediated TLR3/TLR4 signaling |
| VEGFA-VEGFR2 Pathway |
| VEGFR2 mediated cell proliferation |
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Neoplasm Metastasis | 0.141202261 | 52 | 0 | BeFree_CTD_human_LHGDN |
| Squamous cell carcinoma | 0.137150496 | 19 | 0 | BeFree_CTD_human_LHGDN |
| ovarian neoplasm | 0.128715934 | 6 | 0 | BeFree_CTD_human_LHGDN |
| Stomach Neoplasms | 0.128173051 | 4 | 0 | CTD_human_LHGDN |
| Lung Neoplasms | 0.126534468 | 8 | 0 | BeFree_CTD_human_LHGDN |
| Multiple Sclerosis | 0.123452799 | 5 | 1 | BeFree_GAD_GWASCAT |
| Kidney Neoplasm | 0.120542884 | 2 | 0 | BeFree_CTD_human |
| Sepsis | 0.120271442 | 2 | 0 | BeFree_CTD_human |
| Cardiomyopathies | 0.120271442 | 2 | 0 | BeFree_CTD_human |
| Substance Withdrawal Syndrome | 0.12 | 1 | 0 | CTD_human |
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