KLRC2 (killer cell lectin like receptor C2)
- symbol:
- KLRC2
- locus group:
- protein-coding gene
- location:
- 12p13.2
- gene_family:
- CD molecules|Killer cell lectin-like receptors
- alias symbol:
- NKG2-C|CD159c|NKG2C
- alias name:
- NKG2-C type II integral membrane p…
- entrez id:
- 3822
- ensembl gene id:
- ENSG00000205809
- ucsc gene id:
- uc001qyk.4
- refseq accession:
- NM_002260
- hgnc_id:
- HGNC:6375
- approved reserved:
- 1998-01-16
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The group, designated KLRC (NKG2) are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. KLRC2 alternative splice variants have been described but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
自然杀伤（NK）细胞是可介导某些肿瘤细胞和病毒感染细胞的裂解而不先前活化淋巴细胞。它们还可以调节特异性体液和细胞介导的??免疫。 NK细胞优先表达几种钙依赖性（C型）凝集素，已在NK细胞功能的调节有牵连。的组中，指定KLRC（NKG2）表示主要在自然杀伤（NK）细胞和编码一个家族的跨膜蛋白特征在于II型膜取向（胞外C末端）和C型凝集素结构域的存在。所述KLRC（NKG2）基因家族位于NK复杂，它包含在NK细胞中优先表达的几种C-型凝集素基因的区域内。 KLRC2备选剪接变体已被描述，但是它们的全长性质尚未确定。 [由RefSeq的，2008年7月提供]
基因本体信息
KLRC2基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
KLRC2基因的本体（GO）信息：
| 名称 |
|---|
| 4650 Natural killer cell mediated cytotoxicity [PATH:hsa04650] |
| 4612 Antigen processing and presentation [PATH:hsa04612] |
| 名称 |
|---|
| DAP12 interactions |
| DAP12 signaling |
| Immune System |
| Innate Immune System |
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Creutzfeldt-Jakob disease | 0.12 | 1 | 0 | CTD_human |
| Rheumatoid Arthritis | 0.00554839 | 3 | 0 | BeFree_GAD |
| Rheumatism | 0.002367032 | 1 | 0 | GAD |
| Lupus Erythematosus | 0.002367032 | 1 | 0 | GAD |
| Behcet Syndrome | 0.002367032 | 1 | 0 | GAD |
| Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
| Cytomegalovirus Infections | 0.001085767 | 4 | 0 | BeFree |
| Lupus Erythematosus, Systemic | 0.000814326 | 3 | 0 | BeFree |
| Coinfection | 0.000542884 | 2 | 0 | BeFree |
| HIV Infections | 0.000542884 | 2 | 0 | BeFree |
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