This gene encodes a member of the tumor necrosis factor receptor superfamily. The major ligands of this receptor include lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily member 14. The encoded protein plays a role in signalling during the development of lymphoid and other organs, lipid metabolism, immune response, and programmed cell death. Activity of this receptor has also been linked to carcinogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012]
该基因编码的肿瘤坏死因子受体超家族的成员。该受体的主要配体包括淋巴毒素α/β,肿瘤坏死因子配体超家族成员14所编码的蛋白在淋巴和其他器官,脂质代谢,免疫反应,和程序性细胞死亡的发展期间的信令的作用。该受体的活性也与癌变。编码多种亚型选择性剪接的转录物变体已观察到。 [由RefSeq的,2012年8月提供]
LTBR基因(以及对应的蛋白质)的细胞分布位置:
LTBR基因的本体(GO)信息:
名称 |
---|
4064 NF-kappa B signaling pathway [PATH:hsa04064] |
4066 HIF-1 signaling pathway [PATH:hsa04066] |
4060 Cytokine-cytokine receptor interaction [PATH:hsa04060] |
4672 Intestinal immune network for IgA production [PATH:hsa04672] |
5203 Viral carcinogenesis [PATH:hsa05203] |
5166 HTLV-I infection [PATH:hsa05166] |
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Malaria | 0.12 | 1 | 0 | CTD_human |
Congenital leukocyte adherence deficiency | 0.007328931 | 27 | 0 | BeFree |
Leukocyte adhesion deficiency type 1 | 0.00434307 | 16 | 2 | BeFree |
melanoma | 0.003267234 | 3 | 0 | BeFree_LHGDN |
Hepatomegaly | 0.00272435 | 1 | 0 | LHGDN |
Rheumatoid Arthritis | 0.00272435 | 1 | 0 | LHGDN |
Hepatitis | 0.00272435 | 1 | 0 | LHGDN |
Multiple Myeloma | 0.002638474 | 2 | 0 | BeFree_GAD |
Ankylosing spondylitis | 0.002638474 | 1 | 1 | BeFree_GAD |
Pancreatic carcinoma | 0.002171535 | 8 | 0 | BeFree |
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