LZTS1 (leucine zipper tumor suppressor 1)
- symbol:
- LZTS1
- locus group:
- protein-coding gene
- location:
- 8p21.3
- gene_family:
- alias symbol:
- FEZ1
- alias name:
- F37/Esophageal cancer-related gene…
- entrez id:
- 11178
- ensembl gene id:
- ENSG00000061337
- ucsc gene id:
- uc064kuf.1
- refseq accession:
- NM_021020
- hgnc_id:
- HGNC:13861
- approved reserved:
- 2001-02-27
This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer. [provided by RefSeq, Nov 2009]
这个基因编码是在正常组织中广泛表达肿瘤抑制蛋白。在葡萄膜黑色素瘤，这种蛋白质的表达被沉默中迅速转移性和转移性肿瘤细胞，但在慢慢的转移性或nonmetastasizing肿瘤细胞的正常表达。这种蛋白质可以通过与CDK1 / CyclinB1的复杂相互作用在细胞周期控制的作用。这个基因位于染色体区域8p22。杂合性丢失（LOH）的8P臂是许多类型癌症的共同特征。 [由RefSeq的，2009年11月提供]
基因本体信息
LZTS1基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
LZTS1基因的本体（GO）信息：
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Prostatic Neoplasms | 0.122995792 | 2 | 0 | BeFree_CTD_human_LHGDN |
| Esophageal Neoplasms | 0.122638474 | 2 | 0 | BeFree_CTD_human_GAD |
| Malignant neoplasm of breast | 0.003452799 | 5 | 0 | BeFree_GAD |
| Malignant neoplasm of prostate | 0.003181358 | 3 | 0 | BeFree_GAD |
| melanoma | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Squamous cell carcinoma | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Mouth Neoplasms | 0.002367032 | 1 | 0 | GAD |
| Systemic arterial pressure | 0.002367032 | 1 | 1 | GAD |
| Laryngeal neoplasm | 0.002367032 | 1 | 0 | GAD |
| Blood pressure finding | 0.002367032 | 1 | 1 | GAD |
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