LGALS9 (galectin 9)

symbol:
LGALS9
locus group:
protein-coding gene
location:
17q11.2
gene_family:
Lectins, galactoside-binding
alias symbol:
LGALS9A
alias name:
None
entrez id:
3965
ensembl gene id:
ENSG00000168961
ucsc gene id:
uc002gzp.4
refseq accession:
NM_009587
hgnc_id:
HGNC:6570
approved reserved:
1997-06-25
17q11.2
基因染色体位置图

LGALS9(半乳糖凝集素9)是一种属于半乳糖凝集素(Galectin)家族的蛋白质,该家族以其能够结合β-半乳糖苷糖链的能力为特征,参与细胞间相互作用、免疫调节和炎症反应等生物学过程。LGALS9在多种组织中表达,包括免疫细胞、内皮细胞和上皮细胞,其主要功能是通过与糖蛋白(如TIM-3)结合调节免疫细胞的活性,在免疫耐受、抗病毒防御和肿瘤微环境调控中发挥关键作用。LGALS9通过与受体结合可诱导T细胞凋亡或抑制其功能,从而在自身免疫疾病和癌症免疫逃逸中起重要作用。突变或表达异常可能导致免疫系统失调,例如LGALS9过表达与某些癌症(如肝癌、肺癌)的进展和不良预后相关,而降低表达可能削弱免疫监视功能,增加感染或自身免疫疾病风险。此外,LGALS9在病毒感染(如HIV、HCV)中通过调节免疫反应影响疾病进程。半乳糖凝集素家族的共性包括保守的糖识别结构域(CRD)和参与细胞粘附、信号转导及凋亡调控。LGALS9因其双CRD结构可同时结合不同配体,增强其功能多样性。该基因的调控可能成为癌症免疫治疗或自身免疫疾病的新靶点。

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The protein encoded by this gene is an S-type lectin. It is overexpressed in Hodgkin's disease tissue and might participate in the interaction between the H&RS cells with their surrounding cells and might thus play a role in the pathogenesis of this disease and/or its associated immunodeficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

的半乳凝素是在调节细胞 - 细胞和细胞 - 基质相互作用牵连的β-半乳糖苷结合蛋白的一个家族。由该基因编码的蛋白质是一个S型凝集素。它是在霍奇金病组织中过表达,并可能与他们的周围细胞参与在H&RS细胞之间的相互作用,因此可能在该疾病和/或与其相关的免疫缺陷的发病机制中发挥作用。多重选择性剪接转录变异体也发现了这种基因。 [由RefSeq的,2008年7月提供]

LGALS9基因的碱基序列:[NCBI]
Loading Gene Browser...
LGALS9基因的碱基突变:           仅显示部分snp
rs8368       rs361497       rs361498       rs361499       rs732222       rs1050913       rs1984547       rs2304886       rs2304890       rs3094268       rs3094271       rs3094272       rs3094274       rs3107064       rs3751091       rs3751092       rs3751093      

LGALS9基因在不同组织中的表达:    [UniProt]

基因在不同组织中的表达图
正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
AACCCAGACAGTCATCCAC
59
GATGTGGAACCTCTGAGCA
59
TCAGATTTCAAGGTGATGGTG
58
CATTGACGGAGATGGTGTC
58
ACATCAGCTTCCAGAACCC
60
GACTGTCTGGGTAATGGGAG
60
TTGAAGATGGAGGGTACGTG
60
CAGGTGCACCTTGAAATCTG
60
CTACCTGAGTCCAGCTGTC
59
TGAGAACGGTCCCATTGAC
60
TCAGATTTCAAGGTGATGGTG
58
CATTGACGGAGATGGTGTC
58
CAGAGCTTCTCAGTGTGGA
59
GGTAGTATTCAAACAGGTGCTG
59
CAGAGCTTCTCAGTGTGGA
59
GGTAGTATTCAAACAGGTGCTG
59
ATTCAAGGAGGTCTCCAGG
58
AAGTTCACAGCAAACCTGG
59
TATTCAAGGAGGTCTCCAGGA
60
TACCCTCCATCTGGTTCCA
60
转录因子
影响基因
影响类型
参考文献链接(PubMed)
HDAC3
LGALS9
Unknown

LGALS9基因(以及对应的蛋白质)的细胞分布位置:

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

LGALS9基因的本体(GO)信息:

GO库代码
对应的蛋白质
来源代码
GO:0030246
J3KS82 (UniProtKB)
IEA
GO:0030246
J3KSA0 (UniProtKB)
IEA
GO:0030246
J3QKK6 (UniProtKB)
IEA
GO:0030246
J3QS92 (UniProtKB)
IEA
GO:0030246
K7EPS0 (UniProtKB)
IEA
GO:0002519
O00182 (UniProtKB)
IMP
GO:0004871
O00182 (UniProtKB)
IMP
GO:0005534
O00182 (UniProtKB)
TAS
GO:0005615
O00182 (UniProtKB)
IDA
GO:0005622
O00182 (UniProtKB)
IDA
GO:0005622
O00182 (UniProtKB)
IDA
GO:0005634
O00182 (UniProtKB)
IDA
GO:0005737
O00182 (UniProtKB)
IDA
GO:0006935
O00182 (UniProtKB)
IEA
GO:0006954
O00182 (UniProtKB)
IDA
GO:0007565
O00182 (UniProtKB)
IDA
GO:0010628
O00182 (UniProtKB)
IDA
GO:0010629
O00182 (UniProtKB)
IDA
GO:0010629
O00182 (UniProtKB)
IMP
GO:0019899
O00182 (UniProtKB)
IPI
GO:0030246
O00182 (UniProtKB)
IDA
GO:0032496
O00182 (UniProtKB)
IMP
GO:0032682
O00182 (UniProtKB)
IMP
GO:0032689
O00182 (UniProtKB)
IDA
GO:0032720
O00182 (UniProtKB)
IMP
GO:0032753
O00182 (UniProtKB)
IDA
GO:0032753
O00182 (UniProtKB)
IMP
GO:0032834
O00182 (UniProtKB)
IDA
GO:0038066
O00182 (UniProtKB)
IDA
GO:0042346
O00182 (UniProtKB)
IMP
GO:0043123
O00182 (UniProtKB)
IMP
GO:0043305
O00182 (UniProtKB)
IMP
GO:0045953
O00182 (UniProtKB)
IDA
GO:0046007
O00182 (UniProtKB)
IMP
GO:0046598
O00182 (UniProtKB)
IDA
GO:0048030
O00182 (UniProtKB)
IMP
GO:0050718
O00182 (UniProtKB)
IDA
GO:0051092
O00182 (UniProtKB)
IMP
GO:0060135
O00182 (UniProtKB)
IDA
GO:0070062
O00182 (UniProtKB)
IDA
GO:0070241
O00182 (UniProtKB)
IDA
GO:0070371
O00182 (UniProtKB)
IDA
GO:0070374
O00182 (UniProtKB)
IMP
GO:0070374
O00182 (UniProtKB)
IMP
GO:0070555
O00182 (UniProtKB)
IDA
GO:0071346
O00182 (UniProtKB)
IDA
GO:0071636
O00182 (UniProtKB)
IDA
GO:0071639
O00182 (UniProtKB)
IMP
GO:0098586
O00182 (UniProtKB)
IMP
GO:1902715
O00182 (UniProtKB)
IDA
GO:1904469
O00182 (UniProtKB)
IDA
GO:2000484
O00182 (UniProtKB)
IMP
GO:2000510
O00182 (UniProtKB)
IMP
GO:2000562
O00182 (UniProtKB)
IDA
GO:2000563
O00182 (UniProtKB)
IDA
GO:2000667
O00182 (UniProtKB)
IDA
GO:2000670
O00182 (UniProtKB)
IDA
GO:2000778
O00182 (UniProtKB)
IMP
GO:2001181
O00182 (UniProtKB)
IDA
GO:2001181
O00182 (UniProtKB)
IDA
GO:2001184
O00182 (UniProtKB)
IMP
GO:2001184
O00182 (UniProtKB)
IMP
GO:2001190
O00182 (UniProtKB)
IDA
GO:2001200
O00182 (UniProtKB)
IMP
GO:2001269
O00182 (UniProtKB)
IMP
GO:0032673
O00182 (UniProtKB)
IDA
GO:0032674
O00182 (UniProtKB)
IDA
GO:0034134
O00182 (UniProtKB)
IDA
GO:0034142
O00182 (UniProtKB)
IDA
GO:0097029
O00182 (UniProtKB)
IMP
GO:1900744
O00182 (UniProtKB)
IMP

可能调控 LGALS9基因的相关microRNA:     

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称
疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Nephritis 0.12 1 0 CTD_human
Meningitis, Pneumococcal 0.08 1 0 RGD
Squamous cell carcinoma 0.006263026 4 0 BeFree_LHGDN
Neoplasm Metastasis 0.00408156 5 0 BeFree_LHGDN
melanoma 0.003267234 2 0 BeFree_LHGDN
Rheumatoid Arthritis 0.002995792 2 0 BeFree_LHGDN
Aplastic Anemia 0.00272435 1 0 LHGDN
Mammary Neoplasms 0.00272435 1 0 LHGDN
Cervical Intraepithelial Neoplasia 0.00272435 1 0 LHGDN
Mouth Neoplasms 0.00272435 1 0 LHGDN

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