LDOC1 (LDOC1 regulator of NFKB signaling)
- symbol:
- LDOC1
- locus group:
- protein-coding gene
- location:
- Xq27.1
- gene_family:
- alias symbol:
- Mar7|Mart7|SIRH7|RTL7
- alias name:
- Sushi-Ichi retrotransposon homolog…
- entrez id:
- 23641
- ensembl gene id:
- ENSG00000182195
- ucsc gene id:
- uc004fbj.5
- refseq accession:
- NM_012317
- hgnc_id:
- HGNC:6548
- approved reserved:
- 2000-05-19
The protein encoded by this gene contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers. [provided by RefSeq, Jul 2008]
由该基因编码的蛋白质中含有一个亮氨酸拉链样基序和股标有SH3结合域相似性的富含脯氨酸的区域。该蛋白定位于细胞核，在某些肿瘤细胞系被下调。它被认为是调节由核因子κB（NF-κB的）介导的转录反应。的基因已经被提出作为一种肿瘤抑制基因，其蛋白产物可能在一些癌症的发展和/或进展中起重要作用。 [由RefSeq的规定，2008年7月]
基因本体信息
LDOC1基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
LDOC1基因的本体（GO）信息：
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Pancreatic Neoplasm | 0.00272435 | 1 | 0 | LHGDN |
| Squamous cell carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Carcinogenesis | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of pancreas | 0.000271442 | 1 | 0 | BeFree |
| Chronic Lymphocytic Leukemia | 0.000271442 | 1 | 0 | BeFree |
| Hypertensive disease | 0.000271442 | 1 | 0 | BeFree |
| Pancreatic carcinoma | 0.000271442 | 1 | 0 | BeFree |
微信公众号
关注微信订阅号，实时查看信息，关注医学生物学动态。
版权所有 © 2025.Genelibs 济南弘晖生物技术有限公司 鲁ICP备13024435号-2
