KLRG1 (killer cell lectin like receptor G1)
- symbol:
- KLRG1
- locus group:
- protein-coding gene
- location:
- 12p13.31
- gene_family:
- C-type lectin domain family|Killer cell lectin-like receptors
- alias symbol:
- MAFA|2F1|MAFA-L|CLEC15A
- alias name:
- C-type lectin domain family 15, me…
- entrez id:
- 10219
- ensembl gene id:
- ENSG00000139187
- ucsc gene id:
- uc001qvg.4
- refseq accession:
- NM_005810
- hgnc_id:
- HGNC:6380
- approved reserved:
- 1999-09-17
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor (KLR) family, which is a group of transmembrane proteins preferentially expressed in NK cells. Studies in mice suggested that the expression of this gene may be regulated by MHC class I molecules. Alternatively spliced transcript variants have been reported, but their full-length natures have not yet been determined. [provided by RefSeq, Jul 2008]
自然杀伤（NK）细胞是可介导某些肿瘤细胞和病毒感染细胞的裂解而不先前活化淋巴细胞。它们还可以调节特异性体液和细胞介导的??免疫。由该基因编码的蛋白质属于杀伤细胞凝集素样受体（KLR）的家族，其是一组中的NK细胞中优先表达的跨膜蛋白。在小鼠中的研究表明，该基因的表达可以通过MHC I类分子来调节。可变剪接转录物变体已有报道，但是它们的全长性质尚未确定。 [由RefSeq的，2008年7月提供]
基因本体信息
KLRG1基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
KLRG1基因的本体（GO）信息：
| 名称 |
|---|
| Adaptive Immune System |
| Immune System |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Influenza | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Infection | 0.00272435 | 1 | 0 | LHGDN |
| Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
| Virus Diseases | 0.000814326 | 3 | 0 | BeFree |
| Diabetes Mellitus, Non-Insulin-Dependent | 0.000542884 | 2 | 0 | BeFree |
| Diabetes Mellitus | 0.000542884 | 2 | 0 | BeFree |
| Chronic Lymphocytic Leukemia | 0.000271442 | 1 | 0 | BeFree |
| Diabetes | 0.000271442 | 1 | 0 | BeFree |
| Hepatitis C | 0.000271442 | 1 | 0 | BeFree |
| Tuberculosis | 0.000271442 | 1 | 0 | BeFree |
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