LTBR (lymphotoxin beta receptor)

symbol:
LTBR
locus group:
protein-coding gene
location:
12p13.31
gene_family:
Tumor necrosis factor receptor superfamily
alias symbol:
TNFCR|TNFR-RP|TNFR2-RP|TNF-R-III|TNFRSF3
alias name:
TNFR superfamily, member 3
entrez id:
4055
ensembl gene id:
ENSG00000111321
ucsc gene id:
uc001qny.3
refseq accession:
NM_001270987
hgnc_id:
HGNC:6718
approved reserved:
1996-03-12
12p13.31
基因染色体位置图

This gene encodes a member of the tumor necrosis factor receptor superfamily. The major ligands of this receptor include lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily member 14. The encoded protein plays a role in signalling during the development of lymphoid and other organs, lipid metabolism, immune response, and programmed cell death. Activity of this receptor has also been linked to carcinogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012]

该基因编码的肿瘤坏死因子受体超家族的成员。该受体的主要配体包括淋巴毒素α/β,肿瘤坏死因子配体超家族成员14所编码的蛋白在淋巴和其他器官,脂质代谢,免疫反应,和程序性细胞死亡的发展期间的信令的作用。该受体的活性也与癌变。编码多种亚型选择性剪接的转录物变体已观察到。 [由RefSeq的,2012年8月提供]

CCND1基因的碱基序列:[NCBI]
Loading Gene Browser...
LTBR基因的碱基突变:           仅显示部分snp
rs2286600       rs3741914       rs13306619       rs61758858       rs61759861       rs61759919       rs72645119       rs72645120       rs72645121       rs72645122       rs72645123       rs72645124       rs72645125       rs72645126       rs72645127       rs111471598       rs111550798      

LTBR基因在不同组织中的表达:    [UniProt]

基因在不同组织中的表达图
正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
TGGAACTACCTGACCATCTG
59
GGTCTTCCGTTTGCTTGTG
60
CCTTCTTTCTGCTCCTTGC
59
ATCCCAGTTTCCTGCAGAG
59
CCCATTTCTGGAGATGTTTCC
59
GAATGCCATTGGTACCGTG
59
GTCTTCTCCTGCATCTGGA
59
CTTCTTGCTGCCTTCTCAG
59
GAATGTTCTGTGCTGCCTG
60
CCCAACTTCATCTTTGAGCTC
59
CTCAATTAAAGGTGCCTCCA
58
ATTTAGCTGAGACATAGGTGC
58
CAGAGATGTCAGAACCTGC
58
GAAACTTGCTTCGGAACTG
57
CTCAATTAAAGGTGCCTCCA
58
ATTTAGCTGAGACATAGGTGC
58
GAATGTTCTGTGCTGCCTG
60
CTTGGTTCTCACACCTTTGAG
59
CCCAGAGATGTCAGGATCG
59
AAGTATGGATGGGCCTTCG
60
转录因子
影响基因
影响类型
参考文献链接(PubMed)
WWTR1
LTBR
Activation

LTBR基因(以及对应的蛋白质)的细胞分布位置:

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

LTBR基因的本体(GO)信息:

GO库代码
对应的蛋白质
来源代码
GO:0005031
P36941 (UniProtKB)
IBA
GO:0005515
P36941 (UniProtKB)
IPI
GO:0005515
P36941 (UniProtKB)
IPI
GO:0005515
P36941 (UniProtKB)
IPI
GO:0005886
P36941 (UniProtKB)
TAS
GO:0005886
P36941 (UniProtKB)
TAS
GO:0005886
P36941 (UniProtKB)
TAS
GO:0005886
P36941 (UniProtKB)
TAS
GO:0005886
P36941 (UniProtKB)
TAS
GO:0005887
P36941 (UniProtKB)
IBA
GO:0006915
P36941 (UniProtKB)
IEA
GO:0006954
P36941 (UniProtKB)
IBA
GO:0006955
P36941 (UniProtKB)
IBA
GO:0007165
P36941 (UniProtKB)
TAS
GO:0007275
P36941 (UniProtKB)
IBA
GO:0016032
P36941 (UniProtKB)
IEA
GO:0031625
P36941 (UniProtKB)
IPI
GO:0031625
P36941 (UniProtKB)
IPI
GO:0032496
P36941 (UniProtKB)
IBA
GO:0033209
P36941 (UniProtKB)
TAS
GO:0033209
P36941 (UniProtKB)
TAS
GO:0042127
P36941 (UniProtKB)
IBA
GO:0042802
P36941 (UniProtKB)
IPI
GO:0043011
P36941 (UniProtKB)
IEA
GO:0043123
P36941 (UniProtKB)
IEP
GO:0046330
P36941 (UniProtKB)
IMP
GO:0071260
P36941 (UniProtKB)
IEP
GO:2001238
P36941 (UniProtKB)
IMP

可能调控 LTBR基因的相关microRNA:     

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称
疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Malaria 0.12 1 0 CTD_human
Congenital leukocyte adherence deficiency 0.007328931 27 0 BeFree
Leukocyte adhesion deficiency type 1 0.00434307 16 2 BeFree
melanoma 0.003267234 3 0 BeFree_LHGDN
Hepatomegaly 0.00272435 1 0 LHGDN
Rheumatoid Arthritis 0.00272435 1 0 LHGDN
Hepatitis 0.00272435 1 0 LHGDN
Multiple Myeloma 0.002638474 2 0 BeFree_GAD
Ankylosing spondylitis 0.002638474 1 1 BeFree_GAD
Pancreatic carcinoma 0.002171535 8 0 BeFree

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