LASP1 (LIM and SH3 protein 1)
- symbol:
- LASP1
- locus group:
- protein-coding gene
- location:
- 17q12
- gene_family:
- alias symbol:
- MLN50|Lasp-1
- alias name:
- None
- entrez id:
- 3927
- ensembl gene id:
- ENSG00000002834
- ucsc gene id:
- uc002hra.3
- refseq accession:
- NM_006148
- hgnc_id:
- HGNC:6513
- approved reserved:
- 1997-05-22
This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer. [provided by RefSeq, Oct 2012]
该基因编码的LIM蛋白的亚家族，其特征在于一个LIM基序的一个成员，Src同源区3的一个结构域，并且也伴肌家族肌动蛋白结合蛋白的成员。所编码的蛋白质是一个cAMP和cGMP依赖性信号蛋白和细胞膜的扩展结合到肌动蛋白细胞骨架。所编码的蛋白质已被链接到转移性乳腺癌，造血肿瘤如B细胞淋巴瘤，和结肠直肠癌。 [由RefSeq的，2012年10月提供]
基因本体信息
LASP1基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
LASP1基因的本体（GO）信息：
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Autistic Disorder | 0.122638474 | 1 | 0 | BeFree_CTD_human_GAD |
| Neoplasm Metastasis | 0.002442977 | 9 | 0 | BeFree |
| Malignant neoplasm of breast | 0.002442977 | 9 | 0 | BeFree |
| Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
| Breast Carcinoma | 0.002171535 | 8 | 0 | BeFree |
| Liver carcinoma | 0.001085767 | 4 | 0 | BeFree |
| Colorectal Cancer | 0.000814326 | 3 | 0 | BeFree |
| Colorectal Carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Carcinoma of bladder | 0.000814326 | 3 | 0 | BeFree |
| Malignant neoplasm of urinary bladder | 0.000814326 | 3 | 0 | BeFree |
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