KLK3 (kallikrein related peptidase 3)
- symbol:
- KLK3
- locus group:
- protein-coding gene
- location:
- 19q13.33
- gene_family:
- Kallikreins
- alias symbol:
- PSA
- alias name:
- prostate specific antigen
- entrez id:
- 354
- ensembl gene id:
- ENSG00000142515
- ucsc gene id:
- uc021uyi.2
- refseq accession:
- NM_145864
- hgnc_id:
- HGNC:6364
- approved reserved:
- 2001-06-22
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
激肽释放酶是具有多种生理功能的丝氨酸蛋白酶的一个亚组。越来越多的证据表明，许多激肽释放酶在肿瘤发生牵连，部分为新的癌症和其他疾病的生物标志物的潜力。这个基因是位于集群染色体19上其蛋白产物是一个存在于精浆蛋白酶十五激肽释放酶亚家族成员之一。它被认为可能是通过将高分子量精囊蛋白水解精浆凝结物的液化正常工作。这种蛋白质，称为PSA在临床上的血清水平，是在前列腺癌的诊断和监测是有用的。该基因的可变剪接产生编码不同亚型的几个抄本变形。 [由RefSeq的，2008年7月提供]
基因本体信息
KLK3基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
KLK3基因的本体（GO）信息：
| 名称 |
|---|
| 5200 Pathways in cancer [PATH:hsa05200] |
| 5215 Prostate cancer [PATH:hsa05215] |
| 名称 |
|---|
| Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
| Metabolism of proteins |
| Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| RHO GTPase Effectors |
| RHO GTPases activate PKNs |
| Signal Transduction |
| Signaling by Rho GTPases |
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Malignant neoplasm of prostate | 0.261542831 | 781 | 17 | BeFree_GAD_GWASCAT |
| Prostatic Neoplasms | 0.21287732 | 75 | 1 | BeFree_CTD_human_GAD_LHGDN |
| Prostatic Hyperplasia | 0.130540083 | 5 | 0 | CTD_human_GAD_LHGDN |
| Disease Progression | 0.12 | 1 | 0 | CTD_human |
| Neoplasm Recurrence, Local | 0.12 | 1 | 0 | CTD_human |
| Malignant Phyllodes Tumor of Prostate | 0.12 | 1 | 0 | CTD_human |
| Prostate carcinoma | 0.08 | 776 | 17 | BeFree |
| Neoplasm Metastasis | 0.021367963 | 71 | 3 | BeFree_GAD |
| Mammary Neoplasms | 0.014426145 | 17 | 0 | BeFree_LHGDN |
| Benign Prostatic Hyperplasia | 0.014386419 | 53 | 1 | BeFree |
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