KLRB1 (killer cell lectin like receptor B1)
- symbol:
- KLRB1
- locus group:
- protein-coding gene
- location:
- 12p13.31
- gene_family:
- CD molecules|C-type lectin domain family|Killer cell lectin-like receptors
- alias symbol:
- CD161|NKR-P1|NKR-P1A|hNKR-P1A|CLEC5B
- alias name:
- natural killer cell surface protei…
- entrez id:
- 3820
- ensembl gene id:
- ENSG00000111796
- ucsc gene id:
- uc010sgt.3
- refseq accession:
- NM_002258
- hgnc_id:
- HGNC:6373
- approved reserved:
- 1998-01-16
Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus. [provided by RefSeq, Jul 2008]
自然杀伤（NK）细胞是介导的细胞毒性和免疫刺激后分泌的细胞因子的淋巴细胞。的C型凝集素超家族的几个基因，包括啮齿动物NKRP1家族的糖蛋白，是由NK细胞表达，并可能参与NK细胞功能的调节。该KLRB1蛋白含有与C型凝集素的几个图案特性，跨膜结构域和胞质结构域的胞外域。所述KLRB1蛋白被分类为II型膜蛋白，因为它有一个外部C末端。 [由RefSeq的，2008年7月提供]
基因本体信息
KLRB1基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
KLRB1基因的本体（GO）信息：
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| melanoma | 0.12 | 1 | 0 | CTD_human |
| Multiple Sclerosis | 0.005276948 | 4 | 1 | BeFree_GAD |
| Hepatitis C | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Intermittent Claudication | 0.00272435 | 1 | 0 | LHGDN |
| HIV Infections | 0.001900093 | 7 | 0 | BeFree |
| Rheumatoid Arthritis | 0.000814326 | 3 | 0 | BeFree |
| Lymphoproliferative Disorders | 0.000542884 | 2 | 0 | BeFree |
| Eclampsia | 0.000271442 | 1 | 0 | BeFree |
| Hepatitis A | 0.000271442 | 1 | 0 | BeFree |
| Viral respiratory infection | 0.000271442 | 1 | 0 | BeFree |
微信公众号
关注微信订阅号，实时查看信息，关注医学生物学动态。
版权所有 © 2025.Genelibs 济南弘晖生物技术有限公司 鲁ICP备13024435号-2
