LRRK2 (leucine rich repeat kinase 2)

基因基本信息

基因基本信息

symbol:
LRRK2
locus group:
protein-coding gene
location:
12q12
gene_family:
Parkinson disease associated genes
alias symbol:
ROCO2|DKFZp434H2111|FLJ45829|RIPK7
alias name:
dardarin
entrez id:
120892
ensembl gene id:
ENSG00000188906
ucsc gene id:
uc001rmg.5
refseq accession:
NM_198578
hgnc_id:
HGNC:18618
approved reserved:
2004-10-22

基因染色体位置

基因染色体位置

12q12
基因染色体位置图

基因简述

基因简述

LRRK2（Leucine-Rich Repeat Kinase 2）是一种编码富含亮氨酸重复序列激酶2的基因，属于ROCO蛋白家族。该基因主要在中枢神经系统、免疫细胞和肾脏中表达，其编码的蛋白质具有激酶和GTP酶双重活性，参与多种细胞过程，如囊泡运输、细胞骨架重组和自噬调控。LRRK2的生物学功能与神经元的存活和突触可塑性密切相关，尤其在多巴胺能神经元的调控中起关键作用。LRRK2基因的突变，特别是G2019S突变（激酶结构域突变），会导致其激酶活性异常增高，进而干扰细胞内的信号传导和蛋白质降解系统，最终引发神经元损伤。这种突变与家族性和散发性帕金森病（PD）高度相关，是遗传性帕金森病最常见的致病因素之一。此外，LRRK2的异常表达还可能增加炎症反应和神经退行性变的风险。当LRRK2过表达时，其激酶活性过度激活可能导致线粒体功能障碍、突触传递异常以及α-突触核蛋白的异常聚集，从而加速神经退行性病变。相反，LRRK2表达降低或功能缺失可能影响神经元的正常功能，但具体机制尚不完全清楚，可能与自噬和溶酶体功能受损有关。LRRK2属于ROCO基因家族，该家族成员均包含ROC（Ras of complex proteins）结构域和COR（C-terminal of ROC）结构域，具有GTP酶和蛋白激酶双重功能，参与细胞信号转导和应激反应。LRRK2与家族成员LRRK1在功能上有一定相似性，但LRRK2在神经系统中的作用更为突出。研究表明，LRRK2还可能与其他神经退行性疾病（如阿尔茨海默病）和免疫相关疾病（如克罗恩病）存在关联，但其具体机制仍需进一步研究。针对LRRK2的激酶抑制剂目前正在研发中，可能为帕金森病的治疗提供新方向。

This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008]

此基因是富含亮氨酸重复激酶家族的成员，并且编码的蛋白质具有ankryin重复区域，富含亮氨酸重复序列（LRR）结构域，激酶结构域，DFG样基序，一个RAS域中，GTP酶结构域，MLK样结构域，和一个WD40域。该蛋白质是本主要在细胞质中也与线粒体外膜关联。在这种基因突变与帕金森病-8相关联。 [由RefSeq的，2008年7月提供]

OMIM数据库中对LRRK2基因的介绍     Wikipedia数据库中对LRRK2基因的介绍

基因序列

基因序列

LRRK2基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

LRRK2基因的碱基突变：           仅显示部分snp
rs890575       rs1365768       rs1365769       rs1365770       rs1947053       rs2162472       rs2404836       rs2553848       rs2896978       rs3761863       rs3789328       rs3789329       rs3789330       rs3886747       rs4767973       rs4768236       rs4768237      

基因表达

基因表达

LRRK2基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
TAAATCTTCCACACTTGCGG
58
AAAGATTTCCAGTGTGCGG
58
TGAATGGACCTTTATTCCTGAC
58
CCTTCACTTCCTTCACTATCC
58
AAAGTGGAGATCCGAGATCAG
59
ACGGGAAATTCAATTGGCAC
60
AGCCAGAAATGCTGTATAAGTG
59
TCTTCAGAGTTTCACATAGCTG
58
TCGTCTTGGACTCCTATATGAG
59
CACAGAAGTGACCAACCCA
60
TGTTATCCCTGGAAGGTGC
59
CCAGACACTGAATTTCTTGGT
58
ATTTCCAGCCAATGATGAAGTC
59
GACTTCCACATTATTGCCTCTC
59
TGAATGGACCTTTATTCCTGAC
58
CCTTCACTTCCTTCACTATCC
58
GACTGTTAAGCTTAAAGGAGCTG
60
TCACTCAAACACATCAATGGAG
59
GTTATCCCTGGAAGGTGCT
59
CCCAGACACTGAATTTCTTGG
59

转录因子

转录因子

      尚未收录相关数据

基因本体信息

LRRK2基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

LRRK2基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0000149
Q5S007 (UniProtKB)
IPI
GO:0000165
Q5S007 (UniProtKB)
IDA
GO:0000186
Q5S007 (UniProtKB)
IDA
GO:0000187
Q5S007 (UniProtKB)
IMP
GO:0001933
Q5S007 (UniProtKB)
ISS
GO:0001934
Q5S007 (UniProtKB)
IMP
GO:0001934
Q5S007 (UniProtKB)
IDA
GO:0001948
Q5S007 (UniProtKB)
IPI
GO:0003779
Q5S007 (UniProtKB)
IPI
GO:0003924
Q5S007 (UniProtKB)
IDA
GO:0004672
Q5S007 (UniProtKB)
IDA
GO:0004672
Q5S007 (UniProtKB)
IDA
GO:0004672
Q5S007 (UniProtKB)
IDA
GO:0004672
Q5S007 (UniProtKB)
IDA
GO:0004672
Q5S007 (UniProtKB)
IDA
GO:0004674
Q5S007 (UniProtKB)
IDA
GO:0004674
Q5S007 (UniProtKB)
IDA
GO:0004674
Q5S007 (UniProtKB)
IDA
GO:0004674
Q5S007 (UniProtKB)
IDA
GO:0004674
Q5S007 (UniProtKB)
IDA
GO:0004674
Q5S007 (UniProtKB)
TAS
GO:0004674
Q5S007 (UniProtKB)
IDA
GO:0004708
Q5S007 (UniProtKB)
IDA
GO:0005096
Q5S007 (UniProtKB)
IDA
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005515
Q5S007 (UniProtKB)
IPI
GO:0005524
Q5S007 (UniProtKB)
IEA
GO:0005525
Q5S007 (UniProtKB)
IDA
GO:0005525
Q5S007 (UniProtKB)
IDA
GO:0005525
Q5S007 (UniProtKB)
IDA
GO:0005525
Q5S007 (UniProtKB)
TAS
GO:0005615
Q5S007 (UniProtKB)
IDA
GO:0005622
Q5S007 (UniProtKB)
IMP
GO:0005737
Q5S007 (UniProtKB)
IDA
GO:0005737
Q5S007 (UniProtKB)
IDA
GO:0005737
Q5S007 (UniProtKB)
IDA
GO:0005739
Q5S007 (UniProtKB)
IDA
GO:0005741
Q5S007 (UniProtKB)
ISS
GO:0005743
Q5S007 (UniProtKB)
ISS
GO:0005759
Q5S007 (UniProtKB)
ISS
GO:0005764
Q5S007 (UniProtKB)
ISS
GO:0005768
Q5S007 (UniProtKB)
ISS
GO:0005783
Q5S007 (UniProtKB)
ISS
GO:0005783
Q5S007 (UniProtKB)
IDA
GO:0005794
Q5S007 (UniProtKB)
ISS
GO:0005798
Q5S007 (UniProtKB)
IDA
GO:0005802
Q5S007 (UniProtKB)
IEA
GO:0005829
Q5S007 (UniProtKB)
IDA
GO:0005829
Q5S007 (UniProtKB)
IDA
GO:0005829
Q5S007 (UniProtKB)
IDA
GO:0005829
Q5S007 (UniProtKB)
IDA
GO:0005829
Q5S007 (UniProtKB)
TAS
GO:0005829
Q5S007 (UniProtKB)
TAS
GO:0005829
Q5S007 (UniProtKB)
TAS
GO:0005886
Q5S007 (UniProtKB)
IDA
GO:0005901
Q5S007 (UniProtKB)
IDA
GO:0005902
Q5S007 (UniProtKB)
IDA
GO:0006468
Q5S007 (UniProtKB)
IMP
GO:0006468
Q5S007 (UniProtKB)
IDA
GO:0006897
Q5S007 (UniProtKB)
IGI
GO:0006897
Q5S007 (UniProtKB)
IMP
GO:0006914
Q5S007 (UniProtKB)
IEA
GO:0006979
Q5S007 (UniProtKB)
IMP
GO:0007005
Q5S007 (UniProtKB)
IMP
GO:0007030
Q5S007 (UniProtKB)
IMP
GO:0007040
Q5S007 (UniProtKB)
IMP
GO:0007264
Q5S007 (UniProtKB)
IEA
GO:0007528
Q5S007 (UniProtKB)
IMP
GO:0008017
Q5S007 (UniProtKB)
TAS
GO:0008340
Q5S007 (UniProtKB)
IMP
GO:0009267
Q5S007 (UniProtKB)
IMP
GO:0010506
Q5S007 (UniProtKB)
IMP
GO:0010508
Q5S007 (UniProtKB)
ISS
GO:0010508
Q5S007 (UniProtKB)
IMP
GO:0010738
Q5S007 (UniProtKB)
ISS
GO:0010955
Q5S007 (UniProtKB)
IDA
GO:0014041
Q5S007 (UniProtKB)
IMP
GO:0015631
Q5S007 (UniProtKB)
IDA
GO:0016234
Q5S007 (UniProtKB)
IMP
GO:0016242
Q5S007 (UniProtKB)
IMP
GO:0016301
Q5S007 (UniProtKB)
IDA
GO:0016301
Q5S007 (UniProtKB)
IMP
GO:0016310
Q5S007 (UniProtKB)
IMP
GO:0017048
Q5S007 (UniProtKB)
IPI
GO:0017075
Q5S007 (UniProtKB)
IPI
GO:0018105
Q5S007 (UniProtKB)
IDA
GO:0018107
Q5S007 (UniProtKB)
IDA
GO:0018107
Q5S007 (UniProtKB)
IMP
GO:0019722
Q5S007 (UniProtKB)
IMP
GO:0021772
Q5S007 (UniProtKB)
IMP
GO:0022028
Q5S007 (UniProtKB)
IMP
GO:0030054
Q5S007 (UniProtKB)
IEA
GO:0030159
Q5S007 (UniProtKB)
IC
GO:0030276
Q5S007 (UniProtKB)
IPI
GO:0030424
Q5S007 (UniProtKB)
ISS
GO:0030424
Q5S007 (UniProtKB)
IDA
GO:0030425
Q5S007 (UniProtKB)
ISS
GO:0030425
Q5S007 (UniProtKB)
IDA
GO:0030426
Q5S007 (UniProtKB)
IDA
GO:0030529
Q5S007 (UniProtKB)
IEA
GO:0030672
Q5S007 (UniProtKB)
IEA
GO:0031398
Q5S007 (UniProtKB)
IDA
GO:0031398
Q5S007 (UniProtKB)
IDA
GO:0031410
Q5S007 (UniProtKB)
ISS
GO:0031966
Q5S007 (UniProtKB)
IDA
GO:0032091
Q5S007 (UniProtKB)
IMP
GO:0032092
Q5S007 (UniProtKB)
IDA
GO:0032436
Q5S007 (UniProtKB)
ISS
GO:0032473
Q5S007 (UniProtKB)
IDA
GO:0032839
Q5S007 (UniProtKB)
IDA
GO:0034211
Q5S007 (UniProtKB)
IMP
GO:0034211
Q5S007 (UniProtKB)
IDA
GO:0034260
Q5S007 (UniProtKB)
IDA
GO:0034599
Q5S007 (UniProtKB)
IMP
GO:0034599
Q5S007 (UniProtKB)
IMP
GO:0034599
Q5S007 (UniProtKB)
IMP
GO:0034613
Q5S007 (UniProtKB)
ISS
GO:0035556
Q5S007 (UniProtKB)
ISS
GO:0035564
Q5S007 (UniProtKB)
ISS
GO:0035640
Q5S007 (UniProtKB)
IMP
GO:0035641
Q5S007 (UniProtKB)
IEA
GO:0035751
Q5S007 (UniProtKB)
IMP
GO:0036479
Q5S007 (UniProtKB)
IDA
GO:0039706
Q5S007 (UniProtKB)
TAS
GO:0040012
Q5S007 (UniProtKB)
IMP
GO:0042391
Q5S007 (UniProtKB)
IMP
GO:0042802
Q5S007 (UniProtKB)
IPI
GO:0042802
Q5S007 (UniProtKB)
IPI
GO:0042802
Q5S007 (UniProtKB)
IPI
GO:0042802
Q5S007 (UniProtKB)
IPI
GO:0042802
Q5S007 (UniProtKB)
IPI
GO:0042802
Q5S007 (UniProtKB)
IPI
GO:0042802
Q5S007 (UniProtKB)
IPI
GO:0042802
Q5S007 (UniProtKB)
IPI
GO:0042802
Q5S007 (UniProtKB)
IPI
GO:0042802
Q5S007 (UniProtKB)
IPI
GO:0042802
Q5S007 (UniProtKB)
IPI
GO:0042802
Q5S007 (UniProtKB)
IPI
GO:0042802
Q5S007 (UniProtKB)
IPI
GO:0042803
Q5S007 (UniProtKB)
IPI
GO:0043005
Q5S007 (UniProtKB)
IDA
GO:0043005
Q5S007 (UniProtKB)
IDA
GO:0043025
Q5S007 (UniProtKB)
IDA
GO:0043025
Q5S007 (UniProtKB)
IDA
GO:0043068
Q5S007 (UniProtKB)
IDA
GO:0043195
Q5S007 (UniProtKB)
TAS
GO:0043204
Q5S007 (UniProtKB)
ISS
GO:0043204
Q5S007 (UniProtKB)
IDA
GO:0043406
Q5S007 (UniProtKB)
IC
GO:0043547
Q5S007 (UniProtKB)
IEA
GO:0044325
Q5S007 (UniProtKB)
IPI
GO:0044325
Q5S007 (UniProtKB)
IPI
GO:0044753
Q5S007 (UniProtKB)
IDA
GO:0044754
Q5S007 (UniProtKB)
IDA
GO:0046039
Q5S007 (UniProtKB)
IDA
GO:0046777
Q5S007 (UniProtKB)
IDA
GO:0046777
Q5S007 (UniProtKB)
IDA
GO:0046777
Q5S007 (UniProtKB)
IMP
GO:0046777
Q5S007 (UniProtKB)
IDA
GO:0046777
Q5S007 (UniProtKB)
IDA
GO:0048312
Q5S007 (UniProtKB)
IMP
GO:0048812
Q5S007 (UniProtKB)
IMP
GO:0050848
Q5S007 (UniProtKB)
IMP
GO:0051018
Q5S007 (UniProtKB)
IPI
GO:0051646
Q5S007 (UniProtKB)
IMP
GO:0051900
Q5S007 (UniProtKB)
IMP
GO:0051966
Q5S007 (UniProtKB)
ISS
GO:0060070
Q5S007 (UniProtKB)
TAS
GO:0060079
Q5S007 (UniProtKB)
ISS
GO:0060159
Q5S007 (UniProtKB)
ISS
GO:0060161
Q5S007 (UniProtKB)
IMP
GO:0060828
Q5S007 (UniProtKB)
TAS
GO:0061001
Q5S007 (UniProtKB)
ISS
GO:0061001
Q5S007 (UniProtKB)
IMP
GO:0070062
Q5S007 (UniProtKB)
IDA
GO:0070585
Q5S007 (UniProtKB)
TAS
GO:0070997
Q5S007 (UniProtKB)
IMP
GO:0071287
Q5S007 (UniProtKB)
IMP
GO:0072593
Q5S007 (UniProtKB)
IMP
GO:0090140
Q5S007 (UniProtKB)
TAS
GO:0090263
Q5S007 (UniProtKB)
IGI
GO:0090394
Q5S007 (UniProtKB)
ISS
GO:0097487
Q5S007 (UniProtKB)
IDA
GO:0098794
Q5S007 (UniProtKB)
IEA
GO:1901214
Q5S007 (UniProtKB)
IMP
GO:1901215
Q5S007 (UniProtKB)
IGI
GO:1902236
Q5S007 (UniProtKB)
IMP
GO:1902499
Q5S007 (UniProtKB)
IDA
GO:1902692
Q5S007 (UniProtKB)
IMP
GO:1902803
Q5S007 (UniProtKB)
ISS
GO:1902803
Q5S007 (UniProtKB)
TAS
GO:1902823
Q5S007 (UniProtKB)
TAS
GO:1902902
Q5S007 (UniProtKB)
IMP
GO:1903125
Q5S007 (UniProtKB)
IDA
GO:1903206
Q5S007 (UniProtKB)
IMP
GO:1903215
Q5S007 (UniProtKB)
IDA
GO:1903217
Q5S007 (UniProtKB)
IC
GO:1903351
Q5S007 (UniProtKB)
IMP
GO:1904713
Q5S007 (UniProtKB)
NAS
GO:1904887
Q5S007 (UniProtKB)
IPI
GO:1904887
Q5S007 (UniProtKB)
TAS
GO:1990909
Q5S007 (UniProtKB)
IDA
GO:1990909
Q5S007 (UniProtKB)
NAS
GO:2000172
Q5S007 (UniProtKB)
IMP
GO:2000300
Q5S007 (UniProtKB)
IMP

基因相关microRNA

基因相关microRNA

可能调控 LRRK2基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
PARKINSON DISEASE 8 (disorder) 0.44 10 20 CLINVAR_CTD_human_MGD_UNIPROT
Parkinson Disease 0.435830327 289 11 BeFree_CTD_human_GAD_GWASCAT_LHGDN
Parkinsonian Disorders 0.15915715 77 6 BeFree_CTD_human_LHGDN
Nerve Degeneration 0.12 1 0 CTD_human
Endometriosis 0.12 1 0 CTD_human
Renal Cell Carcinoma 0.12 1 0 CTD_human
Alzheimer's Disease 0.020922225 9 3 BeFree_GAD_LHGDN
Neurodegenerative Disorders 0.018236263 17 2 BeFree_LHGDN
Multiple System Atrophy 0.01162585 7 2 BeFree_GAD_LHGDN
Progressive supranuclear palsy 0.01099709 5 0 BeFree_GAD_LHGDN

基因相关服务

基因相关服务

联系方式

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